Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9Z3_LEIIN

TriTrypDb:

LINF_340027500

Length:

954

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9Z3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.645
CLV_C14_Caspase3-7	33	37	PF00656	0.666
CLV_NRD_NRD_1	137	139	PF00675	0.602
CLV_NRD_NRD_1	746	748	PF00675	0.709
CLV_NRD_NRD_1	783	785	PF00675	0.649
CLV_NRD_NRD_1	875	877	PF00675	0.559
CLV_NRD_NRD_1	882	884	PF00675	0.552
CLV_PCSK_KEX2_1	137	139	PF00082	0.602
CLV_PCSK_KEX2_1	746	748	PF00082	0.709
CLV_PCSK_KEX2_1	782	784	PF00082	0.642
CLV_PCSK_KEX2_1	875	877	PF00082	0.559
CLV_PCSK_KEX2_1	882	884	PF00082	0.552
CLV_PCSK_PC7_1	742	748	PF00082	0.569
CLV_PCSK_PC7_1	779	785	PF00082	0.645
CLV_PCSK_SKI1_1	175	179	PF00082	0.641
CLV_PCSK_SKI1_1	631	635	PF00082	0.688
CLV_PCSK_SKI1_1	771	775	PF00082	0.677
DEG_SCF_FBW7_1	449	456	PF00400	0.734
DEG_SCF_FBW7_1	554	560	PF00400	0.724
DEG_SCF_FBW7_1	568	573	PF00400	0.588
DEG_SCF_FBW7_1	705	711	PF00400	0.645
DEG_SPOP_SBC_1	327	331	PF00917	0.590
DEG_SPOP_SBC_1	59	63	PF00917	0.639
DOC_CDC14_PxL_1	430	438	PF14671	0.682
DOC_CKS1_1	341	346	PF01111	0.644
DOC_CKS1_1	386	391	PF01111	0.728
DOC_CKS1_1	416	421	PF01111	0.692
DOC_CKS1_1	554	559	PF01111	0.726
DOC_CKS1_1	693	698	PF01111	0.649
DOC_CKS1_1	705	710	PF01111	0.548
DOC_CKS1_1	904	909	PF01111	0.566
DOC_CYCLIN_RxL_1	172	182	PF00134	0.640
DOC_MAPK_MEF2A_6	350	357	PF00069	0.646
DOC_MAPK_MEF2A_6	821	830	PF00069	0.753
DOC_MAPK_NFAT4_5	350	358	PF00069	0.646
DOC_PP1_RVXF_1	173	179	PF00149	0.645
DOC_PP1_RVXF_1	769	775	PF00149	0.566
DOC_PP2B_LxvP_1	230	233	PF13499	0.617
DOC_PP4_FxxP_1	341	344	PF00568	0.654
DOC_PP4_FxxP_1	416	419	PF00568	0.692
DOC_PP4_FxxP_1	728	731	PF00568	0.595
DOC_PP4_FxxP_1	843	846	PF00568	0.618
DOC_USP7_MATH_1	15	19	PF00917	0.638
DOC_USP7_MATH_1	257	261	PF00917	0.635
DOC_USP7_MATH_1	267	271	PF00917	0.553
DOC_USP7_MATH_1	328	332	PF00917	0.632
DOC_USP7_MATH_1	373	377	PF00917	0.661
DOC_USP7_MATH_1	453	457	PF00917	0.736
DOC_USP7_MATH_1	461	465	PF00917	0.649
DOC_USP7_MATH_1	496	500	PF00917	0.642
DOC_USP7_MATH_1	504	508	PF00917	0.620
DOC_USP7_MATH_1	557	561	PF00917	0.728
DOC_USP7_MATH_1	58	62	PF00917	0.559
DOC_USP7_MATH_1	659	663	PF00917	0.611
DOC_USP7_MATH_1	686	690	PF00917	0.651
DOC_USP7_MATH_1	708	712	PF00917	0.684
DOC_USP7_MATH_1	81	85	PF00917	0.575
DOC_USP7_MATH_1	826	830	PF00917	0.615
DOC_USP7_MATH_1	832	836	PF00917	0.580
DOC_WW_Pin1_4	163	168	PF00397	0.549
DOC_WW_Pin1_4	20	25	PF00397	0.652
