Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9N4_LEIIN

TriTrypDb:

LINF_340012000

Length:

1044

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

A4I9N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.644
CLV_C14_Caspase3-7	645	649	PF00656	0.321
CLV_C14_Caspase3-7	679	683	PF00656	0.388
CLV_C14_Caspase3-7	793	797	PF00656	0.328
CLV_NRD_NRD_1	1039	1041	PF00675	0.594
CLV_NRD_NRD_1	146	148	PF00675	0.447
CLV_NRD_NRD_1	39	41	PF00675	0.491
CLV_NRD_NRD_1	400	402	PF00675	0.404
CLV_NRD_NRD_1	455	457	PF00675	0.396
CLV_NRD_NRD_1	601	603	PF00675	0.562
CLV_NRD_NRD_1	819	821	PF00675	0.578
CLV_NRD_NRD_1	893	895	PF00675	0.557
CLV_PCSK_FUR_1	599	603	PF00082	0.627
CLV_PCSK_KEX2_1	146	148	PF00082	0.506
CLV_PCSK_KEX2_1	39	41	PF00082	0.491
CLV_PCSK_KEX2_1	400	402	PF00082	0.442
CLV_PCSK_KEX2_1	455	457	PF00082	0.396
CLV_PCSK_KEX2_1	601	603	PF00082	0.562
CLV_PCSK_KEX2_1	893	895	PF00082	0.557
CLV_PCSK_SKI1_1	181	185	PF00082	0.535
CLV_PCSK_SKI1_1	192	196	PF00082	0.472
CLV_PCSK_SKI1_1	245	249	PF00082	0.508
CLV_PCSK_SKI1_1	262	266	PF00082	0.460
CLV_PCSK_SKI1_1	330	334	PF00082	0.498
CLV_PCSK_SKI1_1	364	368	PF00082	0.451
CLV_PCSK_SKI1_1	373	377	PF00082	0.356
CLV_PCSK_SKI1_1	477	481	PF00082	0.330
CLV_PCSK_SKI1_1	691	695	PF00082	0.427
DEG_APCC_DBOX_1	363	371	PF00400	0.649
DEG_APCC_DBOX_1	42	50	PF00400	0.628
DEG_APCC_DBOX_1	541	549	PF00400	0.332
DEG_APCC_DBOX_1	601	609	PF00400	0.381
DEG_APCC_DBOX_1	831	839	PF00400	0.278
DEG_APCC_DBOX_1	945	953	PF00400	0.328
DEG_MDM2_SWIB_1	479	487	PF02201	0.271
DEG_SCF_FBW7_1	175	182	PF00400	0.634
DEG_SCF_FBW7_1	568	574	PF00400	0.326
DEG_SPOP_SBC_1	125	129	PF00917	0.695
DEG_SPOP_SBC_1	266	270	PF00917	0.647
DEG_SPOP_SBC_1	3	7	PF00917	0.673
DEG_SPOP_SBC_1	571	575	PF00917	0.407
DOC_CDC14_PxL_1	498	506	PF14671	0.404
DOC_CDC14_PxL_1	964	972	PF14671	0.289
DOC_CKS1_1	176	181	PF01111	0.634
DOC_CKS1_1	568	573	PF01111	0.315
DOC_CKS1_1	939	944	PF01111	0.347
DOC_CYCLIN_RxL_1	713	722	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	741	747	PF00134	0.295
DOC_MAPK_DCC_7	432	441	PF00069	0.636
DOC_MAPK_gen_1	39	46	PF00069	0.725
DOC_MAPK_gen_1	455	461	PF00069	0.624
DOC_MAPK_gen_1	893	900	PF00069	0.316
DOC_MAPK_gen_1	989	999	PF00069	0.338
DOC_MAPK_JIP1_4	163	169	PF00069	0.668
DOC_MAPK_MEF2A_6	432	441	PF00069	0.636
DOC_MAPK_MEF2A_6	62	70	PF00069	0.584
DOC_MAPK_MEF2A_6	893	902	PF00069	0.323
DOC_MAPK_MEF2A_6	992	1001	PF00069	0.290
DOC_PP1_RVXF_1	260	266	PF00149	0.660
DOC_PP2B_LxvP_1	279	282	PF13499	0.647
