Putative proteasome regulatory non-ATP-ase subunit 11

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATPase subunit 11 - putative

Species:

Leishmania infantum

UniProt:

A4I9N5_LEIIN

TriTrypDb:

LINF_340012100

Length:

309

Annotations

Annotations by Jardim et al.

Proteasome, proteasome regulatory non-ATP-ase subunit 11

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 6
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	yes	yes: 6
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 15

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	10
GO:0005737	cytoplasm	2	1
GO:0005838	proteasome regulatory particle	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1905368	peptidase complex	3	10
GO:1905369	endopeptidase complex	4	10

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Expansion

Sequence features

A4I9N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9N5

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016579	protein deubiquitination	6	1
GO:0019538	protein metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	1
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0044877	protein-containing complex binding	2	1
GO:0061578	K63-linked deubiquitinase activity	6	11
GO:0070628	proteasome binding	3	1
GO:0101005	deubiquitinase activity	5	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.755
CLV_NRD_NRD_1	211	213	PF00675	0.484
CLV_NRD_NRD_1	225	227	PF00675	0.623
CLV_PCSK_SKI1_1	179	183	PF00082	0.560
CLV_PCSK_SKI1_1	219	223	PF00082	0.612
CLV_PCSK_SKI1_1	261	265	PF00082	0.612
DEG_Nend_UBRbox_2	1	3	PF02207	0.755
DOC_MAPK_gen_1	212	220	PF00069	0.481
DOC_MAPK_MEF2A_6	202	211	PF00069	0.454
DOC_MAPK_MEF2A_6	213	222	PF00069	0.481

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II09	Leptomonas seymouri	95%	100%
A0A0N1PD30	Leptomonas seymouri	32%	69%
A0A0S4KHQ1	Bodo saltans	29%	76%
A0A151EH88	Theionarchaea archaeon (strain DG-70-1)	23%	94%
A0A1X0P9L3	Trypanosomatidae	72%	100%
A0A3Q8IFA3	Leishmania donovani	100%	100%
A0A3R7M5F1	Trypanosoma rangeli	27%	80%
A0A422N4D2	Trypanosoma rangeli	71%	100%
A4HAH5	Leishmania braziliensis	98%	100%
C9ZW23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	78%

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