DOC_WW_Pin1_4	215	220	PF00397	0.649
DOC_WW_Pin1_4	225	230	PF00397	0.600
DOC_WW_Pin1_4	263	268	PF00397	0.631
DOC_WW_Pin1_4	309	314	PF00397	0.667
DOC_WW_Pin1_4	321	326	PF00397	0.650
DOC_WW_Pin1_4	340	345	PF00397	0.500
DOC_WW_Pin1_4	365	370	PF00397	0.715
DOC_WW_Pin1_4	385	390	PF00397	0.534
DOC_WW_Pin1_4	401	406	PF00397	0.580
DOC_WW_Pin1_4	415	420	PF00397	0.547
DOC_WW_Pin1_4	449	454	PF00397	0.808
DOC_WW_Pin1_4	455	460	PF00397	0.704
DOC_WW_Pin1_4	479	484	PF00397	0.686
DOC_WW_Pin1_4	539	544	PF00397	0.661
DOC_WW_Pin1_4	553	558	PF00397	0.614
DOC_WW_Pin1_4	566	571	PF00397	0.601
DOC_WW_Pin1_4	60	65	PF00397	0.640
DOC_WW_Pin1_4	605	610	PF00397	0.686
DOC_WW_Pin1_4	625	630	PF00397	0.518
DOC_WW_Pin1_4	692	697	PF00397	0.711
DOC_WW_Pin1_4	704	709	PF00397	0.671
DOC_WW_Pin1_4	712	717	PF00397	0.574
DOC_WW_Pin1_4	790	795	PF00397	0.720
DOC_WW_Pin1_4	802	807	PF00397	0.551
DOC_WW_Pin1_4	822	827	PF00397	0.609
DOC_WW_Pin1_4	903	908	PF00397	0.719
LIG_14-3-3_CanoR_1	12	19	PF00244	0.605
LIG_14-3-3_CanoR_1	193	198	PF00244	0.574
LIG_14-3-3_CanoR_1	372	381	PF00244	0.671
LIG_14-3-3_CanoR_1	497	506	PF00244	0.620
LIG_14-3-3_CanoR_1	547	557	PF00244	0.689
LIG_14-3-3_CanoR_1	782	792	PF00244	0.610
LIG_14-3-3_CanoR_1	88	96	PF00244	0.618
LIG_14-3-3_CanoR_1	886	892	PF00244	0.643
LIG_14-3-3_CanoR_1	897	904	PF00244	0.621
LIG_Actin_WH2_2	98	113	PF00022	0.611
LIG_APCC_ABBAyCdc20_2	631	637	PF00400	0.661
LIG_BRCT_BRCA1_1	248	252	PF00533	0.574
LIG_BRCT_BRCA1_1	46	50	PF00533	0.595
LIG_BRCT_BRCA1_1	578	582	PF00533	0.672
LIG_BRCT_BRCA1_1	607	611	PF00533	0.576
LIG_Clathr_ClatBox_1	827	831	PF01394	0.638
LIG_CSL_BTD_1	554	557	PF09270	0.727
LIG_EVH1_2	153	157	PF00568	0.560
LIG_FHA_1	299	305	PF00498	0.692
LIG_FHA_1	344	350	PF00498	0.547
LIG_FHA_1	501	507	PF00498	0.597
LIG_FHA_1	549	555	PF00498	0.762
LIG_FHA_1	674	680	PF00498	0.705
LIG_FHA_1	700	706	PF00498	0.687
LIG_FHA_1	731	737	PF00498	0.574
LIG_FHA_1	807	813	PF00498	0.578
LIG_FHA_1	860	866	PF00498	0.630
LIG_FHA_1	945	951	PF00498	0.639
LIG_FXI_DFP_1	583	587	PF00024	0.663
LIG_HP1_1	826	830	PF01393	0.661
LIG_LIR_Apic_2	339	344	PF02991	0.657
LIG_LIR_Apic_2	414	419	PF02991	0.691
LIG_LIR_Apic_2	726	731	PF02991	0.599
LIG_LIR_Gen_1	181	192	PF02991	0.636
LIG_LIR_Gen_1	404	413	PF02991	0.654
LIG_LIR_Gen_1	859	869	PF02991	0.543
LIG_LIR_LC3C_4	651	654	PF02991	0.579
LIG_LIR_Nem_3	181	187	PF02991	0.626
LIG_LIR_Nem_3	404	410	PF02991	0.659
LIG_LIR_Nem_3	427	433	PF02991	0.684
LIG_LIR_Nem_3	608	614	PF02991	0.570
LIG_LIR_Nem_3	859	864	PF02991	0.534
LIG_LIR_Nem_3	929	935	PF02991	0.631
LIG_LYPXL_yS_3	433	436	PF13949	0.687
LIG_MYND_1	229	233	PF01753	0.620
LIG_PDZ_Class_1	949	954	PF00595	0.639
LIG_PDZ_Wminus1_1	952	954	PF00595	0.649
LIG_Pex14_1	857	861	PF04695	0.617
LIG_Pex14_2	582	586	PF04695	0.662
LIG_Pex14_2	949	953	PF04695	0.637
LIG_SH2_CRK	911	915	PF00017	0.610
LIG_SH2_STAT5	525	528	PF00017	0.685
LIG_SH2_STAT5	735	738	PF00017	0.723
LIG_SH2_STAT5	932	935	PF00017	0.647
LIG_SH3_2	594	599	PF14604	0.597
LIG_SH3_3	102	108	PF00018	0.575
LIG_SH3_3	322	328	PF00018	0.681
LIG_SH3_3	375	381	PF00018	0.681
LIG_SH3_3	551	557	PF00018	0.723
LIG_SH3_3	565	571	PF00018	0.593
LIG_SH3_3	589	595	PF00018	0.708
LIG_SH3_3	814	820	PF00018	0.770
LIG_SH3_3	901	907	PF00018	0.567
LIG_SH3_5	41	45	PF00018	0.592
LIG_Sin3_3	74	81	PF02671	0.542
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.553
LIG_SUMO_SIM_anti_2	678	683	PF11976	0.632
LIG_SUMO_SIM_par_1	825	831	PF11976	0.674
LIG_SxIP_EBH_1	418	428	PF03271	0.685
LIG_TRAF2_1	133	136	PF00917	0.602
LIG_TRAF2_1	639	642	PF00917	0.703
LIG_WRC_WIRS_1	861	866	PF05994	0.544
LIG_WW_3	218	222	PF00397	0.657
LIG_WW_3	628	632	PF00397	0.589
LIG_WW_3	818	822	PF00397	0.608
MOD_CDC14_SPxK_1	347	350	PF00782	0.647
MOD_CDC14_SPxK_1	542	545	PF00782	0.652
MOD_CDC14_SPxK_1	628	631	PF00782	0.673
MOD_CDK_SPK_2	449	454	PF00069	0.672
MOD_CDK_SPK_2	692	697	PF00069	0.711
MOD_CDK_SPxK_1	215	221	PF00069	0.653
MOD_CDK_SPxK_1	344	350	PF00069	0.660
MOD_CDK_SPxK_1	415	421	PF00069	0.690
MOD_CDK_SPxK_1	539	545	PF00069	0.649
MOD_CDK_SPxK_1	625	631	PF00069	0.672
MOD_CDK_SPxxK_3	365	372	PF00069	0.658
MOD_CDK_SPxxK_3	387	394	PF00069	0.730
MOD_CK1_1	11	17	PF00069	0.608
MOD_CK1_1	163	169	PF00069	0.566
MOD_CK1_1	188	194	PF00069	0.652
MOD_CK1_1	260	266	PF00069	0.632
MOD_CK1_1	270	276	PF00069	0.560
MOD_CK1_1	281	287	PF00069	0.554
MOD_CK1_1	331	337	PF00069	0.583
MOD_CK1_1	385	391	PF00069	0.682
MOD_CK1_1	528	534	PF00069	0.662
MOD_CK1_1	537	543	PF00069	0.601
MOD_CK1_1	560	566	PF00069	0.839
MOD_CK1_1	723	729	PF00069	0.608
MOD_CK1_1	860	866	PF00069	0.630
MOD_CK1_1	898	904	PF00069	0.634
MOD_CK2_1	406	412	PF00069	0.657
MOD_CK2_1	504	510	PF00069	0.624
MOD_CK2_1	570	576	PF00069	0.712
MOD_CK2_1	794	800	PF00069	0.743
MOD_CK2_1	841	847	PF00069	0.560
MOD_DYRK1A_RPxSP_1	553	557	PF00069	0.727
MOD_GlcNHglycan	13	16	PF01048	0.564
MOD_GlcNHglycan	141	144	PF01048	0.592
MOD_GlcNHglycan	162	165	PF01048	0.612
