LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Aminotransferase class IV - putative
Species:
Leishmania infantum
UniProt:
A4I9Z9_LEIIN
TriTrypDb:
LINF_340029500
Length:
385

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4I9Z9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9Z9

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044281 small molecule metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0008483 transaminase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016769 transferase activity, transferring nitrogenous groups 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 242 246 PF00656 0.576
CLV_NRD_NRD_1 335 337 PF00675 0.460
CLV_NRD_NRD_1 40 42 PF00675 0.470
CLV_PCSK_KEX2_1 335 337 PF00082 0.460
CLV_PCSK_KEX2_1 40 42 PF00082 0.433
CLV_PCSK_SKI1_1 155 159 PF00082 0.304
CLV_PCSK_SKI1_1 303 307 PF00082 0.329
CLV_PCSK_SKI1_1 309 313 PF00082 0.260
DEG_Nend_UBRbox_1 1 4 PF02207 0.450
DOC_CYCLIN_yCln2_LP_2 119 125 PF00134 0.453
DOC_CYCLIN_yCln2_LP_2 362 368 PF00134 0.347
DOC_MAPK_DCC_7 359 368 PF00069 0.342
DOC_MAPK_gen_1 97 105 PF00069 0.451
DOC_MAPK_MEF2A_6 196 205 PF00069 0.453
DOC_PP1_RVXF_1 156 163 PF00149 0.438
DOC_PP1_RVXF_1 307 313 PF00149 0.551
DOC_PP2B_LxvP_1 119 122 PF13499 0.494
DOC_PP2B_LxvP_1 124 127 PF13499 0.494
DOC_PP4_FxxP_1 176 179 PF00568 0.487
DOC_USP7_MATH_1 10 14 PF00917 0.456
DOC_USP7_MATH_1 185 189 PF00917 0.525
DOC_USP7_MATH_1 190 194 PF00917 0.543
DOC_USP7_MATH_1 250 254 PF00917 0.438
DOC_USP7_MATH_1 322 326 PF00917 0.533
DOC_USP7_MATH_1 59 63 PF00917 0.452
DOC_USP7_MATH_1 72 76 PF00917 0.427
DOC_USP7_MATH_2 127 133 PF00917 0.418
DOC_USP7_UBL2_3 299 303 PF12436 0.533
DOC_WW_Pin1_4 141 146 PF00397 0.453
DOC_WW_Pin1_4 314 319 PF00397 0.458
DOC_WW_Pin1_4 61 66 PF00397 0.454
LIG_14-3-3_CanoR_1 112 118 PF00244 0.533
LIG_14-3-3_CanoR_1 27 33 PF00244 0.530
LIG_14-3-3_CanoR_1 41 51 PF00244 0.322
LIG_Actin_WH2_2 288 305 PF00022 0.533
LIG_APCC_ABBA_1 326 331 PF00400 0.358
LIG_BIR_III_2 84 88 PF00653 0.504
LIG_FHA_1 112 118 PF00498 0.501
LIG_FHA_1 281 287 PF00498 0.451
LIG_FHA_2 299 305 PF00498 0.555
LIG_LIR_Apic_2 174 179 PF02991 0.550
LIG_LIR_Apic_2 245 250 PF02991 0.496
LIG_LIR_Gen_1 57 66 PF02991 0.457
LIG_LIR_Gen_1 86 96 PF02991 0.467
LIG_LIR_Nem_3 282 287 PF02991 0.548
LIG_LIR_Nem_3 57 61 PF02991 0.405
LIG_LIR_Nem_3 86 92 PF02991 0.407
LIG_PCNA_yPIPBox_3 155 163 PF02747 0.587
LIG_Pex14_2 51 55 PF04695 0.363
LIG_SH2_CRK 284 288 PF00017 0.487
LIG_SH2_CRK 89 93 PF00017 0.427
LIG_SH2_SRC 141 144 PF00017 0.533
LIG_SH2_SRC 148 151 PF00017 0.546
LIG_SH2_SRC 338 341 PF00017 0.394
LIG_SH2_STAP1 109 113 PF00017 0.481
LIG_SH2_STAP1 235 239 PF00017 0.533
LIG_SH2_STAP1 338 342 PF00017 0.522
LIG_SH2_STAT3 257 260 PF00017 0.533
