PCI domain-containing protein

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3808) - putative

Species:

Leishmania infantum

UniProt:

A4I9W2_LEIIN

TriTrypDb:

LINF_340022200

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I9W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.474
CLV_C14_Caspase3-7	633	637	PF00656	0.529
CLV_NRD_NRD_1	512	514	PF00675	0.263
CLV_NRD_NRD_1	529	531	PF00675	0.304
CLV_NRD_NRD_1	607	609	PF00675	0.452
CLV_PCSK_KEX2_1	439	441	PF00082	0.288
CLV_PCSK_KEX2_1	548	550	PF00082	0.277
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.288
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.304
CLV_PCSK_SKI1_1	142	146	PF00082	0.168
CLV_PCSK_SKI1_1	291	295	PF00082	0.314
CLV_PCSK_SKI1_1	302	306	PF00082	0.258
CLV_PCSK_SKI1_1	531	535	PF00082	0.287
CLV_PCSK_SKI1_1	56	60	PF00082	0.401
CLV_PCSK_SKI1_1	697	701	PF00082	0.410
CLV_PCSK_SKI1_1	797	801	PF00082	0.565
DEG_APCC_DBOX_1	301	309	PF00400	0.506
DOC_CYCLIN_RxL_1	643	655	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	570	576	PF00134	0.553
DOC_MAPK_gen_1	373	381	PF00069	0.541
DOC_MAPK_gen_1	386	396	PF00069	0.479
DOC_MAPK_gen_1	439	447	PF00069	0.479
DOC_MAPK_gen_1	548	555	PF00069	0.578
DOC_MAPK_gen_1	608	615	PF00069	0.471
DOC_MAPK_gen_1	707	716	PF00069	0.519
DOC_MAPK_MEF2A_6	375	383	PF00069	0.468
DOC_MAPK_MEF2A_6	389	398	PF00069	0.428
DOC_PP1_RVXF_1	647	654	PF00149	0.493
DOC_USP7_MATH_1	205	209	PF00917	0.530
DOC_USP7_MATH_1	333	337	PF00917	0.443
DOC_USP7_MATH_1	347	351	PF00917	0.419
DOC_USP7_MATH_1	406	410	PF00917	0.474
DOC_USP7_MATH_1	5	9	PF00917	0.619
DOC_USP7_MATH_1	652	656	PF00917	0.671
DOC_USP7_MATH_1	680	684	PF00917	0.628
DOC_USP7_MATH_1	756	760	PF00917	0.423
DOC_USP7_UBL2_3	223	227	PF12436	0.431
DOC_USP7_UBL2_3	778	782	PF12436	0.485
DOC_WW_Pin1_4	246	251	PF00397	0.503
DOC_WW_Pin1_4	329	334	PF00397	0.452
DOC_WW_Pin1_4	557	562	PF00397	0.479
DOC_WW_Pin1_4	56	61	PF00397	0.537
DOC_WW_Pin1_4	626	631	PF00397	0.466
DOC_WW_Pin1_4	659	664	PF00397	0.660
DOC_WW_Pin1_4	667	672	PF00397	0.702
DOC_WW_Pin1_4	720	725	PF00397	0.467
LIG_14-3-3_CanoR_1	110	116	PF00244	0.488
LIG_14-3-3_CanoR_1	129	137	PF00244	0.328
LIG_14-3-3_CanoR_1	170	175	PF00244	0.488
LIG_14-3-3_CanoR_1	204	210	PF00244	0.530
LIG_14-3-3_CanoR_1	260	265	PF00244	0.506