DOC_PP2B_LxvP_1	434	437	PF13499	0.584
DOC_PP2B_LxvP_1	741	744	PF13499	0.280
DOC_PP4_FxxP_1	169	172	PF00568	0.675
DOC_PP4_FxxP_1	652	655	PF00568	0.306
DOC_PP4_MxPP_1	569	572	PF00568	0.316
DOC_USP7_MATH_1	117	121	PF00917	0.648
DOC_USP7_MATH_1	133	137	PF00917	0.639
DOC_USP7_MATH_1	292	296	PF00917	0.635
DOC_USP7_MATH_1	359	363	PF00917	0.668
DOC_USP7_MATH_1	572	576	PF00917	0.429
DOC_USP7_MATH_1	653	657	PF00917	0.368
DOC_USP7_MATH_1	676	680	PF00917	0.304
DOC_USP7_MATH_1	787	791	PF00917	0.403
DOC_USP7_MATH_1	879	883	PF00917	0.422
DOC_WW_Pin1_4	157	162	PF00397	0.680
DOC_WW_Pin1_4	171	176	PF00397	0.638
DOC_WW_Pin1_4	257	262	PF00397	0.740
DOC_WW_Pin1_4	49	54	PF00397	0.585
DOC_WW_Pin1_4	567	572	PF00397	0.310
DOC_WW_Pin1_4	651	656	PF00397	0.302
DOC_WW_Pin1_4	707	712	PF00397	0.404
DOC_WW_Pin1_4	892	897	PF00397	0.425
DOC_WW_Pin1_4	938	943	PF00397	0.355
DOC_WW_Pin1_4	978	983	PF00397	0.311
LIG_14-3-3_CanoR_1	1000	1008	PF00244	0.265
LIG_14-3-3_CanoR_1	163	168	PF00244	0.666
LIG_14-3-3_CanoR_1	186	194	PF00244	0.655
LIG_14-3-3_CanoR_1	299	308	PF00244	0.720
LIG_14-3-3_CanoR_1	353	361	PF00244	0.625
LIG_14-3-3_CanoR_1	364	372	PF00244	0.557
LIG_14-3-3_CanoR_1	989	995	PF00244	0.358
LIG_14-3-3_CterR_2	1040	1044	PF00244	0.379
LIG_Actin_WH2_2	490	507	PF00022	0.455
LIG_Actin_WH2_2	633	649	PF00022	0.335
LIG_APCC_ABBA_1	486	491	PF00400	0.254
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BIR_III_4	199	203	PF00653	0.631
LIG_BIR_III_4	223	227	PF00653	0.621
LIG_BRCT_BRCA1_1	165	169	PF00533	0.708
LIG_BRCT_BRCA1_1	997	1001	PF00533	0.282
LIG_Clathr_ClatBox_1	801	805	PF01394	0.374
LIG_CSL_BTD_1	451	454	PF09270	0.573
LIG_deltaCOP1_diTrp_1	450	457	PF00928	0.642
LIG_FHA_1	120	126	PF00498	0.648
LIG_FHA_1	210	216	PF00498	0.575
LIG_FHA_1	302	308	PF00498	0.653
LIG_FHA_1	556	562	PF00498	0.326
LIG_FHA_1	632	638	PF00498	0.311
LIG_FHA_1	719	725	PF00498	0.303
LIG_FHA_1	771	777	PF00498	0.312
LIG_FHA_1	839	845	PF00498	0.348
LIG_FHA_1	893	899	PF00498	0.321
LIG_FHA_1	970	976	PF00498	0.289
LIG_FHA_1	994	1000	PF00498	0.281
LIG_FHA_2	248	254	PF00498	0.679
LIG_FHA_2	323	329	PF00498	0.655
LIG_FHA_2	571	577	PF00498	0.456
LIG_FHA_2	734	740	PF00498	0.327
LIG_FHA_2	744	750	PF00498	0.280
LIG_FHA_2	979	985	PF00498	0.311
LIG_GBD_Chelix_1	561	569	PF00786	0.539
LIG_LIR_Apic_2	166	172	PF02991	0.674
LIG_LIR_Apic_2	426	431	PF02991	0.747
LIG_LIR_Apic_2	650	655	PF02991	0.318
LIG_LIR_Gen_1	1003	1012	PF02991	0.317
LIG_LIR_Gen_1	1021	1030	PF02991	0.319
LIG_LIR_Gen_1	445	454	PF02991	0.594
LIG_LIR_Gen_1	531	540	PF02991	0.290
LIG_LIR_Nem_3	1003	1008	PF02991	0.307
LIG_LIR_Nem_3	1021	1025	PF02991	0.316
LIG_LIR_Nem_3	369	375	PF02991	0.583
LIG_LIR_Nem_3	445	451	PF02991	0.625
LIG_LIR_Nem_3	91	97	PF02991	0.589
LIG_MYND_1	9	13	PF01753	0.629
LIG_MYND_3	967	971	PF01753	0.287
LIG_NRBOX	737	743	PF00104	0.286
LIG_Pex14_1	453	457	PF04695	0.638
LIG_Pex14_2	1001	1005	PF04695	0.299
LIG_Pex14_2	448	452	PF04695	0.644
LIG_Pex14_2	479	483	PF04695	0.271
LIG_SH2_CRK	372	376	PF00017	0.648
LIG_SH2_CRK	462	466	PF00017	0.532
LIG_SH2_CRK	692	696	PF00017	0.275
LIG_SH2_STAP1	1030	1034	PF00017	0.389
LIG_SH2_STAP1	692	696	PF00017	0.275
LIG_SH2_STAP1	761	765	PF00017	0.283
LIG_SH2_STAT3	336	339	PF00017	0.644
LIG_SH2_STAT3	734	737	PF00017	0.323
LIG_SH2_STAT5	1028	1031	PF00017	0.318
LIG_SH2_STAT5	336	339	PF00017	0.644
LIG_SH2_STAT5	443	446	PF00017	0.615
LIG_SH2_STAT5	734	737	PF00017	0.282
LIG_SH2_STAT5	747	750	PF00017	0.301
LIG_SH2_STAT5	842	845	PF00017	0.273
LIG_SH2_STAT5	954	957	PF00017	0.312
LIG_SH3_1	778	784	PF00018	0.353
LIG_SH3_2	176	181	PF14604	0.634
LIG_SH3_3	158	164	PF00018	0.645
LIG_SH3_3	169	175	PF00018	0.642
LIG_SH3_3	497	503	PF00018	0.419
LIG_SH3_3	565	571	PF00018	0.313
LIG_SH3_3	63	69	PF00018	0.583
LIG_SH3_3	7	13	PF00018	0.671
LIG_SH3_3	702	708	PF00018	0.384
LIG_SH3_3	778	784	PF00018	0.353
LIG_Sin3_3	16	23	PF02671	0.570
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.589
LIG_SUMO_SIM_par_1	211	217	PF11976	0.626
LIG_SUMO_SIM_par_1	525	531	PF11976	0.355
LIG_SUMO_SIM_par_1	632	639	PF11976	0.331
LIG_SUMO_SIM_par_1	640	645	PF11976	0.279
LIG_SUMO_SIM_par_1	766	774	PF11976	0.352
LIG_SUMO_SIM_par_1	800	807	PF11976	0.389
LIG_SUMO_SIM_par_1	971	979	PF11976	0.298
LIG_TRAF2_1	295	298	PF00917	0.632
LIG_TYR_ITIM	370	375	PF00017	0.479
LIG_TYR_ITIM	460	465	PF00017	0.394
LIG_UBA3_1	438	442	PF00899	0.476
LIG_WRC_WIRS_1	1019	1024	PF05994	0.424
MOD_CDC14_SPxK_1	160	163	PF00782	0.568
MOD_CDK_SPK_2	257	262	PF00069	0.584
MOD_CDK_SPxK_1	157	163	PF00069	0.571
MOD_CDK_SPxK_1	175	181	PF00069	0.498
MOD_CDK_SPxxK_3	49	56	PF00069	0.466
MOD_CDK_SPxxK_3	892	899	PF00069	0.468
MOD_CK1_1	126	132	PF00069	0.666
MOD_CK1_1	140	146	PF00069	0.465
MOD_CK1_1	174	180	PF00069	0.616
MOD_CK1_1	2	8	PF00069	0.546
MOD_CK1_1	267	273	PF00069	0.567
MOD_CK1_1	274	280	PF00069	0.658
MOD_CK1_1	424	430	PF00069	0.575
MOD_CK1_1	466	472	PF00069	0.565
MOD_CK1_1	567	573	PF00069	0.577
MOD_CK1_1	790	796	PF00069	0.493
MOD_CK1_1	882	888	PF00069	0.599
MOD_CK1_1	910	916	PF00069	0.387
MOD_CK1_1	990	996	PF00069	0.365
MOD_CK2_1	247	253	PF00069	0.561
MOD_CK2_1	292	298	PF00069	0.537
MOD_CK2_1	424	430	PF00069	0.563
MOD_CK2_1	570	576	PF00069	0.493
MOD_CK2_1	624	630	PF00069	0.622
MOD_CK2_1	733	739	PF00069	0.388
MOD_CK2_1	916	922	PF00069	0.295
MOD_CK2_1	978	984	PF00069	0.368
MOD_GlcNHglycan	115	118	PF01048	0.597
MOD_GlcNHglycan	119	122	PF01048	0.596
MOD_GlcNHglycan	13	16	PF01048	0.580
MOD_GlcNHglycan	188	191	PF01048	0.636
MOD_GlcNHglycan	216	219	PF01048	0.520
MOD_GlcNHglycan	27	30	PF01048	0.464
MOD_GlcNHglycan	34	37	PF01048	0.564
MOD_GlcNHglycan	356	359	PF01048	0.555
MOD_GlcNHglycan	423	426	PF01048	0.660
MOD_GlcNHglycan	511	514	PF01048	0.747
MOD_GlcNHglycan	530	533	PF01048	0.301
MOD_GlcNHglycan	630	634	PF01048	0.496
MOD_GlcNHglycan	655	658	PF01048	0.376
MOD_GlcNHglycan	682	685	PF01048	0.319
MOD_GlcNHglycan	721	724	PF01048	0.497
MOD_GlcNHglycan	764	768	PF01048	0.403
MOD_GlcNHglycan	881	885	PF01048	0.588
MOD_GlcNHglycan	887	890	PF01048	0.576
MOD_GlcNHglycan	911	915	PF01048	0.320
MOD_GlcNHglycan	927	930	PF01048	0.371
MOD_GSK3_1	113	120	PF00069	0.585
MOD_GSK3_1	125	132	PF00069	0.710
MOD_GSK3_1	133	140	PF00069	0.547
MOD_GSK3_1	171	178	PF00069	0.618
MOD_GSK3_1	21	28	PF00069	0.499
MOD_GSK3_1	267	274	PF00069	0.577
MOD_GSK3_1	299	306	PF00069	0.715
MOD_GSK3_1	376	383	PF00069	0.540
MOD_GSK3_1	406	413	PF00069	0.541
MOD_GSK3_1	417	424	PF00069	0.560
MOD_GSK3_1	511	518	PF00069	0.647
MOD_GSK3_1	567	574	PF00069	0.407
MOD_GSK3_1	614	621	PF00069	0.359
MOD_GSK3_1	647	654	PF00069	0.534
MOD_GSK3_1	676	683	PF00069	0.454
MOD_GSK3_1	68	75	PF00069	0.576
MOD_GSK3_1	707	714	PF00069	0.479
MOD_GSK3_1	787	794	PF00069	0.493
MOD_GSK3_1	879	886	PF00069	0.576
MOD_GSK3_1	974	981	PF00069	0.357
MOD_LATS_1	828	834	PF00433	0.341
MOD_N-GLC_1	32	37	PF02516	0.625
MOD_N-GLC_1	515	520	PF02516	0.652
MOD_N-GLC_1	861	866	PF02516	0.307
MOD_N-GLC_1	99	104	PF02516	0.490
MOD_NEK2_1	124	129	PF00069	0.601
MOD_NEK2_1	366	371	PF00069	0.481
MOD_NEK2_1	395	400	PF00069	0.515
MOD_NEK2_1	489	494	PF00069	0.271
MOD_NEK2_1	548	553	PF00069	0.378
MOD_NEK2_1	640	645	PF00069	0.343
MOD_NEK2_1	718	723	PF00069	0.403
MOD_NEK2_1	771	776	PF00069	0.309
MOD_NEK2_1	838	843	PF00069	0.381
MOD_NEK2_1	844	849	PF00069	0.464
MOD_NEK2_1	861	866	PF00069	0.240
MOD_NEK2_1	950	955	PF00069	0.343
MOD_NEK2_1	988	993	PF00069	0.374
MOD_NEK2_2	417	422	PF00069	0.555
MOD_NEK2_2	624	629	PF00069	0.446
MOD_NEK2_2	711	716	PF00069	0.391
MOD_NEK2_2	845	850	PF00069	0.321
MOD_PIKK_1	27	33	PF00454	0.529
MOD_PIKK_1	388	394	PF00454	0.477
MOD_PIKK_1	406	412	PF00454	0.567
MOD_PIKK_1	593	599	PF00454	0.443
MOD_PIKK_1	68	74	PF00454	0.539
MOD_PIKK_1	699	705	PF00454	0.432
MOD_PIKK_1	733	739	PF00454	0.388
MOD_PIKK_1	861	867	PF00454	0.341
MOD_PK_1	184	190	PF00069	0.511
MOD_PKA_2	145	151	PF00069	0.595
MOD_PKA_2	234	240	PF00069	0.576
MOD_PKA_2	354	360	PF00069	0.532
MOD_PKA_2	421	427	PF00069	0.563
MOD_PKA_2	463	469	PF00069	0.434
MOD_PKA_2	504	510	PF00069	0.608
MOD_PKA_2	555	561	PF00069	0.446
MOD_PKA_2	988	994	PF00069	0.424
MOD_Plk_1	624	630	PF00069	0.418
MOD_Plk_1	763	769	PF00069	0.409
MOD_Plk_1	838	844	PF00069	0.389
MOD_Plk_1	90	96	PF00069	0.547
MOD_Plk_1	950	956	PF00069	0.336
MOD_Plk_1	99	105	PF00069	0.474
MOD_Plk_4	133	139	PF00069	0.489
MOD_Plk_4	140	146	PF00069	0.477
MOD_Plk_4	21	27	PF00069	0.510
MOD_Plk_4	274	280	PF00069	0.559
MOD_Plk_4	303	309	PF00069	0.662
MOD_Plk_4	331	337	PF00069	0.566
MOD_Plk_4	366	372	PF00069	0.459
MOD_Plk_4	489	495	PF00069	0.276
MOD_Plk_4	564	570	PF00069	0.422
MOD_Plk_4	669	675	PF00069	0.370
MOD_Plk_4	93	99	PF00069	0.468
MOD_Plk_4	969	975	PF00069	0.335
MOD_ProDKin_1	157	163	PF00069	0.608
MOD_ProDKin_1	171	177	PF00069	0.546
MOD_ProDKin_1	257	263	PF00069	0.688
MOD_ProDKin_1	49	55	PF00069	0.469
MOD_ProDKin_1	567	573	PF00069	0.382
MOD_ProDKin_1	651	657	PF00069	0.343
MOD_ProDKin_1	707	713	PF00069	0.480
MOD_ProDKin_1	892	898	PF00069	0.514
MOD_ProDKin_1	938	944	PF00069	0.423
MOD_ProDKin_1	978	984	PF00069	0.368
MOD_SUMO_rev_2	322	332	PF00179	0.658
MOD_SUMO_rev_2	979	988	PF00179	0.433
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.583
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.441
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.543
TRG_ENDOCYTIC_2	1030	1033	PF00928	0.399
TRG_ENDOCYTIC_2	288	291	PF00928	0.601
TRG_ENDOCYTIC_2	372	375	PF00928	0.512
TRG_ENDOCYTIC_2	462	465	PF00928	0.486
TRG_ENDOCYTIC_2	692	695	PF00928	0.316
TRG_ER_diArg_1	145	147	PF00400	0.534
TRG_ER_diArg_1	344	347	PF00400	0.540
TRG_ER_diArg_1	38	40	PF00400	0.629
TRG_ER_diArg_1	399	401	PF00400	0.476
TRG_ER_diArg_1	454	456	PF00400	0.491
TRG_ER_diArg_1	598	601	PF00400	0.490
TRG_ER_diArg_1	892	894	PF00400	0.482
TRG_ER_diLys_1	1041	1044	PF00400	0.502
TRG_NES_CRM1_1	943	956	PF08389	0.403
TRG_NES_CRM1_1	966	979	PF08389	0.336
TRG_Pf-PMV_PEXEL_1	1027	1031	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	821	825	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTI4	Leptomonas seymouri	47%	100%
A4HAH4	Leishmania braziliensis	73%	98%