LIG_SH2_STAT5 141 144 PF00017 0.478
LIG_SH2_STAT5 148 151 PF00017 0.475
LIG_SH2_STAT5 228 231 PF00017 0.555
LIG_SH2_STAT5 247 250 PF00017 0.451
LIG_SH2_STAT5 257 260 PF00017 0.439
LIG_SH2_STAT5 378 381 PF00017 0.450
LIG_SH2_STAT5 5 8 PF00017 0.446
LIG_SUMO_SIM_anti_2 236 242 PF11976 0.451
LIG_SUMO_SIM_par_1 236 242 PF11976 0.451
LIG_SUMO_SIM_par_1 64 70 PF11976 0.403
LIG_SxIP_EBH_1 155 169 PF03271 0.453
LIG_TRAF2_1 269 272 PF00917 0.469
LIG_TYR_ITSM 280 287 PF00017 0.418
LIG_UBA3_1 181 186 PF00899 0.477
LIG_UBA3_1 274 281 PF00899 0.555
LIG_WRC_WIRS_1 55 60 PF05994 0.436
MOD_CK1_1 188 194 PF00069 0.502
MOD_CK1_1 262 268 PF00069 0.541
MOD_CK2_1 105 111 PF00069 0.487
MOD_CK2_1 266 272 PF00069 0.478
MOD_GlcNHglycan 268 271 PF01048 0.347
MOD_GlcNHglycan 60 64 PF01048 0.442
MOD_GlcNHglycan 74 77 PF01048 0.347
MOD_GSK3_1 111 118 PF00069 0.445
MOD_GSK3_1 129 136 PF00069 0.459
MOD_GSK3_1 163 170 PF00069 0.433
MOD_GSK3_1 184 191 PF00069 0.518
MOD_GSK3_1 19 26 PF00069 0.579
MOD_GSK3_1 262 269 PF00069 0.501
MOD_GSK3_1 276 283 PF00069 0.518
MOD_NEK2_1 105 110 PF00069 0.540
MOD_NEK2_1 113 118 PF00069 0.461
MOD_NEK2_1 133 138 PF00069 0.470
MOD_NEK2_1 184 189 PF00069 0.459
MOD_NEK2_1 23 28 PF00069 0.510
MOD_NEK2_1 280 285 PF00069 0.509
MOD_NEK2_1 345 350 PF00069 0.551
MOD_NEK2_1 54 59 PF00069 0.449
MOD_NEK2_2 190 195 PF00069 0.510
MOD_NEK2_2 298 303 PF00069 0.487
MOD_PIKK_1 373 379 PF00454 0.291
MOD_PKA_2 111 117 PF00069 0.508
MOD_Plk_1 19 25 PF00069 0.461
MOD_Plk_4 129 135 PF00069 0.530
MOD_Plk_4 158 164 PF00069 0.483
MOD_Plk_4 190 196 PF00069 0.465
MOD_Plk_4 262 268 PF00069 0.530
MOD_Plk_4 316 322 PF00069 0.537
MOD_Plk_4 4 10 PF00069 0.605
MOD_ProDKin_1 141 147 PF00069 0.453
MOD_ProDKin_1 314 320 PF00069 0.458
MOD_ProDKin_1 61 67 PF00069 0.455
MOD_SUMO_for_1 358 361 PF00179 0.268
MOD_SUMO_rev_2 304 311 PF00179 0.487
MOD_SUMO_rev_2 356 360 PF00179 0.470
TRG_DiLeu_BaEn_1 129 134 PF01217 0.453
TRG_DiLeu_BaEn_1 271 276 PF01217 0.469
TRG_ENDOCYTIC_2 235 238 PF00928 0.506
TRG_ENDOCYTIC_2 284 287 PF00928 0.533
TRG_ENDOCYTIC_2 5 8 PF00928 0.446
TRG_ENDOCYTIC_2 89 92 PF00928 0.363
TRG_ENDOCYTIC_2 93 96 PF00928 0.447
TRG_ER_diArg_1 335 337 PF00400 0.375
TRG_ER_diArg_1 39 41 PF00400 0.475
TRG_ER_diArg_1 96 99 PF00400 0.458

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDK5 Leptomonas seymouri 63% 100%
A0A1X0PAI4 Trypanosomatidae 38% 100%
A0A3Q8IUN5 Leishmania donovani 98% 100%
A0A3R7NT31 Trypanosoma rangeli 35% 100%
A4HAV2 Leishmania braziliensis 83% 100%
C9ZML4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 99%
E9B527 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q2V9 Leishmania major 90% 100%
V5B0F3 Trypanosoma cruzi 33% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS