Enriched_in_surface-labeled_proteome_protein_-_putative

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 11 - putative

Species:

Leishmania infantum

UniProt:

A4I9S9_LEIIN

TriTrypDb:

LINF_340018700

Length:

276

Annotations

Annotations by Jardim et al.

Plasma membrane, Enriched in surface-labeled proteome 11 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 2
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I9S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.433
CLV_PCSK_KEX2_1	173	175	PF00082	0.433
CLV_PCSK_SKI1_1	110	114	PF00082	0.544
CLV_PCSK_SKI1_1	167	171	PF00082	0.443
CLV_PCSK_SKI1_1	51	55	PF00082	0.714
DOC_CKS1_1	221	226	PF01111	0.691
DOC_CYCLIN_yCln2_LP_2	250	253	PF00134	0.630
DOC_PP2B_LxvP_1	250	253	PF13499	0.630
DOC_PP2B_LxvP_1	77	80	PF13499	0.408
DOC_USP7_MATH_1	176	180	PF00917	0.694
DOC_USP7_MATH_1	263	267	PF00917	0.662
DOC_USP7_MATH_1	34	38	PF00917	0.498
DOC_WW_Pin1_4	215	220	PF00397	0.750
LIG_14-3-3_CanoR_1	11	21	PF00244	0.461
LIG_AP2alpha_2	114	116	PF02296	0.342
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BRCT_BRCA1_1	195	199	PF00533	0.617
LIG_CtBP_PxDLS_1	252	256	PF00389	0.631
LIG_FHA_1	16	22	PF00498	0.451
LIG_FHA_1	166	172	PF00498	0.612
LIG_FHA_1	221	227	PF00498	0.703
LIG_FHA_1	80	86	PF00498	0.380
LIG_FHA_2	198	204	PF00498	0.651
LIG_LIR_Gen_1	161	171	PF02991	0.679
LIG_LIR_Nem_3	144	149	PF02991	0.424
LIG_LIR_Nem_3	161	166	PF02991	0.651
LIG_LYPXL_yS_3	248	251	PF13949	0.641
LIG_MYND_1	111	115	PF01753	0.364
LIG_MYND_1	249	253	PF01753	0.631
LIG_NRBOX	20	26	PF00104	0.509
LIG_Pex14_1	159	163	PF04695	0.609
LIG_PTB_Apo_2	83	90	PF02174	0.338
LIG_PTB_Phospho_1	83	89	PF10480	0.398
LIG_SH2_CRK	163	167	PF00017	0.723
LIG_SH2_GRB2like	84	87	PF00017	0.359
LIG_SH2_NCK_1	194	198	PF00017	0.676
LIG_SH2_SRC	84	87	PF00017	0.359
LIG_SH2_STAT5	150	153	PF00017	0.312
LIG_SH2_STAT5	84	87	PF00017	0.359
LIG_SH2_STAT5	89	92	PF00017	0.303
LIG_SH3_3	175	181	PF00018	0.651
LIG_SH3_3	203	209	PF00018	0.655
LIG_SH3_3	210	216	PF00018	0.719
LIG_SH3_3	218	224	PF00018	0.812
LIG_SH3_3	243	249	PF00018	0.730
LIG_SH3_3	46	52	PF00018	0.446
LIG_TRFH_1	248	252	PF08558	0.636
LIG_TYR_ITIM	246	251	PF00017	0.623
MOD_CK1_1	141	147	PF00069	0.407
MOD_CK1_1	211	217	PF00069	0.704
MOD_CK1_1	38	44	PF00069	0.483
MOD_CK2_1	197	203	PF00069	0.652
MOD_CK2_1	234	240	PF00069	0.725
MOD_GlcNHglycan	1	4	PF01048	0.664
MOD_GlcNHglycan	140	143	PF01048	0.315
MOD_GlcNHglycan	195	198	PF01048	0.500
MOD_GlcNHglycan	210	213	PF01048	0.444
MOD_GlcNHglycan	25	28	PF01048	0.562
MOD_GlcNHglycan	93	96	PF01048	0.545
MOD_GSK3_1	176	183	PF00069	0.611
MOD_GSK3_1	193	200	PF00069	0.661
MOD_GSK3_1	211	218	PF00069	0.646
MOD_GSK3_1	34	41	PF00069	0.608
MOD_N-GLC_1	38	43	PF02516	0.743
MOD_NEK2_1	23	28	PF00069	0.450
MOD_NEK2_2	162	167	PF00069	0.594
MOD_OFUCOSY	103	109	PF10250	0.596
MOD_PKA_2	13	19	PF00069	0.570
MOD_PKA_2	47	53	PF00069	0.462
MOD_Plk_4	125	131	PF00069	0.406
MOD_Plk_4	79	85	PF00069	0.431
MOD_ProDKin_1	215	221	PF00069	0.751
MOD_SUMO_rev_2	37	46	PF00179	0.630
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.640
TRG_ENDOCYTIC_2	163	166	PF00928	0.696
TRG_ENDOCYTIC_2	248	251	PF00928	0.641
TRG_ER_diArg_1	172	174	PF00400	0.633
TRG_ER_diArg_1	245	248	PF00400	0.625
TRG_ER_diArg_1	99	102	PF00400	0.351
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W2	Leptomonas seymouri	45%	100%
A0A3S7X7R5	Leishmania donovani	100%	100%
A4HAN6	Leishmania braziliensis	64%	100%
E9B4U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q386	Leishmania major	91%	100%