LIG_14-3-3_CanoR_1	277	281	PF00244	0.436
LIG_14-3-3_CanoR_1	389	395	PF00244	0.538
LIG_14-3-3_CanoR_1	530	536	PF00244	0.506
LIG_14-3-3_CanoR_1	681	685	PF00244	0.598
LIG_14-3-3_CanoR_1	729	734	PF00244	0.371
LIG_14-3-3_CanoR_1	90	100	PF00244	0.498
LIG_Actin_WH2_2	290	308	PF00022	0.506
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BRCT_BRCA1_1	145	149	PF00533	0.494
LIG_BRCT_BRCA1_1	41	45	PF00533	0.378
LIG_BRCT_BRCA1_1	649	653	PF00533	0.672
LIG_BRCT_BRCA1_2	145	151	PF00533	0.530
LIG_deltaCOP1_diTrp_1	160	169	PF00928	0.463
LIG_DLG_GKlike_1	729	737	PF00625	0.480
LIG_FHA_1	270	276	PF00498	0.483
LIG_FHA_1	364	370	PF00498	0.480
LIG_FHA_1	389	395	PF00498	0.487
LIG_FHA_2	504	510	PF00498	0.454
LIG_HCF-1_HBM_1	217	220	PF13415	0.474
LIG_IRF3_LxIS_1	394	399	PF10401	0.446
LIG_LIR_Gen_1	146	153	PF02991	0.482
LIG_LIR_Gen_1	211	220	PF02991	0.476
LIG_LIR_Gen_1	506	515	PF02991	0.505
LIG_LIR_Nem_3	146	152	PF02991	0.511
LIG_LIR_Nem_3	207	212	PF02991	0.431
LIG_LIR_Nem_3	355	360	PF02991	0.477
LIG_LIR_Nem_3	422	426	PF02991	0.426
LIG_LIR_Nem_3	427	432	PF02991	0.426
LIG_LIR_Nem_3	506	510	PF02991	0.505
LIG_LIR_Nem_3	686	691	PF02991	0.353
LIG_LIR_Nem_3	743	749	PF02991	0.371
LIG_PCNA_yPIPBox_3	182	196	PF02747	0.520
LIG_PCNA_yPIPBox_3	622	635	PF02747	0.442
LIG_Pex14_1	731	735	PF04695	0.402
LIG_Pex14_2	149	153	PF04695	0.530
LIG_REV1ctd_RIR_1	75	85	PF16727	0.457
LIG_RPA_C_Fungi	44	56	PF08784	0.481
LIG_SH2_CRK	209	213	PF00017	0.331
LIG_SH2_CRK	343	347	PF00017	0.391
LIG_SH2_CRK	432	436	PF00017	0.346
LIG_SH2_CRK	688	692	PF00017	0.381
LIG_SH2_NCK_1	735	739	PF00017	0.365
LIG_SH2_NCK_1	742	746	PF00017	0.324
LIG_SH2_SRC	357	360	PF00017	0.391
LIG_SH2_SRC	432	435	PF00017	0.346
LIG_SH2_SRC	634	637	PF00017	0.389
LIG_SH2_STAP1	426	430	PF00017	0.322
LIG_SH2_STAP1	592	596	PF00017	0.413
LIG_SH2_STAP1	72	76	PF00017	0.346
LIG_SH2_STAP1	735	739	PF00017	0.387
LIG_SH2_STAP1	742	746	PF00017	0.362
LIG_SH2_STAT3	788	791	PF00017	0.351
LIG_SH2_STAT5	357	360	PF00017	0.391
LIG_SH2_STAT5	461	464	PF00017	0.345
LIG_SH2_STAT5	619	622	PF00017	0.430
LIG_SH2_STAT5	634	637	PF00017	0.381
LIG_SH2_STAT5	746	749	PF00017	0.398
LIG_SH3_3	244	250	PF00018	0.400
LIG_SH3_3	570	576	PF00018	0.499
LIG_SH3_3	584	590	PF00018	0.380
LIG_SH3_3	665	671	PF00018	0.737
