ATP-binding cassette protein subfamily C, member 8

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily C - member 8 - putative

Species:

Leishmania infantum

UniProt:

A4I9N7_LEIIN

TriTrypDb:

LINF_340012300

Length:

2089

Annotations

LeishMANIAdb annotations

An ABC transporter related to genes in fungi and other microbes. . Exact number of TM segments unclear.

Annotations by Jardim et al.

Transporters, ATP-binding cassette C, member 8 ABCC8

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

A4I9N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9N7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005215	transporter activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0015399	primary active transmembrane transporter activity	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0022804	active transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1343	1347	PF00656	0.640
CLV_C14_Caspase3-7	1383	1387	PF00656	0.300
CLV_C14_Caspase3-7	1635	1639	PF00656	0.449
CLV_C14_Caspase3-7	1934	1938	PF00656	0.506
CLV_C14_Caspase3-7	1951	1955	PF00656	0.380
CLV_C14_Caspase3-7	2034	2038	PF00656	0.628
CLV_C14_Caspase3-7	269	273	PF00656	0.366
CLV_C14_Caspase3-7	681	685	PF00656	0.688
CLV_MEL_PAP_1	1708	1714	PF00089	0.298
CLV_NRD_NRD_1	1002	1004	PF00675	0.537

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIP6	Leptomonas seymouri	65%	100%
A0A0U1LQE1	Talaromyces islandicus	24%	100%
A0A3S7X7G7	Leishmania donovani	100%	100%
A4HAH7	Leishmania braziliensis	84%	99%
E9B4N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q3E0	Leishmania major	96%	100%

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