P25-alpha domain-containing protein

Quick info Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p25-alpha - putative

Species:

Leishmania infantum

UniProt:

A4I9W5_LEIIN

TriTrypDb:

LINF_340022500

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Phosphorylation

Promastigote/Amastigote: 110

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I9W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9W5

Function

Biological processes
Term	Name	Level	Count
GO:0031334	positive regulation of protein-containing complex assembly	6	2
GO:0032271	regulation of protein polymerization	6	2
GO:0032273	positive regulation of protein polymerization	7	2
GO:0043254	regulation of protein-containing complex assembly	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0044089	positive regulation of cellular component biogenesis	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0065007	biological regulation	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.460
CLV_C14_Caspase3-7	21	25	PF00656	0.443
CLV_NRD_NRD_1	117	119	PF00675	0.243
CLV_NRD_NRD_1	37	39	PF00675	0.242
CLV_PCSK_KEX2_1	117	119	PF00082	0.243
CLV_PCSK_SKI1_1	131	135	PF00082	0.557
CLV_PCSK_SKI1_1	18	22	PF00082	0.243
CLV_PCSK_SKI1_1	8	12	PF00082	0.243
DEG_Nend_UBRbox_2	1	3	PF02207	0.561
DOC_MAPK_gen_1	33	42	PF00069	0.468
DOC_MAPK_gen_1	56	66	PF00069	0.380
DOC_MAPK_MEF2A_6	59	68	PF00069	0.380
DOC_PP1_RVXF_1	36	43	PF00149	0.485
DOC_USP7_MATH_1	73	77	PF00917	0.490
DOC_USP7_UBL2_3	14	18	PF12436	0.453
DOC_USP7_UBL2_3	31	35	PF12436	0.390
DOC_WW_Pin1_4	57	62	PF00397	0.497
LIG_14-3-3_CanoR_1	125	133	PF00244	0.700
LIG_14-3-3_CanoR_1	38	43	PF00244	0.454
LIG_FHA_2	100	106	PF00498	0.454
LIG_FHA_2	19	25	PF00498	0.443
LIG_FHA_2	58	64	PF00498	0.552
LIG_FHA_2	76	82	PF00498	0.358
LIG_LIR_Gen_1	26	37	PF02991	0.443
LIG_LIR_Gen_1	4	10	PF02991	0.514
LIG_LIR_Gen_1	41	50	PF02991	0.443
LIG_LIR_Nem_3	127	133	PF02991	0.403
LIG_LIR_Nem_3	26	32	PF02991	0.443
LIG_LIR_Nem_3	41	45	PF02991	0.443
LIG_SH2_CRK	130	134	PF00017	0.429
LIG_SH2_STAT5	92	95	PF00017	0.443
LIG_SUMO_SIM_anti_2	63	68	PF11976	0.380
LIG_TYR_ITSM	126	133	PF00017	0.520
MOD_CK1_1	19	25	PF00069	0.468
MOD_CK1_1	4	10	PF00069	0.470
MOD_CK1_1	75	81	PF00069	0.493
MOD_CK1_1	90	96	PF00069	0.395
MOD_CK2_1	38	44	PF00069	0.481
MOD_GlcNHglycan	75	78	PF01048	0.321
MOD_GSK3_1	16	23	PF00069	0.455
MOD_GSK3_1	75	82	PF00069	0.545
MOD_NEK2_1	1	6	PF00069	0.460
MOD_NEK2_1	27	32	PF00069	0.550
MOD_PKA_1	38	44	PF00069	0.453
MOD_PKA_2	124	130	PF00069	0.453
MOD_Plk_1	1	7	PF00069	0.468
MOD_Plk_1	87	93	PF00069	0.468
MOD_ProDKin_1	57	63	PF00069	0.497
MOD_SUMO_rev_2	7	16	PF00179	0.443
MOD_SUMO_rev_2	81	91	PF00179	0.443
TRG_ENDOCYTIC_2	130	133	PF00928	0.425
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.243

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI7	Leptomonas seymouri	81%	92%
A0A0N1PDJ8	Leptomonas seymouri	76%	92%
A0A0S4IQF6	Bodo saltans	69%	72%
A0A1X0PAD0	Trypanosomatidae	71%	93%
A0A3R7N9A0	Trypanosoma rangeli	67%	93%
A0A3S7X7W0	Leishmania donovani	99%	100%
A4H7S1	Leishmania braziliensis	90%	76%
A4H7S2	Leishmania braziliensis	91%	100%
A4I9W4	Leishmania infantum	100%	100%
A4IIY2	Xenopus tropicalis	39%	81%
C9ZMR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	95%
E9B4X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q0P5Y3	Mus musculus	40%	84%
Q2VPM9	Xenopus laevis	41%	81%
Q3T077	Bos taurus	39%	83%
Q3ZCC8	Bos taurus	39%	81%
Q4Q349	Leishmania major	98%	100%
Q4Q350	Leishmania major	99%	100%
Q5PPN5	Rattus norvegicus	40%	81%
Q9BW30	Homo sapiens	39%	81%
Q9CRB6	Mus musculus	40%	81%