LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I9U8_LEIIN
TriTrypDb:
LINF_340020600
Length:
576

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9U8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9U8

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004842 ubiquitin-protein transferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0019787 ubiquitin-like protein transferase activity 3 1
GO:0061630 ubiquitin protein ligase activity 5 1
GO:0061659 ubiquitin-like protein ligase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 475 479 PF00656 0.734
CLV_C14_Caspase3-7 565 569 PF00656 0.728
CLV_NRD_NRD_1 486 488 PF00675 0.541
CLV_PCSK_KEX2_1 34 36 PF00082 0.552
CLV_PCSK_KEX2_1 522 524 PF00082 0.562
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.556
CLV_PCSK_PC1ET2_1 522 524 PF00082 0.574
CLV_PCSK_SKI1_1 193 197 PF00082 0.599
CLV_PCSK_SKI1_1 382 386 PF00082 0.506
CLV_PCSK_SKI1_1 494 498 PF00082 0.602
CLV_PCSK_SKI1_1 51 55 PF00082 0.644
DEG_SCF_FBW7_1 293 300 PF00400 0.706
DEG_SPOP_SBC_1 116 120 PF00917 0.730
DOC_CKS1_1 140 145 PF01111 0.692
DOC_CKS1_1 249 254 PF01111 0.746
DOC_CKS1_1 282 287 PF01111 0.736
DOC_CKS1_1 294 299 PF01111 0.578
DOC_CKS1_1 325 330 PF01111 0.810
DOC_CKS1_1 501 506 PF01111 0.625
DOC_CKS1_1 83 88 PF01111 0.628
DOC_MAPK_MEF2A_6 264 271 PF00069 0.727
DOC_PP2B_LxvP_1 544 547 PF13499 0.697
DOC_USP7_MATH_1 116 120 PF00917 0.761
DOC_USP7_MATH_1 235 239 PF00917 0.677
DOC_USP7_MATH_1 24 28 PF00917 0.566
DOC_USP7_MATH_1 242 246 PF00917 0.718
DOC_USP7_MATH_1 275 279 PF00917 0.712
DOC_USP7_MATH_1 283 287 PF00917 0.757
DOC_USP7_MATH_1 297 301 PF00917 0.601
DOC_USP7_MATH_1 318 322 PF00917 0.718
DOC_USP7_MATH_1 45 49 PF00917 0.488
DOC_USP7_MATH_1 549 553 PF00917 0.644
DOC_USP7_UBL2_3 60 64 PF12436 0.531
DOC_WW_Pin1_4 139 144 PF00397 0.625
DOC_WW_Pin1_4 244 249 PF00397 0.734
DOC_WW_Pin1_4 262 267 PF00397 0.657
DOC_WW_Pin1_4 271 276 PF00397 0.628
DOC_WW_Pin1_4 281 286 PF00397 0.617
DOC_WW_Pin1_4 287 292 PF00397 0.677
DOC_WW_Pin1_4 293 298 PF00397 0.665
DOC_WW_Pin1_4 302 307 PF00397 0.811
DOC_WW_Pin1_4 314 319 PF00397 0.686
DOC_WW_Pin1_4 321 326 PF00397 0.731
DOC_WW_Pin1_4 36 41 PF00397 0.579
DOC_WW_Pin1_4 409 414 PF00397 0.788
DOC_WW_Pin1_4 416 421 PF00397 0.567
DOC_WW_Pin1_4 500 505 PF00397 0.633
DOC_WW_Pin1_4 82 87 PF00397 0.615
LIG_14-3-3_CanoR_1 152 160 PF00244 0.540
LIG_14-3-3_CanoR_1 367 375 PF00244 0.523
LIG_14-3-3_CanoR_1 408 413 PF00244 0.787
LIG_14-3-3_CanoR_1 494 504 PF00244 0.594
LIG_14-3-3_CanoR_1 548 556 PF00244 0.608
LIG_APCC_ABBA_1 195 200 PF00400 0.540
LIG_BIR_II_1 1 5 PF00653 0.684
LIG_BIR_III_3 1 5 PF00653 0.684
LIG_CtBP_PxDLS_1 148 152 PF00389 0.643
LIG_FHA_1 140 146 PF00498 0.710
LIG_FHA_1 169 175 PF00498 0.554
LIG_FHA_1 282 288 PF00498 0.722
LIG_FHA_1 496 502 PF00498 0.559
LIG_FHA_1 568 574 PF00498 0.733
LIG_FHA_1 83 89 PF00498 0.551
LIG_FHA_2 124 130 PF00498 0.666
LIG_FHA_2 358 364 PF00498 0.672
LIG_FHA_2 417 423 PF00498 0.627
LIG_FHA_2 473 479 PF00498 0.729
LIG_FHA_2 501 507 PF00498 0.494
LIG_FHA_2 52 58 PF00498 0.629
LIG_FHA_2 533 539 PF00498 0.654
LIG_FHA_2 549 555 PF00498 0.498
LIG_LIR_Apic_2 183 187 PF02991 0.487
LIG_LIR_Nem_3 525 530 PF02991 0.546
LIG_NRBOX 69 75 PF00104 0.631
LIG_PALB2_WD40_1 186 194 PF16756 0.476
LIG_SH2_CRK 184 188 PF00017 0.479
LIG_SH2_STAT3 463 466 PF00017 0.520
LIG_SH2_STAT3 81 84 PF00017 0.697
LIG_SH2_STAT5 167 170 PF00017 0.529
LIG_SH2_STAT5 374 377 PF00017 0.506
LIG_SH2_STAT5 379 382 PF00017 0.474
LIG_SH2_STAT5 528 531 PF00017 0.534
LIG_SH2_STAT5 66 69 PF00017 0.629
LIG_SH2_STAT5 81 84 PF00017 0.449
LIG_SH3_3 134 140 PF00018 0.581
LIG_SH3_3 246 252 PF00018 0.774
LIG_SH3_3 260 266 PF00018 0.737
LIG_SH3_3 282 288 PF00018 0.762
LIG_SH3_3 322 328 PF00018 0.725
LIG_SUMO_SIM_anti_2 470 475 PF11976 0.409
LIG_SUMO_SIM_anti_2 515 522 PF11976 0.559
LIG_TRAF2_1 4 7 PF00917 0.587
LIG_TRAF2_1 503 506 PF00917 0.496
LIG_UBA3_1 518 522 PF00899 0.559
LIG_WRPW_2 63 66 PF00400 0.603
MOD_CDK_SPK_2 271 276 PF00069 0.685
MOD_CDK_SPxxK_3 248 255 PF00069 0.746
MOD_CDK_SPxxK_3 416 423 PF00069 0.691
MOD_CK1_1 118 124 PF00069 0.711
MOD_CK1_1 212 218 PF00069 0.626
MOD_CK1_1 244 250 PF00069 0.774
MOD_CK1_1 27 33 PF00069 0.598
MOD_CK1_1 274 280 PF00069 0.663
MOD_CK1_1 314 320 PF00069 0.709
MOD_CK1_1 321 327 PF00069 0.665
MOD_CK1_1 398 404 PF00069 0.778
MOD_CK1_1 416 422 PF00069 0.606
MOD_CK1_1 483 489 PF00069 0.607
MOD_CK1_1 532 538 PF00069 0.699
MOD_CK2_1 416 422 PF00069 0.619
MOD_CK2_1 500 506 PF00069 0.504
MOD_CK2_1 51 57 PF00069 0.634
MOD_CK2_1 548 554 PF00069 0.708
MOD_GlcNHglycan 244 247 PF01048 0.809
MOD_GlcNHglycan 26 29 PF01048 0.580
MOD_GlcNHglycan 313 316 PF01048 0.765
MOD_GlcNHglycan 320 323 PF01048 0.796
MOD_GlcNHglycan 334 337 PF01048 0.720
MOD_GlcNHglycan 400 403 PF01048 0.748
MOD_GlcNHglycan 416 419 PF01048 0.451
MOD_GlcNHglycan 443 446 PF01048 0.560
MOD_GlcNHglycan 450 453 PF01048 0.490
MOD_GlcNHglycan 480 485 PF01048 0.639
MOD_GlcNHglycan 531 534 PF01048 0.666
MOD_GlcNHglycan 541 544 PF01048 0.573
MOD_GlcNHglycan 551 554 PF01048 0.381
MOD_GSK3_1 112 119 PF00069 0.733
MOD_GSK3_1 120 127 PF00069 0.609
MOD_GSK3_1 212 219 PF00069 0.660
