Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9P5_LEIIN

TriTrypDb:

LINF_340014600

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	378	382	PF00656	0.702
CLV_C14_Caspase3-7	479	483	PF00656	0.719
CLV_C14_Caspase3-7	610	614	PF00656	0.549
CLV_C14_Caspase3-7	816	820	PF00656	0.613
CLV_C14_Caspase3-7	917	921	PF00656	0.692
CLV_NRD_NRD_1	295	297	PF00675	0.515
CLV_NRD_NRD_1	376	378	PF00675	0.680
CLV_NRD_NRD_1	433	435	PF00675	0.510
CLV_NRD_NRD_1	750	752	PF00675	0.494
CLV_NRD_NRD_1	770	772	PF00675	0.263
CLV_NRD_NRD_1	874	876	PF00675	0.660
CLV_PCSK_FUR_1	768	772	PF00082	0.475
CLV_PCSK_KEX2_1	295	297	PF00082	0.515
CLV_PCSK_KEX2_1	376	378	PF00082	0.677
CLV_PCSK_KEX2_1	433	435	PF00082	0.510
CLV_PCSK_KEX2_1	749	751	PF00082	0.498
CLV_PCSK_KEX2_1	770	772	PF00082	0.593
CLV_PCSK_KEX2_1	860	862	PF00082	0.747
CLV_PCSK_KEX2_1	874	876	PF00082	0.621
CLV_PCSK_PC1ET2_1	860	862	PF00082	0.553
CLV_PCSK_SKI1_1	433	437	PF00082	0.528
CLV_PCSK_SKI1_1	707	711	PF00082	0.420
CLV_PCSK_SKI1_1	74	78	PF00082	0.507
CLV_PCSK_SKI1_1	751	755	PF00082	0.532
DEG_APCC_DBOX_1	911	919	PF00400	0.613
DEG_APCC_KENBOX_2	552	556	PF00400	0.509
DEG_SCF_FBW7_1	699	706	PF00400	0.489
DOC_CKS1_1	132	137	PF01111	0.616
DOC_CKS1_1	233	238	PF01111	0.534
DOC_CKS1_1	700	705	PF01111	0.482
DOC_CYCLIN_RxL_1	186	194	PF00134	0.270
DOC_CYCLIN_RxL_1	247	257	PF00134	0.450
DOC_CYCLIN_RxL_1	44	55	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.604
DOC_MAPK_gen_1	295	302	PF00069	0.592
DOC_MAPK_gen_1	707	715	PF00069	0.483
DOC_MAPK_MEF2A_6	590	598	PF00069	0.540
DOC_MAPK_MEF2A_6	707	715	PF00069	0.483
DOC_PP1_RVXF_1	361	367	PF00149	0.438
DOC_PP1_RVXF_1	523	529	PF00149	0.699
DOC_PP2B_LxvP_1	204	207	PF13499	0.561
DOC_PP2B_LxvP_1	508	511	PF13499	0.689
DOC_PP2B_LxvP_1	731	734	PF13499	0.588
DOC_PP4_FxxP_1	84	87	PF00568	0.575
DOC_USP7_MATH_1	12	16	PF00917	0.697
DOC_USP7_MATH_1	161	165	PF00917	0.737
DOC_USP7_MATH_1	382	386	PF00917	0.787
DOC_USP7_MATH_1	463	467	PF00917	0.675
DOC_USP7_MATH_1	490	494	PF00917	0.716
DOC_USP7_MATH_1	497	501	PF00917	0.630
DOC_USP7_MATH_1	609	613	PF00917	0.695
DOC_USP7_MATH_1	676	680	PF00917	0.453
DOC_USP7_MATH_1	703	707	PF00917	0.496
DOC_USP7_MATH_1	734	738	PF00917	0.549
DOC_USP7_MATH_1	840	844	PF00917	0.670
DOC_USP7_MATH_1	900	904	PF00917	0.726
DOC_USP7_MATH_1	91	95	PF00917	0.550
DOC_USP7_UBL2_3	82	86	PF12436	0.483
DOC_WW_Pin1_4	131	136	PF00397	0.558
DOC_WW_Pin1_4	218	223	PF00397	0.660
DOC_WW_Pin1_4	232	237	PF00397	0.521
DOC_WW_Pin1_4	320	325	PF00397	0.710
DOC_WW_Pin1_4	364	369	PF00397	0.480
DOC_WW_Pin1_4	39	44	PF00397	0.587
DOC_WW_Pin1_4	474	479	PF00397	0.623
DOC_WW_Pin1_4	506	511	PF00397	0.812
DOC_WW_Pin1_4	605	610	PF00397	0.650
DOC_WW_Pin1_4	699	704	PF00397	0.560
DOC_WW_Pin1_4	884	889	PF00397	0.728
LIG_14-3-3_CanoR_1	16	23	PF00244	0.688
LIG_14-3-3_CanoR_1	195	200	PF00244	0.454
LIG_14-3-3_CanoR_1	289	295	PF00244	0.557
LIG_14-3-3_CanoR_1	329	335	PF00244	0.602
LIG_14-3-3_CanoR_1	343	348	PF00244	0.412
LIG_14-3-3_CanoR_1	464	469	PF00244	0.724
LIG_14-3-3_CanoR_1	544	549	PF00244	0.465
LIG_14-3-3_CanoR_1	618	628	PF00244	0.581
LIG_14-3-3_CanoR_1	751	761	PF00244	0.566
LIG_14-3-3_CanoR_1	770	776	PF00244	0.530
LIG_14-3-3_CanoR_1	828	833	PF00244	0.640
LIG_14-3-3_CanoR_1	839	845	PF00244	0.639
LIG_14-3-3_CanoR_1	874	878	PF00244	0.751
LIG_BIR_III_2	219	223	PF00653	0.642
LIG_BIR_III_2	482	486	PF00653	0.729
LIG_BIR_III_2	9	13	PF00653	0.634
LIG_BIR_III_4	151	155	PF00653	0.730
LIG_CaM_NSCaTE_8	579	586	PF13499	0.389
LIG_CSL_BTD_1	365	368	PF09270	0.571
LIG_EH1_1	198	206	PF00400	0.555
LIG_EH1_1	760	768	PF00400	0.469
LIG_eIF4E_1	199	205	PF01652	0.474
LIG_eIF4E_1	761	767	PF01652	0.548
LIG_FHA_1	188	194	PF00498	0.483
LIG_FHA_1	200	206	PF00498	0.481
LIG_FHA_1	265	271	PF00498	0.616
LIG_FHA_1	321	327	PF00498	0.667
LIG_FHA_1	449	455	PF00498	0.684
LIG_FHA_1	536	542	PF00498	0.514
LIG_FHA_1	578	584	PF00498	0.469
LIG_FHA_1	620	626	PF00498	0.591
LIG_FHA_1	656	662	PF00498	0.438
LIG_FHA_1	699	705	PF00498	0.497
LIG_FHA_1	840	846	PF00498	0.737
LIG_FHA_1	885	891	PF00498	0.678
LIG_FHA_1	93	99	PF00498	0.593
LIG_FHA_2	111	117	PF00498	0.363
LIG_FHA_2	233	239	PF00498	0.523
LIG_FHA_2	474	480	PF00498	0.794
LIG_FHA_2	608	614	PF00498	0.634
LIG_FHA_2	619	625	PF00498	0.601
LIG_FHA_2	772	778	PF00498	0.602
LIG_FHA_2	814	820	PF00498	0.623
LIG_FHA_2	95	101	PF00498	0.580
LIG_GBD_Chelix_1	245	253	PF00786	0.448
LIG_LIR_Apic_2	648	654	PF02991	0.458
LIG_LIR_Apic_2	83	87	PF02991	0.504
LIG_LIR_Gen_1	666	676	PF02991	0.466
LIG_LIR_Gen_1	719	728	PF02991	0.476
LIG_LIR_Gen_1	787	794	PF02991	0.506
LIG_LIR_Nem_3	350	356	PF02991	0.432
LIG_LIR_Nem_3	666	672	PF02991	0.413
LIG_LIR_Nem_3	719	723	PF02991	0.480
LIG_LIR_Nem_3	787	792	PF02991	0.504
LIG_MYND_1	888	892	PF01753	0.670
LIG_NRBOX	536	542	PF00104	0.586
LIG_NRBOX	627	633	PF00104	0.558
LIG_SH2_CRK	409	413	PF00017	0.416
LIG_SH2_CRK	669	673	PF00017	0.456
LIG_SH2_NCK_1	620	624	PF00017	0.559
LIG_SH2_STAP1	409	413	PF00017	0.469
LIG_SH2_STAP1	599	603	PF00017	0.454
LIG_SH2_STAP1	647	651	PF00017	0.506
LIG_SH2_STAP1	669	673	PF00017	0.528
LIG_SH2_STAT3	185	188	PF00017	0.566
LIG_SH2_STAT3	630	633	PF00017	0.426
LIG_SH2_STAT3	761	764	PF00017	0.551
LIG_SH2_STAT5	199	202	PF00017	0.478
LIG_SH2_STAT5	428	431	PF00017	0.445
LIG_SH2_STAT5	620	623	PF00017	0.555
LIG_SH2_STAT5	630	633	PF00017	0.377
LIG_SH2_STAT5	651	654	PF00017	0.453
LIG_SH2_STAT5	712	715	PF00017	0.440
LIG_SH2_STAT5	752	755	PF00017	0.482
LIG_SH2_STAT5	761	764	PF00017	0.396
LIG_SH2_STAT5	914	917	PF00017	0.632
LIG_SH3_3	132	138	PF00018	0.660
LIG_SH3_3	230	236	PF00018	0.517
LIG_SH3_3	504	510	PF00018	0.711
LIG_SH3_3	712	718	PF00018	0.569
LIG_SH3_3	809	815	PF00018	0.621
LIG_Sin3_3	299	306	PF02671	0.537
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.532
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.529
LIG_SUMO_SIM_anti_2	450	459	PF11976	0.693
LIG_SUMO_SIM_anti_2	48	56	PF11976	0.605
LIG_SUMO_SIM_anti_2	580	585	PF11976	0.394
LIG_SUMO_SIM_par_1	189	194	PF11976	0.268
LIG_SUMO_SIM_par_1	450	459	PF11976	0.557
LIG_SUMO_SIM_par_1	512	519	PF11976	0.670
LIG_SUMO_SIM_par_1	579	585	PF11976	0.467
LIG_SUMO_SIM_par_1	593	600	PF11976	0.469
LIG_TYR_ITIM	342	347	PF00017	0.626
LIG_TYR_ITIM	407	412	PF00017	0.469
LIG_TYR_ITIM	76	81	PF00017	0.557
LIG_UBA3_1	545	553	PF00899	0.509
MOD_CDK_SPK_2	232	237	PF00069	0.544
MOD_CK1_1	14	20	PF00069	0.773
MOD_CK1_1	159	165	PF00069	0.762
MOD_CK1_1	317	323	PF00069	0.700
MOD_CK1_1	384	390	PF00069	0.694
MOD_CK1_1	493	499	PF00069	0.782
MOD_CK1_1	50	56	PF00069	0.578
MOD_CK1_1	509	515	PF00069	0.548
MOD_CK1_1	529	535	PF00069	0.609
MOD_CK1_1	612	618	PF00069	0.669
MOD_CK1_1	894	900	PF00069	0.624
MOD_CK1_1	94	100	PF00069	0.593
MOD_CK2_1	110	116	PF00069	0.482
MOD_CK2_1	232	238	PF00069	0.519
MOD_CK2_1	309	315	PF00069	0.684
MOD_CK2_1	398	404	PF00069	0.583
MOD_CK2_1	473	479	PF00069	0.712
MOD_CK2_1	618	624	PF00069	0.573
MOD_GlcNHglycan	161	164	PF01048	0.697
MOD_GlcNHglycan	176	179	PF01048	0.415
MOD_GlcNHglycan	182	185	PF01048	0.418
MOD_GlcNHglycan	37	40	PF01048	0.631
MOD_GlcNHglycan	387	390	PF01048	0.680
MOD_GlcNHglycan	492	495	PF01048	0.746
MOD_GlcNHglycan	504	507	PF01048	0.596
MOD_GlcNHglycan	518	521	PF01048	0.704
MOD_GlcNHglycan	584	587	PF01048	0.470
MOD_GlcNHglycan	615	618	PF01048	0.701
MOD_GlcNHglycan	754	757	PF01048	0.545
MOD_GSK3_1	10	17	PF00069	0.714
MOD_GSK3_1	157	164	PF00069	0.709
MOD_GSK3_1	180	187	PF00069	0.474
MOD_GSK3_1	191	198	PF00069	0.415
MOD_GSK3_1	214	221	PF00069	0.772
MOD_GSK3_1	314	321	PF00069	0.783
MOD_GSK3_1	324	331	PF00069	0.493
MOD_GSK3_1	35	42	PF00069	0.617
MOD_GSK3_1	377	384	PF00069	0.683
MOD_GSK3_1	469	476	PF00069	0.717
MOD_GSK3_1	47	54	PF00069	0.411
MOD_GSK3_1	489	496	PF00069	0.524
MOD_GSK3_1	502	509	PF00069	0.809
MOD_GSK3_1	605	612	PF00069	0.654
MOD_GSK3_1	699	706	PF00069	0.532
MOD_GSK3_1	766	773	PF00069	0.551
MOD_GSK3_1	813	820	PF00069	0.637
MOD_GSK3_1	824	831	PF00069	0.574
MOD_N-GLC_1	140	145	PF02516	0.722
MOD_NEK2_1	110	115	PF00069	0.456
MOD_NEK2_1	191	196	PF00069	0.305
MOD_NEK2_1	371	376	PF00069	0.637
MOD_NEK2_1	412	417	PF00069	0.458
MOD_NEK2_1	502	507	PF00069	0.631
MOD_NEK2_1	582	587	PF00069	0.427
MOD_NEK2_1	631	636	PF00069	0.407
MOD_NEK2_1	64	69	PF00069	0.496
MOD_NEK2_1	667	672	PF00069	0.495
MOD_NEK2_1	766	771	PF00069	0.510
MOD_NEK2_1	824	829	PF00069	0.654
MOD_NEK2_1	922	927	PF00069	0.589
MOD_NEK2_2	470	475	PF00069	0.714
MOD_NEK2_2	873	878	PF00069	0.747
MOD_PIKK_1	184	190	PF00454	0.554
MOD_PIKK_1	199	205	PF00454	0.361
MOD_PIKK_1	264	270	PF00454	0.573
MOD_PIKK_1	569	575	PF00454	0.585
MOD_PIKK_1	655	661	PF00454	0.426
MOD_PK_1	464	470	PF00069	0.723
MOD_PK_1	806	812	PF00069	0.631
MOD_PK_1	828	834	PF00069	0.698
MOD_PKA_1	376	382	PF00069	0.701
MOD_PKA_1	770	776	PF00069	0.465
MOD_PKA_2	15	21	PF00069	0.683
MOD_PKA_2	328	334	PF00069	0.629
MOD_PKA_2	376	382	PF00069	0.701
MOD_PKA_2	463	469	PF00069	0.720
MOD_PKA_2	62	68	PF00069	0.495
MOD_PKA_2	655	661	PF00069	0.426
MOD_PKA_2	770	776	PF00069	0.465
MOD_PKA_2	873	879	PF00069	0.746
MOD_PKA_2	923	929	PF00069	0.728
MOD_PKB_1	768	776	PF00069	0.385
MOD_Plk_1	191	197	PF00069	0.477
MOD_Plk_1	241	247	PF00069	0.460
MOD_Plk_1	47	53	PF00069	0.463
MOD_Plk_2-3	624	630	PF00069	0.514
MOD_Plk_2-3	813	819	PF00069	0.656
MOD_Plk_4	241	247	PF00069	0.478
MOD_Plk_4	448	454	PF00069	0.666
MOD_Plk_4	47	53	PF00069	0.523
MOD_Plk_4	544	550	PF00069	0.495
MOD_Plk_4	840	846	PF00069	0.677
MOD_ProDKin_1	131	137	PF00069	0.572
MOD_ProDKin_1	218	224	PF00069	0.646
MOD_ProDKin_1	232	238	PF00069	0.514
MOD_ProDKin_1	320	326	PF00069	0.697
MOD_ProDKin_1	364	370	PF00069	0.495
MOD_ProDKin_1	39	45	PF00069	0.576
MOD_ProDKin_1	474	480	PF00069	0.624
MOD_ProDKin_1	506	512	PF00069	0.812
MOD_ProDKin_1	605	611	PF00069	0.665
MOD_ProDKin_1	699	705	PF00069	0.552
MOD_ProDKin_1	884	890	PF00069	0.734
MOD_SUMO_rev_2	694	699	PF00179	0.621
TRG_DiLeu_BaEn_1	431	436	PF01217	0.506
TRG_DiLeu_BaEn_1	450	455	PF01217	0.693
TRG_DiLeu_BaEn_2	336	342	PF01217	0.491
TRG_DiLeu_BaEn_2	715	721	PF01217	0.491
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.481
TRG_DiLeu_BaLyEn_6	704	709	PF01217	0.478
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.524
TRG_DiLeu_BaLyEn_6	777	782	PF01217	0.539
TRG_DiLeu_BaLyEn_6	885	890	PF01217	0.656
TRG_DiLeu_LyEn_5	431	436	PF01217	0.506
TRG_ENDOCYTIC_2	344	347	PF00928	0.644
TRG_ENDOCYTIC_2	409	412	PF00928	0.417
TRG_ENDOCYTIC_2	669	672	PF00928	0.458
TRG_ENDOCYTIC_2	712	715	PF00928	0.493
TRG_ENDOCYTIC_2	78	81	PF00928	0.550
TRG_ER_diArg_1	294	296	PF00400	0.562
TRG_ER_diArg_1	375	377	PF00400	0.665
TRG_ER_diArg_1	433	435	PF00400	0.510
TRG_ER_diArg_1	749	751	PF00400	0.501
TRG_ER_diArg_1	767	770	PF00400	0.452
TRG_ER_diArg_1	873	875	PF00400	0.677
TRG_NES_CRM1_1	779	795	PF08389	0.525
TRG_Pf-PMV_PEXEL_1	867	871	PF00026	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK2	Leptomonas seymouri	50%	91%
A0A3Q8IH15	Leishmania donovani	100%	100%
A4HAK1	Leishmania braziliensis	80%	99%
C9ZMZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B4Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q3B7	Leishmania major	94%	99%