LeishMANIAdb
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Flagellar attachment zone protein 1

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Flagellar attachment zone protein 1
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4I9N8_LEIIN
TriTrypDb:
Length:
1277

Annotations

Annotations by Jardim et al.

Flagella, flagellar attachment zone Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Phosphorylation

Amastigote: 1009, 423, 565, 645, 787, 867
Promastigote/Amastigote: 430, 652, 874

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I9N8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9N8

Function

Biological processes
Term Name Level Count
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044782 cilium organization 5 1
GO:0060271 cilium assembly 6 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
GO:1903047 mitotic cell cycle process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 240 244 PF00656 0.585
CLV_C14_Caspase3-7 412 416 PF00656 0.697
CLV_C14_Caspase3-7 634 638 PF00656 0.531
CLV_C14_Caspase3-7 856 860 PF00656 0.529
CLV_NRD_NRD_1 122 124 PF00675 0.488
CLV_NRD_NRD_1 165 167 PF00675 0.559
CLV_NRD_NRD_1 93 95 PF00675 0.477
CLV_PCSK_FUR_1 397 401 PF00082 0.653
CLV_PCSK_FUR_1 533 537 PF00082 0.676
CLV_PCSK_FUR_1 619 623 PF00082 0.541
CLV_PCSK_FUR_1 755 759 PF00082 0.550
CLV_PCSK_FUR_1 841 845 PF00082 0.543
CLV_PCSK_FUR_1 977 981 PF00082 0.467
CLV_PCSK_KEX2_1 236 238 PF00082 0.533
CLV_PCSK_KEX2_1 306 308 PF00082 0.452
CLV_PCSK_KEX2_1 399 401 PF00082 0.488
CLV_PCSK_KEX2_1 535 537 PF00082 0.532
CLV_PCSK_KEX2_1 621 623 PF00082 0.549
CLV_PCSK_KEX2_1 757 759 PF00082 0.543
CLV_PCSK_KEX2_1 843 845 PF00082 0.583
CLV_PCSK_KEX2_1 93 95 PF00082 0.477
CLV_PCSK_KEX2_1 979 981 PF00082 0.460
CLV_PCSK_PC1ET2_1 236 238 PF00082 0.592
CLV_PCSK_PC1ET2_1 306 308 PF00082 0.452
CLV_PCSK_PC1ET2_1 399 401 PF00082 0.488
CLV_PCSK_PC1ET2_1 535 537 PF00082 0.534
CLV_PCSK_PC1ET2_1 621 623 PF00082 0.549
CLV_PCSK_PC1ET2_1 757 759 PF00082 0.552
CLV_PCSK_PC1ET2_1 843 845 PF00082 0.552
CLV_PCSK_PC1ET2_1 979 981 PF00082 0.469
CLV_PCSK_SKI1_1 1196 1200 PF00082 0.497
CLV_PCSK_SKI1_1 123 127 PF00082 0.492
CLV_PCSK_SKI1_1 1251 1255 PF00082 0.435
CLV_PCSK_SKI1_1 258 262 PF00082 0.432
CLV_PCSK_SKI1_1 307 311 PF00082 0.332
CLV_PCSK_SKI1_1 360 364 PF00082 0.596
CLV_PCSK_SKI1_1 38 42 PF00082 0.506
CLV_PCSK_SKI1_1 61 65 PF00082 0.448
DEG_APCC_DBOX_1 1073 1081 PF00400 0.536
DEG_APCC_DBOX_1 85 93 PF00400 0.579
DEG_APCC_KENBOX_2 1189 1193 PF00400 0.621
DEG_MDM2_SWIB_1 1235 1242 PF02201 0.641
DEG_Nend_Nbox_1 1 3 PF02207 0.595
DEG_SPOP_SBC_1 346 350 PF00917 0.477
DOC_MAPK_gen_1 109 116 PF00069 0.455
DOC_MAPK_gen_1 1106 1114 PF00069 0.563
DOC_MAPK_MEF2A_6 283 292 PF00069 0.422
DOC_PP1_RVXF_1 358 364 PF00149 0.465
DOC_USP7_MATH_1 425 429 PF00917 0.697
