LeishMANIAdb
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Putative NLI-interacting factor

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative NLI-interacting factor
Gene product:
PTP1-interacting protein - 39 kDa - putative
Species:
Leishmania infantum
UniProt:
A4I9T8_LEIIN
TriTrypDb:
LINF_340019600
Length:
358

Annotations

Annotations by Jardim et al.

Oxidoreductase, NLI-interacting factor

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0005829 cytosol 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I9T8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9T8

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016311 dephosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016787 hydrolase activity 2 3
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0016791 phosphatase activity 5 3
GO:0042578 phosphoric ester hydrolase activity 4 3
GO:0004721 phosphoprotein phosphatase activity 3 2
GO:0140096 catalytic activity, acting on a protein 2 2
GO:0004725 protein tyrosine phosphatase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 183 185 PF00675 0.402
CLV_NRD_NRD_1 227 229 PF00675 0.415
CLV_NRD_NRD_1 320 322 PF00675 0.350
CLV_PCSK_KEX2_1 227 229 PF00082 0.415
CLV_PCSK_KEX2_1 320 322 PF00082 0.347
CLV_PCSK_SKI1_1 221 225 PF00082 0.348
CLV_PCSK_SKI1_1 259 263 PF00082 0.457
CLV_PCSK_SKI1_1 4 8 PF00082 0.616
CLV_PCSK_SKI1_1 98 102 PF00082 0.288
DEG_APCC_DBOX_1 258 266 PF00400 0.442
DOC_CDC14_PxL_1 176 184 PF14671 0.245
DOC_CDC14_PxL_1 262 270 PF14671 0.315
DOC_CKS1_1 200 205 PF01111 0.359
DOC_CYCLIN_RxL_1 1 11 PF00134 0.398
DOC_CYCLIN_yCln2_LP_2 39 45 PF00134 0.511
DOC_MAPK_gen_1 184 192 PF00069 0.384
DOC_MAPK_gen_1 254 264 PF00069 0.441
DOC_MAPK_gen_1 47 56 PF00069 0.279
DOC_MAPK_MEF2A_6 20 27 PF00069 0.443
DOC_MAPK_MEF2A_6 309 317 PF00069 0.500
DOC_MAPK_MEF2A_6 47 56 PF00069 0.248
DOC_MAPK_NFAT4_5 49 57 PF00069 0.292
DOC_PP1_RVXF_1 327 333 PF00149 0.604
DOC_PP2B_LxvP_1 37 40 PF13499 0.417
DOC_USP7_MATH_1 146 150 PF00917 0.424
DOC_USP7_MATH_1 18 22 PF00917 0.500
DOC_USP7_MATH_1 353 357 PF00917 0.597
DOC_USP7_UBL2_3 147 151 PF12436 0.308
DOC_WW_Pin1_4 199 204 PF00397 0.309
DOC_WW_Pin1_4 320 325 PF00397 0.469
LIG_14-3-3_CanoR_1 137 145 PF00244 0.376
LIG_14-3-3_CanoR_1 166 171 PF00244 0.270
LIG_14-3-3_CanoR_1 184 190 PF00244 0.439
LIG_14-3-3_CanoR_1 320 324 PF00244 0.488
LIG_14-3-3_CanoR_1 8 18 PF00244 0.433
LIG_Actin_RPEL_3 68 87 PF02755 0.175
LIG_APCC_ABBA_1 66 71 PF00400 0.236
LIG_EVH1_1 37 41 PF00568 0.446
LIG_FHA_1 165 171 PF00498 0.342
LIG_FHA_1 279 285 PF00498 0.414
LIG_FHA_1 299 305 PF00498 0.194
LIG_FHA_1 49 55 PF00498 0.250
LIG_FHA_2 314 320 PF00498 0.553
LIG_GBD_Chelix_1 52 60 PF00786 0.245
LIG_LIR_Apic_2 32 38 PF02991 0.445
LIG_LIR_Gen_1 138 146 PF02991 0.431
LIG_LIR_Gen_1 88 97 PF02991 0.309
LIG_LIR_Nem_3 138 143 PF02991 0.288
LIG_LIR_Nem_3 159 164 PF02991 0.370
LIG_LIR_Nem_3 285 290 PF02991 0.488
LIG_LIR_Nem_3 88 92 PF02991 0.268
LIG_PDZ_Class_1 353 358 PF00595 0.579
LIG_Pex14_2 108 112 PF04695 0.402
LIG_Pex14_2 31 35 PF04695 0.483
LIG_PTB_Apo_2 331 338 PF02174 0.436
LIG_SH2_CRK 89 93 PF00017 0.405
LIG_SH2_NCK_1 140 144 PF00017 0.199
LIG_SH2_STAT5 120 123 PF00017 0.280
LIG_SH2_STAT5 178 181 PF00017 0.305
LIG_SH2_STAT5 292 295 PF00017 0.299
LIG_SH3_1 197 203 PF00018 0.250
LIG_SH3_3 197 203 PF00018 0.250
LIG_SH3_3 30 36 PF00018 0.352
LIG_SH3_3 312 318 PF00018 0.404
LIG_SH3_3 38 44 PF00018 0.355
LIG_SUMO_SIM_par_1 187 194 PF11976 0.241
LIG_SUMO_SIM_par_1 50 55 PF11976 0.232
LIG_SxIP_EBH_1 320 331 PF03271 0.548
LIG_TRFH_1 199 203 PF08558 0.245
LIG_TYR_ITIM 87 92 PF00017 0.308
LIG_WW_2 41 44 PF00397 0.541
MOD_CDK_SPK_2 199 204 PF00069 0.338
MOD_CK1_1 138 144 PF00069 0.384
MOD_CK1_1 154 160 PF00069 0.415
MOD_CK2_1 138 144 PF00069 0.403
MOD_CK2_1 313 319 PF00069 0.544
MOD_Cter_Amidation 182 185 PF01082 0.415
MOD_GlcNHglycan 11 14 PF01048 0.561
MOD_GlcNHglycan 305 308 PF01048 0.474
MOD_GlcNHglycan 334 337 PF01048 0.433
MOD_GlcNHglycan 339 342 PF01048 0.454
MOD_GlcNHglycan 351 354 PF01048 0.607
MOD_GSK3_1 152 159 PF00069 0.305
MOD_GSK3_1 162 169 PF00069 0.201
MOD_GSK3_1 195 202 PF00069 0.323
MOD_GSK3_1 328 335 PF00069 0.466
MOD_GSK3_1 343 350 PF00069 0.428
MOD_GSK3_1 56 63 PF00069 0.292
MOD_GSK3_1 69 76 PF00069 0.292
MOD_NEK2_1 152 157 PF00069 0.334
MOD_NEK2_1 164 169 PF00069 0.190
MOD_NEK2_1 298 303 PF00069 0.376
MOD_NEK2_1 313 318 PF00069 0.385
MOD_NEK2_1 332 337 PF00069 0.276
MOD_NEK2_1 347 352 PF00069 0.477
MOD_NEK2_1 60 65 PF00069 0.283
MOD_NEK2_2 343 348 PF00069 0.427
MOD_PIKK_1 164 170 PF00454 0.271
MOD_PK_1 185 191 PF00069 0.308
MOD_PKA_1 184 190 PF00069 0.415
MOD_PKA_2 319 325 PF00069 0.433
MOD_Plk_1 343 349 PF00069 0.552
MOD_Plk_1 56 62 PF00069 0.232
MOD_Plk_4 185 191 PF00069 0.296
MOD_Plk_4 328 334 PF00069 0.551
MOD_Plk_4 48 54 PF00069 0.237
MOD_Plk_4 56 62 PF00069 0.225
MOD_Plk_4 82 88 PF00069 0.439
MOD_ProDKin_1 199 205 PF00069 0.309
MOD_ProDKin_1 320 326 PF00069 0.472
TRG_ENDOCYTIC_2 140 143 PF00928 0.308
TRG_ENDOCYTIC_2 178 181 PF00928 0.280
TRG_ENDOCYTIC_2 89 92 PF00928 0.377
TRG_ER_diArg_1 226 228 PF00400 0.415
TRG_NES_CRM1_1 134 148 PF08389 0.308
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.437
TRG_Pf-PMV_PEXEL_1 4 9 PF00026 0.479
TRG_PTS1 355 358 PF00515 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6D2 Leptomonas seymouri 75% 100%
A0A0S4IR87 Bodo saltans 28% 80%
A0A0S4IXS3 Bodo saltans 33% 92%
A0A0S4J698 Bodo saltans 33% 76%
A0A0S4J952 Bodo saltans 35% 100%
A0A0S4JFL1 Bodo saltans 35% 100%
A0A0S4JIG1 Bodo saltans 28% 98%
A0A0S4JJI6 Bodo saltans 44% 95%
A0A0S4JU68 Bodo saltans 36% 100%
A0A1X0NUJ8 Trypanosomatidae 53% 98%
A0A3S7X7S3 Leishmania donovani 100% 100%
A0A422N4T2 Trypanosoma rangeli 54% 100%
A4HAP2 Leishmania braziliensis 87% 100%
C9ZXU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
C9ZXU8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9B4U9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q377 Leishmania major 96% 100%
V5B4L5 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS