RIBOSOMAL_L9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9S7_LEIIN

TriTrypDb:

LINF_340018400

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9S7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.469
CLV_NRD_NRD_1	136	138	PF00675	0.394
CLV_NRD_NRD_1	182	184	PF00675	0.525
CLV_NRD_NRD_1	2	4	PF00675	0.511
CLV_NRD_NRD_1	344	346	PF00675	0.340
CLV_NRD_NRD_1	432	434	PF00675	0.664
CLV_NRD_NRD_1	437	439	PF00675	0.700
CLV_NRD_NRD_1	69	71	PF00675	0.389
CLV_PCSK_KEX2_1	135	137	PF00082	0.403
CLV_PCSK_KEX2_1	182	184	PF00082	0.525
CLV_PCSK_KEX2_1	2	4	PF00082	0.529
CLV_PCSK_KEX2_1	344	346	PF00082	0.340
CLV_PCSK_KEX2_1	432	434	PF00082	0.547
CLV_PCSK_KEX2_1	69	71	PF00082	0.389
CLV_PCSK_SKI1_1	137	141	PF00082	0.390
CLV_PCSK_SKI1_1	154	158	PF00082	0.257
CLV_PCSK_SKI1_1	183	187	PF00082	0.502
CLV_PCSK_SKI1_1	26	30	PF00082	0.643
CLV_PCSK_SKI1_1	318	322	PF00082	0.478
CLV_PCSK_SKI1_1	357	361	PF00082	0.375
CLV_PCSK_SKI1_1	363	367	PF00082	0.417
CLV_PCSK_SKI1_1	378	382	PF00082	0.494
CLV_PCSK_SKI1_1	7	11	PF00082	0.526
CLV_PCSK_SKI1_1	70	74	PF00082	0.377
DEG_APCC_DBOX_1	1	9	PF00400	0.575
DEG_APCC_DBOX_1	25	33	PF00400	0.621
DEG_Nend_UBRbox_1	1	4	PF02207	0.645
DEG_SCF_FBW7_2	219	225	PF00400	0.345
DOC_CKS1_1	219	224	PF01111	0.357
DOC_CKS1_1	274	279	PF01111	0.341
DOC_CKS1_1	45	50	PF01111	0.475
DOC_CYCLIN_RxL_1	148	160	PF00134	0.392
DOC_CYCLIN_RxL_1	2	13	PF00134	0.543
DOC_MAPK_gen_1	193	201	PF00069	0.459
DOC_MAPK_gen_1	2	10	PF00069	0.545
DOC_MAPK_gen_1	69	77	PF00069	0.356
DOC_MAPK_MEF2A_6	3	12	PF00069	0.596
DOC_PP1_RVXF_1	252	258	PF00149	0.374
DOC_PP2B_LxvP_1	163	166	PF13499	0.326
DOC_PP2B_LxvP_1	202	205	PF13499	0.375
DOC_PP4_FxxP_1	114	117	PF00568	0.335
DOC_USP7_MATH_1	205	209	PF00917	0.435
DOC_USP7_UBL2_3	38	42	PF12436	0.489
DOC_WW_Pin1_4	13	18	PF00397	0.552
DOC_WW_Pin1_4	218	223	PF00397	0.355
DOC_WW_Pin1_4	256	261	PF00397	0.320
DOC_WW_Pin1_4	273	278	PF00397	0.350
DOC_WW_Pin1_4	32	37	PF00397	0.523
DOC_WW_Pin1_4	331	336	PF00397	0.497
DOC_WW_Pin1_4	44	49	PF00397	0.460
DOC_WW_Pin1_4	443	448	PF00397	0.580
LIG_14-3-3_CanoR_1	136	146	PF00244	0.406
LIG_14-3-3_CanoR_1	2	6	PF00244	0.522
LIG_14-3-3_CanoR_1	69	77	PF00244	0.356
LIG_Actin_WH2_2	225	241	PF00022	0.384
LIG_APCC_ABBA_1	99	104	PF00400	0.388
LIG_BRCT_BRCA1_1	15	19	PF00533	0.550
LIG_deltaCOP1_diTrp_1	43	51	PF00928	0.473
LIG_FHA_1	158	164	PF00498	0.396
LIG_FHA_1	274	280	PF00498	0.359
LIG_FHA_1	319	325	PF00498	0.404
LIG_FHA_1	71	77	PF00498	0.343
LIG_FHA_2	124	130	PF00498	0.505
LIG_FHA_2	248	254	PF00498	0.438
LIG_FHA_2	289	295	PF00498	0.375
LIG_FHA_2	297	303	PF00498	0.431
LIG_FHA_2	331	337	PF00498	0.420
LIG_FHA_2	364	370	PF00498	0.447
LIG_LIR_Apic_2	112	117	PF02991	0.347
LIG_LIR_Apic_2	409	414	PF02991	0.561
LIG_LIR_Apic_2	43	48	PF02991	0.465
LIG_LIR_Apic_2	442	447	PF02991	0.495
LIG_LIR_Gen_1	127	134	PF02991	0.410
LIG_LIR_Gen_1	140	151	PF02991	0.320
LIG_LIR_Gen_1	226	236	PF02991	0.347
LIG_LIR_Gen_1	389	398	PF02991	0.564
LIG_LIR_Nem_3	127	133	PF02991	0.389
LIG_LIR_Nem_3	140	146	PF02991	0.382
LIG_LIR_Nem_3	226	232	PF02991	0.365
LIG_LIR_Nem_3	291	295	PF02991	0.401
LIG_LIR_Nem_3	389	395	PF02991	0.552
LIG_LIR_Nem_3	39	44	PF02991	0.478
LIG_LIR_Nem_3	93	99	PF02991	0.338
LIG_NRBOX	4	10	PF00104	0.641
LIG_Pex14_2	41	45	PF04695	0.456
LIG_PTB_Apo_2	228	235	PF02174	0.321