DOC_USP7_MATH_1 458 462 PF00917 0.523
DOC_USP7_MATH_1 542 546 PF00917 0.604
DOC_USP7_MATH_1 647 651 PF00917 0.700
DOC_USP7_MATH_1 680 684 PF00917 0.545
DOC_USP7_MATH_1 764 768 PF00917 0.476
DOC_USP7_MATH_1 869 873 PF00917 0.808
DOC_USP7_MATH_1 902 906 PF00917 0.515
DOC_USP7_MATH_1 986 990 PF00917 0.394
DOC_USP7_UBL2_3 109 113 PF12436 0.453
DOC_USP7_UBL2_3 199 203 PF12436 0.618
DOC_WW_Pin1_4 1006 1011 PF00397 0.493
DOC_WW_Pin1_4 129 134 PF00397 0.595
DOC_WW_Pin1_4 206 211 PF00397 0.496
DOC_WW_Pin1_4 294 299 PF00397 0.461
DOC_WW_Pin1_4 427 432 PF00397 0.747
DOC_WW_Pin1_4 562 567 PF00397 0.625
DOC_WW_Pin1_4 649 654 PF00397 0.644
DOC_WW_Pin1_4 784 789 PF00397 0.496
DOC_WW_Pin1_4 871 876 PF00397 0.617
LIG_14-3-3_CanoR_1 123 131 PF00244 0.602
LIG_14-3-3_CanoR_1 283 287 PF00244 0.584
LIG_14-3-3_CanoR_1 385 391 PF00244 0.456
LIG_14-3-3_CanoR_1 445 455 PF00244 0.677
LIG_14-3-3_CanoR_1 543 547 PF00244 0.698
LIG_14-3-3_CanoR_1 667 677 PF00244 0.679
LIG_14-3-3_CanoR_1 765 769 PF00244 0.569
LIG_14-3-3_CanoR_1 889 899 PF00244 0.683
LIG_14-3-3_CanoR_1 987 991 PF00244 0.488
LIG_14-3-3_CanoR_1 99 107 PF00244 0.469
LIG_Actin_WH2_2 110 125 PF00022 0.589
LIG_Actin_WH2_2 53 68 PF00022 0.385
LIG_BIR_III_4 415 419 PF00653 0.586
LIG_BIR_III_4 484 488 PF00653 0.526
LIG_BIR_III_4 637 641 PF00653 0.550
LIG_BIR_III_4 706 710 PF00653 0.528
LIG_BIR_III_4 859 863 PF00653 0.553
LIG_BIR_III_4 928 932 PF00653 0.527
LIG_CSK_EPIYA_1 470 474 PF00017 0.645
LIG_CSK_EPIYA_1 692 696 PF00017 0.519
LIG_CSK_EPIYA_1 914 918 PF00017 0.514
LIG_FHA_1 1022 1028 PF00498 0.534
LIG_FHA_1 1215 1221 PF00498 0.579
LIG_FHA_1 1226 1232 PF00498 0.473
LIG_FHA_1 175 181 PF00498 0.306
LIG_FHA_1 269 275 PF00498 0.622
LIG_FHA_1 282 288 PF00498 0.445
LIG_FHA_1 347 353 PF00498 0.298
LIG_FHA_1 375 381 PF00498 0.315
LIG_FHA_1 42 48 PF00498 0.478
LIG_FHA_1 52 58 PF00498 0.484
LIG_FHA_1 578 584 PF00498 0.633
LIG_FHA_1 800 806 PF00498 0.614
LIG_FHA_2 1039 1045 PF00498 0.459
LIG_FHA_2 1058 1064 PF00498 0.311
LIG_FHA_2 1161 1167 PF00498 0.492
LIG_FHA_2 149 155 PF00498 0.577
LIG_FHA_2 309 315 PF00498 0.582
LIG_FHA_2 34 40 PF00498 0.459
LIG_FHA_2 353 359 PF00498 0.588
LIG_FHA_2 474 480 PF00498 0.681
LIG_FHA_2 595 601 PF00498 0.554
LIG_FHA_2 696 702 PF00498 0.553
LIG_FHA_2 817 823 PF00498 0.525
LIG_FHA_2 918 924 PF00498 0.551
LIG_Integrin_isoDGR_2 72 74 PF01839 0.489
LIG_LIR_Apic_2 164 168 PF02991 0.481
LIG_LIR_Gen_1 1138 1147 PF02991 0.621
LIG_LIR_Gen_1 1211 1220 PF02991 0.593
LIG_LIR_Gen_1 1236 1247 PF02991 0.635
LIG_LIR_Gen_1 157 165 PF02991 0.402
LIG_LIR_Gen_1 42 47 PF02991 0.475
LIG_LIR_Nem_3 1102 1108 PF02991 0.487
LIG_LIR_Nem_3 1138 1143 PF02991 0.560
LIG_LIR_Nem_3 1211 1215 PF02991 0.577
LIG_LIR_Nem_3 1236 1242 PF02991 0.642
LIG_LIR_Nem_3 157 161 PF02991 0.411
LIG_LIR_Nem_3 42 46 PF02991 0.484