LIG_SH3_3	674	680	PF00018	0.671
LIG_SH3_5	630	634	PF00018	0.517
LIG_SUMO_SIM_par_1	610	617	PF11976	0.436
LIG_TRAF2_1	23	26	PF00917	0.656
LIG_TRAF2_1	239	242	PF00917	0.346
LIG_TRAF2_1	498	501	PF00917	0.210
LIG_UBA3_1	690	697	PF00899	0.399
LIG_UBA3_1	760	766	PF00899	0.483
MOD_CDC14_SPxK_1	249	252	PF00782	0.308
MOD_CDK_SPxK_1	246	252	PF00069	0.308
MOD_CDK_SPxxK_3	659	666	PF00069	0.545
MOD_CDK_SPxxK_3	720	727	PF00069	0.500
MOD_CK1_1	143	149	PF00069	0.394
MOD_CK1_1	208	214	PF00069	0.432
MOD_CK1_1	255	261	PF00069	0.335
MOD_CK1_1	4	10	PF00069	0.678
MOD_CK1_1	449	455	PF00069	0.275
MOD_CK1_1	508	514	PF00069	0.346
MOD_CK1_1	659	665	PF00069	0.624
MOD_CK1_1	91	97	PF00069	0.413
MOD_CK2_1	162	168	PF00069	0.391
MOD_CK2_1	45	51	PF00069	0.466
MOD_CK2_1	495	501	PF00069	0.438
MOD_CK2_1	634	640	PF00069	0.485
MOD_CK2_1	65	71	PF00069	0.304
MOD_CK2_1	680	686	PF00069	0.557
MOD_CK2_1	7	13	PF00069	0.636
MOD_GlcNHglycan	130	133	PF01048	0.391
MOD_GlcNHglycan	164	167	PF01048	0.349
MOD_GlcNHglycan	192	195	PF01048	0.378
MOD_GlcNHglycan	265	269	PF01048	0.348
MOD_GlcNHglycan	3	6	PF01048	0.615
MOD_GlcNHglycan	335	338	PF01048	0.358
MOD_GlcNHglycan	349	352	PF01048	0.343
MOD_GlcNHglycan	7	10	PF01048	0.532
MOD_GlcNHglycan	769	772	PF01048	0.581
MOD_GSK3_1	1	8	PF00069	0.712
MOD_GSK3_1	128	135	PF00069	0.284
MOD_GSK3_1	136	143	PF00069	0.295
MOD_GSK3_1	204	211	PF00069	0.389
MOD_GSK3_1	226	233	PF00069	0.386
MOD_GSK3_1	242	249	PF00069	0.435
MOD_GSK3_1	260	267	PF00069	0.304
MOD_GSK3_1	329	336	PF00069	0.346
MOD_GSK3_1	390	397	PF00069	0.337
MOD_GSK3_1	505	512	PF00069	0.337
MOD_GSK3_1	553	560	PF00069	0.441
MOD_GSK3_1	647	654	PF00069	0.569
MOD_GSK3_1	667	674	PF00069	0.453
MOD_N-GLC_1	205	210	PF02516	0.314
MOD_N-GLC_1	45	50	PF02516	0.590
MOD_N-GLC_1	56	61	PF02516	0.407
MOD_N-GLC_2	402	404	PF02516	0.424
MOD_NEK2_1	127	132	PF00069	0.301
MOD_NEK2_1	188	193	PF00069	0.331
MOD_NEK2_1	264	269	PF00069	0.372
MOD_NEK2_1	292	297	PF00069	0.389
MOD_NEK2_1	353	358	PF00069	0.335
MOD_NEK2_1	374	379	PF00069	0.250
MOD_NEK2_1	396	401	PF00069	0.351
MOD_NEK2_1	448	453	PF00069	0.347
MOD_NEK2_1	45	50	PF00069	0.504
MOD_NEK2_1	651	656	PF00069	0.657
MOD_NEK2_2	226	231	PF00069	0.210
MOD_NEK2_2	634	639	PF00069	0.427
MOD_NEK2_2	85	90	PF00069	0.379
MOD_PIKK_1	132	138	PF00454	0.358
