Ran gtpase-activating protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9U2_LEIIN

TriTrypDb:

LINF_340020000

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A4I9U2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9U2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.453
CLV_NRD_NRD_1	30	32	PF00675	0.450
CLV_NRD_NRD_1	410	412	PF00675	0.563
CLV_NRD_NRD_1	580	582	PF00675	0.658
CLV_NRD_NRD_1	623	625	PF00675	0.689
CLV_NRD_NRD_1	7	9	PF00675	0.469
CLV_NRD_NRD_1	715	717	PF00675	0.632
CLV_PCSK_FUR_1	4	8	PF00082	0.493
CLV_PCSK_KEX2_1	121	123	PF00082	0.488
CLV_PCSK_KEX2_1	30	32	PF00082	0.450
CLV_PCSK_KEX2_1	409	411	PF00082	0.586
CLV_PCSK_KEX2_1	6	8	PF00082	0.438
CLV_PCSK_KEX2_1	623	625	PF00082	0.689
CLV_PCSK_KEX2_1	71	73	PF00082	0.543
CLV_PCSK_KEX2_1	715	717	PF00082	0.608
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.586
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.540
CLV_PCSK_PC7_1	2	8	PF00082	0.487
CLV_PCSK_PC7_1	405	411	PF00082	0.554
CLV_PCSK_SKI1_1	230	234	PF00082	0.414
CLV_PCSK_SKI1_1	295	299	PF00082	0.480
CLV_PCSK_SKI1_1	488	492	PF00082	0.423
CLV_PCSK_SKI1_1	638	642	PF00082	0.755
CLV_PCSK_SKI1_1	7	11	PF00082	0.433
DEG_APCC_DBOX_1	6	14	PF00400	0.462
DEG_APCC_DBOX_1	611	619	PF00400	0.631
DEG_Nend_UBRbox_1	1	4	PF02207	0.473
DOC_CDC14_PxL_1	349	357	PF14671	0.430
DOC_CKS1_1	226	231	PF01111	0.463
DOC_CKS1_1	34	39	PF01111	0.478
DOC_CYCLIN_RxL_1	160	169	PF00134	0.358
DOC_CYCLIN_RxL_1	264	273	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.372
DOC_MAPK_DCC_7	278	287	PF00069	0.597
DOC_MAPK_gen_1	440	450	PF00069	0.384
DOC_MAPK_MEF2A_6	443	450	PF00069	0.504
DOC_PP1_RVXF_1	228	235	PF00149	0.419
DOC_PP2B_LxvP_1	542	545	PF13499	0.592
DOC_USP7_MATH_1	149	153	PF00917	0.640
DOC_USP7_MATH_1	19	23	PF00917	0.604
DOC_USP7_MATH_1	301	305	PF00917	0.536
DOC_USP7_MATH_1	323	327	PF00917	0.418
DOC_USP7_MATH_1	42	46	PF00917	0.433
DOC_USP7_MATH_1	519	523	PF00917	0.691
DOC_USP7_MATH_1	567	571	PF00917	0.622
DOC_USP7_MATH_1	607	611	PF00917	0.623
DOC_USP7_MATH_1	652	656	PF00917	0.721
DOC_USP7_MATH_1	706	710	PF00917	0.674
DOC_WW_Pin1_4	130	135	PF00397	0.469
DOC_WW_Pin1_4	225	230	PF00397	0.463
DOC_WW_Pin1_4	246	251	PF00397	0.466
DOC_WW_Pin1_4	33	38	PF00397	0.590
DOC_WW_Pin1_4	563	568	PF00397	0.650
DOC_WW_Pin1_4	622	627	PF00397	0.706
DOC_WW_Pin1_4	654	659	PF00397	0.586
LIG_14-3-3_CanoR_1	121	130	PF00244	0.512
LIG_14-3-3_CanoR_1	197	206	PF00244	0.575
LIG_14-3-3_CanoR_1	334	342	PF00244	0.427
LIG_14-3-3_CanoR_1	405	412	PF00244	0.590
LIG_14-3-3_CanoR_1	458	466	PF00244	0.387
LIG_14-3-3_CanoR_1	488	495	PF00244	0.426
LIG_14-3-3_CanoR_1	574	579	PF00244	0.641
LIG_14-3-3_CanoR_1	676	682	PF00244	0.656
LIG_FHA_1	131	137	PF00498	0.499
LIG_FHA_1	226	232	PF00498	0.454
LIG_FHA_1	252	258	PF00498	0.375
LIG_FHA_1	328	334	PF00498	0.392
