Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9U5_LEIIN

TriTrypDb:

LINF_340020300

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.751
CLV_C14_Caspase3-7	577	581	PF00656	0.682
CLV_C14_Caspase3-7	593	597	PF00656	0.631
CLV_NRD_NRD_1	163	165	PF00675	0.654
CLV_NRD_NRD_1	193	195	PF00675	0.770
CLV_NRD_NRD_1	235	237	PF00675	0.617
CLV_NRD_NRD_1	462	464	PF00675	0.652
CLV_NRD_NRD_1	466	468	PF00675	0.631
CLV_NRD_NRD_1	511	513	PF00675	0.509
CLV_NRD_NRD_1	569	571	PF00675	0.712
CLV_NRD_NRD_1	58	60	PF00675	0.632
CLV_NRD_NRD_1	650	652	PF00675	0.576
CLV_NRD_NRD_1	7	9	PF00675	0.578
CLV_NRD_NRD_1	715	717	PF00675	0.635
CLV_NRD_NRD_1	90	92	PF00675	0.720
CLV_PCSK_FUR_1	161	165	PF00082	0.710
CLV_PCSK_FUR_1	460	464	PF00082	0.713
CLV_PCSK_KEX2_1	160	162	PF00082	0.653
CLV_PCSK_KEX2_1	163	165	PF00082	0.655
CLV_PCSK_KEX2_1	235	237	PF00082	0.645
CLV_PCSK_KEX2_1	462	464	PF00082	0.662
CLV_PCSK_KEX2_1	465	467	PF00082	0.642
CLV_PCSK_KEX2_1	511	513	PF00082	0.570
CLV_PCSK_KEX2_1	569	571	PF00082	0.680
CLV_PCSK_KEX2_1	58	60	PF00082	0.727
CLV_PCSK_KEX2_1	650	652	PF00082	0.576
CLV_PCSK_KEX2_1	7	9	PF00082	0.578
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.630
CLV_PCSK_PC7_1	462	468	PF00082	0.685
CLV_PCSK_SKI1_1	157	161	PF00082	0.764
CLV_PCSK_SKI1_1	390	394	PF00082	0.562
CLV_PCSK_SKI1_1	638	642	PF00082	0.540
DEG_COP1_1	675	685	PF00400	0.518
DEG_MDM2_SWIB_1	392	399	PF02201	0.400
DEG_Nend_UBRbox_1	1	4	PF02207	0.537
DEG_SCF_FBW7_2	290	297	PF00400	0.674
DEG_SCF_TRCP1_1	573	579	PF00400	0.550
DEG_SPOP_SBC_1	125	129	PF00917	0.727
DEG_SPOP_SBC_1	223	227	PF00917	0.651
DEG_SPOP_SBC_1	363	367	PF00917	0.572
DEG_SPOP_SBC_1	479	483	PF00917	0.685
DOC_CKS1_1	485	490	PF01111	0.628
DOC_CYCLIN_RxL_1	635	642	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	419	422	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.621
DOC_MAPK_gen_1	7	13	PF00069	0.478
DOC_MAPK_MEF2A_6	687	696	PF00069	0.544
DOC_PP1_RVXF_1	529	535	PF00149	0.510
DOC_PP2B_LxvP_1	207	210	PF13499	0.706
DOC_PP2B_LxvP_1	419	422	PF13499	0.445
DOC_PP2B_LxvP_1	425	428	PF13499	0.484
DOC_PP4_FxxP_1	476	479	PF00568	0.610
DOC_PP4_FxxP_1	534	537	PF00568	0.527
DOC_PP4_FxxP_1	602	605	PF00568	0.690
DOC_USP7_MATH_1	118	122	PF00917	0.762
DOC_USP7_MATH_1	125	129	PF00917	0.726
DOC_USP7_MATH_1	169	173	PF00917	0.753
DOC_USP7_MATH_1	224	228	PF00917	0.708
DOC_USP7_MATH_1	247	251	PF00917	0.732
DOC_USP7_MATH_1	356	360	PF00917	0.708
DOC_USP7_MATH_1	363	367	PF00917	0.717
DOC_USP7_MATH_1	433	437	PF00917	0.681
DOC_USP7_MATH_1	443	447	PF00917	0.617
DOC_USP7_MATH_1	480	484	PF00917	0.615
DOC_USP7_MATH_1	545	549	PF00917	0.605
DOC_USP7_MATH_1	605	609	PF00917	0.684
DOC_USP7_MATH_1	660	664	PF00917	0.643
DOC_USP7_MATH_1	736	740	PF00917	0.608
DOC_USP7_MATH_1	76	80	PF00917	0.718
DOC_USP7_UBL2_3	332	336	PF12436	0.600
DOC_WW_Pin1_4	17	22	PF00397	0.593
DOC_WW_Pin1_4	176	181	PF00397	0.743
DOC_WW_Pin1_4	184	189	PF00397	0.707
DOC_WW_Pin1_4	209	214	PF00397	0.611
DOC_WW_Pin1_4	269	274	PF00397	0.688
DOC_WW_Pin1_4	276	281	PF00397	0.606
DOC_WW_Pin1_4	290	295	PF00397	0.506
DOC_WW_Pin1_4	484	489	PF00397	0.629
DOC_WW_Pin1_4	491	496	PF00397	0.488
DOC_WW_Pin1_4	630	635	PF00397	0.617
DOC_WW_Pin1_4	672	677	PF00397	0.583
LIG_14-3-3_CanoR_1	138	144	PF00244	0.533
LIG_14-3-3_CanoR_1	175	180	PF00244	0.632
LIG_14-3-3_CanoR_1	26	32	PF00244	0.658
LIG_14-3-3_CanoR_1	687	695	PF00244	0.567
LIG_14-3-3_CanoR_1	716	726	PF00244	0.750
LIG_14-3-3_CanoR_1	741	748	PF00244	0.543
LIG_BIR_III_4	246	250	PF00653	0.707
LIG_BRCT_BRCA1_1	315	319	PF00533	0.588
LIG_BRCT_BRCA1_1	43	47	PF00533	0.685
LIG_CaM_IQ_9	450	465	PF13499	0.646
LIG_CaM_IQ_9	499	514	PF13499	0.554
LIG_EH_1	473	477	PF12763	0.538
LIG_eIF4E_1	635	641	PF01652	0.668
LIG_FHA_1	256	262	PF00498	0.651
LIG_FHA_1	266	272	PF00498	0.667
LIG_FHA_1	306	312	PF00498	0.597
LIG_FHA_1	379	385	PF00498	0.685
LIG_FHA_1	404	410	PF00498	0.568
LIG_FHA_1	485	491	PF00498	0.651
LIG_FHA_1	62	68	PF00498	0.704
LIG_FHA_1	691	697	PF00498	0.562
LIG_FHA_2	365	371	PF00498	0.747
LIG_FHA_2	429	435	PF00498	0.651
LIG_FHA_2	451	457	PF00498	0.619
LIG_LIR_Gen_1	30	39	PF02991	0.648
LIG_LIR_Gen_1	389	399	PF02991	0.582
LIG_LIR_Nem_3	30	34	PF02991	0.664
LIG_LIR_Nem_3	389	395	PF02991	0.581
LIG_LIR_Nem_3	45	51	PF02991	0.559
LIG_LIR_Nem_3	671	677	PF02991	0.658
LIG_MLH1_MIPbox_1	44	48	PF16413	0.611
LIG_MYND_1	205	209	PF01753	0.637
LIG_MYND_1	491	495	PF01753	0.593
LIG_Pex14_2	392	396	PF04695	0.393
LIG_Pex14_2	47	51	PF04695	0.560
LIG_REV1ctd_RIR_1	45	51	PF16727	0.497
LIG_SH2_CRK	526	530	PF00017	0.539
LIG_SH2_CRK	775	779	PF00017	0.603
LIG_SH2_STAP1	285	289	PF00017	0.721
LIG_SH2_STAP1	610	614	PF00017	0.690
LIG_SH2_STAP1	677	681	PF00017	0.661
LIG_SH2_STAP1	688	692	PF00017	0.572
LIG_SH2_STAT5	285	288	PF00017	0.748
LIG_SH2_STAT5	334	337	PF00017	0.517
LIG_SH2_STAT5	520	523	PF00017	0.601
LIG_SH2_STAT5	635	638	PF00017	0.668
LIG_SH2_STAT5	775	778	PF00017	0.604
LIG_SH3_1	680	686	PF00018	0.574
LIG_SH3_3	105	111	PF00018	0.695
LIG_SH3_3	203	209	PF00018	0.652
LIG_SH3_3	346	352	PF00018	0.680
LIG_SH3_3	436	442	PF00018	0.638
LIG_SH3_3	482	488	PF00018	0.687
LIG_SH3_3	622	628	PF00018	0.705
LIG_SH3_3	680	686	PF00018	0.549
LIG_SH3_3	765	771	PF00018	0.616
LIG_SUMO_SIM_anti_2	689	697	PF11976	0.543
LIG_SUMO_SIM_par_1	308	314	PF11976	0.595
LIG_SUMO_SIM_par_1	692	697	PF11976	0.547
LIG_SUMO_SIM_par_1	704	711	PF11976	0.541
LIG_TRAF2_1	367	370	PF00917	0.540
LIG_UBA3_1	499	507	PF00899	0.551
LIG_WRC_WIRS_1	28	33	PF05994	0.657
LIG_WW_2	488	491	PF00397	0.582
MOD_CDK_SPK_2	290	295	PF00069	0.680
MOD_CDK_SPxxK_3	491	498	PF00069	0.532
MOD_CK1_1	178	184	PF00069	0.660
MOD_CK1_1	186	192	PF00069	0.702
MOD_CK1_1	238	244	PF00069	0.691
MOD_CK1_1	318	324	PF00069	0.544
MOD_CK1_1	371	377	PF00069	0.673
MOD_CK1_1	446	452	PF00069	0.785
MOD_CK1_1	553	559	PF00069	0.604
MOD_CK1_1	574	580	PF00069	0.715
MOD_CK1_1	581	587	PF00069	0.612
MOD_CK1_1	608	614	PF00069	0.770
MOD_CK1_1	633	639	PF00069	0.704
MOD_CK1_1	663	669	PF00069	0.585
MOD_CK1_1	672	678	PF00069	0.633
MOD_CK1_1	718	724	PF00069	0.723
MOD_CK1_1	757	763	PF00069	0.569
MOD_CK1_1	79	85	PF00069	0.676
MOD_CK2_1	124	130	PF00069	0.648
MOD_CK2_1	364	370	PF00069	0.755
MOD_CK2_1	450	456	PF00069	0.658
MOD_CK2_1	491	497	PF00069	0.507
MOD_CK2_1	705	711	PF00069	0.559
MOD_CK2_1	719	725	PF00069	0.727
MOD_CK2_1	756	762	PF00069	0.617
MOD_Cter_Amidation	161	164	PF01082	0.661
MOD_Cter_Amidation	229	232	PF01082	0.764
MOD_Cter_Amidation	233	236	PF01082	0.665
MOD_Cter_Amidation	460	463	PF01082	0.715
MOD_Cter_Amidation	56	59	PF01082	0.640
MOD_GlcNHglycan	171	174	PF01048	0.747
MOD_GlcNHglycan	180	183	PF01048	0.664
MOD_GlcNHglycan	237	240	PF01048	0.730
MOD_GlcNHglycan	249	252	PF01048	0.624
MOD_GlcNHglycan	313	316	PF01048	0.589
MOD_GlcNHglycan	370	373	PF01048	0.681
MOD_GlcNHglycan	445	448	PF01048	0.755
MOD_GlcNHglycan	468	471	PF01048	0.735
MOD_GlcNHglycan	482	485	PF01048	0.512
MOD_GlcNHglycan	547	550	PF01048	0.595
MOD_GlcNHglycan	573	576	PF01048	0.646
MOD_GlcNHglycan	580	584	PF01048	0.616
MOD_GlcNHglycan	662	665	PF01048	0.600
MOD_GlcNHglycan	721	724	PF01048	0.627
MOD_GlcNHglycan	738	741	PF01048	0.678
MOD_GlcNHglycan	743	746	PF01048	0.632
MOD_GlcNHglycan	749	752	PF01048	0.627
MOD_GlcNHglycan	78	81	PF01048	0.640
MOD_GlcNHglycan	85	88	PF01048	0.638
MOD_GSK3_1	114	121	PF00069	0.727
MOD_GSK3_1	132	139	PF00069	0.476
MOD_GSK3_1	171	178	PF00069	0.688
MOD_GSK3_1	183	190	PF00069	0.697
MOD_GSK3_1	238	245	PF00069	0.641
MOD_GSK3_1	265	272	PF00069	0.751
MOD_GSK3_1	289	296	PF00069	0.684
MOD_GSK3_1	311	318	PF00069	0.585
MOD_GSK3_1	320	327	PF00069	0.622
MOD_GSK3_1	364	371	PF00069	0.685
MOD_GSK3_1	443	450	PF00069	0.688
MOD_GSK3_1	474	481	PF00069	0.763
MOD_GSK3_1	574	581	PF00069	0.694
MOD_GSK3_1	605	612	PF00069	0.753
MOD_GSK3_1	629	636	PF00069	0.631
MOD_GSK3_1	639	646	PF00069	0.490
MOD_GSK3_1	686	693	PF00069	0.567
MOD_GSK3_1	701	708	PF00069	0.481
MOD_GSK3_1	711	718	PF00069	0.594
MOD_GSK3_1	743	750	PF00069	0.619
MOD_GSK3_1	76	83	PF00069	0.657
MOD_NEK2_1	124	129	PF00069	0.676
MOD_NEK2_1	289	294	PF00069	0.751
MOD_NEK2_1	319	324	PF00069	0.539
MOD_NEK2_2	27	32	PF00069	0.676
MOD_NEK2_2	43	48	PF00069	0.726
MOD_PIKK_1	356	362	PF00454	0.701
MOD_PIKK_1	450	456	PF00454	0.682
MOD_PIKK_1	513	519	PF00454	0.484
MOD_PIKK_1	613	619	PF00454	0.650
MOD_PK_1	435	441	PF00069	0.619
MOD_PKA_1	235	241	PF00069	0.671
MOD_PKA_1	466	472	PF00069	0.723
MOD_PKA_1	716	722	PF00069	0.685
MOD_PKA_2	235	241	PF00069	0.671
MOD_PKA_2	303	309	PF00069	0.516
MOD_PKA_2	32	38	PF00069	0.698
MOD_PKA_2	466	472	PF00069	0.624
MOD_PKA_2	686	692	PF00069	0.564
MOD_PKA_2	715	721	PF00069	0.743
MOD_PKA_2	83	89	PF00069	0.771
MOD_Plk_1	540	546	PF00069	0.505
MOD_Plk_1	595	601	PF00069	0.748
MOD_Plk_1	734	740	PF00069	0.698
MOD_Plk_2-3	705	711	PF00069	0.559
MOD_Plk_4	238	244	PF00069	0.660
MOD_Plk_4	272	278	PF00069	0.688
MOD_Plk_4	315	321	PF00069	0.561
MOD_Plk_4	43	49	PF00069	0.597
MOD_Plk_4	553	559	PF00069	0.552
MOD_Plk_4	581	587	PF00069	0.648
MOD_Plk_4	605	611	PF00069	0.662
MOD_Plk_4	63	69	PF00069	0.624
MOD_ProDKin_1	17	23	PF00069	0.593
MOD_ProDKin_1	176	182	PF00069	0.742
MOD_ProDKin_1	184	190	PF00069	0.709
MOD_ProDKin_1	209	215	PF00069	0.611
MOD_ProDKin_1	269	275	PF00069	0.688
MOD_ProDKin_1	276	282	PF00069	0.604
MOD_ProDKin_1	290	296	PF00069	0.501
MOD_ProDKin_1	484	490	PF00069	0.625
MOD_ProDKin_1	491	497	PF00069	0.482
MOD_ProDKin_1	630	636	PF00069	0.614
MOD_ProDKin_1	672	678	PF00069	0.582
MOD_SUMO_rev_2	452	459	PF00179	0.645
TRG_DiLeu_BaEn_1	415	420	PF01217	0.546
TRG_DiLeu_BaEn_2	625	631	PF01217	0.709
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.575
TRG_ENDOCYTIC_2	526	529	PF00928	0.541
TRG_ENDOCYTIC_2	775	778	PF00928	0.581
TRG_ER_diArg_1	161	164	PF00400	0.713
TRG_ER_diArg_1	460	463	PF00400	0.654
TRG_ER_diArg_1	465	467	PF00400	0.662
TRG_ER_diArg_1	510	512	PF00400	0.394
TRG_ER_diArg_1	531	534	PF00400	0.511
TRG_ER_diArg_1	649	651	PF00400	0.564
TRG_NLS_MonoExtC_3	159	164	PF00514	0.640
TRG_NLS_MonoExtN_4	157	164	PF00514	0.692
TRG_Pf-PMV_PEXEL_1	498	503	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL05	Leptomonas seymouri	44%	100%
A0A1X0P9E8	Trypanosomatidae	32%	100%
A0A3S7X7P6	Leishmania donovani	99%	100%
A4HAP9	Leishmania braziliensis	74%	100%
C9ZMT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9B4V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q370	Leishmania major	91%	100%
V5BT09	Trypanosoma cruzi	30%	100%