MOD_PIKK_1	175	181	PF00454	0.414
MOD_PIKK_1	230	236	PF00454	0.346
MOD_PIKK_1	408	414	PF00454	0.285
MOD_PIKK_1	459	465	PF00454	0.327
MOD_PIKK_1	518	524	PF00454	0.308
MOD_PKA_1	439	445	PF00069	0.391
MOD_PKA_2	128	134	PF00069	0.309
MOD_PKA_2	276	282	PF00069	0.300
MOD_PKA_2	374	380	PF00069	0.331
MOD_PKA_2	388	394	PF00069	0.250
MOD_PKA_2	439	445	PF00069	0.391
MOD_PKA_2	680	686	PF00069	0.524
MOD_PKA_2	91	97	PF00069	0.377
MOD_Plk_1	140	146	PF00069	0.376
MOD_Plk_1	205	211	PF00069	0.314
MOD_Plk_1	394	400	PF00069	0.378
MOD_Plk_1	750	756	PF00069	0.443
MOD_Plk_1	85	91	PF00069	0.288
MOD_Plk_4	140	146	PF00069	0.391
MOD_Plk_4	208	214	PF00069	0.383
MOD_Plk_4	252	258	PF00069	0.308
MOD_Plk_4	292	298	PF00069	0.346
MOD_Plk_4	326	332	PF00069	0.284
MOD_Plk_4	353	359	PF00069	0.335
MOD_Plk_4	374	380	PF00069	0.266
MOD_Plk_4	560	566	PF00069	0.528
MOD_Plk_4	695	701	PF00069	0.351
MOD_Plk_4	756	762	PF00069	0.469
MOD_ProDKin_1	246	252	PF00069	0.387
MOD_ProDKin_1	329	335	PF00069	0.316
MOD_ProDKin_1	557	563	PF00069	0.483
MOD_ProDKin_1	56	62	PF00069	0.538
MOD_ProDKin_1	626	632	PF00069	0.461
MOD_ProDKin_1	659	665	PF00069	0.662
MOD_ProDKin_1	667	673	PF00069	0.702
MOD_ProDKin_1	720	726	PF00069	0.466
MOD_SUMO_rev_2	498	503	PF00179	0.420
TRG_DiLeu_BaEn_1	316	321	PF01217	0.424
TRG_DiLeu_BaEn_1	686	691	PF01217	0.457
TRG_DiLeu_BaEn_4	500	506	PF01217	0.226
TRG_DiLeu_LyEn_5	686	691	PF01217	0.393
TRG_ENDOCYTIC_2	209	212	PF00928	0.290
TRG_ENDOCYTIC_2	213	216	PF00928	0.294
TRG_ENDOCYTIC_2	343	346	PF00928	0.356
TRG_ENDOCYTIC_2	357	360	PF00928	0.342
TRG_ENDOCYTIC_2	432	435	PF00928	0.352
TRG_ENDOCYTIC_2	688	691	PF00928	0.385
TRG_ENDOCYTIC_2	696	699	PF00928	0.355
TRG_ER_diArg_1	89	92	PF00400	0.391
TRG_NES_CRM1_1	20	34	PF08389	0.537
TRG_NES_CRM1_1	372	384	PF08389	0.346
TRG_NLS_MonoExtC_3	566	572	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I210	Leptomonas seymouri	60%	100%
A0A1X0PAU9	Trypanosomatidae	30%	100%
A0A3Q8IUJ9	Leishmania donovani	100%	100%
A0A3R7K1I3	Trypanosoma rangeli	28%	100%
A4H7S4	Leishmania braziliensis	74%	100%
C9ZMS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D3ZC96	Rattus norvegicus	22%	100%
E9B4X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q352	Leishmania major	91%	100%
V5B3F2	Trypanosoma cruzi	29%	100%