MOD_GlcNHglycan	190	193	PF01048	0.569
MOD_GlcNHglycan	248	251	PF01048	0.536
MOD_GlcNHglycan	280	283	PF01048	0.587
MOD_GlcNHglycan	306	310	PF01048	0.583
MOD_GlcNHglycan	330	333	PF01048	0.678
MOD_GlcNHglycan	338	341	PF01048	0.676
MOD_GlcNHglycan	36	39	PF01048	0.650
MOD_GlcNHglycan	375	378	PF01048	0.706
MOD_GlcNHglycan	430	433	PF01048	0.704
MOD_GlcNHglycan	455	458	PF01048	0.719
MOD_GlcNHglycan	463	466	PF01048	0.675
MOD_GlcNHglycan	527	530	PF01048	0.628
MOD_GlcNHglycan	588	591	PF01048	0.664
MOD_GlcNHglycan	623	626	PF01048	0.708
MOD_GlcNHglycan	684	687	PF01048	0.782
MOD_GlcNHglycan	688	691	PF01048	0.759
MOD_GlcNHglycan	768	771	PF01048	0.645
MOD_GlcNHglycan	83	86	PF01048	0.601
MOD_GlcNHglycan	878	882	PF01048	0.626
MOD_GlcNHglycan	91	94	PF01048	0.643
MOD_GlcNHglycan	944	947	PF01048	0.533
MOD_GSK3_1	11	18	PF00069	0.580
MOD_GSK3_1	156	163	PF00069	0.631
MOD_GSK3_1	182	189	PF00069	0.620
MOD_GSK3_1	240	247	PF00069	0.647
MOD_GSK3_1	256	263	PF00069	0.504
MOD_GSK3_1	30	37	PF00069	0.558
MOD_GSK3_1	305	312	PF00069	0.594
MOD_GSK3_1	327	334	PF00069	0.681
MOD_GSK3_1	336	343	PF00069	0.631
MOD_GSK3_1	357	364	PF00069	0.609
MOD_GSK3_1	40	47	PF00069	0.566
MOD_GSK3_1	411	418	PF00069	0.693
MOD_GSK3_1	420	427	PF00069	0.617
MOD_GSK3_1	445	452	PF00069	0.775
MOD_GSK3_1	453	460	PF00069	0.655
MOD_GSK3_1	496	503	PF00069	0.631
MOD_GSK3_1	524	531	PF00069	0.683
MOD_GSK3_1	549	556	PF00069	0.765
MOD_GSK3_1	566	573	PF00069	0.602
MOD_GSK3_1	577	584	PF00069	0.638
MOD_GSK3_1	621	628	PF00069	0.660
MOD_GSK3_1	641	648	PF00069	0.518
MOD_GSK3_1	682	689	PF00069	0.609
MOD_GSK3_1	704	711	PF00069	0.690
MOD_GSK3_1	790	797	PF00069	0.759
MOD_GSK3_1	802	809	PF00069	0.650
MOD_GSK3_1	822	829	PF00069	0.556
MOD_GSK3_1	856	863	PF00069	0.644
MOD_GSK3_1	917	924	PF00069	0.615
MOD_GSK3_1	935	942	PF00069	0.489
MOD_N-GLC_1	267	272	PF02516	0.547
MOD_N-GLC_1	334	339	PF02516	0.668
MOD_N-GLC_1	401	406	PF02516	0.570
MOD_N-GLC_1	802	807	PF02516	0.628
MOD_NEK2_1	112	117	PF00069	0.642
MOD_NEK2_1	357	362	PF00069	0.575
MOD_NEK2_1	436	441	PF00069	0.650
MOD_NEK2_1	720	725	PF00069	0.784
MOD_NEK2_1	830	835	PF00069	0.621
MOD_NEK2_1	864	869	PF00069	0.559
MOD_NEK2_1	877	882	PF00069	0.724
MOD_NEK2_1	895	900	PF00069	0.528
MOD_NEK2_1	916	921	PF00069	0.584
MOD_NEK2_1	939	944	PF00069	0.636
MOD_NEK2_1	949	954	PF00069	0.564
MOD_PIKK_1	103	109	PF00454	0.658
MOD_PIKK_1	299	305	PF00454	0.642
MOD_PIKK_1	498	504	PF00454	0.598
MOD_PIKK_1	560	566	PF00454	0.833
MOD_PIKK_1	730	736	PF00454	0.636