LIG_LYPXL_SIV_4 224 232 PF13949 0.549
LIG_NRBOX 1194 1200 PF00104 0.498
LIG_PCNA_yPIPBox_3 1190 1199 PF02747 0.409
LIG_Pex14_2 1235 1239 PF04695 0.588
LIG_SH2_CRK 1105 1109 PF00017 0.499
LIG_SH2_CRK 165 169 PF00017 0.285
LIG_SH2_CRK 21 25 PF00017 0.380
LIG_SH2_CRK 229 233 PF00017 0.589
LIG_SH2_CRK 43 47 PF00017 0.470
LIG_SH2_NCK_1 344 348 PF00017 0.476
LIG_SH2_SRC 23 26 PF00017 0.505
LIG_SH2_SRC 5 8 PF00017 0.568
LIG_SH2_STAP1 1140 1144 PF00017 0.454
LIG_SH2_STAP1 43 47 PF00017 0.470
LIG_SH2_STAP1 473 477 PF00017 0.699
LIG_SH2_STAP1 695 699 PF00017 0.569
LIG_SH2_STAP1 917 921 PF00017 0.568
LIG_SH2_STAT5 1038 1041 PF00017 0.484
LIG_SH2_STAT5 23 26 PF00017 0.505
LIG_SH2_STAT5 353 356 PF00017 0.319
LIG_SH2_STAT5 43 46 PF00017 0.477
LIG_SH2_STAT5 5 8 PF00017 0.464
LIG_SH2_STAT5 594 597 PF00017 0.581
LIG_SH2_STAT5 816 819 PF00017 0.498
LIG_SH3_3 1023 1029 PF00018 0.532
LIG_SH3_3 285 291 PF00018 0.578
LIG_SH3_3 292 298 PF00018 0.432
LIG_SH3_3 579 585 PF00018 0.582
LIG_SH3_3 801 807 PF00018 0.743
LIG_SUMO_SIM_anti_2 112 119 PF11976 0.463
LIG_TRAF2_1 1041 1044 PF00917 0.451
LIG_TRAF2_1 476 479 PF00917 0.539
LIG_TRAF2_1 597 600 PF00917 0.544
LIG_TRAF2_1 698 701 PF00917 0.539
LIG_TRAF2_1 819 822 PF00917 0.675
LIG_TRAF2_1 920 923 PF00917 0.539
LIG_TYR_ITIM 19 24 PF00017 0.455
LIG_UBA3_1 81 88 PF00899 0.492
LIG_WRC_WIRS_1 1212 1217 PF05994 0.564
LIG_WRC_WIRS_1 278 283 PF05994 0.576
MOD_CDK_SPxxK_3 427 434 PF00069 0.697
MOD_CDK_SPxxK_3 649 656 PF00069 0.701
MOD_CDK_SPxxK_3 871 878 PF00069 0.703
MOD_CK1_1 1214 1220 PF00069 0.582
MOD_CK1_1 186 192 PF00069 0.551
MOD_CK1_1 268 274 PF00069 0.604
MOD_CK1_1 423 429 PF00069 0.614
MOD_CK1_1 645 651 PF00069 0.616
MOD_CK1_1 867 873 PF00069 0.712
MOD_CK2_1 1038 1044 PF00069 0.471
MOD_CK2_1 1057 1063 PF00069 0.371
MOD_CK2_1 1096 1102 PF00069 0.443
MOD_CK2_1 1160 1166 PF00069 0.490
MOD_CK2_1 148 154 PF00069 0.567
MOD_CK2_1 308 314 PF00069 0.580
MOD_CK2_1 33 39 PF00069 0.453
MOD_CK2_1 352 358 PF00069 0.588
MOD_CK2_1 386 392 PF00069 0.622
MOD_CK2_1 473 479 PF00069 0.691
MOD_CK2_1 594 600 PF00069 0.565
MOD_CK2_1 695 701 PF00069 0.560
MOD_CK2_1 816 822 PF00069 0.537
MOD_CK2_1 917 923 PF00069 0.561
MOD_GlcNHglycan 1002 1005 PF01048 0.562
MOD_GlcNHglycan 185 188 PF01048 0.610
MOD_GlcNHglycan 292 295 PF01048 0.456
MOD_GlcNHglycan 369 372 PF01048 0.468
MOD_GlcNHglycan 422 425 PF01048 0.609
MOD_GlcNHglycan 440 443 PF01048 0.560
MOD_GlcNHglycan 558 561 PF01048 0.654
MOD_GlcNHglycan 644 647 PF01048 0.613
MOD_GlcNHglycan 662 665 PF01048 0.565
MOD_GlcNHglycan 780 783 PF01048 0.645
MOD_GlcNHglycan 866 869 PF01048 0.684
MOD_GlcNHglycan 884 887 PF01048 0.704
MOD_GSK3_1 1225 1232 PF00069 0.640
MOD_GSK3_1 186 193 PF00069 0.598
MOD_GSK3_1 26 33 PF00069 0.401
MOD_GSK3_1 264 271 PF00069 0.461
MOD_GSK3_1 277 284 PF00069 0.326
