UPF0235 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UPF0235 protein

Gene product:

Uncharacterised ACR - YggU family COG1872 - putative

Species:

Leishmania infantum

UniProt:

A4I9S6_LEIIN

TriTrypDb:

LINF_340018300

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I9S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	181	185	PF00082	0.503
CLV_PCSK_SKI1_1	22	26	PF00082	0.450
CLV_PCSK_SKI1_1	79	83	PF00082	0.540
CLV_Separin_Metazoa	65	69	PF03568	0.422
DEG_APCC_DBOX_1	190	198	PF00400	0.500
DEG_APCC_DBOX_1	4	12	PF00400	0.452
DEG_SCF_FBW7_1	41	47	PF00400	0.422
DOC_CKS1_1	41	46	PF01111	0.422
DOC_CYCLIN_RxL_1	19	26	PF00134	0.407
DOC_MAPK_gen_1	179	187	PF00069	0.396
DOC_MAPK_MEF2A_6	179	187	PF00069	0.448
DOC_PP4_FxxP_1	38	41	PF00568	0.422
DOC_USP7_MATH_1	102	106	PF00917	0.576
DOC_USP7_MATH_1	132	136	PF00917	0.623
DOC_USP7_MATH_1	137	141	PF00917	0.593
DOC_USP7_MATH_1	152	156	PF00917	0.604
DOC_USP7_MATH_1	29	33	PF00917	0.357
DOC_USP7_UBL2_3	120	124	PF12436	0.604
DOC_WW_Pin1_4	154	159	PF00397	0.698
DOC_WW_Pin1_4	40	45	PF00397	0.440
LIG_14-3-3_CanoR_1	179	184	PF00244	0.375
LIG_14-3-3_CanoR_1	34	42	PF00244	0.317
LIG_14-3-3_CanoR_1	79	88	PF00244	0.435
LIG_FHA_1	180	186	PF00498	0.494
LIG_FHA_1	193	199	PF00498	0.452
LIG_FHA_1	41	47	PF00498	0.461
LIG_FHA_2	45	51	PF00498	0.421
LIG_LIR_Apic_2	36	41	PF02991	0.422
LIG_LIR_Gen_1	92	102	PF02991	0.505
LIG_LIR_Nem_3	82	88	PF02991	0.539
LIG_LIR_Nem_3	92	97	PF02991	0.477
LIG_PCNA_yPIPBox_3	63	76	PF02747	0.346
LIG_SH2_CRK	94	98	PF00017	0.506
LIG_SH2_STAP1	85	89	PF00017	0.516
LIG_SH2_STAP1	94	98	PF00017	0.494
LIG_SH2_STAT5	23	26	PF00017	0.438
LIG_SH2_STAT5	69	72	PF00017	0.438
LIG_SH2_STAT5	88	91	PF00017	0.520
LIG_SH3_3	182	188	PF00018	0.441
LIG_SH3_3	38	44	PF00018	0.422
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.534
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.269
LIG_TYR_ITSM	90	97	PF00017	0.502
MOD_CK1_1	135	141	PF00069	0.663
MOD_CK1_1	93	99	PF00069	0.540
MOD_Cter_Amidation	122	125	PF01082	0.628
MOD_GlcNHglycan	104	107	PF01048	0.548
MOD_GlcNHglycan	115	118	PF01048	0.642
MOD_GlcNHglycan	121	124	PF01048	0.662
MOD_GlcNHglycan	143	146	PF01048	0.692
MOD_GlcNHglycan	159	162	PF01048	0.562
MOD_GlcNHglycan	31	34	PF01048	0.391
MOD_GlcNHglycan	35	38	PF01048	0.367
MOD_GSK3_1	132	139	PF00069	0.637
MOD_GSK3_1	175	182	PF00069	0.489
MOD_GSK3_1	29	36	PF00069	0.354
MOD_GSK3_1	40	47	PF00069	0.346
MOD_GSK3_1	89	96	PF00069	0.553
MOD_NEK2_1	1	6	PF00069	0.579
MOD_NEK2_1	111	116	PF00069	0.466
MOD_NEK2_1	136	141	PF00069	0.694
MOD_NEK2_2	23	28	PF00069	0.372
MOD_PKA_2	33	39	PF00069	0.312
MOD_Plk_1	168	174	PF00069	0.538
MOD_Plk_4	168	174	PF00069	0.420
MOD_Plk_4	179	185	PF00069	0.399
MOD_Plk_4	93	99	PF00069	0.515
MOD_ProDKin_1	154	160	PF00069	0.698
MOD_ProDKin_1	40	46	PF00069	0.440
MOD_SUMO_rev_2	114	122	PF00179	0.597
TRG_ENDOCYTIC_2	94	97	PF00928	0.501
TRG_NLS_MonoExtN_4	121	128	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK74	Leptomonas seymouri	53%	100%
A0A1X0P9D1	Trypanosomatidae	31%	100%
A0A3Q8IKV6	Leishmania donovani	100%	100%
A0A422NGS4	Trypanosoma rangeli	32%	100%
C9ZMV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AI65	Leishmania braziliensis	72%	99%
E9B4T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q389	Leishmania major	93%	100%