Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9Y8_LEIIN

TriTrypDb:

LINF_340026800

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I9Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.651
CLV_C14_Caspase3-7	165	169	PF00656	0.613
CLV_MEL_PAP_1	407	413	PF00089	0.564
CLV_NRD_NRD_1	251	253	PF00675	0.544
CLV_NRD_NRD_1	63	65	PF00675	0.459
CLV_NRD_NRD_1	80	82	PF00675	0.600
CLV_NRD_NRD_1	86	88	PF00675	0.549
CLV_PCSK_FUR_1	61	65	PF00082	0.554
CLV_PCSK_KEX2_1	115	117	PF00082	0.736
CLV_PCSK_KEX2_1	251	253	PF00082	0.660
CLV_PCSK_KEX2_1	425	427	PF00082	0.624
CLV_PCSK_KEX2_1	63	65	PF00082	0.459
CLV_PCSK_KEX2_1	79	81	PF00082	0.598
CLV_PCSK_KEX2_1	86	88	PF00082	0.474
CLV_PCSK_KEX2_1	99	101	PF00082	0.675
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.736
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.516
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.704
CLV_PCSK_SKI1_1	404	408	PF00082	0.550
CLV_PCSK_SKI1_1	425	429	PF00082	0.519
CLV_PCSK_SKI1_1	432	436	PF00082	0.421
CLV_Separin_Metazoa	446	450	PF03568	0.521
DEG_APCC_DBOX_1	186	194	PF00400	0.592
DEG_APCC_DBOX_1	340	348	PF00400	0.666
DEG_SPOP_SBC_1	152	156	PF00917	0.580
DEG_SPOP_SBC_1	472	476	PF00917	0.712
DOC_CYCLIN_RxL_1	183	195	PF00134	0.594
DOC_CYCLIN_RxL_1	401	408	PF00134	0.573
DOC_MAPK_FxFP_2	216	219	PF00069	0.551
DOC_MAPK_gen_1	173	181	PF00069	0.508
DOC_MAPK_gen_1	251	260	PF00069	0.655
DOC_MAPK_gen_1	79	85	PF00069	0.585
DOC_MAPK_MEF2A_6	14	22	PF00069	0.622
DOC_PP4_FxxP_1	216	219	PF00568	0.551
DOC_USP7_MATH_1	152	156	PF00917	0.739
DOC_USP7_MATH_1	2	6	PF00917	0.477
DOC_USP7_MATH_1	297	301	PF00917	0.640
DOC_USP7_MATH_1	473	477	PF00917	0.603
DOC_USP7_MATH_2	122	128	PF00917	0.712
DOC_USP7_UBL2_3	197	201	PF12436	0.498
DOC_WW_Pin1_4	103	108	PF00397	0.666
DOC_WW_Pin1_4	115	120	PF00397	0.604
DOC_WW_Pin1_4	228	233	PF00397	0.696
DOC_WW_Pin1_4	405	410	PF00397	0.533
DOC_WW_Pin1_4	468	473	PF00397	0.633
LIG_14-3-3_CanoR_1	100	107	PF00244	0.665
LIG_14-3-3_CanoR_1	110	115	PF00244	0.753
LIG_14-3-3_CanoR_1	183	187	PF00244	0.571
LIG_14-3-3_CanoR_1	353	357	PF00244	0.560
LIG_14-3-3_CanoR_1	410	414	PF00244	0.543
LIG_14-3-3_CanoR_1	426	430	PF00244	0.412
LIG_AP2alpha_2	214	216	PF02296	0.538
LIG_APCC_ABBA_1	20	25	PF00400	0.575
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BRCT_BRCA1_1	407	411	PF00533	0.624
LIG_Clathr_ClatBox_1	190	194	PF01394	0.594
LIG_DLG_GKlike_1	110	118	PF00625	0.665
LIG_FHA_1	144	150	PF00498	0.618
LIG_FHA_1	480	486	PF00498	0.634
LIG_FHA_2	158	164	PF00498	0.592
LIG_FHA_2	272	278	PF00498	0.625
LIG_FHA_2	41	47	PF00498	0.570
LIG_FHA_2	426	432	PF00498	0.395
LIG_IRF3_LxIS_1	12	19	PF10401	0.463
LIG_LIR_Apic_2	214	219	PF02991	0.504
LIG_LIR_Gen_1	377	386	PF02991	0.576
LIG_LIR_Gen_1	412	419	PF02991	0.616
LIG_LIR_Nem_3	377	381	PF02991	0.535
LIG_LIR_Nem_3	412	416	PF02991	0.630
LIG_MAD2	211	219	PF02301	0.594
LIG_NRBOX	432	438	PF00104	0.448
LIG_NRBOX	54	60	PF00104	0.415
LIG_PCNA_yPIPBox_3	425	437	PF02747	0.589
LIG_Rb_pABgroove_1	342	350	PF01858	0.591
LIG_SH2_STAP1	318	322	PF00017	0.472
LIG_SH2_STAP1	348	352	PF00017	0.627
LIG_SH3_1	116	122	PF00018	0.619
LIG_SH3_3	116	122	PF00018	0.712
LIG_SH3_3	209	215	PF00018	0.527
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.547
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.585
LIG_SUMO_SIM_par_1	37	43	PF11976	0.526
LIG_SUMO_SIM_par_1	482	490	PF11976	0.589
