Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9S5_LEIIN

TriTrypDb:

LINF_340018200

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9S5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.436
CLV_C14_Caspase3-7	242	246	PF00656	0.612
CLV_PCSK_SKI1_1	192	196	PF00082	0.753
CLV_PCSK_SKI1_1	201	205	PF00082	0.630
CLV_PCSK_SKI1_1	265	269	PF00082	0.736
CLV_PCSK_SKI1_1	30	34	PF00082	0.585
CLV_PCSK_SKI1_1	53	57	PF00082	0.516
DEG_APCC_DBOX_1	191	199	PF00400	0.610
DEG_SPOP_SBC_1	126	130	PF00917	0.560
DOC_CYCLIN_RxL_1	189	199	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.607
DOC_MAPK_HePTP_8	90	102	PF00069	0.516
DOC_MAPK_MEF2A_6	251	260	PF00069	0.489
DOC_MAPK_MEF2A_6	84	92	PF00069	0.506
DOC_MAPK_MEF2A_6	93	102	PF00069	0.501
DOC_PP2B_LxvP_1	184	187	PF13499	0.584
DOC_PP2B_PxIxI_1	97	103	PF00149	0.514
DOC_PP4_FxxP_1	74	77	PF00568	0.557
DOC_USP7_MATH_1	113	117	PF00917	0.535
DOC_USP7_MATH_1	126	130	PF00917	0.484
DOC_USP7_MATH_1	140	144	PF00917	0.506
DOC_USP7_MATH_1	176	180	PF00917	0.606
DOC_USP7_MATH_1	213	217	PF00917	0.660
DOC_USP7_MATH_1	306	310	PF00917	0.590
DOC_USP7_MATH_1	48	52	PF00917	0.721
DOC_WW_Pin1_4	203	208	PF00397	0.600
DOC_WW_Pin1_4	209	214	PF00397	0.594
DOC_WW_Pin1_4	219	224	PF00397	0.578
DOC_WW_Pin1_4	44	49	PF00397	0.586
LIG_14-3-3_CanoR_1	124	133	PF00244	0.517
LIG_14-3-3_CanoR_1	177	187	PF00244	0.610
LIG_14-3-3_CanoR_1	295	302	PF00244	0.678
LIG_14-3-3_CanoR_1	53	58	PF00244	0.549
LIG_14-3-3_CanoR_1	7	13	PF00244	0.579
LIG_14-3-3_CterR_2	383	385	PF00244	0.650
LIG_Actin_WH2_2	187	203	PF00022	0.641
LIG_Actin_WH2_2	340	355	PF00022	0.467
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_BIR_III_2	45	49	PF00653	0.591
LIG_BRCT_BRCA1_1	129	133	PF00533	0.548
LIG_deltaCOP1_diTrp_1	280	283	PF00928	0.458
LIG_FHA_1	147	153	PF00498	0.541
LIG_FHA_1	179	185	PF00498	0.661
LIG_FHA_1	58	64	PF00498	0.552
LIG_FHA_1	77	83	PF00498	0.628
LIG_FHA_1	97	103	PF00498	0.514
LIG_FHA_2	286	292	PF00498	0.518
LIG_FHA_2	357	363	PF00498	0.498
LIG_FHA_2	366	372	PF00498	0.548
LIG_FHA_2	54	60	PF00498	0.479
LIG_FHA_2	89	95	PF00498	0.495
LIG_LIR_Apic_2	280	284	PF02991	0.465
LIG_LIR_Apic_2	71	77	PF02991	0.556
LIG_LIR_Gen_1	101	111	PF02991	0.532
LIG_LIR_Gen_1	362	372	PF02991	0.491
LIG_LIR_Nem_3	101	107	PF02991	0.564
LIG_LIR_Nem_3	2	8	PF02991	0.627
LIG_LIR_Nem_3	280	286	PF02991	0.482
LIG_LIR_Nem_3	362	367	PF02991	0.493
LIG_Pex14_2	40	44	PF04695	0.617
LIG_SH2_CRK	104	108	PF00017	0.521
LIG_SH3_2	210	215	PF14604	0.586
LIG_SH3_3	204	210	PF00018	0.591
LIG_SH3_3	217	223	PF00018	0.622