LIG_FHA_1	34	40	PF00498	0.488
LIG_FHA_1	377	383	PF00498	0.344
LIG_FHA_1	470	476	PF00498	0.447
LIG_FHA_1	678	684	PF00498	0.685
LIG_FHA_2	101	107	PF00498	0.417
LIG_FHA_2	419	425	PF00498	0.569
LIG_FHA_2	487	493	PF00498	0.576
LIG_FHA_2	606	612	PF00498	0.608
LIG_LIR_Gen_1	179	188	PF02991	0.417
LIG_LIR_Gen_1	89	100	PF02991	0.434
LIG_LIR_Nem_3	179	183	PF02991	0.412
LIG_LIR_Nem_3	537	542	PF02991	0.616
LIG_LIR_Nem_3	573	578	PF02991	0.604
LIG_PCNA_yPIPBox_3	452	464	PF02747	0.361
LIG_PCNA_yPIPBox_3	484	494	PF02747	0.449
LIG_Pex14_1	29	33	PF04695	0.427
LIG_PTB_Apo_2	104	111	PF02174	0.428
LIG_SH2_CRK	539	543	PF00017	0.623
LIG_SH2_CRK	575	579	PF00017	0.601
LIG_SH2_NCK_1	420	424	PF00017	0.517
LIG_SH2_NCK_1	495	499	PF00017	0.506
LIG_SH2_STAT3	707	710	PF00017	0.692
LIG_SH2_STAT5	224	227	PF00017	0.462
LIG_SH2_STAT5	270	273	PF00017	0.346
LIG_SH2_STAT5	33	36	PF00017	0.484
LIG_SH2_STAT5	420	423	PF00017	0.567
LIG_SH2_STAT5	495	498	PF00017	0.402
LIG_SH3_1	443	449	PF00018	0.423
LIG_SH3_3	284	290	PF00018	0.635
LIG_SH3_3	443	449	PF00018	0.427
LIG_SH3_3	591	597	PF00018	0.683
LIG_SUMO_SIM_par_1	163	169	PF11976	0.403
LIG_SUMO_SIM_par_1	354	359	PF11976	0.304
LIG_SUMO_SIM_par_1	384	389	PF11976	0.380
LIG_SUMO_SIM_par_1	54	59	PF11976	0.452
LIG_TRAF2_1	439	442	PF00917	0.535
LIG_UBA3_1	447	456	PF00899	0.437
LIG_WRC_WIRS_1	177	182	PF05994	0.412
LIG_WRC_WIRS_1	231	236	PF05994	0.324
MOD_CDC14_SPxK_1	566	569	PF00782	0.616
MOD_CDK_SPK_2	225	230	PF00069	0.445
MOD_CDK_SPxK_1	563	569	PF00069	0.610
MOD_CK1_1	132	138	PF00069	0.493
MOD_CK1_1	154	160	PF00069	0.498
MOD_CK1_1	326	332	PF00069	0.397
MOD_CK1_1	389	395	PF00069	0.386
MOD_CK1_1	413	419	PF00069	0.582
MOD_CK1_1	432	438	PF00069	0.703
MOD_CK1_1	534	540	PF00069	0.585
MOD_CK1_1	547	553	PF00069	0.574
MOD_CK1_1	561	567	PF00069	0.565
MOD_CK1_1	592	598	PF00069	0.700
MOD_CK1_1	629	635	PF00069	0.712
MOD_CK1_1	689	695	PF00069	0.765
MOD_CK2_1	100	106	PF00069	0.416
MOD_CK2_1	418	424	PF00069	0.568
MOD_CK2_1	436	442	PF00069	0.552
MOD_CK2_1	486	492	PF00069	0.552
MOD_CK2_1	567	573	PF00069	0.693
MOD_CK2_1	625	631	PF00069	0.681
MOD_Cter_Amidation	292	295	PF01082	0.481
MOD_GlcNHglycan	137	140	PF01048	0.612
MOD_GlcNHglycan	199	202	PF01048	0.571
MOD_GlcNHglycan	213	216	PF01048	0.324
MOD_GlcNHglycan	263	266	PF01048	0.506
MOD_GlcNHglycan	431	434	PF01048	0.694
MOD_GlcNHglycan	44	47	PF01048	0.465
MOD_GlcNHglycan	483	487	PF01048	0.351
MOD_GlcNHglycan	521	524	PF01048	0.640
MOD_GlcNHglycan	549	552	PF01048	0.608
MOD_GlcNHglycan	58	61	PF01048	0.523
MOD_GlcNHglycan	654	657	PF01048	0.683
MOD_GlcNHglycan	694	697	PF01048	0.779
MOD_GlcNHglycan	96	99	PF01048	0.501
MOD_GSK3_1	145	152	PF00069	0.743
MOD_GSK3_1	19	26	PF00069	0.486
MOD_GSK3_1	322	329	PF00069	0.376
MOD_GSK3_1	410	417	PF00069	0.580
MOD_GSK3_1	428	435	PF00069	0.617
MOD_GSK3_1	482	489	PF00069	0.415
MOD_GSK3_1	493	500	PF00069	0.356
MOD_GSK3_1	530	537	PF00069	0.646
MOD_GSK3_1	561	568	PF00069	0.642
MOD_GSK3_1	622	629	PF00069	0.661
MOD_GSK3_1	652	659	PF00069	0.630
MOD_GSK3_1	692	699	PF00069	0.737
MOD_N-GLC_1	113	118	PF02516	0.529
MOD_N-GLC_1	130	135	PF02516	0.453
MOD_N-GLC_1	321	326	PF02516	0.369
MOD_N-GLC_1	456	461	PF02516	0.346
MOD_N-GLC_1	468	473	PF02516	0.357
MOD_N-GLC_1	486	491	PF02516	0.529
MOD_N-GLC_2	668	670	PF02516	0.498
MOD_NEK2_1	100	105	PF00069	0.381
MOD_NEK2_1	13	18	PF00069	0.464
MOD_NEK2_1	321	326	PF00069	0.472
MOD_NEK2_1	356	361	PF00069	0.366
MOD_NEK2_1	386	391	PF00069	0.337
MOD_NEK2_1	404	409	PF00069	0.488
MOD_NEK2_1	414	419	PF00069	0.599
MOD_NEK2_1	510	515	PF00069	0.458
MOD_NEK2_1	530	535	PF00069	0.623
MOD_NEK2_1	630	635	PF00069	0.660
MOD_NEK2_1	677	682	PF00069	0.616
MOD_PIKK_1	151	157	PF00454	0.534
MOD_PIKK_1	458	464	PF00454	0.370
MOD_PIKK_1	630	636	PF00454	0.681
MOD_PIKK_1	656	662	PF00454	0.653
MOD_PIKK_1	706	712	PF00454	0.689
MOD_PK_1	574	580	PF00069	0.595
MOD_PKA_1	410	416	PF00069	0.589
MOD_PKA_2	209	215	PF00069	0.456
MOD_PKA_2	404	410	PF00069	0.484
MOD_PKA_2	547	553	PF00069	0.618
MOD_PKA_2	573	579	PF00069	0.613
MOD_PKA_2	675	681	PF00069	0.641
MOD_Plk_1	301	307	PF00069	0.519
MOD_Plk_1	326	332	PF00069	0.359
MOD_Plk_1	356	362	PF00069	0.310
MOD_Plk_1	386	392	PF00069	0.365
MOD_Plk_1	456	462	PF00069	0.348
MOD_Plk_1	486	492	PF00069	0.459
MOD_Plk_1	670	676	PF00069	0.734
MOD_Plk_1	686	692	PF00069	0.589
MOD_Plk_4	100	106	PF00069	0.401
MOD_Plk_4	220	226	PF00069	0.380
MOD_Plk_4	230	236	PF00069	0.326
MOD_Plk_4	327	333	PF00069	0.403
MOD_Plk_4	410	416	PF00069	0.547
MOD_Plk_4	549	555	PF00069	0.557
MOD_Plk_4	589	595	PF00069	0.720
MOD_Plk_4	661	667	PF00069	0.596
MOD_Plk_4	670	676	PF00069	0.458
MOD_ProDKin_1	130	136	PF00069	0.478
MOD_ProDKin_1	225	231	PF00069	0.455
MOD_ProDKin_1	246	252	PF00069	0.461
MOD_ProDKin_1	33	39	PF00069	0.582
MOD_ProDKin_1	563	569	PF00069	0.654
MOD_ProDKin_1	622	628	PF00069	0.705
MOD_ProDKin_1	654	660	PF00069	0.586
MOD_SUMO_for_1	505	508	PF00179	0.394
MOD_SUMO_rev_2	15	25	PF00179	0.346
MOD_SUMO_rev_2	500	507	PF00179	0.397
TRG_DiLeu_BaLyEn_6	443	448	PF01217	0.374
TRG_ENDOCYTIC_2	539	542	PF00928	0.621
TRG_ENDOCYTIC_2	575	578	PF00928	0.600
TRG_ER_diArg_1	1	4	PF00400	0.552
TRG_ER_diArg_1	120	122	PF00400	0.450
TRG_ER_diArg_1	29	31	PF00400	0.426
TRG_ER_diArg_1	410	412	PF00400	0.627
TRG_ER_diArg_1	5	8	PF00400	0.473
TRG_ER_diArg_1	578	581	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T2	Leptomonas seymouri	53%	94%
A0A3Q8IHF2	Leishmania donovani	100%	100%
A0A3R7MW53	Trypanosoma rangeli	29%	100%
A4HAP6	Leishmania braziliensis	72%	100%
E9B4V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	97%
Q4Q373	Leishmania major	93%	99%
V5B3D0	Trypanosoma cruzi	28%	100%