LIG_SUMO_SIM_par_1	70	75	PF11976	0.572
LIG_TRAF2_1	135	138	PF00917	0.649
LIG_TRAF2_1	428	431	PF00917	0.502
LIG_UBA3_1	190	197	PF00899	0.567
MOD_CDK_SPK_2	115	120	PF00069	0.731
MOD_CDK_SPK_2	228	233	PF00069	0.503
MOD_CDK_SPK_2	405	410	PF00069	0.533
MOD_CDK_SPxxK_3	103	110	PF00069	0.649
MOD_CK1_1	108	114	PF00069	0.637
MOD_CK1_1	150	156	PF00069	0.699
MOD_CK1_1	228	234	PF00069	0.701
MOD_CK1_1	237	243	PF00069	0.668
MOD_CK1_1	304	310	PF00069	0.573
MOD_CK1_1	324	330	PF00069	0.687
MOD_CK1_1	471	477	PF00069	0.646
MOD_CK1_1	5	11	PF00069	0.559
MOD_CK2_1	128	134	PF00069	0.666
MOD_CK2_1	352	358	PF00069	0.625
MOD_CK2_1	40	46	PF00069	0.603
MOD_CK2_1	425	431	PF00069	0.396
MOD_CK2_1	72	78	PF00069	0.505
MOD_GlcNHglycan	110	113	PF01048	0.662
MOD_GlcNHglycan	129	133	PF01048	0.740
MOD_GlcNHglycan	141	144	PF01048	0.744
MOD_GlcNHglycan	227	230	PF01048	0.637
MOD_GlcNHglycan	254	257	PF01048	0.737
MOD_GlcNHglycan	287	290	PF01048	0.529
MOD_GlcNHglycan	305	309	PF01048	0.618
MOD_GlcNHglycan	323	327	PF01048	0.569
MOD_GlcNHglycan	475	478	PF01048	0.692
MOD_GlcNHglycan	7	10	PF01048	0.603
MOD_GSK3_1	101	108	PF00069	0.663
MOD_GSK3_1	124	131	PF00069	0.772
MOD_GSK3_1	139	146	PF00069	0.689
MOD_GSK3_1	147	154	PF00069	0.676
MOD_GSK3_1	159	166	PF00069	0.567
MOD_GSK3_1	228	235	PF00069	0.693
MOD_GSK3_1	246	253	PF00069	0.769
MOD_GSK3_1	297	304	PF00069	0.640
MOD_GSK3_1	321	328	PF00069	0.673
MOD_GSK3_1	385	392	PF00069	0.594
MOD_GSK3_1	405	412	PF00069	0.513
MOD_GSK3_1	468	475	PF00069	0.587
MOD_LATS_1	250	256	PF00433	0.526
MOD_N-GLC_1	271	276	PF02516	0.585
MOD_N-GLC_1	301	306	PF02516	0.634
MOD_NEK2_1	16	21	PF00069	0.524
MOD_NEK2_1	225	230	PF00069	0.722
MOD_NEK2_1	298	303	PF00069	0.654
MOD_NEK2_1	322	327	PF00069	0.512
MOD_NEK2_1	65	70	PF00069	0.546
MOD_PIKK_1	192	198	PF00454	0.500
MOD_PIKK_1	2	8	PF00454	0.460
MOD_PIKK_1	234	240	PF00454	0.636
MOD_PIKK_1	385	391	PF00454	0.582
MOD_PIKK_1	451	457	PF00454	0.603
MOD_PIKK_1	72	78	PF00454	0.575
MOD_PIKK_1	90	96	PF00454	0.747
MOD_PKA_1	425	431	PF00069	0.396
MOD_PKA_2	182	188	PF00069	0.509
MOD_PKA_2	232	238	PF00069	0.546
MOD_PKA_2	250	256	PF00069	0.689
MOD_PKA_2	285	291	PF00069	0.510
MOD_PKA_2	340	346	PF00069	0.630
MOD_PKA_2	352	358	PF00069	0.464
MOD_PKA_2	368	374	PF00069	0.479
MOD_PKA_2	409	415	PF00069	0.543
MOD_PKA_2	425	431	PF00069	0.396
MOD_PKA_2	89	95	PF00069	0.747
MOD_Plk_1	256	262	PF00069	0.689
MOD_Plk_2-3	124	130	PF00069	0.671
MOD_Plk_2-3	163	169	PF00069	0.531
MOD_Plk_4	368	374	PF00069	0.529
MOD_Plk_4	479	485	PF00069	0.666
MOD_ProDKin_1	103	109	PF00069	0.667
MOD_ProDKin_1	115	121	PF00069	0.603
MOD_ProDKin_1	228	234	PF00069	0.696
MOD_ProDKin_1	405	411	PF00069	0.529
MOD_ProDKin_1	468	474	PF00069	0.637
MOD_SUMO_rev_2	355	361	PF00179	0.679
MOD_SUMO_rev_2	412	422	PF00179	0.530
TRG_DiLeu_BaEn_1	54	59	PF01217	0.539
TRG_ER_diArg_1	251	254	PF00400	0.529
TRG_ER_diArg_1	61	64	PF00400	0.469
TRG_ER_diArg_1	79	81	PF00400	0.611
TRG_ER_diArg_1	85	87	PF00400	0.536
TRG_NES_CRM1_1	11	25	PF08389	0.578
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED0	Leptomonas seymouri	57%	100%
A0A1X0P9K0	Trypanosomatidae	30%	100%
A0A3Q8INC5	Leishmania donovani	100%	100%
A0A422NY19	Trypanosoma rangeli	29%	100%
A4HAS8	Leishmania braziliensis	75%	100%
C9ZMP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B502	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2Y4	Leishmania major	92%	100%
V5BPZ9	Trypanosoma cruzi	29%	97%