LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Thioredoxin/Thioredoxin-like domain/Thioredoxin-like - putative
Species:
Leishmania infantum
UniProt:
A4I9Z2_LEIIN
TriTrypDb:
LINF_340027200
Length:
433

Annotations

Annotations by Jardim et al.

Redox homeostasis, thioredoxin, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 1
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005788 endoplasmic reticulum lumen 5 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I9Z2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9Z2

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0003756 protein disulfide isomerase activity 3 11
GO:0003824 catalytic activity 1 11
GO:0016853 isomerase activity 2 11
GO:0016860 intramolecular oxidoreductase activity 3 11
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0015035 protein-disulfide reductase activity 3 1
GO:0015036 disulfide oxidoreductase activity 4 1
GO:0016491 oxidoreductase activity 2 1
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.497
CLV_NRD_NRD_1 316 318 PF00675 0.538
CLV_PCSK_SKI1_1 146 150 PF00082 0.445
CLV_PCSK_SKI1_1 253 257 PF00082 0.377
CLV_PCSK_SKI1_1 398 402 PF00082 0.479
DEG_Nend_UBRbox_4 1 3 PF02207 0.527
DEG_SPOP_SBC_1 199 203 PF00917 0.354
DOC_MAPK_gen_1 165 172 PF00069 0.422
DOC_MAPK_gen_1 190 198 PF00069 0.525
DOC_MAPK_gen_1 317 327 PF00069 0.491
DOC_MAPK_MEF2A_6 165 172 PF00069 0.534
DOC_MAPK_MEF2A_6 190 198 PF00069 0.557
DOC_MAPK_MEF2A_6 290 298 PF00069 0.580
DOC_MAPK_MEF2A_6 344 351 PF00069 0.507
DOC_PP2B_PxIxI_1 217 223 PF00149 0.347
DOC_PP4_FxxP_1 311 314 PF00568 0.422
DOC_PP4_FxxP_1 58 61 PF00568 0.333
DOC_USP7_MATH_1 133 137 PF00917 0.406
DOC_USP7_MATH_1 199 203 PF00917 0.448
DOC_USP7_MATH_1 270 274 PF00917 0.613
DOC_USP7_MATH_1 289 293 PF00917 0.554
DOC_USP7_MATH_1 378 382 PF00917 0.538
DOC_USP7_UBL2_3 113 117 PF12436 0.321
DOC_USP7_UBL2_3 206 210 PF12436 0.414
DOC_WW_Pin1_4 185 190 PF00397 0.441
DOC_WW_Pin1_4 2 7 PF00397 0.555
DOC_WW_Pin1_4 200 205 PF00397 0.454
DOC_WW_Pin1_4 223 228 PF00397 0.573
DOC_WW_Pin1_4 301 306 PF00397 0.498
DOC_WW_Pin1_4 320 325 PF00397 0.524
DOC_WW_Pin1_4 37 42 PF00397 0.293
LIG_14-3-3_CanoR_1 290 295 PF00244 0.666
LIG_14-3-3_CanoR_1 32 39 PF00244 0.527
LIG_Actin_WH2_2 210 226 PF00022 0.561
LIG_Actin_WH2_2 375 392 PF00022 0.383
LIG_Clathr_ClatBox_1 348 352 PF01394 0.424
LIG_EH1_1 15 23 PF00400 0.590
LIG_FHA_1 114 120 PF00498 0.430
LIG_FHA_1 302 308 PF00498 0.459
LIG_FHA_1 314 320 PF00498 0.478
LIG_FHA_1 81 87 PF00498 0.352
LIG_FHA_2 149 155 PF00498 0.591
LIG_FHA_2 224 230 PF00498 0.474
LIG_HP1_1 53 57 PF01393 0.445
LIG_LIR_Apic_2 309 314 PF02991 0.455
LIG_LIR_Gen_1 233 242 PF02991 0.484
LIG_LIR_Gen_1 396 405 PF02991 0.394
LIG_LIR_Gen_1 72 80 PF02991 0.318
LIG_LIR_LC3C_4 136 139 PF02991 0.271
LIG_LIR_Nem_3 233 239 PF02991 0.492
LIG_LIR_Nem_3 396 402 PF02991 0.388
LIG_LIR_Nem_3 72 76 PF02991 0.318
LIG_PCNA_yPIPBox_3 210 223 PF02747 0.534
LIG_Pex14_2 58 62 PF04695 0.333
LIG_SH2_NCK_1 225 229 PF00017 0.565
LIG_SH2_NCK_1 248 252 PF00017 0.376
LIG_SH2_SRC 248 251 PF00017 0.372
LIG_SH2_STAP1 241 245 PF00017 0.489
LIG_SH2_STAP1 73 77 PF00017 0.394
LIG_SH2_STAT3 125 128 PF00017 0.445
LIG_SH2_STAT5 225 228 PF00017 0.552
LIG_SH2_STAT5 303 306 PF00017 0.550
LIG_SH2_STAT5 342 345 PF00017 0.566
LIG_SH3_3 291 297 PF00018 0.505
LIG_SUMO_SIM_anti_2 385 390 PF11976 0.495
LIG_TRAF2_1 121 124 PF00917 0.271
LIG_TYR_ITIM 246 251 PF00017 0.394
LIG_TYR_ITIM 397 402 PF00017 0.426
LIG_UBA3_1 167 175 PF00899 0.542
LIG_UBA3_1 181 190 PF00899 0.524
MOD_CDC14_SPxK_1 203 206 PF00782 0.428
MOD_CDK_SPK_2 185 190 PF00069 0.465
MOD_CDK_SPK_2 301 306 PF00069 0.529
MOD_CDK_SPxK_1 200 206 PF00069 0.419
MOD_CDK_SPxxK_3 185 192 PF00069 0.466
MOD_CK1_1 118 124 PF00069 0.445
MOD_CK1_1 264 270 PF00069 0.651
MOD_CK1_1 34 40 PF00069 0.449
MOD_CK1_1 392 398 PF00069 0.539
MOD_CK1_1 4 10 PF00069 0.687
MOD_CK2_1 118 124 PF00069 0.406
MOD_CK2_1 148 154 PF00069 0.553
MOD_CK2_1 199 205 PF00069 0.366
MOD_CK2_1 223 229 PF00069 0.459
MOD_CK2_1 272 278 PF00069 0.752
MOD_CK2_1 326 332 PF00069 0.515
MOD_CK2_1 371 377 PF00069 0.649
MOD_GlcNHglycan 113 116 PF01048 0.485
MOD_GlcNHglycan 172 175 PF01048 0.446
MOD_GlcNHglycan 262 266 PF01048 0.610
MOD_GlcNHglycan 33 36 PF01048 0.425
MOD_GlcNHglycan 6 9 PF01048 0.674
MOD_GSK3_1 111 118 PF00069 0.477
MOD_GSK3_1 142 149 PF00069 0.482
MOD_GSK3_1 278 285 PF00069 0.700
MOD_GSK3_1 30 37 PF00069 0.553
MOD_GSK3_1 378 385 PF00069 0.554
MOD_GSK3_1 389 396 PF00069 0.474
MOD_GSK3_1 76 83 PF00069 0.376
MOD_LATS_1 391 397 PF00433 0.396
MOD_NEK2_1 1 6 PF00069 0.644
MOD_NEK2_1 148 153 PF00069 0.539
MOD_NEK2_1 198 203 PF00069 0.496
MOD_NEK2_1 21 26 PF00069 0.573
MOD_NEK2_1 212 217 PF00069 0.435
MOD_NEK2_1 351 356 PF00069 0.481
MOD_NEK2_1 382 387 PF00069 0.515
MOD_NEK2_1 389 394 PF00069 0.472
MOD_NEK2_1 47 52 PF00069 0.312
MOD_NEK2_1 76 81 PF00069 0.352
MOD_PIKK_1 119 125 PF00454 0.489
MOD_PIKK_1 212 218 PF00454 0.574
MOD_PIKK_1 278 284 PF00454 0.755
MOD_PIKK_1 351 357 PF00454 0.554
MOD_PK_1 290 296 PF00069 0.582
MOD_PKA_2 289 295 PF00069 0.654
MOD_PKA_2 31 37 PF00069 0.493
MOD_PKA_2 389 395 PF00069 0.457
MOD_Plk_4 133 139 PF00069 0.413
MOD_Plk_4 382 388 PF00069 0.556
MOD_ProDKin_1 185 191 PF00069 0.435
MOD_ProDKin_1 2 8 PF00069 0.553
MOD_ProDKin_1 200 206 PF00069 0.459
MOD_ProDKin_1 223 229 PF00069 0.581
MOD_ProDKin_1 301 307 PF00069 0.492
MOD_ProDKin_1 320 326 PF00069 0.515
MOD_ProDKin_1 37 43 PF00069 0.293
MOD_SUMO_rev_2 229 236 PF00179 0.496
TRG_DiLeu_BaEn_3 233 239 PF01217 0.500
TRG_DiLeu_BaLyEn_6 344 349 PF01217 0.449
TRG_ENDOCYTIC_2 248 251 PF00928 0.372
TRG_ENDOCYTIC_2 399 402 PF00928 0.449
TRG_ENDOCYTIC_2 73 76 PF00928 0.474
TRG_NES_CRM1_1 358 371 PF08389 0.475
TRG_NLS_MonoExtN_4 314 321 PF00514 0.583
TRG_Pf-PMV_PEXEL_1 417 422 PF00026 0.538

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Y0 Leptomonas seymouri 58% 95%
A0A0S4J6N7 Bodo saltans 35% 99%
A0A1X0PAY2 Trypanosomatidae 41% 100%
A0A3Q8IL31 Leishmania donovani 100% 100%
A4HAT2 Leishmania braziliensis 75% 100%
C9ZMN6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9B506 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O13704 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
Q4Q2Y0 Leishmania major 91% 100%
V5BFX1 Trypanosoma cruzi 42% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS