AAA domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9S0_LEIIN

TriTrypDb:

LINF_340017700

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 23

Expansion

Sequence features

A4I9S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.681
CLV_C14_Caspase3-7	452	456	PF00656	0.564
CLV_C14_Caspase3-7	47	51	PF00656	0.593
CLV_NRD_NRD_1	17	19	PF00675	0.628
CLV_NRD_NRD_1	208	210	PF00675	0.609
CLV_NRD_NRD_1	405	407	PF00675	0.646
CLV_NRD_NRD_1	467	469	PF00675	0.639
CLV_NRD_NRD_1	483	485	PF00675	0.402
CLV_NRD_NRD_1	74	76	PF00675	0.508
CLV_NRD_NRD_1	95	97	PF00675	0.640
CLV_PCSK_FUR_1	93	97	PF00082	0.639
CLV_PCSK_KEX2_1	19	21	PF00082	0.616
CLV_PCSK_KEX2_1	208	210	PF00082	0.609
CLV_PCSK_KEX2_1	405	407	PF00082	0.646
CLV_PCSK_KEX2_1	467	469	PF00082	0.639
CLV_PCSK_KEX2_1	483	485	PF00082	0.459
CLV_PCSK_KEX2_1	74	76	PF00082	0.508
CLV_PCSK_KEX2_1	95	97	PF00082	0.640
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.616
CLV_PCSK_SKI1_1	143	147	PF00082	0.525
CLV_PCSK_SKI1_1	151	155	PF00082	0.507
CLV_PCSK_SKI1_1	208	212	PF00082	0.607
CLV_PCSK_SKI1_1	483	487	PF00082	0.568
CLV_PCSK_SKI1_1	488	492	PF00082	0.601
CLV_PCSK_SKI1_1	503	507	PF00082	0.363
CLV_PCSK_SKI1_1	535	539	PF00082	0.431
DEG_APCC_DBOX_1	207	215	PF00400	0.620
DEG_APCC_DBOX_1	467	475	PF00400	0.625
DEG_APCC_DBOX_1	534	542	PF00400	0.564
DEG_SCF_FBW7_2	1	8	PF00400	0.624
DOC_CKS1_1	222	227	PF01111	0.682
DOC_CKS1_1	39	44	PF01111	0.516
DOC_CKS1_1	497	502	PF01111	0.622
DOC_CYCLIN_RxL_1	206	215	PF00134	0.626
DOC_CYCLIN_RxL_1	500	507	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	154	157	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.614
DOC_MAPK_gen_1	208	214	PF00069	0.608
DOC_MAPK_gen_1	467	473	PF00069	0.467
DOC_MAPK_gen_1	483	491	PF00069	0.469
DOC_MAPK_gen_1	531	538	PF00069	0.542
DOC_MAPK_gen_1	74	82	PF00069	0.505
DOC_MAPK_HePTP_8	485	497	PF00069	0.621
DOC_MAPK_MEF2A_6	247	254	PF00069	0.705
DOC_MAPK_MEF2A_6	372	379	PF00069	0.616
DOC_MAPK_MEF2A_6	488	497	PF00069	0.463
DOC_MAPK_MEF2A_6	547	555	PF00069	0.515
DOC_PP2B_LxvP_1	154	157	PF13499	0.506
DOC_PP2B_LxvP_1	165	168	PF13499	0.503
DOC_PP2B_LxvP_1	198	201	PF13499	0.597
DOC_PP2B_LxvP_1	30	33	PF13499	0.568
DOC_PP2B_LxvP_1	82	85	PF13499	0.578
DOC_PP4_FxxP_1	164	167	PF00568	0.517
DOC_USP7_MATH_1	218	222	PF00917	0.728
DOC_USP7_MATH_1	229	233	PF00917	0.642
DOC_USP7_MATH_1	293	297	PF00917	0.625
DOC_USP7_MATH_1	421	425	PF00917	0.623
DOC_USP7_MATH_1	89	93	PF00917	0.597
DOC_USP7_MATH_1	94	98	PF00917	0.614
DOC_WW_Pin1_4	1	6	PF00397	0.626
DOC_WW_Pin1_4	20	25	PF00397	0.610
DOC_WW_Pin1_4	221	226	PF00397	0.670
DOC_WW_Pin1_4	275	280	PF00397	0.754
DOC_WW_Pin1_4	38	43	PF00397	0.511
DOC_WW_Pin1_4	417	422	PF00397	0.727
DOC_WW_Pin1_4	496	501	PF00397	0.637
LIG_14-3-3_CanoR_1	209	215	PF00244	0.454
LIG_14-3-3_CanoR_1	372	378	PF00244	0.623
LIG_14-3-3_CanoR_1	483	491	PF00244	0.546
LIG_14-3-3_CanoR_1	93	99	PF00244	0.636
LIG_Actin_WH2_2	129	145	PF00022	0.512
LIG_BRCT_BRCA1_1	270	274	PF00533	0.603
LIG_BRCT_BRCA1_1	375	379	PF00533	0.582
LIG_BRCT_BRCA1_1	551	555	PF00533	0.494
LIG_deltaCOP1_diTrp_1	174	180	PF00928	0.639
LIG_EVH1_2	156	160	PF00568	0.513
LIG_FHA_1	142	148	PF00498	0.542
LIG_FHA_1	368	374	PF00498	0.725
LIG_FHA_1	39	45	PF00498	0.572
LIG_FHA_1	484	490	PF00498	0.570
LIG_FHA_1	497	503	PF00498	0.464
LIG_FHA_2	176	182	PF00498	0.480
LIG_FHA_2	378	384	PF00498	0.593
LIG_FHA_2	411	417	PF00498	0.646
LIG_FHA_2	45	51	PF00498	0.576
LIG_FHA_2	511	517	PF00498	0.612
LIG_GBD_Chelix_1	501	509	PF00786	0.606
LIG_LIR_Nem_3	174	179	PF02991	0.486
LIG_LIR_Nem_3	204	210	PF02991	0.595
LIG_LIR_Nem_3	504	509	PF02991	0.446
LIG_LIR_Nem_3	544	549	PF02991	0.516
LIG_MAD2	209	217	PF02301	0.627
LIG_NRBOX	336	342	PF00104	0.596
LIG_PCNA_yPIPBox_3	535	549	PF02747	0.580
LIG_Pex14_2	160	164	PF04695	0.512
LIG_Pex14_2	506	510	PF04695	0.604
LIG_Pex14_2	524	528	PF04695	0.564
LIG_SH2_CRK	207	211	PF00017	0.629
LIG_SH2_PTP2	124	127	PF00017	0.487
LIG_SH2_STAP1	344	348	PF00017	0.594
LIG_SH2_STAT5	124	127	PF00017	0.532
LIG_SH2_STAT5	304	307	PF00017	0.628
LIG_SH2_STAT5	79	82	PF00017	0.527
LIG_SH3_1	18	24	PF00018	0.574
LIG_SH3_1	476	482	PF00018	0.642
LIG_SH3_2	479	484	PF14604	0.663
LIG_SH3_3	142	148	PF00018	0.542
LIG_SH3_3	18	24	PF00018	0.574
LIG_SH3_3	211	217	PF00018	0.620
LIG_SH3_3	261	267	PF00018	0.732
LIG_SH3_3	280	286	PF00018	0.569
LIG_SH3_3	36	42	PF00018	0.530
LIG_SH3_3	476	482	PF00018	0.642
LIG_SH3_3	494	500	PF00018	0.480
LIG_SH3_3	82	88	PF00018	0.586
LIG_SUMO_SIM_par_1	210	215	PF11976	0.608
LIG_SUMO_SIM_par_1	41	47	PF11976	0.574
LIG_TRAF2_1	103	106	PF00917	0.605
LIG_TRAF2_1	440	443	PF00917	0.748
LIG_TRAF2_1	461	464	PF00917	0.565
MOD_CDC14_SPxK_1	420	423	PF00782	0.685
MOD_CDK_SPxK_1	417	423	PF00069	0.686
MOD_CDK_SPxxK_3	496	503	PF00069	0.631
MOD_CK1_1	221	227	PF00069	0.684
MOD_CK1_1	231	237	PF00069	0.816
MOD_CK1_1	272	278	PF00069	0.722
MOD_CK1_1	294	300	PF00069	0.678
MOD_CK1_1	303	309	PF00069	0.595
MOD_CK1_1	359	365	PF00069	0.638
MOD_CK1_1	367	373	PF00069	0.607
MOD_CK1_1	504	510	PF00069	0.601
MOD_CK1_1	54	60	PF00069	0.541
MOD_CK1_1	97	103	PF00069	0.662
MOD_CK2_1	175	181	PF00069	0.488
MOD_CK2_1	377	383	PF00069	0.593
MOD_CK2_1	410	416	PF00069	0.636
MOD_CK2_1	510	516	PF00069	0.606
MOD_DYRK1A_RPxSP_1	20	24	PF00069	0.569
MOD_GlcNHglycan	139	142	PF01048	0.542
MOD_GlcNHglycan	15	18	PF01048	0.628
MOD_GlcNHglycan	214	217	PF01048	0.501
MOD_GlcNHglycan	231	234	PF01048	0.615
MOD_GlcNHglycan	237	240	PF01048	0.707
MOD_GlcNHglycan	310	313	PF01048	0.734
MOD_GlcNHglycan	315	318	PF01048	0.750
MOD_GlcNHglycan	358	362	PF01048	0.756
MOD_GlcNHglycan	96	99	PF01048	0.591
MOD_GSK3_1	137	144	PF00069	0.547
MOD_GSK3_1	220	227	PF00069	0.775
MOD_GSK3_1	228	235	PF00069	0.690
MOD_GSK3_1	250	257	PF00069	0.789
MOD_GSK3_1	268	275	PF00069	0.511
MOD_GSK3_1	277	284	PF00069	0.667
MOD_GSK3_1	287	294	PF00069	0.648
MOD_GSK3_1	296	303	PF00069	0.640
MOD_GSK3_1	353	360	PF00069	0.513
MOD_GSK3_1	373	380	PF00069	0.392
MOD_GSK3_1	408	415	PF00069	0.613
MOD_GSK3_1	417	424	PF00069	0.624
MOD_GSK3_1	430	437	PF00069	0.704
MOD_GSK3_1	549	556	PF00069	0.513
MOD_NEK2_1	212	217	PF00069	0.634
MOD_NEK2_1	269	274	PF00069	0.725
MOD_NEK2_1	441	446	PF00069	0.615
MOD_NEK2_1	501	506	PF00069	0.437
MOD_NEK2_1	509	514	PF00069	0.534
MOD_NEK2_1	541	546	PF00069	0.576
MOD_NEK2_1	549	554	PF00069	0.509
MOD_NEK2_1	78	83	PF00069	0.522
MOD_NEK2_2	141	146	PF00069	0.538
MOD_PIKK_1	405	411	PF00454	0.671
MOD_PKA_1	405	411	PF00069	0.671
MOD_PKA_1	483	489	PF00069	0.557
MOD_PKA_2	308	314	PF00069	0.707
MOD_PKA_2	356	362	PF00069	0.756
MOD_PKA_2	405	411	PF00069	0.671
MOD_PKA_2	483	489	PF00069	0.557
MOD_PKA_2	94	100	PF00069	0.681
MOD_Plk_1	106	112	PF00069	0.567
MOD_Plk_1	291	297	PF00069	0.818
MOD_Plk_1	510	516	PF00069	0.606
MOD_Plk_2-3	393	399	PF00069	0.604
MOD_Plk_4	175	181	PF00069	0.492
MOD_Plk_4	250	256	PF00069	0.654
MOD_Plk_4	269	275	PF00069	0.501
MOD_Plk_4	277	283	PF00069	0.768
MOD_Plk_4	328	334	PF00069	0.519
MOD_Plk_4	501	507	PF00069	0.488
MOD_Plk_4	541	547	PF00069	0.429
MOD_Plk_4	549	555	PF00069	0.506
MOD_ProDKin_1	1	7	PF00069	0.622
MOD_ProDKin_1	20	26	PF00069	0.609
MOD_ProDKin_1	221	227	PF00069	0.672
MOD_ProDKin_1	275	281	PF00069	0.756
MOD_ProDKin_1	38	44	PF00069	0.513
MOD_ProDKin_1	417	423	PF00069	0.727
MOD_ProDKin_1	496	502	PF00069	0.629
MOD_SUMO_rev_2	257	265	PF00179	0.801
TRG_ENDOCYTIC_2	207	210	PF00928	0.630
TRG_ENDOCYTIC_2	79	82	PF00928	0.527
TRG_ER_diArg_1	18	21	PF00400	0.621
TRG_ER_diArg_1	207	209	PF00400	0.642
TRG_ER_diArg_1	404	406	PF00400	0.631
TRG_ER_diArg_1	467	470	PF00400	0.551
TRG_ER_diArg_1	482	484	PF00400	0.530
TRG_ER_diArg_1	73	75	PF00400	0.497
TRG_ER_diArg_1	93	96	PF00400	0.540
TRG_NLS_MonoCore_2	18	23	PF00514	0.577
TRG_NLS_MonoExtC_3	17	22	PF00514	0.623
TRG_NLS_MonoExtN_4	18	23	PF00514	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II07	Leishmania donovani	99%	100%
A4HAM8	Leishmania braziliensis	68%	100%
E9B4T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q395	Leishmania major	90%	99%