DNA-(apurinic or apyrimidinic site) lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

8-oxoguanine DNA glycosylase - putative

Species:

Leishmania infantum

UniProt:

A4I9Y9_LEIIN

TriTrypDb:

LINF_340026900

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I9Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9Y9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006284	base-excision repair	6	11
GO:0006289	nucleotide-excision repair	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006285	base-excision repair, AP site formation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000702	oxidized base lesion DNA N-glycosylase activity	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0003824	catalytic activity	1	12
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4	11
GO:0005488	binding	1	12
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	6	12
GO:0016787	hydrolase activity	2	12
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	12
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	12
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0019104	DNA N-glycosylase activity	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	4	11
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.446
CLV_C14_Caspase3-7	297	301	PF00656	0.531
CLV_NRD_NRD_1	114	116	PF00675	0.337
CLV_NRD_NRD_1	180	182	PF00675	0.364
CLV_NRD_NRD_1	274	276	PF00675	0.328
CLV_NRD_NRD_1	298	300	PF00675	0.255
CLV_NRD_NRD_1	421	423	PF00675	0.278
CLV_NRD_NRD_1	463	465	PF00675	0.547
CLV_NRD_NRD_1	488	490	PF00675	0.459
CLV_NRD_NRD_1	523	525	PF00675	0.591
CLV_NRD_NRD_1	563	565	PF00675	0.429
CLV_NRD_NRD_1	85	87	PF00675	0.348
CLV_PCSK_FUR_1	82	86	PF00082	0.231
CLV_PCSK_KEX2_1	114	116	PF00082	0.278
CLV_PCSK_KEX2_1	298	300	PF00082	0.305
CLV_PCSK_KEX2_1	465	467	PF00082	0.605
CLV_PCSK_KEX2_1	84	86	PF00082	0.300
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.605
CLV_PCSK_SKI1_1	13	17	PF00082	0.414
CLV_PCSK_SKI1_1	196	200	PF00082	0.294
CLV_PCSK_SKI1_1	371	375	PF00082	0.322
CLV_PCSK_SKI1_1	411	415	PF00082	0.278
DEG_APCC_DBOX_1	410	418	PF00400	0.442
DEG_SPOP_SBC_1	133	137	PF00917	0.399
DEG_SPOP_SBC_1	14	18	PF00917	0.397
DOC_CKS1_1	38	43	PF01111	0.529
DOC_CYCLIN_RxL_1	156	166	PF00134	0.522
DOC_CYCLIN_RxL_1	337	348	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.538
DOC_MAPK_gen_1	20	29	PF00069	0.567
DOC_MAPK_gen_1	422	430	PF00069	0.470
DOC_MAPK_gen_1	489	497	PF00069	0.373
DOC_MAPK_MEF2A_6	159	167	PF00069	0.459
DOC_MAPK_MEF2A_6	20	27	PF00069	0.478
DOC_PP1_RVXF_1	338	345	PF00149	0.442
DOC_PP2B_LxvP_1	217	220	PF13499	0.446
DOC_PP2B_LxvP_1	415	418	PF13499	0.456
DOC_PP2B_LxvP_1	453	456	PF13499	0.414
DOC_USP7_MATH_1	133	137	PF00917	0.552
DOC_USP7_MATH_1	21	25	PF00917	0.487
DOC_USP7_MATH_1	274	278	PF00917	0.520
DOC_USP7_MATH_1	303	307	PF00917	0.501
DOC_USP7_MATH_1	454	458	PF00917	0.579
DOC_USP7_MATH_1	8	12	PF00917	0.573
DOC_USP7_UBL2_3	370	374	PF12436	0.487
DOC_WW_Pin1_4	129	134	PF00397	0.561
DOC_WW_Pin1_4	174	179	PF00397	0.524
DOC_WW_Pin1_4	301	306	PF00397	0.534
DOC_WW_Pin1_4	313	318	PF00397	0.542
DOC_WW_Pin1_4	37	42	PF00397	0.456
DOC_WW_Pin1_4	376	381	PF00397	0.532
DOC_WW_Pin1_4	477	482	PF00397	0.515
DOC_WW_Pin1_4	499	504	PF00397	0.539
DOC_WW_Pin1_4	523	528	PF00397	0.576
LIG_14-3-3_CanoR_1	159	164	PF00244	0.508
LIG_14-3-3_CanoR_1	308	317	PF00244	0.376
LIG_14-3-3_CanoR_1	513	520	PF00244	0.596
LIG_14-3-3_CanoR_1	86	92	PF00244	0.478
LIG_14-3-3_CanoR_1	9	13	PF00244	0.555
LIG_Actin_WH2_1	42	59	PF00022	0.478
LIG_Actin_WH2_2	187	202	PF00022	0.392
LIG_BRCT_BRCA1_1	229	233	PF00533	0.535
LIG_BRCT_BRCA1_1	340	344	PF00533	0.425
LIG_BRCT_BRCA1_1	555	559	PF00533	0.310
LIG_deltaCOP1_diTrp_1	168	174	PF00928	0.498
LIG_deltaCOP1_diTrp_1	318	325	PF00928	0.536
LIG_deltaCOP1_diTrp_1	541	547	PF00928	0.299
LIG_FHA_1	129	135	PF00498	0.503
LIG_FHA_1	14	20	PF00498	0.445
LIG_FHA_1	245	251	PF00498	0.456
LIG_FHA_1	266	272	PF00498	0.459
LIG_FHA_1	434	440	PF00498	0.542
LIG_FHA_2	254	260	PF00498	0.392
LIG_FHA_2	295	301	PF00498	0.557
LIG_LIR_Apic_2	321	326	PF02991	0.535
LIG_LIR_Gen_1	158	167	PF02991	0.523
LIG_LIR_Gen_1	316	326	PF02991	0.453
LIG_LIR_Nem_3	11	15	PF02991	0.426
LIG_LIR_Nem_3	112	116	PF02991	0.503
LIG_LIR_Nem_3	158	163	PF02991	0.523
LIG_LIR_Nem_3	230	236	PF02991	0.458
LIG_LIR_Nem_3	316	322	PF02991	0.439
LIG_LIR_Nem_3	324	328	PF02991	0.473
LIG_LIR_Nem_3	541	547	PF02991	0.480
LIG_MYND_2	380	384	PF01753	0.446
LIG_Pex14_1	319	323	PF04695	0.535
LIG_Pex14_2	543	547	PF04695	0.334
LIG_PTB_Apo_2	390	397	PF02174	0.478
LIG_PTB_Phospho_1	390	396	PF10480	0.478
LIG_SH2_CRK	323	327	PF00017	0.478
LIG_SH2_CRK	38	42	PF00017	0.431
LIG_SH2_CRK	396	400	PF00017	0.553
LIG_SH2_PTP2	218	221	PF00017	0.535
LIG_SH2_SRC	218	221	PF00017	0.522
LIG_SH2_STAP1	396	400	PF00017	0.445
LIG_SH2_STAT3	405	408	PF00017	0.431
LIG_SH2_STAT5	160	163	PF00017	0.431
LIG_SH2_STAT5	188	191	PF00017	0.474
LIG_SH2_STAT5	218	221	PF00017	0.535
LIG_SH2_STAT5	350	353	PF00017	0.460
LIG_SH2_STAT5	452	455	PF00017	0.372
LIG_SH3_1	524	530	PF00018	0.550
LIG_SH3_1	72	78	PF00018	0.392
LIG_SH3_2	77	82	PF14604	0.392
LIG_SH3_3	268	274	PF00018	0.513
LIG_SH3_3	524	530	PF00018	0.495
LIG_SH3_3	72	78	PF00018	0.573
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.542
LIG_TRAF2_1	152	155	PF00917	0.502
LIG_TRAF2_1	474	477	PF00917	0.677
LIG_TRAF2_1	508	511	PF00917	0.435
LIG_TYR_ITIM	111	116	PF00017	0.535
LIG_TYR_ITIM	558	563	PF00017	0.264
LIG_WRC_WIRS_1	232	237	PF05994	0.360
LIG_WW_1	529	532	PF00397	0.529
MOD_CDK_SPK_2	37	42	PF00069	0.456
MOD_CDK_SPxxK_3	174	181	PF00069	0.478
MOD_CDK_SPxxK_3	301	308	PF00069	0.462
MOD_CK1_1	132	138	PF00069	0.508
MOD_CK1_1	177	183	PF00069	0.478
MOD_CK1_1	306	312	PF00069	0.555
MOD_CK1_1	313	319	PF00069	0.486
MOD_CK1_1	321	327	PF00069	0.472
MOD_CK1_1	502	508	PF00069	0.531
MOD_CK1_1	515	521	PF00069	0.629
MOD_CK1_1	523	529	PF00069	0.532
MOD_CK2_1	149	155	PF00069	0.506
MOD_CK2_1	471	477	PF00069	0.526
MOD_CK2_1	91	97	PF00069	0.576
MOD_CMANNOS	171	174	PF00535	0.231
MOD_Cter_Amidation	420	423	PF01082	0.242
MOD_Cter_Amidation	462	465	PF01082	0.703
MOD_GlcNHglycan	125	128	PF01048	0.314
MOD_GlcNHglycan	144	147	PF01048	0.231
MOD_GlcNHglycan	200	203	PF01048	0.246
MOD_GlcNHglycan	276	279	PF01048	0.362
MOD_GlcNHglycan	396	399	PF01048	0.336
MOD_GlcNHglycan	456	459	PF01048	0.627
MOD_GlcNHglycan	514	517	PF01048	0.537
MOD_GlcNHglycan	61	64	PF01048	0.299
MOD_GlcNHglycan	89	92	PF01048	0.370
MOD_GSK3_1	128	135	PF00069	0.561
MOD_GSK3_1	138	145	PF00069	0.550
MOD_GSK3_1	155	162	PF00069	0.483
MOD_GSK3_1	21	28	PF00069	0.505
MOD_GSK3_1	227	234	PF00069	0.505
MOD_GSK3_1	274	281	PF00069	0.470
MOD_GSK3_1	285	292	PF00069	0.460
MOD_GSK3_1	306	313	PF00069	0.472
MOD_GSK3_1	353	360	PF00069	0.470
MOD_GSK3_1	37	44	PF00069	0.420
MOD_GSK3_1	394	401	PF00069	0.462
MOD_GSK3_1	511	518	PF00069	0.563
MOD_GSK3_1	87	94	PF00069	0.480
MOD_N-GLC_1	241	246	PF02516	0.335
MOD_N-GLC_1	433	438	PF02516	0.278
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	134	139	PF00069	0.457
MOD_NEK2_1	15	20	PF00069	0.394
MOD_NEK2_1	198	203	PF00069	0.444
MOD_NEK2_1	235	240	PF00069	0.467
MOD_NEK2_1	25	30	PF00069	0.474
MOD_NEK2_1	253	258	PF00069	0.427
MOD_NEK2_1	357	362	PF00069	0.478
MOD_NEK2_1	433	438	PF00069	0.478
MOD_NEK2_1	520	525	PF00069	0.491
MOD_NEK2_1	70	75	PF00069	0.539
MOD_PIKK_1	235	241	PF00454	0.431
MOD_PIKK_1	285	291	PF00454	0.406
MOD_PIKK_1	357	363	PF00454	0.478
MOD_PKA_1	464	470	PF00069	0.574
MOD_PKA_2	123	129	PF00069	0.428
MOD_PKA_2	138	144	PF00069	0.488
MOD_PKA_2	244	250	PF00069	0.442
MOD_PKA_2	274	280	PF00069	0.522
MOD_PKA_2	41	47	PF00069	0.456
MOD_PKA_2	512	518	PF00069	0.545
MOD_PKA_2	520	526	PF00069	0.581
MOD_PKA_2	8	14	PF00069	0.488
MOD_Plk_1	241	247	PF00069	0.535
MOD_Plk_1	335	341	PF00069	0.496
MOD_Plk_1	433	439	PF00069	0.478
MOD_Plk_4	318	324	PF00069	0.535
MOD_Plk_4	353	359	PF00069	0.461
MOD_Plk_4	41	47	PF00069	0.440
MOD_Plk_4	515	521	PF00069	0.445
MOD_Plk_4	553	559	PF00069	0.306
MOD_ProDKin_1	129	135	PF00069	0.561
MOD_ProDKin_1	174	180	PF00069	0.524
MOD_ProDKin_1	301	307	PF00069	0.534
MOD_ProDKin_1	313	319	PF00069	0.542
MOD_ProDKin_1	37	43	PF00069	0.456
MOD_ProDKin_1	376	382	PF00069	0.532
MOD_ProDKin_1	477	483	PF00069	0.510
MOD_ProDKin_1	499	505	PF00069	0.537
MOD_ProDKin_1	523	529	PF00069	0.566
TRG_DiLeu_BaEn_2	352	358	PF01217	0.446
TRG_ENDOCYTIC_2	113	116	PF00928	0.547
TRG_ENDOCYTIC_2	160	163	PF00928	0.431
TRG_ENDOCYTIC_2	218	221	PF00928	0.535
TRG_ENDOCYTIC_2	396	399	PF00928	0.459
TRG_ENDOCYTIC_2	560	563	PF00928	0.411
TRG_ER_diArg_1	113	115	PF00400	0.478
TRG_ER_diArg_1	466	469	PF00400	0.605
TRG_ER_diArg_1	561	564	PF00400	0.421
TRG_ER_diArg_1	82	85	PF00400	0.431
TRG_NES_CRM1_1	155	168	PF08389	0.478
TRG_NLS_MonoExtC_3	463	468	PF00514	0.640
TRG_NLS_MonoExtN_4	464	469	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I223	Leptomonas seymouri	46%	96%
A0A0S4ING5	Bodo saltans	28%	100%
A0A1X0P9L2	Trypanosomatidae	31%	100%
A0A3R7MS38	Trypanosoma rangeli	35%	100%
A0A3S7X7Y5	Leishmania donovani	99%	100%
A4HAS9	Leishmania braziliensis	69%	100%
C9ZMN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B503	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2Y3	Leishmania major	87%	100%
V5BKI1	Trypanosoma cruzi	34%	100%