Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9W3_LEIIN

TriTrypDb:

LINF_340022300

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 327, 330, 342, 80, 83

Expansion

Sequence features

A4I9W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.679
CLV_C14_Caspase3-7	330	334	PF00656	0.587
CLV_C14_Caspase3-7	97	101	PF00656	0.694
CLV_NRD_NRD_1	360	362	PF00675	0.681
CLV_NRD_NRD_1	37	39	PF00675	0.620
CLV_PCSK_KEX2_1	360	362	PF00082	0.681
CLV_PCSK_KEX2_1	37	39	PF00082	0.620
CLV_PCSK_SKI1_1	218	222	PF00082	0.684
CLV_PCSK_SKI1_1	297	301	PF00082	0.570
CLV_PCSK_SKI1_1	462	466	PF00082	0.505
DEG_APCC_DBOX_1	359	367	PF00400	0.624
DEG_APCC_KENBOX_2	260	264	PF00400	0.585
DEG_SCF_FBW7_2	6	11	PF00400	0.543
DEG_SPOP_SBC_1	182	186	PF00917	0.650
DEG_SPOP_SBC_1	423	427	PF00917	0.623
DOC_CYCLIN_RxL_1	476	487	PF00134	0.505
DOC_CYCLIN_yClb5_NLxxxL_5	144	153	PF00134	0.534
DOC_USP7_MATH_1	143	147	PF00917	0.582
DOC_USP7_MATH_1	355	359	PF00917	0.602
DOC_USP7_MATH_1	376	380	PF00917	0.638
DOC_USP7_MATH_1	455	459	PF00917	0.586
DOC_WW_Pin1_4	132	137	PF00397	0.615
DOC_WW_Pin1_4	273	278	PF00397	0.543
DOC_WW_Pin1_4	387	392	PF00397	0.711
DOC_WW_Pin1_4	4	9	PF00397	0.756
LIG_14-3-3_CanoR_1	138	143	PF00244	0.669
LIG_14-3-3_CanoR_1	180	189	PF00244	0.612
LIG_14-3-3_CanoR_1	360	364	PF00244	0.625
LIG_APCC_ABBA_1	15	20	PF00400	0.606
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BIR_III_4	333	337	PF00653	0.531
LIG_FHA_1	139	145	PF00498	0.622
LIG_FHA_1	182	188	PF00498	0.621
LIG_FHA_1	34	40	PF00498	0.686
LIG_FHA_2	113	119	PF00498	0.549
LIG_FHA_2	226	232	PF00498	0.567
LIG_FHA_2	249	255	PF00498	0.644
LIG_FHA_2	302	308	PF00498	0.610
LIG_FHA_2	360	366	PF00498	0.598
LIG_FHA_2	425	431	PF00498	0.766
LIG_FHA_2	441	447	PF00498	0.504
LIG_FHA_2	493	499	PF00498	0.516
LIG_LIR_Gen_1	238	246	PF02991	0.618
LIG_LIR_Nem_3	463	468	PF02991	0.509
LIG_LIR_Nem_3	53	59	PF02991	0.565
LIG_PCNA_PIPBox_1	485	494	PF02747	0.516
LIG_PCNA_yPIPBox_3	479	492	PF02747	0.466
LIG_PTB_Apo_2	381	388	PF02174	0.600
LIG_SH2_GRB2like	105	108	PF00017	0.690
LIG_SH2_NCK_1	105	109	PF00017	0.581
LIG_SH2_STAT5	175	178	PF00017	0.615
LIG_SH2_STAT5	245	248	PF00017	0.635
LIG_SH2_STAT5	491	494	PF00017	0.572
LIG_SH2_STAT5	56	59	PF00017	0.564
LIG_SH3_3	130	136	PF00018	0.612
LIG_SH3_3	274	280	PF00018	0.551
LIG_TRAF2_1	383	386	PF00917	0.623
LIG_TRAF2_1	414	417	PF00917	0.574
LIG_WRC_WIRS_1	328	333	PF05994	0.664
MOD_CDC14_SPxK_1	135	138	PF00782	0.692
MOD_CDK_SPxK_1	132	138	PF00069	0.691
MOD_CDK_SPxK_1	273	279	PF00069	0.546
MOD_CK1_1	106	112	PF00069	0.618
MOD_CK1_1	183	189	PF00069	0.679
MOD_CK1_1	234	240	PF00069	0.555
MOD_CK1_1	273	279	PF00069	0.553
MOD_CK1_1	298	304	PF00069	0.622
MOD_CK1_1	327	333	PF00069	0.616
MOD_CK1_1	428	434	PF00069	0.789
