Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

R3H-associated N-terminal domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I9V7_LEIIN

TriTrypDb:

LINF_340021700

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I9V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9V7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.556
CLV_C14_Caspase3-7	301	305	PF00656	0.601
CLV_C14_Caspase3-7	77	81	PF00656	0.607
CLV_NRD_NRD_1	101	103	PF00675	0.498
CLV_NRD_NRD_1	133	135	PF00675	0.345
CLV_NRD_NRD_1	319	321	PF00675	0.613
CLV_NRD_NRD_1	341	343	PF00675	0.543
CLV_NRD_NRD_1	498	500	PF00675	0.574
CLV_NRD_NRD_1	502	504	PF00675	0.573
CLV_PCSK_FUR_1	339	343	PF00082	0.510
CLV_PCSK_FUR_1	99	103	PF00082	0.596
CLV_PCSK_KEX2_1	101	103	PF00082	0.498
CLV_PCSK_KEX2_1	319	321	PF00082	0.625
CLV_PCSK_KEX2_1	338	340	PF00082	0.486
CLV_PCSK_KEX2_1	341	343	PF00082	0.532
CLV_PCSK_KEX2_1	50	52	PF00082	0.640
CLV_PCSK_KEX2_1	86	88	PF00082	0.454
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.520
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.570
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.558
CLV_PCSK_SKI1_1	102	106	PF00082	0.474
CLV_PCSK_SKI1_1	151	155	PF00082	0.356
DEG_SCF_FBW7_1	489	495	PF00400	0.674
DOC_CKS1_1	10	15	PF01111	0.613
DOC_CKS1_1	489	494	PF01111	0.710
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.649
DOC_MAPK_DCC_7	324	333	PF00069	0.526
DOC_MAPK_MEF2A_6	324	333	PF00069	0.550
DOC_PP2B_LxvP_1	395	398	PF13499	0.737
DOC_PP2B_LxvP_1	445	448	PF13499	0.637
DOC_PP4_FxxP_1	455	458	PF00568	0.591
DOC_PP4_FxxP_1	490	493	PF00568	0.623
DOC_USP7_MATH_1	168	172	PF00917	0.428
DOC_USP7_MATH_1	242	246	PF00917	0.429
DOC_USP7_MATH_1	346	350	PF00917	0.616
DOC_USP7_MATH_1	511	515	PF00917	0.634
DOC_USP7_UBL2_3	264	268	PF12436	0.588
DOC_USP7_UBL2_3	500	504	PF12436	0.536
DOC_WW_Pin1_4	220	225	PF00397	0.416
DOC_WW_Pin1_4	266	271	PF00397	0.612
DOC_WW_Pin1_4	352	357	PF00397	0.601
DOC_WW_Pin1_4	358	363	PF00397	0.656
DOC_WW_Pin1_4	364	369	PF00397	0.633
DOC_WW_Pin1_4	388	393	PF00397	0.748
DOC_WW_Pin1_4	481	486	PF00397	0.720
DOC_WW_Pin1_4	488	493	PF00397	0.715
DOC_WW_Pin1_4	9	14	PF00397	0.582
LIG_14-3-3_CanoR_1	101	109	PF00244	0.565
LIG_14-3-3_CanoR_1	461	467	PF00244	0.671
LIG_APCC_ABBA_1	201	206	PF00400	0.425
LIG_APCC_ABBAyCdc20_2	200	206	PF00400	0.425
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_BRCT_BRCA1_1	271	275	PF00533	0.532
LIG_Clathr_ClatBox_1	195	199	PF01394	0.407
LIG_CtBP_PxDLS_1	270	274	PF00389	0.549
LIG_FHA_1	247	253	PF00498	0.425
LIG_FHA_1	353	359	PF00498	0.696
LIG_FHA_1	40	46	PF00498	0.524
LIG_FHA_1	440	446	PF00498	0.672
LIG_FHA_1	461	467	PF00498	0.686
LIG_FHA_1	489	495	PF00498	0.674
LIG_FHA_1	53	59	PF00498	0.316
LIG_FHA_2	103	109	PF00498	0.477
LIG_FHA_2	299	305	PF00498	0.587
LIG_FHA_2	376	382	PF00498	0.726
LIG_LIR_Apic_2	71	76	PF02991	0.526
LIG_LIR_Gen_1	175	184	PF02991	0.396
LIG_LIR_Gen_1	197	205	PF02991	0.425
LIG_LIR_Gen_1	256	263	PF02991	0.439
LIG_LIR_Gen_1	311	316	PF02991	0.535
LIG_LIR_Nem_3	175	179	PF02991	0.356
LIG_LIR_Nem_3	197	201	PF02991	0.437
LIG_LIR_Nem_3	225	231	PF02991	0.342
LIG_LIR_Nem_3	256	262	PF02991	0.396
LIG_LIR_Nem_3	279	284	PF02991	0.387
LIG_LIR_Nem_3	311	315	PF02991	0.529
LIG_LIR_Nem_3	37	43	PF02991	0.475
LIG_LIR_Nem_3	438	443	PF02991	0.656
LIG_LYPXL_yS_3	125	128	PF13949	0.298
LIG_MYND_1	485	489	PF01753	0.709
LIG_NRP_CendR_1	521	522	PF00754	0.619
LIG_PCNA_yPIPBox_3	132	145	PF02747	0.317
LIG_PTB_Apo_2	139	146	PF02174	0.339
LIG_SH2_CRK	281	285	PF00017	0.347
LIG_SH2_CRK	293	297	PF00017	0.378
LIG_SH2_NCK_1	73	77	PF00017	0.531
LIG_SH2_PTP2	312	315	PF00017	0.534
LIG_SH2_STAP1	34	38	PF00017	0.463
LIG_SH2_STAT5	312	315	PF00017	0.599
LIG_SH2_STAT5	456	459	PF00017	0.666
LIG_SH3_3	162	168	PF00018	0.286
LIG_SH3_3	212	218	PF00018	0.327
LIG_SH3_3	310	316	PF00018	0.408
LIG_SH3_3	323	329	PF00018	0.563
LIG_SH3_3	362	368	PF00018	0.709
LIG_SH3_3	386	392	PF00018	0.707
LIG_SH3_3	395	401	PF00018	0.740
LIG_SH3_3	486	492	PF00018	0.774
LIG_SH3_3	92	98	PF00018	0.557
LIG_SUMO_SIM_par_1	462	467	PF11976	0.667
LIG_TYR_ITIM	310	315	PF00017	0.530
LIG_UBA3_1	333	338	PF00899	0.490
MOD_CDK_SPxxK_3	220	227	PF00069	0.425
MOD_CK1_1	269	275	PF00069	0.583
MOD_CK1_1	351	357	PF00069	0.617
MOD_CK1_1	6	12	PF00069	0.641
MOD_CK1_1	74	80	PF00069	0.462
MOD_CK2_1	102	108	PF00069	0.490
MOD_CK2_1	375	381	PF00069	0.713
MOD_Cter_Amidation	48	51	PF01082	0.577
MOD_GlcNHglycan	13	16	PF01048	0.497
MOD_GlcNHglycan	259	262	PF01048	0.479
MOD_GlcNHglycan	304	308	PF01048	0.593
MOD_GlcNHglycan	350	353	PF01048	0.679
MOD_GlcNHglycan	410	413	PF01048	0.761
MOD_GlcNHglycan	431	434	PF01048	0.812
MOD_GlcNHglycan	479	482	PF01048	0.708
MOD_GlcNHglycan	509	512	PF01048	0.718
MOD_GSK3_1	168	175	PF00069	0.434
MOD_GSK3_1	19	26	PF00069	0.573
MOD_GSK3_1	242	249	PF00069	0.422
MOD_GSK3_1	294	301	PF00069	0.500
MOD_GSK3_1	311	318	PF00069	0.430
MOD_GSK3_1	348	355	PF00069	0.582
MOD_GSK3_1	435	442	PF00069	0.672
MOD_GSK3_1	477	484	PF00069	0.670
MOD_GSK3_1	488	495	PF00069	0.711
MOD_GSK3_1	507	514	PF00069	0.710
MOD_GSK3_1	54	61	PF00069	0.391
MOD_LATS_1	444	450	PF00433	0.599
MOD_NEK2_1	303	308	PF00069	0.642
MOD_NEK2_1	460	465	PF00069	0.707
MOD_NEK2_1	494	499	PF00069	0.650
MOD_PIKK_1	246	252	PF00454	0.450
MOD_PIKK_1	494	500	PF00454	0.595
MOD_PIKK_1	511	517	PF00454	0.630
MOD_PIKK_1	6	12	PF00454	0.572
MOD_PKA_2	23	29	PF00069	0.565
MOD_PKA_2	460	466	PF00069	0.675
MOD_Plk_1	168	174	PF00069	0.470
MOD_Plk_2-3	298	304	PF00069	0.516
MOD_Plk_4	269	275	PF00069	0.547
MOD_Plk_4	308	314	PF00069	0.469
MOD_Plk_4	435	441	PF00069	0.662
MOD_ProDKin_1	220	226	PF00069	0.416
MOD_ProDKin_1	266	272	PF00069	0.601
MOD_ProDKin_1	352	358	PF00069	0.607
MOD_ProDKin_1	364	370	PF00069	0.634
MOD_ProDKin_1	388	394	PF00069	0.747
MOD_ProDKin_1	481	487	PF00069	0.722
MOD_ProDKin_1	488	494	PF00069	0.705
MOD_ProDKin_1	9	15	PF00069	0.581
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.376
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.485
TRG_ENDOCYTIC_2	125	128	PF00928	0.298
TRG_ENDOCYTIC_2	281	284	PF00928	0.352
TRG_ENDOCYTIC_2	292	295	PF00928	0.356
TRG_ENDOCYTIC_2	312	315	PF00928	0.259
TRG_ENDOCYTIC_2	456	459	PF00928	0.622
TRG_ER_diArg_1	119	122	PF00400	0.425
TRG_ER_diArg_1	136	139	PF00400	0.304
TRG_ER_diArg_1	200	203	PF00400	0.407
TRG_ER_diArg_1	339	342	PF00400	0.602
TRG_ER_diArg_1	98	101	PF00400	0.489
TRG_NES_CRM1_1	178	193	PF08389	0.376
TRG_NES_CRM1_1	194	206	PF08389	0.425
TRG_NLS_Bipartite_1	101	116	PF00514	0.508
TRG_NLS_Bipartite_1	123	138	PF00514	0.342
TRG_NLS_MonoExtC_3	337	342	PF00514	0.502
TRG_NLS_MonoExtC_3	498	503	PF00514	0.555
TRG_NLS_MonoExtN_4	131	138	PF00514	0.342
TRG_NLS_MonoExtN_4	499	504	PF00514	0.532
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P399	Leptomonas seymouri	70%	80%
A0A0S4ILK0	Bodo saltans	40%	100%
A0A1X0P9H7	Trypanosomatidae	52%	100%
A0A3S7X7Q4	Leishmania donovani	100%	100%
A0A422N0N2	Trypanosoma rangeli	50%	100%
A4H7S9	Leishmania braziliensis	82%	100%
C9ZMS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B4X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q357	Leishmania major	94%	100%