Putative enoyl-[acyl-carrier-protein] reductase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-[acyl-carrier-protein] reductase - putative

Species:

Leishmania infantum

UniProt:

A4I9N1_LEIIN

TriTrypDb:

LINF_340011700

Length:

317

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, enoyl-[acyl-carrier-] reductase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0110165	cellular anatomical entity	1	8

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I9N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9N1

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004497	monooxygenase activity	3	8
GO:0016491	oxidoreductase activity	2	8
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	8
GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	4	8
GO:0018580	nitronate monooxygenase activity	5	8
GO:0051213	dioxygenase activity	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.443
CLV_NRD_NRD_1	244	246	PF00675	0.267
CLV_NRD_NRD_1	57	59	PF00675	0.454
CLV_PCSK_KEX2_1	212	214	PF00082	0.254
CLV_PCSK_KEX2_1	244	246	PF00082	0.267
CLV_PCSK_KEX2_1	57	59	PF00082	0.454
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.254
CLV_PCSK_SKI1_1	121	125	PF00082	0.276
CLV_PCSK_SKI1_1	160	164	PF00082	0.263
CLV_PCSK_SKI1_1	233	237	PF00082	0.296

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE9	Leptomonas seymouri	81%	100%
A0A3Q8IE60	Leishmania donovani	100%	100%
A4HAH1	Leishmania braziliensis	86%	100%
A4HBY5	Leishmania braziliensis	86%	100%
A5IR97	Staphylococcus aureus (strain JH9)	32%	89%
A6QFD2	Staphylococcus aureus (strain Newman)	31%	89%
A6U025	Staphylococcus aureus (strain JH1)	32%	89%
A8Z1H7	Staphylococcus aureus (strain USA300 / TCH1516)	31%	89%
B2TEK6	Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)	33%	87%
D0V3Y4	Pseudomonas sp.	33%	91%

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