MOD_CK1_1	80	86	PF00069	0.630
MOD_CK2_1	112	118	PF00069	0.552
MOD_CK2_1	204	210	PF00069	0.612
MOD_CK2_1	248	254	PF00069	0.666
MOD_CK2_1	301	307	PF00069	0.632
MOD_GlcNHglycan	145	148	PF01048	0.559
MOD_GlcNHglycan	170	173	PF01048	0.632
MOD_GlcNHglycan	272	275	PF01048	0.546
MOD_GlcNHglycan	297	300	PF01048	0.616
MOD_GlcNHglycan	319	322	PF01048	0.783
MOD_GlcNHglycan	341	344	PF01048	0.677
MOD_GlcNHglycan	350	354	PF01048	0.584
MOD_GlcNHglycan	502	506	PF01048	0.472
MOD_GSK3_1	134	141	PF00069	0.685
MOD_GSK3_1	188	195	PF00069	0.704
MOD_GSK3_1	206	213	PF00069	0.662
MOD_GSK3_1	221	228	PF00069	0.606
MOD_GSK3_1	231	238	PF00069	0.530
MOD_GSK3_1	248	255	PF00069	0.654
MOD_GSK3_1	291	298	PF00069	0.558
MOD_GSK3_1	308	315	PF00069	0.764
MOD_GSK3_1	323	330	PF00069	0.513
MOD_GSK3_1	339	346	PF00069	0.514
MOD_GSK3_1	355	362	PF00069	0.520
MOD_GSK3_1	424	431	PF00069	0.657
MOD_GSK3_1	6	13	PF00069	0.696
MOD_LATS_1	422	428	PF00433	0.711
MOD_N-GLC_1	106	111	PF02516	0.693
MOD_N-GLC_1	180	185	PF02516	0.612
MOD_N-GLC_1	343	348	PF02516	0.661
MOD_N-GLC_1	435	440	PF02516	0.618
MOD_NEK2_1	10	15	PF00069	0.731
MOD_NEK2_1	232	237	PF00069	0.526
MOD_NEK2_1	25	30	PF00069	0.533
MOD_NEK2_1	293	298	PF00069	0.589
MOD_NEK2_1	317	322	PF00069	0.730
MOD_NEK2_1	324	329	PF00069	0.582
MOD_NEK2_1	339	344	PF00069	0.555
MOD_NEK2_1	359	364	PF00069	0.468
MOD_NEK2_1	492	497	PF00069	0.514
MOD_NEK2_2	240	245	PF00069	0.667
MOD_NEK2_2	355	360	PF00069	0.603
MOD_PIKK_1	100	106	PF00454	0.675
MOD_PIKK_1	291	297	PF00454	0.529
MOD_PK_1	221	227	PF00069	0.555
MOD_PK_1	77	83	PF00069	0.658
MOD_PKA_2	359	365	PF00069	0.625
MOD_PKB_1	178	186	PF00069	0.601
MOD_Plk_1	106	112	PF00069	0.694
MOD_Plk_1	113	119	PF00069	0.610
MOD_Plk_1	125	131	PF00069	0.487
MOD_Plk_1	252	258	PF00069	0.657
MOD_Plk_1	435	441	PF00069	0.613
MOD_Plk_1	473	479	PF00069	0.471
MOD_Plk_1	501	507	PF00069	0.474
MOD_Plk_1	77	83	PF00069	0.630
MOD_Plk_2-3	125	131	PF00069	0.606
MOD_Plk_4	183	189	PF00069	0.696
MOD_Plk_4	192	198	PF00069	0.588
MOD_Plk_4	240	246	PF00069	0.621
MOD_Plk_4	285	291	PF00069	0.532
MOD_Plk_4	435	441	PF00069	0.601
MOD_Plk_4	77	83	PF00069	0.670
MOD_ProDKin_1	132	138	PF00069	0.615
MOD_ProDKin_1	273	279	PF00069	0.546
MOD_ProDKin_1	387	393	PF00069	0.711
MOD_ProDKin_1	4	10	PF00069	0.757
TRG_DiLeu_BaEn_1	463	468	PF01217	0.509
TRG_DiLeu_BaEn_4	416	422	PF01217	0.626
TRG_ER_diArg_1	215	218	PF00400	0.636
TRG_ER_diArg_1	359	361	PF00400	0.629
TRG_ER_diArg_1	37	39	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	479	484	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X2	Leptomonas seymouri	55%	92%
A0A3S7X7T0	Leishmania donovani	99%	100%
A4H7S3	Leishmania braziliensis	76%	100%
E9B4X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q351	Leishmania major	95%	100%