Putative eukaryotic translation initiation factor 2-alpha kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 2-alpha kinase - putative

Species:

Leishmania infantum

UniProt:

A4I9Y7_LEIIN

TriTrypDb:

LINF_340026700

Length:

1467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	3
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	3
GO:1990578	perinuclear endoplasmic reticulum membrane	4	1

Expansion

Sequence features

A4I9Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9Y7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0001932	regulation of protein phosphorylation	7	1
GO:0006417	regulation of translation	6	1
GO:0006446	regulation of translational initiation	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	6	1
GO:0010999	regulation of eIF2 alpha phosphorylation by heme	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0042325	regulation of phosphorylation	7	1
GO:0043555	regulation of translation in response to stress	7	1
GO:0043558	regulation of translational initiation in response to stress	8	1
GO:0048583	regulation of response to stimulus	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0080134	regulation of response to stress	4	1
GO:0080135	regulation of cellular response to stress	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	4
GO:0003743	translation initiation factor activity	4	4
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008135	translation factor activity, RNA binding	3	4
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0045182	translation regulator activity	1	5
GO:0090079	translation regulator activity, nucleic acid binding	2	4
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004683	calmodulin-dependent protein kinase activity	5	1
GO:0004686	elongation factor-2 kinase activity	6	1
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	2	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1316	1320	PF00656	0.749
CLV_C14_Caspase3-7	171	175	PF00656	0.551
CLV_C14_Caspase3-7	994	998	PF00656	0.552
CLV_NRD_NRD_1	1110	1112	PF00675	0.304
CLV_NRD_NRD_1	1219	1221	PF00675	0.349
CLV_NRD_NRD_1	1398	1400	PF00675	0.787
CLV_NRD_NRD_1	1425	1427	PF00675	0.668
CLV_NRD_NRD_1	199	201	PF00675	0.692
CLV_NRD_NRD_1	24	26	PF00675	0.629
CLV_NRD_NRD_1	356	358	PF00675	0.755
CLV_PCSK_KEX2_1	1109	1111	PF00082	0.306
CLV_PCSK_KEX2_1	1389	1391	PF00082	0.771
CLV_PCSK_KEX2_1	1397	1399	PF00082	0.760
CLV_PCSK_KEX2_1	199	201	PF00082	0.692
CLV_PCSK_KEX2_1	24	26	PF00082	0.629
CLV_PCSK_KEX2_1	30	32	PF00082	0.588
CLV_PCSK_KEX2_1	356	358	PF00082	0.768
CLV_PCSK_KEX2_1	823	825	PF00082	0.553
CLV_PCSK_PC1ET2_1	1109	1111	PF00082	0.346
CLV_PCSK_PC1ET2_1	1389	1391	PF00082	0.829
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.589
CLV_PCSK_PC1ET2_1	823	825	PF00082	0.510
CLV_PCSK_PC7_1	20	26	PF00082	0.631
CLV_PCSK_SKI1_1	1065	1069	PF00082	0.419
CLV_PCSK_SKI1_1	1180	1184	PF00082	0.292
CLV_PCSK_SKI1_1	1206	1210	PF00082	0.324
CLV_PCSK_SKI1_1	1220	1224	PF00082	0.245
CLV_PCSK_SKI1_1	1331	1335	PF00082	0.397
CLV_PCSK_SKI1_1	1370	1374	PF00082	0.731
CLV_PCSK_SKI1_1	1427	1431	PF00082	0.674
CLV_PCSK_SKI1_1	340	344	PF00082	0.702
CLV_PCSK_SKI1_1	41	45	PF00082	0.415
CLV_PCSK_SKI1_1	466	470	PF00082	0.688
CLV_PCSK_SKI1_1	770	774	PF00082	0.581
CLV_Separin_Metazoa	1062	1066	PF03568	0.619
CLV_Separin_Metazoa	742	746	PF03568	0.799
DEG_APCC_DBOX_1	1219	1227	PF00400	0.565
DEG_APCC_DBOX_1	1330	1338	PF00400	0.536
DEG_APCC_DBOX_1	515	523	PF00400	0.545
DEG_MDM2_SWIB_1	970	978	PF02201	0.546
DEG_SCF_FBW7_1	783	790	PF00400	0.728
DEG_SIAH_1	298	306	PF03145	0.528
DEG_SPOP_SBC_1	1292	1296	PF00917	0.772
DEG_SPOP_SBC_1	1299	1303	PF00917	0.702
DEG_SPOP_SBC_1	1355	1359	PF00917	0.591
DEG_SPOP_SBC_1	317	321	PF00917	0.596
DEG_SPOP_SBC_1	369	373	PF00917	0.563
DEG_SPOP_SBC_1	787	791	PF00917	0.718
DOC_CDC14_PxL_1	459	467	PF14671	0.605
DOC_CKS1_1	1438	1443	PF01111	0.536
DOC_CKS1_1	232	237	PF01111	0.477
DOC_CKS1_1	567	572	PF01111	0.517
DOC_CYCLIN_RxL_1	1216	1227	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.491
DOC_MAPK_gen_1	1220	1231	PF00069	0.676
DOC_MAPK_gen_1	1329	1337	PF00069	0.539
DOC_MAPK_gen_1	199	205	PF00069	0.484
DOC_MAPK_MEF2A_6	1224	1233	PF00069	0.679
DOC_MAPK_MEF2A_6	144	151	PF00069	0.479
DOC_MAPK_MEF2A_6	273	280	PF00069	0.383
DOC_MAPK_MEF2A_6	41	48	PF00069	0.548
DOC_MAPK_MEF2A_6	461	469	PF00069	0.456
DOC_MAPK_NFAT4_5	273	281	PF00069	0.420
DOC_MAPK_NFAT4_5	41	49	PF00069	0.619
DOC_PP1_RVXF_1	464	470	PF00149	0.459
DOC_PP1_RVXF_1	914	920	PF00149	0.546
DOC_PP2B_LxvP_1	1188	1191	PF13499	0.619
DOC_PP2B_LxvP_1	147	150	PF13499	0.476
DOC_PP4_FxxP_1	1321	1324	PF00568	0.840
DOC_PP4_FxxP_1	307	310	PF00568	0.474
DOC_PP4_FxxP_1	460	463	PF00568	0.483
DOC_USP7_MATH_1	1114	1118	PF00917	0.591
DOC_USP7_MATH_1	1235	1239	PF00917	0.690
DOC_USP7_MATH_1	1254	1258	PF00917	0.759
DOC_USP7_MATH_1	1299	1303	PF00917	0.837
DOC_USP7_MATH_1	1313	1317	PF00917	0.691
DOC_USP7_MATH_1	1349	1353	PF00917	0.584
DOC_USP7_MATH_1	1356	1360	PF00917	0.569
DOC_USP7_MATH_1	1420	1424	PF00917	0.534
DOC_USP7_MATH_1	169	173	PF00917	0.578
DOC_USP7_MATH_1	317	321	PF00917	0.596