MOD_GSK3_1 286 293 PF00069 0.370
MOD_GSK3_1 419 426 PF00069 0.689
MOD_GSK3_1 641 648 PF00069 0.637
MOD_GSK3_1 863 870 PF00069 0.680
MOD_GSK3_1 88 95 PF00069 0.588
MOD_N-GLC_2 1260 1262 PF02516 0.644
MOD_NEK2_1 281 286 PF00069 0.575
MOD_NEK2_1 333 338 PF00069 0.606
MOD_NEK2_1 386 391 PF00069 0.620
MOD_PIKK_1 446 452 PF00454 0.811
MOD_PIKK_1 668 674 PF00454 0.681
MOD_PIKK_1 890 896 PF00454 0.619
MOD_PK_1 88 94 PF00069 0.586
MOD_PKA_1 123 129 PF00069 0.602
MOD_PKA_2 1229 1235 PF00069 0.669
MOD_PKA_2 282 288 PF00069 0.578
MOD_PKA_2 444 450 PF00069 0.685
MOD_PKA_2 542 548 PF00069 0.696
MOD_PKA_2 666 672 PF00069 0.686
MOD_PKA_2 764 770 PF00069 0.551
MOD_PKA_2 888 894 PF00069 0.689
MOD_PKA_2 92 98 PF00069 0.597
MOD_PKA_2 986 992 PF00069 0.486
MOD_Plk_1 1237 1243 PF00069 0.502
MOD_Plk_1 41 47 PF00069 0.485
MOD_Plk_2-3 1096 1102 PF00069 0.311
MOD_Plk_4 1211 1217 PF00069 0.537
MOD_Plk_4 282 288 PF00069 0.578
MOD_ProDKin_1 1006 1012 PF00069 0.493
MOD_ProDKin_1 129 135 PF00069 0.584
MOD_ProDKin_1 206 212 PF00069 0.486
MOD_ProDKin_1 294 300 PF00069 0.470
MOD_ProDKin_1 427 433 PF00069 0.747
MOD_ProDKin_1 562 568 PF00069 0.626
MOD_ProDKin_1 649 655 PF00069 0.645
MOD_ProDKin_1 784 790 PF00069 0.496
MOD_ProDKin_1 871 877 PF00069 0.617
MOD_SUMO_for_1 1085 1088 PF00179 0.395
MOD_SUMO_for_1 262 265 PF00179 0.592
MOD_SUMO_for_1 524 527 PF00179 0.534
MOD_SUMO_for_1 746 749 PF00179 0.442
MOD_SUMO_for_1 968 971 PF00179 0.422
MOD_SUMO_rev_2 193 200 PF00179 0.487
MOD_SUMO_rev_2 316 325 PF00179 0.574
MOD_SUMO_rev_2 478 482 PF00179 0.663
MOD_SUMO_rev_2 507 514 PF00179 0.548
MOD_SUMO_rev_2 700 704 PF00179 0.533
MOD_SUMO_rev_2 729 736 PF00179 0.419
MOD_SUMO_rev_2 922 926 PF00179 0.530
MOD_SUMO_rev_2 951 958 PF00179 0.419
TRG_DiLeu_BaEn_1 112 117 PF01217 0.455
TRG_DiLeu_BaEn_1 1139 1144 PF01217 0.629
TRG_DiLeu_BaEn_1 1149 1154 PF01217 0.443
TRG_ENDOCYTIC_2 1105 1108 PF00928 0.504
TRG_ENDOCYTIC_2 1140 1143 PF00928 0.522
TRG_ENDOCYTIC_2 1212 1215 PF00928 0.436
TRG_ENDOCYTIC_2 21 24 PF00928 0.372
TRG_ENDOCYTIC_2 229 232 PF00928 0.578
TRG_ENDOCYTIC_2 43 46 PF00928 0.477
TRG_ENDOCYTIC_2 459 462 PF00928 0.634
TRG_ENDOCYTIC_2 681 684 PF00928 0.629
TRG_ENDOCYTIC_2 78 81 PF00928 0.600
TRG_ENDOCYTIC_2 903 906 PF00928 0.633
TRG_ER_diArg_1 1243 1246 PF00400 0.628
TRG_ER_diArg_1 92 94 PF00400 0.470
TRG_NES_CRM1_1 495 510 PF08389 0.514
TRG_NES_CRM1_1 717 732 PF08389 0.513
TRG_NES_CRM1_1 939 954 PF08389 0.518
TRG_Pf-PMV_PEXEL_1 1196 1200 PF00026 0.497
TRG_Pf-PMV_PEXEL_1 38 42 PF00026 0.506

Homologs

Protein Taxonomy Sequence identity Coverage
A4HAH8 Leishmania braziliensis 77% 100%
E9B4N7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 93%
Q4Q3D9 Leishmania major 93% 100%
Q585H6 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 28% 75%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS