D-isomer specific 2-hydroxyacid dehydrogenase-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

d-isomer specific 2-hydroxyacid dehydrogenase- protein

Species:

Leishmania infantum

UniProt:

A4I9V3_LEIIN

TriTrypDb:

LINF_340021100

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9V3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0036094	small molecule binding	2	10
GO:0051287	NAD binding	4	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.213
CLV_NRD_NRD_1	199	201	PF00675	0.549
CLV_NRD_NRD_1	29	31	PF00675	0.296
CLV_NRD_NRD_1	60	62	PF00675	0.213
CLV_PCSK_KEX2_1	101	103	PF00082	0.310
CLV_PCSK_KEX2_1	29	31	PF00082	0.246
CLV_PCSK_KEX2_1	60	62	PF00082	0.227
CLV_PCSK_SKI1_1	101	105	PF00082	0.219
CLV_PCSK_SKI1_1	106	110	PF00082	0.212
DEG_APCC_DBOX_1	29	37	PF00400	0.405
DEG_Nend_Nbox_1	1	3	PF02207	0.227
DOC_MAPK_gen_1	111	119	PF00069	0.498
DOC_MAPK_gen_1	29	36	PF00069	0.435
DOC_MAPK_gen_1	65	74	PF00069	0.473
DOC_MAPK_MEF2A_6	113	121	PF00069	0.391
DOC_USP7_MATH_1	155	159	PF00917	0.340
DOC_USP7_MATH_1	193	197	PF00917	0.279
DOC_USP7_MATH_1	22	26	PF00917	0.527
DOC_USP7_UBL2_3	15	19	PF12436	0.465
DOC_USP7_UBL2_3	65	69	PF12436	0.459
LIG_14-3-3_CanoR_1	123	128	PF00244	0.413
LIG_AP2alpha_2	21	23	PF02296	0.424
LIG_BRCT_BRCA1_1	114	118	PF00533	0.478
LIG_deltaCOP1_diTrp_1	17	23	PF00928	0.465
LIG_FHA_1	197	203	PF00498	0.446
LIG_LIR_Gen_1	115	125	PF02991	0.410
LIG_LIR_Gen_1	21	28	PF02991	0.420
LIG_LIR_Nem_3	115	121	PF02991	0.418
LIG_LIR_Nem_3	17	23	PF02991	0.446
LIG_PDZ_Class_2	199	204	PF00595	0.351
LIG_Pex14_2	104	108	PF04695	0.446
LIG_REV1ctd_RIR_1	101	110	PF16727	0.427
LIG_REV1ctd_RIR_1	186	195	PF16727	0.236
LIG_SH2_CRK	38	42	PF00017	0.450
LIG_SH2_GRB2like	3	6	PF00017	0.418
LIG_SH2_STAT5	3	6	PF00017	0.296
LIG_SUMO_SIM_anti_2	158	166	PF11976	0.282
LIG_SUMO_SIM_par_1	158	166	PF11976	0.317
LIG_TYR_ITIM	36	41	PF00017	0.422
LIG_UBA3_1	132	138	PF00899	0.459
MOD_CK1_1	158	164	PF00069	0.359
MOD_CK1_1	174	180	PF00069	0.591
MOD_CK1_1	196	202	PF00069	0.410
MOD_CK2_1	11	17	PF00069	0.288
MOD_CK2_1	123	129	PF00069	0.427
MOD_CK2_1	21	27	PF00069	0.438
MOD_CK2_1	80	86	PF00069	0.478
MOD_GlcNHglycan	114	117	PF01048	0.215
MOD_GlcNHglycan	61	64	PF01048	0.213
MOD_NEK2_1	11	16	PF00069	0.312
MOD_NEK2_1	169	174	PF00069	0.472
MOD_NEK2_1	54	59	PF00069	0.416
MOD_NEK2_1	80	85	PF00069	0.478
MOD_NEK2_1	89	94	PF00069	0.440
MOD_PIKK_1	182	188	PF00454	0.254
MOD_PK_1	123	129	PF00069	0.459
MOD_PKA_1	137	143	PF00069	0.406
MOD_PKA_2	174	180	PF00069	0.340
MOD_PKA_2	59	65	PF00069	0.413
MOD_Plk_1	80	86	PF00069	0.478
MOD_Plk_4	155	161	PF00069	0.381
MOD_Plk_4	89	95	PF00069	0.459
MOD_SUMO_rev_2	62	67	PF00179	0.479
TRG_ENDOCYTIC_2	38	41	PF00928	0.422
TRG_ER_diArg_1	101	103	PF00400	0.460
TRG_ER_diArg_1	28	30	PF00400	0.446
TRG_ER_diArg_1	59	61	PF00400	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JA38	Bodo saltans	46%	73%
A0A3R7MNZ9	Trypanosoma rangeli	51%	98%
A0A422MS17	Trypanosoma rangeli	44%	100%
A0A422MS45	Trypanosoma rangeli	53%	98%
A0A422MS54	Trypanosoma rangeli	56%	75%
A4HAQ6	Leishmania braziliensis	68%	100%
E9B4W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	69%
E9B4W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
P0C1E8	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	35%	67%
P0C1E9	Corynebacterium melassecola	35%	67%
Q1QWN6	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	30%	66%
Q2VEQ7	Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)	36%	66%
Q9X1C1	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	34%	67%