DOC_USP7_MATH_1	369	373	PF00917	0.563
DOC_USP7_MATH_1	416	420	PF00917	0.623
DOC_USP7_MATH_1	468	472	PF00917	0.615
DOC_USP7_MATH_1	52	56	PF00917	0.408
DOC_USP7_MATH_1	592	596	PF00917	0.621
DOC_USP7_MATH_1	603	607	PF00917	0.524
DOC_USP7_MATH_1	722	726	PF00917	0.836
DOC_USP7_MATH_1	729	733	PF00917	0.649
DOC_USP7_MATH_1	797	801	PF00917	0.853
DOC_USP7_MATH_1	815	819	PF00917	0.649
DOC_USP7_MATH_1	827	831	PF00917	0.720
DOC_USP7_MATH_1	832	836	PF00917	0.719
DOC_USP7_MATH_1	841	845	PF00917	0.711
DOC_USP7_MATH_1	94	98	PF00917	0.534
DOC_USP7_UBL2_3	912	916	PF12436	0.546
DOC_WW_Pin1_4	1135	1140	PF00397	0.546
DOC_WW_Pin1_4	1246	1251	PF00397	0.718
DOC_WW_Pin1_4	1288	1293	PF00397	0.803
DOC_WW_Pin1_4	1320	1325	PF00397	0.785
DOC_WW_Pin1_4	1400	1405	PF00397	0.567
DOC_WW_Pin1_4	1437	1442	PF00397	0.536
DOC_WW_Pin1_4	165	170	PF00397	0.530
DOC_WW_Pin1_4	231	236	PF00397	0.585
DOC_WW_Pin1_4	244	249	PF00397	0.528
DOC_WW_Pin1_4	295	300	PF00397	0.506
DOC_WW_Pin1_4	306	311	PF00397	0.559
DOC_WW_Pin1_4	328	333	PF00397	0.602
DOC_WW_Pin1_4	363	368	PF00397	0.574
DOC_WW_Pin1_4	566	571	PF00397	0.494
DOC_WW_Pin1_4	692	697	PF00397	0.802
DOC_WW_Pin1_4	699	704	PF00397	0.739
DOC_WW_Pin1_4	752	757	PF00397	0.848
DOC_WW_Pin1_4	783	788	PF00397	0.727
DOC_WW_Pin1_4	804	809	PF00397	0.760
DOC_WW_Pin1_4	817	822	PF00397	0.767
DOC_WW_Pin1_4	828	833	PF00397	0.781
LIG_14-3-3_CanoR_1	1180	1189	PF00244	0.530
LIG_14-3-3_CanoR_1	1390	1395	PF00244	0.569
LIG_14-3-3_CanoR_1	1461	1466	PF00244	0.631
LIG_14-3-3_CanoR_1	154	159	PF00244	0.485
LIG_14-3-3_CanoR_1	199	204	PF00244	0.490
LIG_14-3-3_CanoR_1	333	342	PF00244	0.510
LIG_14-3-3_CanoR_1	370	377	PF00244	0.590
LIG_14-3-3_CanoR_1	382	391	PF00244	0.461
LIG_14-3-3_CanoR_1	393	398	PF00244	0.523
LIG_14-3-3_CanoR_1	480	484	PF00244	0.638
LIG_14-3-3_CanoR_1	497	503	PF00244	0.468
LIG_14-3-3_CanoR_1	674	684	PF00244	0.757
LIG_14-3-3_CanoR_1	770	775	PF00244	0.802
LIG_14-3-3_CanoR_1	872	878	PF00244	0.741
LIG_14-3-3_CanoR_1	887	892	PF00244	0.728
LIG_14-3-3_CanoR_1	90	94	PF00244	0.483
LIG_14-3-3_CanoR_1	931	939	PF00244	0.546
LIG_Actin_WH2_2	465	482	PF00022	0.497
LIG_BIR_III_4	123	127	PF00653	0.549
LIG_BIR_III_4	486	490	PF00653	0.581
LIG_BRCT_BRCA1_1	1055	1059	PF00533	0.466
LIG_BRCT_BRCA1_1	1155	1159	PF00533	0.546
LIG_BRCT_BRCA1_1	235	239	PF00533	0.636
LIG_BRCT_BRCA1_1	62	66	PF00533	0.545
LIG_BRCT_BRCA1_1	646	650	PF00533	0.384
LIG_Clathr_ClatBox_1	12	16	PF01394	0.664
LIG_deltaCOP1_diTrp_1	1050	1058	PF00928	0.546
LIG_deltaCOP1_diTrp_1	861	869	PF00928	0.804
LIG_DLG_GKlike_1	887	895	PF00625	0.785
LIG_eIF4E_1	1003	1009	PF01652	0.563
LIG_EVH1_2	614	618	PF00568	0.474
LIG_FHA_1	1266	1272	PF00498	0.774
LIG_FHA_1	128	134	PF00498	0.566
LIG_FHA_1	174	180	PF00498	0.545
LIG_FHA_1	200	206	PF00498	0.529
LIG_FHA_1	211	217	PF00498	0.427
LIG_FHA_1	371	377	PF00498	0.533
LIG_FHA_1	416	422	PF00498	0.553
LIG_FHA_1	441	447	PF00498	0.587
LIG_FHA_1	542	548	PF00498	0.556
LIG_FHA_1	567	573	PF00498	0.568
LIG_FHA_1	603	609	PF00498	0.550
LIG_FHA_1	684	690	PF00498	0.793
LIG_FHA_1	713	719	PF00498	0.821
LIG_FHA_1	728	734	PF00498	0.807
LIG_FHA_1	852	858	PF00498	0.823
LIG_FHA_2	1019	1025	PF00498	0.545
LIG_FHA_2	1045	1051	PF00498	0.546
LIG_FHA_2	1145	1151	PF00498	0.496
LIG_FHA_2	1172	1178	PF00498	0.546
LIG_FHA_2	166	172	PF00498	0.579
LIG_FHA_2	563	569	PF00498	0.520
LIG_FHA_2	771	777	PF00498	0.807
LIG_FHA_2	881	887	PF00498	0.750
LIG_FHA_2	896	902	PF00498	0.641
LIG_GSK3_LRP6_1	1246	1251	PF00069	0.743
LIG_Integrin_RGD_1	250	252	PF01839	0.737
LIG_LIR_Apic_2	1138	1144	PF02991	0.546
LIG_LIR_Apic_2	1319	1324	PF02991	0.787
LIG_LIR_Apic_2	1433	1438	PF02991	0.548
LIG_LIR_Apic_2	457	463	PF02991	0.498
LIG_LIR_Apic_2	565	570	PF02991	0.531
LIG_LIR_Apic_2	759	764	PF02991	0.817
LIG_LIR_Gen_1	1031	1040	PF02991	0.505
LIG_LIR_Gen_1	1050	1059	PF02991	0.563
LIG_LIR_Gen_1	1171	1179	PF02991	0.546
LIG_LIR_Gen_1	157	167	PF02991	0.503
LIG_LIR_Gen_1	40	51	PF02991	0.494
LIG_LIR_Gen_1	589	596	PF02991	0.617
LIG_LIR_Gen_1	633	644	PF02991	0.359
LIG_LIR_Gen_1	702	711	PF02991	0.768
LIG_LIR_Nem_3	1031	1036	PF02991	0.505
LIG_LIR_Nem_3	1050	1054	PF02991	0.547
LIG_LIR_Nem_3	1056	1061	PF02991	0.512
LIG_LIR_Nem_3	1171	1175	PF02991	0.585
LIG_LIR_Nem_3	157	162	PF02991	0.484
LIG_LIR_Nem_3	166	170	PF02991	0.534
LIG_LIR_Nem_3	40	46	PF02991	0.494
LIG_LIR_Nem_3	573	577	PF02991	0.596
LIG_LIR_Nem_3	589	593	PF02991	0.576
LIG_LIR_Nem_3	633	639	PF02991	0.332
LIG_LIR_Nem_3	702	707	PF02991	0.736
LIG_MLH1_MIPbox_1	1055	1059	PF16413	0.466
LIG_Pex14_2	307	311	PF04695	0.574
LIG_Pex14_2	334	338	PF04695	0.583
LIG_Pex14_2	43	47	PF04695	0.397
LIG_Pex14_2	907	911	PF04695	0.607
LIG_Pex14_2	970	974	PF04695	0.546
LIG_PTB_Apo_2	1429	1436	PF02174	0.622
LIG_PTB_Apo_2	349	356	PF02174	0.550
LIG_PTB_Phospho_1	1429	1435	PF10480	0.624
LIG_PTB_Phospho_1	349	355	PF10480	0.548
LIG_Rb_pABgroove_1	337	345	PF01858	0.503
LIG_REV1ctd_RIR_1	1056	1064	PF16727	0.619
LIG_SH2_CRK	1033	1037	PF00017	0.546
LIG_SH2_CRK	1435	1439	PF00017	0.549
LIG_SH2_CRK	274	278	PF00017	0.394
LIG_SH2_CRK	91	95	PF00017	0.555
LIG_SH2_NCK_1	1141	1145	PF00017	0.619