LIG_SH3_3	335	341	PF00018	0.572
LIG_SUMO_SIM_anti_2	334	340	PF11976	0.580
LIG_SUMO_SIM_par_1	147	154	PF11976	0.578
LIG_TYR_ITIM	102	107	PF00017	0.500
LIG_WRC_WIRS_1	1	6	PF05994	0.559
LIG_WRC_WIRS_1	361	366	PF05994	0.481
MOD_CDC14_SPxK_1	212	215	PF00782	0.588
MOD_CDK_SPxK_1	209	215	PF00069	0.586
MOD_CK1_1	129	135	PF00069	0.557
MOD_CK1_1	206	212	PF00069	0.604
MOD_CK1_1	222	228	PF00069	0.579
MOD_CK1_1	301	307	PF00069	0.594
MOD_CK1_1	355	361	PF00069	0.480
MOD_CK1_1	47	53	PF00069	0.610
MOD_CK2_1	113	119	PF00069	0.541
MOD_CK2_1	163	169	PF00069	0.612
MOD_CK2_1	285	291	PF00069	0.503
MOD_CK2_1	356	362	PF00069	0.476
MOD_CK2_1	365	371	PF00069	0.502
MOD_CK2_1	53	59	PF00069	0.523
MOD_CK2_1	88	94	PF00069	0.498
MOD_GlcNHglycan	146	149	PF01048	0.733
MOD_GlcNHglycan	153	156	PF01048	0.647
MOD_GlcNHglycan	217	220	PF01048	0.725
MOD_GlcNHglycan	234	237	PF01048	0.591
MOD_GlcNHglycan	308	311	PF01048	0.612
MOD_GlcNHglycan	368	371	PF01048	0.497
MOD_GlcNHglycan	49	53	PF01048	0.668
MOD_GSK3_1	125	132	PF00069	0.542
MOD_GSK3_1	140	147	PF00069	0.534
MOD_GSK3_1	159	166	PF00069	0.543
MOD_GSK3_1	209	216	PF00069	0.621
MOD_GSK3_1	221	228	PF00069	0.698
MOD_GSK3_1	261	268	PF00069	0.500
MOD_GSK3_1	351	358	PF00069	0.516
MOD_GSK3_1	362	369	PF00069	0.530
MOD_GSK3_1	40	47	PF00069	0.592
MOD_GSK3_1	53	60	PF00069	0.516
MOD_GSK3_1	88	95	PF00069	0.499
MOD_N-GLC_1	19	24	PF02516	0.640
MOD_NEK2_1	127	132	PF00069	0.608
MOD_NEK2_1	151	156	PF00069	0.654
MOD_NEK2_1	256	261	PF00069	0.459
MOD_NEK2_1	352	357	PF00069	0.545
MOD_PIKK_1	132	138	PF00454	0.531
MOD_PIKK_1	19	25	PF00454	0.578
MOD_PIKK_1	295	301	PF00454	0.649
MOD_PIKK_1	76	82	PF00454	0.613
MOD_PKA_2	176	182	PF00069	0.625
MOD_PKA_2	286	292	PF00069	0.518
MOD_PKA_2	92	98	PF00069	0.502
MOD_Plk_1	25	31	PF00069	0.608
MOD_Plk_1	265	271	PF00069	0.611
MOD_Plk_1	333	339	PF00069	0.594
MOD_Plk_4	146	152	PF00069	0.612
MOD_Plk_4	333	339	PF00069	0.594
MOD_ProDKin_1	203	209	PF00069	0.602
MOD_ProDKin_1	219	225	PF00069	0.578
MOD_ProDKin_1	44	50	PF00069	0.587
TRG_DiLeu_BaEn_1	110	115	PF01217	0.536
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.483
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.501
TRG_ENDOCYTIC_2	104	107	PF00928	0.531
TRG_ER_diArg_1	294	297	PF00400	0.564
TRG_NES_CRM1_1	80	94	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWJ1	Leptomonas seymouri	51%	79%
A0A3Q8IH36	Leishmania donovani	100%	100%
A4HAN3	Leishmania braziliensis	78%	98%
E9B4T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q4Q390	Leishmania major	95%	100%