Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9X8_LEIIN

TriTrypDb:

LINF_340025100

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	4
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I9X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.564
CLV_NRD_NRD_1	84	86	PF00675	0.451
CLV_PCSK_KEX2_1	13	15	PF00082	0.564
CLV_PCSK_KEX2_1	84	86	PF00082	0.453
CLV_PCSK_SKI1_1	147	151	PF00082	0.673
CLV_PCSK_SKI1_1	31	35	PF00082	0.583
CLV_PCSK_SKI1_1	78	82	PF00082	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.725
DOC_PP1_RVXF_1	120	127	PF00149	0.546
DOC_USP7_MATH_1	39	43	PF00917	0.763
DOC_WW_Pin1_4	152	157	PF00397	0.529
LIG_14-3-3_CanoR_1	84	94	PF00244	0.703
LIG_BRCT_BRCA1_1	129	133	PF00533	0.513
LIG_BRCT_BRCA1_1	138	142	PF00533	0.364
LIG_CSL_BTD_1	153	156	PF09270	0.530
LIG_deltaCOP1_diTrp_1	115	120	PF00928	0.641
LIG_deltaCOP1_diTrp_1	151	157	PF00928	0.419
LIG_FHA_2	102	108	PF00498	0.772
LIG_FHA_2	44	50	PF00498	0.804
LIG_LIR_Gen_1	115	126	PF02991	0.630
LIG_LIR_Gen_1	62	71	PF02991	0.707
LIG_LIR_Nem_3	115	121	PF02991	0.636
LIG_LIR_Nem_3	151	157	PF02991	0.517
LIG_LIR_Nem_3	62	66	PF02991	0.714
LIG_NBox_RRM_1	2	12	PF00076	0.623
LIG_SH2_STAP1	138	142	PF00017	0.377
LIG_SH2_STAT5	140	143	PF00017	0.483
LIG_SH2_STAT5	148	151	PF00017	0.432
LIG_SH2_STAT5	93	96	PF00017	0.737
LIG_SH3_1	150	156	PF00018	0.534
LIG_SH3_1	96	102	PF00018	0.692
LIG_SH3_2	153	158	PF14604	0.480
LIG_SH3_3	150	156	PF00018	0.504
LIG_SH3_3	96	102	PF00018	0.692
LIG_TRAF2_1	55	58	PF00917	0.727
MOD_CDC14_SPxK_1	155	158	PF00782	0.478
MOD_CDK_SPxK_1	152	158	PF00069	0.478
MOD_CK1_1	87	93	PF00069	0.753
MOD_CK2_1	101	107	PF00069	0.715
MOD_CK2_1	85	91	PF00069	0.693
MOD_Cter_Amidation	82	85	PF01082	0.479
MOD_GlcNHglycan	14	17	PF01048	0.578
MOD_GlcNHglycan	41	44	PF01048	0.544
MOD_GSK3_1	128	135	PF00069	0.416
MOD_GSK3_1	39	46	PF00069	0.751
MOD_NEK2_1	127	132	PF00069	0.397
MOD_NEK2_1	133	138	PF00069	0.366
MOD_NEK2_1	7	12	PF00069	0.690
MOD_PIKK_1	69	75	PF00454	0.724
MOD_PKA_1	84	90	PF00069	0.691
MOD_PKA_2	12	18	PF00069	0.740
MOD_PKA_2	84	90	PF00069	0.691
MOD_Plk_1	48	54	PF00069	0.807
MOD_Plk_4	133	139	PF00069	0.411
MOD_Plk_4	59	65	PF00069	0.714
MOD_Plk_4	7	13	PF00069	0.663
MOD_ProDKin_1	152	158	PF00069	0.533
MOD_SUMO_for_1	149	152	PF00179	0.535
TRG_ER_diArg_1	12	14	PF00400	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P996	Leptomonas seymouri	53%	97%
A0A3Q8INA7	Leishmania donovani	99%	100%
A4HAR4	Leishmania braziliensis	68%	100%
E9B4Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q300	Leishmania major	89%	100%