Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9R1_LEIIN

TriTrypDb:

LINF_340016400

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9R1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.451
CLV_C14_Caspase3-7	51	55	PF00656	0.564
CLV_C14_Caspase3-7	99	103	PF00656	0.593
CLV_NRD_NRD_1	251	253	PF00675	0.558
CLV_NRD_NRD_1	384	386	PF00675	0.451
CLV_NRD_NRD_1	456	458	PF00675	0.524
CLV_PCSK_KEX2_1	251	253	PF00082	0.550
CLV_PCSK_KEX2_1	26	28	PF00082	0.422
CLV_PCSK_KEX2_1	386	388	PF00082	0.483
CLV_PCSK_KEX2_1	403	405	PF00082	0.629
CLV_PCSK_KEX2_1	447	449	PF00082	0.598
CLV_PCSK_KEX2_1	456	458	PF00082	0.499
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.408
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.483
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.629
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.598
CLV_PCSK_SKI1_1	27	31	PF00082	0.415
CLV_PCSK_SKI1_1	326	330	PF00082	0.449
CLV_PCSK_SKI1_1	456	460	PF00082	0.559
CLV_PCSK_SKI1_1	583	587	PF00082	0.469
CLV_Separin_Metazoa	525	529	PF03568	0.366
DEG_APCC_DBOX_1	582	590	PF00400	0.394
DEG_SPOP_SBC_1	450	454	PF00917	0.613
DOC_CKS1_1	203	208	PF01111	0.605
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.422
DOC_MAPK_MEF2A_6	353	360	PF00069	0.404
DOC_MAPK_MEF2A_6	84	91	PF00069	0.429
DOC_USP7_MATH_1	12	16	PF00917	0.491
DOC_USP7_MATH_1	122	126	PF00917	0.614
DOC_USP7_MATH_1	166	170	PF00917	0.569
DOC_USP7_MATH_1	2	6	PF00917	0.529
DOC_USP7_MATH_1	204	208	PF00917	0.600
DOC_USP7_MATH_1	450	454	PF00917	0.609
DOC_USP7_MATH_1	504	508	PF00917	0.495
DOC_USP7_MATH_1	536	540	PF00917	0.441
DOC_USP7_MATH_1	63	67	PF00917	0.595
DOC_USP7_UBL2_3	345	349	PF12436	0.553
DOC_USP7_UBL2_3	399	403	PF12436	0.607
DOC_WW_Pin1_4	130	135	PF00397	0.547
DOC_WW_Pin1_4	202	207	PF00397	0.604
DOC_WW_Pin1_4	229	234	PF00397	0.565
DOC_WW_Pin1_4	275	280	PF00397	0.534
DOC_WW_Pin1_4	434	439	PF00397	0.691
DOC_WW_Pin1_4	442	447	PF00397	0.634
DOC_WW_Pin1_4	66	71	PF00397	0.479
LIG_14-3-3_CanoR_1	141	149	PF00244	0.532
LIG_14-3-3_CanoR_1	192	200	PF00244	0.622
LIG_14-3-3_CanoR_1	275	279	PF00244	0.479
LIG_14-3-3_CanoR_1	427	435	PF00244	0.559
LIG_14-3-3_CanoR_1	448	458	PF00244	0.587
LIG_14-3-3_CanoR_1	479	487	PF00244	0.468
LIG_14-3-3_CanoR_1	546	555	PF00244	0.413
LIG_14-3-3_CanoR_1	583	593	PF00244	0.459
LIG_14-3-3_CanoR_1	597	601	PF00244	0.397
LIG_14-3-3_CanoR_1	84	88	PF00244	0.449
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_BRCT_BRCA1_1	454	458	PF00533	0.565
LIG_Clathr_ClatBox_1	335	339	PF01394	0.447
LIG_FHA_1	153	159	PF00498	0.504
LIG_FHA_1	181	187	PF00498	0.632
LIG_FHA_1	203	209	PF00498	0.569
LIG_FHA_1	271	277	PF00498	0.425
LIG_FHA_1	36	42	PF00498	0.540
LIG_FHA_1	501	507	PF00498	0.698
LIG_FHA_1	84	90	PF00498	0.418
LIG_FHA_2	169	175	PF00498	0.767
LIG_FHA_2	18	24	PF00498	0.464
LIG_FHA_2	185	191	PF00498	0.563
LIG_FHA_2	217	223	PF00498	0.646
LIG_FHA_2	302	308	PF00498	0.429
LIG_FHA_2	517	523	PF00498	0.517
LIG_FHA_2	549	555	PF00498	0.378
LIG_FHA_2	576	582	PF00498	0.457
LIG_GBD_Chelix_1	249	257	PF00786	0.447
LIG_LIR_Apic_2	102	108	PF02991	0.626
LIG_LIR_Gen_1	330	341	PF02991	0.408
LIG_LIR_Gen_1	587	598	PF02991	0.515
LIG_LIR_Gen_1	605	615	PF02991	0.405
LIG_LIR_Nem_3	605	610	PF02991	0.392
LIG_LYPXL_yS_3	355	358	PF13949	0.397
LIG_PCNA_PIPBox_1	601	610	PF02747	0.450
LIG_PCNA_yPIPBox_3	597	608	PF02747	0.445
LIG_SH2_CRK	531	535	PF00017	0.383
LIG_SH2_STAP1	531	535	PF00017	0.358
LIG_SH2_STAP1	548	552	PF00017	0.362
LIG_SH2_STAT3	598	601	PF00017	0.447
LIG_SH2_STAT5	303	306	PF00017	0.437
LIG_SH2_STAT5	333	336	PF00017	0.412
LIG_SH2_STAT5	375	378	PF00017	0.444
LIG_SH2_STAT5	40	43	PF00017	0.504
LIG_SH2_STAT5	607	610	PF00017	0.359
LIG_SH3_3	121	127	PF00018	0.655
LIG_SH3_3	253	259	PF00018	0.376
LIG_SH3_3	273	279	PF00018	0.340
LIG_SH3_3	317	323	PF00018	0.474
LIG_SH3_3	432	438	PF00018	0.807
LIG_SUMO_SIM_anti_2	521	528	PF11976	0.493
LIG_SUMO_SIM_par_1	207	214	PF11976	0.522
LIG_TRAF2_1	220	223	PF00917	0.644
LIG_TRAF2_1	519	522	PF00917	0.466
LIG_TRAF2_1	551	554	PF00917	0.487
LIG_TRAF2_1	578	581	PF00917	0.457
MOD_CDC14_SPxK_1	445	448	PF00782	0.601
MOD_CDK_SPK_2	442	447	PF00069	0.651
MOD_CDK_SPxK_1	442	448	PF00069	0.608
MOD_CK1_1	133	139	PF00069	0.669
MOD_CK1_1	140	146	PF00069	0.572
MOD_CK1_1	180	186	PF00069	0.666
MOD_CK1_1	207	213	PF00069	0.588
MOD_CK1_1	214	220	PF00069	0.608
MOD_CK1_1	225	231	PF00069	0.577
MOD_CK1_1	278	284	PF00069	0.647
MOD_CK1_1	292	298	PF00069	0.446
MOD_CK1_1	4	10	PF00069	0.518
MOD_CK1_1	407	413	PF00069	0.615
MOD_CK1_1	499	505	PF00069	0.584
MOD_CK1_1	66	72	PF00069	0.592
MOD_CK2_1	168	174	PF00069	0.767
MOD_CK2_1	216	222	PF00069	0.647
MOD_CK2_1	293	299	PF00069	0.587
MOD_CK2_1	413	419	PF00069	0.590
MOD_CK2_1	458	464	PF00069	0.478
MOD_CK2_1	516	522	PF00069	0.584
MOD_CK2_1	536	542	PF00069	0.449
MOD_CK2_1	548	554	PF00069	0.326
MOD_CK2_1	575	581	PF00069	0.459
MOD_DYRK1A_RPxSP_1	275	279	PF00069	0.485
MOD_GlcNHglycan	111	114	PF01048	0.481
MOD_GlcNHglycan	177	180	PF01048	0.799
MOD_GlcNHglycan	227	230	PF01048	0.582
MOD_GlcNHglycan	246	249	PF01048	0.266
MOD_GlcNHglycan	280	283	PF01048	0.463
MOD_GlcNHglycan	364	367	PF01048	0.404
MOD_GlcNHglycan	390	394	PF01048	0.593
MOD_GlcNHglycan	415	418	PF01048	0.647
MOD_GlcNHglycan	432	435	PF01048	0.576
MOD_GlcNHglycan	499	502	PF01048	0.455
MOD_GlcNHglycan	65	68	PF01048	0.653
MOD_GlcNHglycan	9	12	PF01048	0.508
MOD_GSK3_1	133	140	PF00069	0.728
MOD_GSK3_1	150	157	PF00069	0.380
MOD_GSK3_1	175	182	PF00069	0.639
MOD_GSK3_1	2	9	PF00069	0.511
MOD_GSK3_1	207	214	PF00069	0.596
MOD_GSK3_1	218	225	PF00069	0.621
MOD_GSK3_1	270	277	PF00069	0.489
MOD_GSK3_1	278	285	PF00069	0.473
MOD_GSK3_1	289	296	PF00069	0.378
MOD_GSK3_1	389	396	PF00069	0.680
MOD_GSK3_1	404	411	PF00069	0.568
MOD_GSK3_1	426	433	PF00069	0.624
MOD_GSK3_1	442	449	PF00069	0.573
MOD_GSK3_1	492	499	PF00069	0.512
MOD_GSK3_1	500	507	PF00069	0.474
MOD_GSK3_1	575	582	PF00069	0.418
MOD_N-GLC_1	413	418	PF02516	0.606
MOD_N-GLC_2	62	64	PF02516	0.569
MOD_NEK2_1	1	6	PF00069	0.557
MOD_NEK2_1	137	142	PF00069	0.522
MOD_NEK2_1	271	276	PF00069	0.451
MOD_NEK2_1	315	320	PF00069	0.612
MOD_NEK2_1	440	445	PF00069	0.625
MOD_NEK2_1	458	463	PF00069	0.443
MOD_NEK2_1	496	501	PF00069	0.516
MOD_PIKK_1	152	158	PF00454	0.492
MOD_PIKK_1	27	33	PF00454	0.412
MOD_PIKK_1	494	500	PF00454	0.528
MOD_PIKK_1	562	568	PF00454	0.426
MOD_PIKK_1	575	581	PF00454	0.356
MOD_PKA_2	140	146	PF00069	0.595
MOD_PKA_2	166	172	PF00069	0.600
MOD_PKA_2	260	266	PF00069	0.471
MOD_PKA_2	274	280	PF00069	0.400
MOD_PKA_2	407	413	PF00069	0.595
MOD_PKA_2	426	432	PF00069	0.504
MOD_PKA_2	478	484	PF00069	0.596
MOD_PKA_2	596	602	PF00069	0.400
MOD_PKA_2	83	89	PF00069	0.448
MOD_PKB_1	404	412	PF00069	0.632
MOD_Plk_1	222	228	PF00069	0.616
MOD_Plk_4	154	160	PF00069	0.556
MOD_Plk_4	204	210	PF00069	0.620
MOD_Plk_4	211	217	PF00069	0.600
MOD_Plk_4	536	542	PF00069	0.582
MOD_ProDKin_1	130	136	PF00069	0.546
MOD_ProDKin_1	202	208	PF00069	0.604
MOD_ProDKin_1	229	235	PF00069	0.562
MOD_ProDKin_1	275	281	PF00069	0.533
MOD_ProDKin_1	434	440	PF00069	0.695
MOD_ProDKin_1	442	448	PF00069	0.633
MOD_ProDKin_1	66	72	PF00069	0.463
MOD_SUMO_rev_2	339	346	PF00179	0.464
TRG_DiLeu_BaEn_4	222	228	PF01217	0.645
TRG_ENDOCYTIC_2	333	336	PF00928	0.390
TRG_ENDOCYTIC_2	355	358	PF00928	0.397
TRG_ENDOCYTIC_2	531	534	PF00928	0.378
TRG_ENDOCYTIC_2	590	593	PF00928	0.399
TRG_ENDOCYTIC_2	607	610	PF00928	0.385
TRG_ENDOCYTIC_2	73	76	PF00928	0.406
TRG_ER_diArg_1	250	252	PF00400	0.471
TRG_ER_diArg_1	323	326	PF00400	0.524
TRG_ER_diArg_1	456	458	PF00400	0.524
TRG_NES_CRM1_1	370	383	PF08389	0.443
TRG_NLS_MonoExtC_3	384	389	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P311	Leptomonas seymouri	41%	98%
A0A3S7X7P4	Leishmania donovani	100%	100%
A4HAL4	Leishmania braziliensis	68%	100%
E9B4S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3A4	Leishmania major	90%	100%