MOD_PIKK_1	783	789	PF00454	0.633
MOD_PIKK_1	830	836	PF00454	0.663
MOD_PKA_1	783	789	PF00069	0.586
MOD_PKA_2	11	17	PF00069	0.608
MOD_PKA_2	131	137	PF00069	0.570
MOD_PKA_2	453	459	PF00069	0.685
MOD_PKA_2	496	502	PF00069	0.687
MOD_PKA_2	548	554	PF00069	0.690
MOD_PKA_2	783	789	PF00069	0.616
MOD_PKA_2	896	902	PF00069	0.697
MOD_PKA_2	935	941	PF00069	0.628
MOD_PKB_1	547	555	PF00069	0.667
MOD_Plk_1	267	273	PF00069	0.549
MOD_Plk_1	537	543	PF00069	0.692
MOD_Plk_1	645	651	PF00069	0.706
MOD_Plk_1	851	857	PF00069	0.611
MOD_Plk_1	928	934	PF00069	0.619
MOD_Plk_2-3	641	647	PF00069	0.661
MOD_Plk_4	267	273	PF00069	0.587
MOD_Plk_4	45	51	PF00069	0.594
MOD_Plk_4	600	606	PF00069	0.650
MOD_Plk_4	648	654	PF00069	0.663
MOD_Plk_4	708	714	PF00069	0.665
MOD_Plk_4	723	729	PF00069	0.496
MOD_Plk_4	860	866	PF00069	0.570
MOD_Plk_4	928	934	PF00069	0.638
MOD_ProDKin_1	163	169	PF00069	0.548
MOD_ProDKin_1	20	26	PF00069	0.650
MOD_ProDKin_1	215	221	PF00069	0.653
MOD_ProDKin_1	225	231	PF00069	0.599
MOD_ProDKin_1	263	269	PF00069	0.631
MOD_ProDKin_1	309	315	PF00069	0.668
MOD_ProDKin_1	321	327	PF00069	0.648
MOD_ProDKin_1	340	346	PF00069	0.493
MOD_ProDKin_1	365	371	PF00069	0.717
MOD_ProDKin_1	385	391	PF00069	0.533
MOD_ProDKin_1	401	407	PF00069	0.582
MOD_ProDKin_1	415	421	PF00069	0.549
MOD_ProDKin_1	449	455	PF00069	0.809
MOD_ProDKin_1	457	463	PF00069	0.673
MOD_ProDKin_1	479	485	PF00069	0.684
MOD_ProDKin_1	539	545	PF00069	0.664
MOD_ProDKin_1	553	559	PF00069	0.612
MOD_ProDKin_1	566	572	PF00069	0.600
MOD_ProDKin_1	60	66	PF00069	0.642
MOD_ProDKin_1	605	611	PF00069	0.685
MOD_ProDKin_1	625	631	PF00069	0.521
MOD_ProDKin_1	692	698	PF00069	0.710
MOD_ProDKin_1	704	710	PF00069	0.673
MOD_ProDKin_1	712	718	PF00069	0.572
MOD_ProDKin_1	790	796	PF00069	0.722
MOD_ProDKin_1	802	808	PF00069	0.550
MOD_ProDKin_1	822	828	PF00069	0.610
MOD_ProDKin_1	903	909	PF00069	0.719
MOD_SUMO_rev_2	469	478	PF00179	0.641
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.629
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.647
TRG_ENDOCYTIC_2	433	436	PF00928	0.687
TRG_ER_diArg_1	149	152	PF00400	0.535
TRG_ER_diArg_1	220	223	PF00400	0.667
TRG_ER_diArg_1	544	547	PF00400	0.654
TRG_ER_diArg_1	782	784	PF00400	0.642
TRG_ER_diArg_1	874	876	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7X9	Leishmania donovani	99%	88%
A4HAT3	Leishmania braziliensis	57%	100%
E9B507	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q2X9	Leishmania major	85%	100%