LIG_SH2_PTP2	450	453	PF00017	0.529
LIG_SH2_SRC	774	777	PF00017	0.816
LIG_SH2_STAP1	1444	1448	PF00017	0.562
LIG_SH2_STAP1	286	290	PF00017	0.437
LIG_SH2_STAP1	937	941	PF00017	0.546
LIG_SH2_STAT3	1066	1069	PF00017	0.619
LIG_SH2_STAT3	560	563	PF00017	0.541
LIG_SH2_STAT5	1042	1045	PF00017	0.543
LIG_SH2_STAT5	1076	1079	PF00017	0.538
LIG_SH2_STAT5	1444	1447	PF00017	0.622
LIG_SH2_STAT5	167	170	PF00017	0.508
LIG_SH2_STAT5	189	192	PF00017	0.508
LIG_SH2_STAT5	211	214	PF00017	0.517
LIG_SH2_STAT5	390	393	PF00017	0.526
LIG_SH2_STAT5	450	453	PF00017	0.503
LIG_SH2_STAT5	91	94	PF00017	0.524
LIG_SH2_STAT5	971	974	PF00017	0.546
LIG_SH3_1	1244	1250	PF00018	0.736
LIG_SH3_1	1435	1441	PF00018	0.549
LIG_SH3_1	754	760	PF00018	0.777
LIG_SH3_2	65	70	PF14604	0.488
LIG_SH3_3	1149	1155	PF00018	0.546
LIG_SH3_3	1242	1248	PF00018	0.716
LIG_SH3_3	1435	1441	PF00018	0.568
LIG_SH3_3	1460	1466	PF00018	0.627
LIG_SH3_3	277	283	PF00018	0.422
LIG_SH3_3	299	305	PF00018	0.586
LIG_SH3_3	569	575	PF00018	0.547
LIG_SH3_3	62	68	PF00018	0.479
LIG_SH3_3	728	734	PF00018	0.833
LIG_SH3_3	754	760	PF00018	0.847
LIG_SH3_3	826	832	PF00018	0.812
LIG_SUMO_SIM_anti_2	1268	1275	PF11976	0.671
LIG_SUMO_SIM_anti_2	1330	1336	PF11976	0.536
LIG_SUMO_SIM_anti_2	96	104	PF11976	0.463
LIG_SUMO_SIM_par_1	1162	1167	PF11976	0.536
LIG_SUMO_SIM_par_1	1229	1234	PF11976	0.685
LIG_SUMO_SIM_par_1	1267	1275	PF11976	0.673
LIG_SUMO_SIM_par_1	127	132	PF11976	0.496
LIG_SUMO_SIM_par_1	848	858	PF11976	0.827
LIG_TRAF2_1	1238	1241	PF00917	0.773
LIG_TRAF2_1	739	742	PF00917	0.815
LIG_TRAF2_1	773	776	PF00917	0.767
LIG_TRAF2_1	900	903	PF00917	0.718
LIG_TYR_ITIM	272	277	PF00017	0.402
LIG_UBA3_1	1222	1228	PF00899	0.601
LIG_UBA3_1	906	912	PF00899	0.612
LIG_WRC_WIRS_1	1169	1174	PF05994	0.585
LIG_WRC_WIRS_1	636	641	PF05994	0.411
LIG_WRC_WIRS_1	708	713	PF05994	0.777
LIG_WW_3	247	251	PF00397	0.595
LIG_WW_3	655	659	PF00397	0.699
LIG_WW_3	755	759	PF00397	0.765
MOD_CDC14_SPxK_1	247	250	PF00782	0.595
MOD_CDC14_SPxK_1	755	758	PF00782	0.765
MOD_CDK_SPK_2	295	300	PF00069	0.490
MOD_CDK_SPK_2	328	333	PF00069	0.602
MOD_CDK_SPxK_1	244	250	PF00069	0.596
MOD_CDK_SPxK_1	752	758	PF00069	0.765
MOD_CDK_SPxK_1	817	823	PF00069	0.810
MOD_CDK_SPxxK_3	363	370	PF00069	0.598
MOD_CDK_SPxxK_3	817	824	PF00069	0.773
MOD_CK1_1	1004	1010	PF00069	0.546
MOD_CK1_1	1013	1019	PF00069	0.513
MOD_CK1_1	1320	1326	PF00069	0.784
MOD_CK1_1	1378	1384	PF00069	0.554
MOD_CK1_1	157	163	PF00069	0.473
MOD_CK1_1	242	248	PF00069	0.576
MOD_CK1_1	309	315	PF00069	0.595
MOD_CK1_1	328	334	PF00069	0.587
MOD_CK1_1	403	409	PF00069	0.566
MOD_CK1_1	435	441	PF00069	0.575
MOD_CK1_1	482	488	PF00069	0.485
MOD_CK1_1	525	531	PF00069	0.572
MOD_CK1_1	59	65	PF00069	0.488
MOD_CK1_1	595	601	PF00069	0.585
MOD_CK1_1	676	682	PF00069	0.774
MOD_CK1_1	712	718	PF00069	0.756
MOD_CK1_1	727	733	PF00069	0.813
MOD_CK1_1	736	742	PF00069	0.816
MOD_CK1_1	83	89	PF00069	0.554
MOD_CK1_1	846	852	PF00069	0.748
MOD_CK1_1	889	895	PF00069	0.779
MOD_CK2_1	1139	1145	PF00069	0.619
MOD_CK2_1	1171	1177	PF00069	0.546
MOD_CK2_1	1235	1241	PF00069	0.707
MOD_CK2_1	1422	1428	PF00069	0.590
MOD_CK2_1	165	171	PF00069	0.578
MOD_CK2_1	250	256	PF00069	0.611
MOD_CK2_1	468	474	PF00069	0.612
MOD_CK2_1	562	568	PF00069	0.473
MOD_CK2_1	736	742	PF00069	0.812
MOD_CK2_1	770	776	PF00069	0.734
MOD_CK2_1	895	901	PF00069	0.834
MOD_Cter_Amidation	28	31	PF01082	0.593
MOD_GlcNHglycan	1012	1015	PF01048	0.378
MOD_GlcNHglycan	1055	1058	PF01048	0.266
MOD_GlcNHglycan	1116	1119	PF01048	0.330
MOD_GlcNHglycan	1273	1277	PF01048	0.555
MOD_GlcNHglycan	1313	1316	PF01048	0.573
MOD_GlcNHglycan	1346	1349	PF01048	0.626
MOD_GlcNHglycan	1358	1361	PF01048	0.791
MOD_GlcNHglycan	1400	1403	PF01048	0.770
MOD_GlcNHglycan	1422	1425	PF01048	0.777
MOD_GlcNHglycan	1463	1466	PF01048	0.835
MOD_GlcNHglycan	26	29	PF01048	0.629
MOD_GlcNHglycan	31	34	PF01048	0.580
MOD_GlcNHglycan	311	314	PF01048	0.831
MOD_GlcNHglycan	320	323	PF01048	0.698
MOD_GlcNHglycan	418	421	PF01048	0.726
MOD_GlcNHglycan	427	431	PF01048	0.792
MOD_GlcNHglycan	453	456	PF01048	0.744
MOD_GlcNHglycan	499	502	PF01048	0.744
MOD_GlcNHglycan	524	527	PF01048	0.746
MOD_GlcNHglycan	584	587	PF01048	0.759
MOD_GlcNHglycan	594	597	PF01048	0.681
MOD_GlcNHglycan	605	608	PF01048	0.699
MOD_GlcNHglycan	619	623	PF01048	0.706
MOD_GlcNHglycan	62	65	PF01048	0.767
MOD_GlcNHglycan	724	727	PF01048	0.446
MOD_GlcNHglycan	82	85	PF01048	0.741
MOD_GlcNHglycan	834	837	PF01048	0.587
MOD_GlcNHglycan	843	846	PF01048	0.604
MOD_GlcNHglycan	875	878	PF01048	0.527
MOD_GSK3_1	1009	1016	PF00069	0.543
MOD_GSK3_1	1018	1025	PF00069	0.525
MOD_GSK3_1	1135	1142	PF00069	0.547
MOD_GSK3_1	1153	1160	PF00069	0.470
MOD_GSK3_1	1288	1295	PF00069	0.740
MOD_GSK3_1	1300	1307	PF00069	0.810
MOD_GSK3_1	1313	1320	PF00069	0.654
MOD_GSK3_1	1337	1344	PF00069	0.422
MOD_GSK3_1	1356	1363	PF00069	0.521
MOD_GSK3_1	1378	1385	PF00069	0.621
MOD_GSK3_1	1418	1425	PF00069	0.573
MOD_GSK3_1	165	172	PF00069	0.539
MOD_GSK3_1	250	257	PF00069	0.554
MOD_GSK3_1	286	293	PF00069	0.436
MOD_GSK3_1	312	319	PF00069	0.633
MOD_GSK3_1	389	396	PF00069	0.498
MOD_GSK3_1	411	418	PF00069	0.537