MOD_GSK3_1 237 244 PF00069 0.658
MOD_GSK3_1 267 274 PF00069 0.794
MOD_GSK3_1 283 290 PF00069 0.708
MOD_GSK3_1 293 300 PF00069 0.663
MOD_GSK3_1 314 321 PF00069 0.678
MOD_GSK3_1 332 339 PF00069 0.665
MOD_GSK3_1 340 347 PF00069 0.587
MOD_GSK3_1 353 360 PF00069 0.778
MOD_GSK3_1 392 399 PF00069 0.697
MOD_GSK3_1 400 407 PF00069 0.760
MOD_GSK3_1 409 416 PF00069 0.577
MOD_GSK3_1 51 58 PF00069 0.588
MOD_GSK3_1 529 536 PF00069 0.603
MOD_N-GLC_1 124 129 PF02516 0.712
MOD_N-GLC_1 409 414 PF02516 0.798
MOD_NEK2_1 151 156 PF00069 0.606
MOD_NEK2_1 168 173 PF00069 0.561
MOD_NEK2_1 269 274 PF00069 0.784
MOD_NEK2_1 311 316 PF00069 0.730
MOD_NEK2_1 492 497 PF00069 0.668
MOD_NEK2_1 567 572 PF00069 0.657
MOD_NEK2_2 336 341 PF00069 0.661
MOD_NEK2_2 45 50 PF00069 0.571
MOD_PIKK_1 210 216 PF00454 0.718
MOD_PIKK_1 340 346 PF00454 0.777
MOD_PIKK_1 439 445 PF00454 0.574
MOD_PK_1 55 61 PF00069 0.633
MOD_PKA_1 522 528 PF00069 0.565
MOD_PKA_2 103 109 PF00069 0.735
MOD_PKA_2 112 118 PF00069 0.703
MOD_PKA_2 151 157 PF00069 0.551
MOD_PKA_2 332 338 PF00069 0.771
MOD_PKA_2 522 528 PF00069 0.588
MOD_PKA_2 549 555 PF00069 0.623
MOD_Plk_1 385 391 PF00069 0.560
MOD_Plk_1 567 573 PF00069 0.648
MOD_Plk_2-3 91 97 PF00069 0.768
MOD_Plk_4 297 303 PF00069 0.597
MOD_Plk_4 336 342 PF00069 0.757
MOD_Plk_4 497 503 PF00069 0.593
MOD_Plk_4 77 83 PF00069 0.609
MOD_ProDKin_1 139 145 PF00069 0.631
MOD_ProDKin_1 244 250 PF00069 0.734
MOD_ProDKin_1 262 268 PF00069 0.660
MOD_ProDKin_1 271 277 PF00069 0.626
MOD_ProDKin_1 281 287 PF00069 0.619
MOD_ProDKin_1 293 299 PF00069 0.666
MOD_ProDKin_1 302 308 PF00069 0.809
MOD_ProDKin_1 314 320 PF00069 0.688
MOD_ProDKin_1 321 327 PF00069 0.732
MOD_ProDKin_1 36 42 PF00069 0.582
MOD_ProDKin_1 409 415 PF00069 0.785
MOD_ProDKin_1 416 422 PF00069 0.562
MOD_ProDKin_1 500 506 PF00069 0.629
MOD_ProDKin_1 82 88 PF00069 0.619
MOD_SUMO_for_1 375 378 PF00179 0.548
TRG_DiLeu_BaEn_1 516 521 PF01217 0.551
TRG_DiLeu_BaEn_1 7 12 PF01217 0.570
TRG_DiLeu_BaEn_4 516 522 PF01217 0.558
TRG_DiLeu_BaLyEn_6 83 88 PF01217 0.614
TRG_ER_diArg_1 158 161 PF00400 0.516
TRG_ER_diArg_1 255 258 PF00400 0.762
TRG_ER_diArg_1 547 550 PF00400 0.697
TRG_Pf-PMV_PEXEL_1 387 391 PF00026 0.614
TRG_Pf-PMV_PEXEL_1 494 499 PF00026 0.690

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6C9 Leptomonas seymouri 53% 98%
A0A3S7X7T6 Leishmania donovani 97% 100%
A0A422NU22 Trypanosoma rangeli 28% 93%
A4HAQ2 Leishmania braziliensis 77% 99%
E9B4V9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q367 Leishmania major 94% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS