Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9T3_LEIIN

TriTrypDb:

LINF_340019100

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.611
CLV_MEL_PAP_1	61	67	PF00089	0.506
CLV_NRD_NRD_1	102	104	PF00675	0.367
CLV_NRD_NRD_1	292	294	PF00675	0.389
CLV_NRD_NRD_1	325	327	PF00675	0.468
CLV_NRD_NRD_1	460	462	PF00675	0.425
CLV_NRD_NRD_1	88	90	PF00675	0.487
CLV_PCSK_KEX2_1	213	215	PF00082	0.510
CLV_PCSK_KEX2_1	292	294	PF00082	0.389
CLV_PCSK_KEX2_1	325	327	PF00082	0.468
CLV_PCSK_KEX2_1	342	344	PF00082	0.517
CLV_PCSK_KEX2_1	387	389	PF00082	0.410
CLV_PCSK_KEX2_1	460	462	PF00082	0.425
CLV_PCSK_KEX2_1	87	89	PF00082	0.526
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.510
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.484
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.388
CLV_PCSK_PC7_1	383	389	PF00082	0.521
CLV_PCSK_SKI1_1	103	107	PF00082	0.509
CLV_PCSK_SKI1_1	147	151	PF00082	0.414
CLV_PCSK_SKI1_1	296	300	PF00082	0.405
CLV_PCSK_SKI1_1	339	343	PF00082	0.499
CLV_PCSK_SKI1_1	406	410	PF00082	0.544
CLV_PCSK_SKI1_1	5	9	PF00082	0.643
DEG_SPOP_SBC_1	302	306	PF00917	0.603
DOC_CYCLIN_yClb5_NLxxxL_5	219	226	PF00134	0.467
DOC_MAPK_gen_1	292	299	PF00069	0.391
DOC_MAPK_HePTP_8	322	338	PF00069	0.503
DOC_MAPK_HePTP_8	61	73	PF00069	0.493
DOC_MAPK_MEF2A_6	41	48	PF00069	0.560
DOC_MAPK_MEF2A_6	64	73	PF00069	0.497
DOC_PP2B_LxvP_1	240	243	PF13499	0.552
DOC_PP2B_LxvP_1	40	43	PF13499	0.460
DOC_PP2B_PxIxI_1	16	22	PF00149	0.539
DOC_USP7_MATH_1	249	253	PF00917	0.666
DOC_USP7_MATH_1	261	265	PF00917	0.715
DOC_USP7_MATH_1	274	278	PF00917	0.728
DOC_USP7_MATH_1	315	319	PF00917	0.504
DOC_USP7_MATH_1	411	415	PF00917	0.587
DOC_WW_Pin1_4	311	316	PF00397	0.556
DOC_WW_Pin1_4	429	434	PF00397	0.792
DOC_WW_Pin1_4	442	447	PF00397	0.621
LIG_14-3-3_CanoR_1	130	138	PF00244	0.469
LIG_14-3-3_CanoR_1	147	156	PF00244	0.425
LIG_14-3-3_CanoR_1	169	175	PF00244	0.649
LIG_14-3-3_CanoR_1	235	241	PF00244	0.582
LIG_14-3-3_CanoR_1	64	68	PF00244	0.564
LIG_BIR_II_1	1	5	PF00653	0.489
LIG_eIF4E_1	402	408	PF01652	0.486
LIG_FHA_1	16	22	PF00498	0.742
LIG_FHA_1	345	351	PF00498	0.615
LIG_FHA_1	419	425	PF00498	0.600
LIG_FHA_1	447	453	PF00498	0.568
LIG_FHA_1	56	62	PF00498	0.519
LIG_FHA_2	202	208	PF00498	0.457
LIG_FHA_2	265	271	PF00498	0.746
LIG_FHA_2	346	352	PF00498	0.583
LIG_FHA_2	369	375	PF00498	0.521
LIG_FHA_2	424	430	PF00498	0.581
LIG_LIR_Nem_3	329	334	PF02991	0.511
LIG_SH2_SRC	137	140	PF00017	0.364
LIG_SH2_STAP1	120	124	PF00017	0.494
LIG_SH2_STAP1	139	143	PF00017	0.639
LIG_SH2_STAT5	137	140	PF00017	0.408
LIG_SH3_3	26	32	PF00018	0.634
LIG_SH3_3	414	420	PF00018	0.608
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.406
LIG_SUMO_SIM_anti_2	333	338	PF11976	0.480
LIG_SUMO_SIM_par_1	17	22	PF11976	0.629
LIG_SUMO_SIM_par_1	277	283	PF11976	0.491
LIG_SxIP_EBH_1	23	33	PF03271	0.510
LIG_TRAF2_1	208	211	PF00917	0.479
LIG_TRAF2_1	98	101	PF00917	0.613
LIG_WW_3	27	31	PF00397	0.551
MOD_CDK_SPK_2	442	447	PF00069	0.602
MOD_CK1_1	12	18	PF00069	0.742
MOD_CK1_1	184	190	PF00069	0.611
MOD_CK1_1	264	270	PF00069	0.568
MOD_CK1_1	304	310	PF00069	0.677
MOD_CK2_1	201	207	PF00069	0.462
MOD_CK2_1	264	270	PF00069	0.604
MOD_CK2_1	311	317	PF00069	0.610
MOD_CK2_1	368	374	PF00069	0.526
MOD_GlcNHglycan	11	14	PF01048	0.735
MOD_GlcNHglycan	131	134	PF01048	0.463
MOD_GlcNHglycan	151	154	PF01048	0.404
MOD_GlcNHglycan	183	186	PF01048	0.639
MOD_GlcNHglycan	194	197	PF01048	0.457
MOD_GlcNHglycan	246	249	PF01048	0.641
MOD_GlcNHglycan	256	259	PF01048	0.670
MOD_GlcNHglycan	270	273	PF01048	0.467
MOD_GlcNHglycan	282	285	PF01048	0.578
MOD_GlcNHglycan	306	309	PF01048	0.632
MOD_GlcNHglycan	94	97	PF01048	0.452
MOD_GSK3_1	11	18	PF00069	0.730
MOD_GSK3_1	145	152	PF00069	0.580
MOD_GSK3_1	244	251	PF00069	0.627
MOD_GSK3_1	264	271	PF00069	0.435
MOD_GSK3_1	302	309	PF00069	0.675
MOD_GSK3_1	311	318	PF00069	0.688
MOD_GSK3_1	425	432	PF00069	0.751
MOD_GSK3_1	442	449	PF00069	0.503
MOD_N-GLC_1	268	273	PF02516	0.630
MOD_NEK2_1	149	154	PF00069	0.496
MOD_NEK2_1	280	285	PF00069	0.616
MOD_NEK2_2	63	68	PF00069	0.495
MOD_PIKK_1	190	196	PF00454	0.516
MOD_PKA_2	129	135	PF00069	0.462
MOD_PKA_2	15	21	PF00069	0.672
MOD_PKA_2	354	360	PF00069	0.552
MOD_PKA_2	453	459	PF00069	0.463
MOD_PKA_2	63	69	PF00069	0.486
MOD_Plk_1	145	151	PF00069	0.583
MOD_Plk_1	316	322	PF00069	0.566
MOD_Plk_2-3	345	351	PF00069	0.641
MOD_Plk_2-3	374	380	PF00069	0.477
MOD_Plk_4	15	21	PF00069	0.676
MOD_Plk_4	236	242	PF00069	0.527
MOD_Plk_4	275	281	PF00069	0.540
MOD_ProDKin_1	311	317	PF00069	0.550
MOD_ProDKin_1	429	435	PF00069	0.790
MOD_ProDKin_1	442	448	PF00069	0.610
MOD_SUMO_rev_2	205	215	PF00179	0.512
TRG_ER_diArg_1	292	294	PF00400	0.389
TRG_ER_diArg_1	324	326	PF00400	0.463
TRG_ER_diArg_1	459	461	PF00400	0.408
TRG_ER_diArg_1	87	89	PF00400	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY58	Leptomonas seymouri	46%	85%
A0A3Q8II15	Leishmania donovani	99%	100%
A0A422MPI6	Trypanosoma rangeli	23%	100%
A4HBJ3	Leishmania braziliensis	64%	100%
C9ZMU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B4U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q382	Leishmania major	90%	100%
V5BIT8	Trypanosoma cruzi	26%	100%