MOD_GSK3_1	426	433	PF00069	0.500
MOD_GSK3_1	436	443	PF00069	0.561
MOD_GSK3_1	518	525	PF00069	0.635
MOD_GSK3_1	52	59	PF00069	0.417
MOD_GSK3_1	562	569	PF00069	0.531
MOD_GSK3_1	582	589	PF00069	0.381
MOD_GSK3_1	592	599	PF00069	0.539
MOD_GSK3_1	603	610	PF00069	0.503
MOD_GSK3_1	673	680	PF00069	0.734
MOD_GSK3_1	720	727	PF00069	0.762
MOD_GSK3_1	729	736	PF00069	0.780
MOD_GSK3_1	752	759	PF00069	0.795
MOD_GSK3_1	76	83	PF00069	0.543
MOD_GSK3_1	770	777	PF00069	0.834
MOD_GSK3_1	783	790	PF00069	0.730
MOD_GSK3_1	793	800	PF00069	0.812
MOD_GSK3_1	828	835	PF00069	0.801
MOD_GSK3_1	841	848	PF00069	0.706
MOD_GSK3_1	882	889	PF00069	0.757
MOD_GSK3_1	89	96	PF00069	0.433
MOD_GSK3_1	891	898	PF00069	0.739
MOD_GSK3_1	997	1004	PF00069	0.545
MOD_LATS_1	1396	1402	PF00433	0.657
MOD_N-GLC_1	1114	1119	PF02516	0.323
MOD_N-GLC_1	192	197	PF02516	0.691
MOD_N-GLC_1	242	247	PF02516	0.806
MOD_N-GLC_1	400	405	PF02516	0.755
MOD_N-GLC_1	440	445	PF02516	0.829
MOD_N-GLC_1	846	851	PF02516	0.637
MOD_NEK2_1	1008	1013	PF00069	0.455
MOD_NEK2_1	1168	1173	PF00069	0.533
MOD_NEK2_1	1204	1209	PF00069	0.598
MOD_NEK2_1	1293	1298	PF00069	0.751
MOD_NEK2_1	1375	1380	PF00069	0.525
MOD_NEK2_1	1382	1387	PF00069	0.520
MOD_NEK2_1	1418	1423	PF00069	0.536
MOD_NEK2_1	192	197	PF00069	0.491
MOD_NEK2_1	221	226	PF00069	0.536
MOD_NEK2_1	239	244	PF00069	0.573
MOD_NEK2_1	380	385	PF00069	0.563
MOD_NEK2_1	618	623	PF00069	0.619
MOD_NEK2_1	644	649	PF00069	0.364
MOD_NEK2_1	880	885	PF00069	0.749
MOD_NEK2_1	89	94	PF00069	0.482
MOD_NEK2_1	996	1001	PF00069	0.563
MOD_NEK2_2	635	640	PF00069	0.355
MOD_NEK2_2	921	926	PF00069	0.619
MOD_PIKK_1	233	239	PF00454	0.633
MOD_PIKK_1	290	296	PF00454	0.460
MOD_PIKK_1	333	339	PF00454	0.585
MOD_PIKK_1	382	388	PF00454	0.512
MOD_PIKK_1	56	62	PF00454	0.749
MOD_PIKK_1	683	689	PF00454	0.778
MOD_PIKK_1	891	897	PF00454	0.823
MOD_PK_1	393	399	PF00069	0.549
MOD_PKA_1	1398	1404	PF00069	0.597
MOD_PKA_1	199	205	PF00069	0.488
MOD_PKA_1	24	30	PF00069	0.788
MOD_PKA_2	1044	1050	PF00069	0.546
MOD_PKA_2	1398	1404	PF00069	0.593
MOD_PKA_2	199	205	PF00069	0.488
MOD_PKA_2	24	30	PF00069	0.791
MOD_PKA_2	369	375	PF00069	0.590
MOD_PKA_2	479	485	PF00069	0.582
MOD_PKA_2	496	502	PF00069	0.549
MOD_PKA_2	673	679	PF00069	0.762
MOD_PKA_2	886	892	PF00069	0.816
MOD_PKA_2	89	95	PF00069	0.483
MOD_PKA_2	930	936	PF00069	0.546
MOD_PKB_1	1178	1186	PF00069	0.530
MOD_Plk_1	1004	1010	PF00069	0.525
MOD_Plk_1	1130	1136	PF00069	0.526
MOD_Plk_1	1448	1454	PF00069	0.522
MOD_Plk_1	1459	1465	PF00069	0.548
MOD_Plk_1	15	21	PF00069	0.788
MOD_Plk_1	192	198	PF00069	0.485
MOD_Plk_1	284	290	PF00069	0.451
MOD_Plk_1	400	406	PF00069	0.554
MOD_Plk_1	736	742	PF00069	0.784
MOD_Plk_1	851	857	PF00069	0.826
MOD_Plk_1	880	886	PF00069	0.764
MOD_Plk_1	996	1002	PF00069	0.568
MOD_Plk_2-3	541	547	PF00069	0.562
MOD_Plk_2-3	709	715	PF00069	0.816
MOD_Plk_2-3	851	857	PF00069	0.753
MOD_Plk_4	1004	1010	PF00069	0.568
MOD_Plk_4	1204	1210	PF00069	0.619
MOD_Plk_4	1383	1389	PF00069	0.576
MOD_Plk_4	1449	1455	PF00069	0.552
MOD_Plk_4	154	160	PF00069	0.483
MOD_Plk_4	193	199	PF00069	0.482
MOD_Plk_4	442	448	PF00069	0.557
MOD_Plk_4	468	474	PF00069	0.585
MOD_Plk_4	562	568	PF00069	0.583
MOD_Plk_4	921	927	PF00069	0.619
MOD_ProDKin_1	1135	1141	PF00069	0.546
MOD_ProDKin_1	1246	1252	PF00069	0.720
MOD_ProDKin_1	1288	1294	PF00069	0.803
MOD_ProDKin_1	1320	1326	PF00069	0.784
MOD_ProDKin_1	1400	1406	PF00069	0.566
MOD_ProDKin_1	1437	1443	PF00069	0.537
MOD_ProDKin_1	165	171	PF00069	0.532
MOD_ProDKin_1	231	237	PF00069	0.587
MOD_ProDKin_1	244	250	PF00069	0.531
MOD_ProDKin_1	295	301	PF00069	0.511
MOD_ProDKin_1	306	312	PF00069	0.559
MOD_ProDKin_1	328	334	PF00069	0.597
MOD_ProDKin_1	363	369	PF00069	0.572
MOD_ProDKin_1	566	572	PF00069	0.493
MOD_ProDKin_1	692	698	PF00069	0.801
MOD_ProDKin_1	699	705	PF00069	0.738
MOD_ProDKin_1	752	758	PF00069	0.850
MOD_ProDKin_1	783	789	PF00069	0.727
MOD_ProDKin_1	804	810	PF00069	0.761
MOD_ProDKin_1	817	823	PF00069	0.768
MOD_ProDKin_1	828	834	PF00069	0.781
MOD_SUMO_rev_2	1081	1090	PF00179	0.546
MOD_SUMO_rev_2	1323	1330	PF00179	0.781
MOD_SUMO_rev_2	901	907	PF00179	0.688
TRG_DiLeu_BaEn_3	775	781	PF01217	0.778
TRG_DiLeu_BaEn_4	474	480	PF01217	0.573
TRG_DiLeu_BaLyEn_6	572	577	PF01217	0.491
TRG_DiLeu_LyEn_5	264	269	PF01217	0.582
TRG_ENDOCYTIC_2	1033	1036	PF00928	0.524
TRG_ENDOCYTIC_2	167	170	PF00928	0.537
TRG_ENDOCYTIC_2	189	192	PF00928	0.508
TRG_ENDOCYTIC_2	274	277	PF00928	0.421
TRG_ENDOCYTIC_2	450	453	PF00928	0.529
TRG_ER_diArg_1	1052	1055	PF00400	0.538
TRG_ER_diArg_1	1178	1181	PF00400	0.530
TRG_ER_diArg_1	1397	1399	PF00400	0.590
TRG_ER_diArg_1	198	200	PF00400	0.478
TRG_ER_diArg_1	24	26	PF00400	0.824
TRG_ER_diArg_1	355	357	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	1180	1184	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	1220	1225	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	770	775	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U7	Leptomonas seymouri	48%	99%
A0A3S5H7W8	Leishmania donovani	100%	100%
A4HAS7	Leishmania braziliensis	71%	99%
E9B501	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q2Y5	Leishmania major	91%	100%