LIG_PTB_Phospho_1	228	234	PF10480	0.342
LIG_SH2_CRK	392	396	PF00017	0.658
LIG_SH2_CRK	444	448	PF00017	0.694
LIG_SH2_CRK	96	100	PF00017	0.333
LIG_SH2_NCK_1	392	396	PF00017	0.606
LIG_SH2_STAP1	348	352	PF00017	0.434
LIG_SH2_STAT3	37	40	PF00017	0.504
LIG_SH2_STAT3	416	419	PF00017	0.570
LIG_SH2_STAT5	109	112	PF00017	0.548
LIG_SH2_STAT5	234	237	PF00017	0.354
LIG_SH2_STAT5	246	249	PF00017	0.421
LIG_SH2_STAT5	342	345	PF00017	0.347
LIG_SH3_2	178	183	PF14604	0.428
LIG_SH3_3	114	120	PF00018	0.344
LIG_SH3_3	172	178	PF00018	0.404
LIG_SH3_3	319	325	PF00018	0.445
LIG_SH3_3	370	376	PF00018	0.548
LIG_SUMO_SIM_anti_2	160	166	PF11976	0.400
LIG_SUMO_SIM_par_1	118	129	PF11976	0.382
LIG_SUMO_SIM_par_1	278	284	PF11976	0.357
LIG_SUMO_SIM_par_1	439	446	PF11976	0.599
LIG_TRAF2_1	366	369	PF00917	0.485
LIG_UBA3_1	162	167	PF00899	0.331
MOD_CDC14_SPxK_1	35	38	PF00782	0.510
MOD_CDK_SPxK_1	32	38	PF00069	0.523
MOD_CDK_SPxxK_3	13	20	PF00069	0.552
MOD_CDK_SPxxK_3	331	338	PF00069	0.495
MOD_CDK_SPxxK_3	443	450	PF00069	0.512
MOD_CK1_1	13	19	PF00069	0.550
MOD_CK1_1	208	214	PF00069	0.461
MOD_CK2_1	247	253	PF00069	0.406
MOD_CK2_1	256	262	PF00069	0.302
MOD_CK2_1	330	336	PF00069	0.415
MOD_CK2_1	363	369	PF00069	0.423
MOD_CK2_1	443	449	PF00069	0.744
MOD_Cter_Amidation	436	439	PF01082	0.623
MOD_GlcNHglycan	12	15	PF01048	0.551
MOD_GSK3_1	115	122	PF00069	0.349
MOD_GSK3_1	230	237	PF00069	0.404
MOD_N-GLC_1	10	15	PF02516	0.547
MOD_N-GLC_1	230	235	PF02516	0.445
MOD_N-GLC_2	287	289	PF02516	0.349
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	157	162	PF00069	0.446
MOD_NEK2_1	206	211	PF00069	0.538
MOD_NEK2_1	390	395	PF00069	0.715
MOD_PIKK_1	138	144	PF00454	0.526
MOD_PIKK_1	208	214	PF00454	0.354
MOD_PKA_2	1	7	PF00069	0.519
MOD_PKA_2	102	108	PF00069	0.514
MOD_PKA_2	337	343	PF00069	0.531
MOD_PKA_2	421	427	PF00069	0.442
MOD_PKB_1	135	143	PF00069	0.525
MOD_Plk_1	206	212	PF00069	0.411
MOD_Plk_1	230	236	PF00069	0.424
MOD_Plk_2-3	124	130	PF00069	0.392
MOD_Plk_2-3	288	294	PF00069	0.377
MOD_Plk_4	230	236	PF00069	0.442
MOD_Plk_4	318	324	PF00069	0.400
MOD_Plk_4	71	77	PF00069	0.421
MOD_ProDKin_1	13	19	PF00069	0.550
MOD_ProDKin_1	218	224	PF00069	0.358
MOD_ProDKin_1	256	262	PF00069	0.324
MOD_ProDKin_1	273	279	PF00069	0.348
MOD_ProDKin_1	32	38	PF00069	0.523
MOD_ProDKin_1	331	337	PF00069	0.495
MOD_ProDKin_1	44	50	PF00069	0.470
MOD_ProDKin_1	443	449	PF00069	0.584
MOD_SUMO_rev_2	92	99	PF00179	0.358
TRG_DiLeu_BaEn_1	377	382	PF01217	0.480
TRG_DiLeu_BaEn_4	369	375	PF01217	0.583
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.552
TRG_ENDOCYTIC_2	392	395	PF00928	0.564
TRG_ENDOCYTIC_2	96	99	PF00928	0.333
TRG_ER_diArg_1	1	3	PF00400	0.551
TRG_ER_diArg_1	134	137	PF00400	0.406
TRG_ER_diArg_1	181	183	PF00400	0.555
TRG_ER_diArg_1	343	345	PF00400	0.344
TRG_ER_diArg_1	431	433	PF00400	0.573
TRG_NES_CRM1_1	197	207	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	154	159	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC51	Leptomonas seymouri	81%	100%
A0A0S4ITQ6	Bodo saltans	60%	92%
A0A1X0PA81	Trypanosomatidae	70%	100%
A0A3Q8IHD9	Leishmania donovani	100%	100%
A4HAN4	Leishmania braziliensis	92%	100%
C9ZMV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9B4T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q388	Leishmania major	98%	100%
V5BIT5	Trypanosoma cruzi	69%	100%