LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9N0_LEIIN

TriTrypDb:

LINF_340011600

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9N0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.698
CLV_C14_Caspase3-7	600	604	PF00656	0.627
CLV_C14_Caspase3-7	767	771	PF00656	0.595
CLV_NRD_NRD_1	139	141	PF00675	0.594
CLV_NRD_NRD_1	142	144	PF00675	0.649
CLV_NRD_NRD_1	287	289	PF00675	0.570
CLV_NRD_NRD_1	372	374	PF00675	0.545
CLV_NRD_NRD_1	432	434	PF00675	0.495
CLV_NRD_NRD_1	438	440	PF00675	0.499
CLV_NRD_NRD_1	593	595	PF00675	0.600
CLV_NRD_NRD_1	779	781	PF00675	0.575
CLV_NRD_NRD_1	92	94	PF00675	0.802
CLV_PCSK_FUR_1	140	144	PF00082	0.625
CLV_PCSK_FUR_1	777	781	PF00082	0.436
CLV_PCSK_KEX2_1	139	141	PF00082	0.594
CLV_PCSK_KEX2_1	142	144	PF00082	0.649
CLV_PCSK_KEX2_1	269	271	PF00082	0.635
CLV_PCSK_KEX2_1	287	289	PF00082	0.570
CLV_PCSK_KEX2_1	372	374	PF00082	0.545
CLV_PCSK_KEX2_1	432	434	PF00082	0.502
CLV_PCSK_KEX2_1	438	440	PF00082	0.485
CLV_PCSK_KEX2_1	533	535	PF00082	0.600
CLV_PCSK_KEX2_1	593	595	PF00082	0.600
CLV_PCSK_KEX2_1	779	781	PF00082	0.513
CLV_PCSK_KEX2_1	788	790	PF00082	0.692
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.735
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.600
CLV_PCSK_PC1ET2_1	788	790	PF00082	0.698
CLV_PCSK_SKI1_1	201	205	PF00082	0.604
CLV_PCSK_SKI1_1	260	264	PF00082	0.662
CLV_PCSK_SKI1_1	343	347	PF00082	0.535
CLV_PCSK_SKI1_1	52	56	PF00082	0.605
CLV_PCSK_SKI1_1	780	784	PF00082	0.670
DEG_APCC_DBOX_1	342	350	PF00400	0.532
DEG_APCC_DBOX_1	458	466	PF00400	0.649
DEG_SIAH_1	576	584	PF03145	0.690
DEG_SPOP_SBC_1	500	504	PF00917	0.749
DEG_SPOP_SBC_1	626	630	PF00917	0.659
DEG_SPOP_SBC_1	674	678	PF00917	0.734
DEG_SPOP_SBC_1	717	721	PF00917	0.594
DOC_ANK_TNKS_1	319	326	PF00023	0.631
DOC_CKS1_1	106	111	PF01111	0.753
DOC_CYCLIN_RxL_1	340	350	PF00134	0.552
DOC_MAPK_gen_1	139	149	PF00069	0.623
DOC_MAPK_gen_1	399	407	PF00069	0.504
DOC_MAPK_gen_1	457	464	PF00069	0.495
DOC_MAPK_MEF2A_6	140	149	PF00069	0.626
DOC_MAPK_NFAT4_5	142	150	PF00069	0.613
DOC_PP2B_PxIxI_1	108	114	PF00149	0.806
DOC_USP7_MATH_1	112	116	PF00917	0.741
DOC_USP7_MATH_1	181	185	PF00917	0.679
DOC_USP7_MATH_1	194	198	PF00917	0.696
DOC_USP7_MATH_1	24	28	PF00917	0.689
DOC_USP7_MATH_1	246	250	PF00917	0.578
DOC_USP7_MATH_1	480	484	PF00917	0.731
DOC_USP7_MATH_1	500	504	PF00917	0.543
DOC_USP7_MATH_1	583	587	PF00917	0.691
DOC_USP7_MATH_1	596	600	PF00917	0.761
DOC_USP7_MATH_1	607	611	PF00917	0.674
DOC_USP7_MATH_1	615	619	PF00917	0.674
DOC_USP7_MATH_1	626	630	PF00917	0.651
DOC_USP7_MATH_1	631	635	PF00917	0.701
DOC_USP7_MATH_1	655	659	PF00917	0.683
DOC_USP7_MATH_1	675	679	PF00917	0.502
DOC_USP7_MATH_1	699	703	PF00917	0.721
DOC_USP7_MATH_1	768	772	PF00917	0.587
DOC_USP7_MATH_1	80	84	PF00917	0.641
DOC_WW_Pin1_4	102	107	PF00397	0.781
DOC_WW_Pin1_4	17	22	PF00397	0.723
DOC_WW_Pin1_4	192	197	PF00397	0.757
DOC_WW_Pin1_4	546	551	PF00397	0.664
DOC_WW_Pin1_4	557	562	PF00397	0.769
DOC_WW_Pin1_4	569	574	PF00397	0.615
DOC_WW_Pin1_4	592	597	PF00397	0.734
DOC_WW_Pin1_4	608	613	PF00397	0.575
DOC_WW_Pin1_4	622	627	PF00397	0.811
DOC_WW_Pin1_4	632	637	PF00397	0.684
DOC_WW_Pin1_4	682	687	PF00397	0.774
DOC_WW_Pin1_4	795	800	PF00397	0.703
LIG_14-3-3_CanoR_1	142	148	PF00244	0.633
LIG_14-3-3_CanoR_1	501	506	PF00244	0.738
LIG_14-3-3_CanoR_1	569	573	PF00244	0.563
LIG_14-3-3_CanoR_1	669	673	PF00244	0.822
LIG_14-3-3_CanoR_1	709	718	PF00244	0.811
LIG_14-3-3_CanoR_1	789	797	PF00244	0.661
LIG_Actin_WH2_2	126	141	PF00022	0.581
LIG_Actin_WH2_2	25	40	PF00022	0.696
LIG_Actin_WH2_2	342	359	PF00022	0.529
LIG_BIR_II_1	1	5	PF00653	0.828
LIG_CAP-Gly_1	839	845	PF01302	0.762
LIG_Clathr_ClatBox_1	346	350	PF01394	0.530
LIG_Clathr_ClatBox_1	420	424	PF01394	0.545
LIG_CtBP_PxDLS_1	85	89	PF00389	0.731
LIG_FHA_1	106	112	PF00498	0.754
LIG_FHA_1	11	17	PF00498	0.610
LIG_FHA_1	218	224	PF00498	0.759
LIG_FHA_1	242	248	PF00498	0.558
LIG_FHA_1	29	35	PF00498	0.732
LIG_FHA_1	333	339	PF00498	0.628
LIG_FHA_1	400	406	PF00498	0.626
LIG_FHA_1	46	52	PF00498	0.699
LIG_FHA_1	490	496	PF00498	0.711
LIG_FHA_1	502	508	PF00498	0.590
LIG_FHA_1	742	748	PF00498	0.585
LIG_FHA_1	782	788	PF00498	0.562
LIG_FHA_2	150	156	PF00498	0.761
LIG_FHA_2	230	236	PF00498	0.689
LIG_FHA_2	749	755	PF00498	0.612
LIG_LIR_Gen_1	305	316	PF02991	0.540
LIG_LIR_Nem_3	264	268	PF02991	0.584
LIG_LIR_Nem_3	305	311	PF02991	0.483
LIG_LIR_Nem_3	324	330	PF02991	0.544
LIG_LIR_Nem_3	798	803	PF02991	0.689
LIG_NRBOX	511	517	PF00104	0.578
LIG_PCNA_yPIPBox_3	201	212	PF02747	0.585
LIG_PDZ_Class_2	840	845	PF00595	0.635
LIG_Pex14_2	823	827	PF04695	0.684
LIG_REV1ctd_RIR_1	277	286	PF16727	0.609
LIG_SH2_CRK	327	331	PF00017	0.529
LIG_SH2_CRK	513	517	PF00017	0.567
LIG_SH2_STAP1	261	265	PF00017	0.571
LIG_SH2_STAP1	304	308	PF00017	0.544
LIG_SH2_STAP1	471	475	PF00017	0.634
LIG_SH2_STAT5	171	174	PF00017	0.621
LIG_SH2_STAT5	211	214	PF00017	0.571
LIG_SH3_2	496	501	PF14604	0.741
LIG_SH3_3	103	109	PF00018	0.718
LIG_SH3_3	493	499	PF00018	0.742
LIG_SH3_3	503	509	PF00018	0.655
LIG_SH3_3	630	636	PF00018	0.774
LIG_SH3_3	669	675	PF00018	0.748
LIG_SH3_3	683	689	PF00018	0.671
LIG_SH3_3	722	728	PF00018	0.767
LIG_SH3_3	793	799	PF00018	0.690
LIG_SH3_CIN85_PxpxPR_1	496	501	PF14604	0.741
LIG_SUMO_SIM_par_1	30	36	PF11976	0.722
LIG_TRAF2_1	165	168	PF00917	0.632
LIG_TRAF2_1	428	431	PF00917	0.518
LIG_TRAF2_1	751	754	PF00917	0.674
LIG_WRC_WIRS_1	308	313	PF05994	0.514
LIG_WW_3	498	502	PF00397	0.743
MOD_CDC14_SPxK_1	595	598	PF00782	0.638
MOD_CDC14_SPxK_1	798	801	PF00782	0.711
MOD_CDK_SPK_2	627	632	PF00069	0.795
MOD_CDK_SPxK_1	557	563	PF00069	0.748
MOD_CDK_SPxK_1	592	598	PF00069	0.638
MOD_CDK_SPxK_1	682	688	PF00069	0.813
MOD_CDK_SPxK_1	795	801	PF00069	0.704
MOD_CK1_1	105	111	PF00069	0.671
MOD_CK1_1	148	154	PF00069	0.630
MOD_CK1_1	19	25	PF00069	0.689
MOD_CK1_1	199	205	PF00069	0.613
MOD_CK1_1	229	235	PF00069	0.692
MOD_CK1_1	3	9	PF00069	0.825
MOD_CK1_1	466	472	PF00069	0.611
MOD_CK1_1	599	605	PF00069	0.803
MOD_CK1_1	618	624	PF00069	0.493
MOD_CK1_1	658	664	PF00069	0.815
MOD_CK1_1	665	671	PF00069	0.686
MOD_CK1_1	677	683	PF00069	0.545
MOD_CK1_1	702	708	PF00069	0.685
MOD_CK1_1	711	717	PF00069	0.703
MOD_CK1_1	719	725	PF00069	0.650
MOD_CK1_1	748	754	PF00069	0.532
MOD_CK1_1	826	832	PF00069	0.616
MOD_CK1_1	98	104	PF00069	0.719
MOD_CK2_1	1	7	PF00069	0.830
MOD_CK2_1	149	155	PF00069	0.732
MOD_CK2_1	216	222	PF00069	0.692
MOD_CK2_1	229	235	PF00069	0.706
MOD_CK2_1	280	286	PF00069	0.575
MOD_CK2_1	299	305	PF00069	0.553
MOD_CK2_1	30	36	PF00069	0.621
MOD_CK2_1	388	394	PF00069	0.645
MOD_CK2_1	425	431	PF00069	0.516
MOD_CK2_1	746	752	PF00069	0.648
MOD_CK2_1	84	90	PF00069	0.815
MOD_DYRK1A_RPxSP_1	569	573	PF00069	0.563
MOD_GlcNHglycan	100	103	PF01048	0.732
MOD_GlcNHglycan	114	117	PF01048	0.581
MOD_GlcNHglycan	161	164	PF01048	0.733
MOD_GlcNHglycan	183	186	PF01048	0.693
MOD_GlcNHglycan	241	244	PF01048	0.622
MOD_GlcNHglycan	273	276	PF01048	0.678
MOD_GlcNHglycan	473	476	PF01048	0.712
MOD_GlcNHglycan	617	620	PF01048	0.723
MOD_GlcNHglycan	621	624	PF01048	0.773
MOD_GlcNHglycan	650	653	PF01048	0.689
MOD_GlcNHglycan	657	661	PF01048	0.772
MOD_GlcNHglycan	721	724	PF01048	0.694
MOD_GlcNHglycan	752	758	PF01048	0.554
MOD_GlcNHglycan	764	769	PF01048	0.575
MOD_GlcNHglycan	807	810	PF01048	0.736
MOD_GSK3_1	145	152	PF00069	0.702
MOD_GSK3_1	19	26	PF00069	0.678
MOD_GSK3_1	192	199	PF00069	0.694
MOD_GSK3_1	28	35	PF00069	0.565
MOD_GSK3_1	487	494	PF00069	0.703
MOD_GSK3_1	592	599	PF00069	0.687
MOD_GSK3_1	615	622	PF00069	0.691
MOD_GSK3_1	627	634	PF00069	0.806
MOD_GSK3_1	636	643	PF00069	0.784
MOD_GSK3_1	655	662	PF00069	0.720
MOD_GSK3_1	664	671	PF00069	0.640
MOD_GSK3_1	673	680	PF00069	0.541
MOD_GSK3_1	699	706	PF00069	0.777
MOD_GSK3_1	708	715	PF00069	0.573
MOD_GSK3_1	734	741	PF00069	0.607
MOD_GSK3_1	760	767	PF00069	0.539
MOD_GSK3_1	80	87	PF00069	0.700
MOD_GSK3_1	98	105	PF00069	0.754
MOD_N-GLC_1	332	337	PF02516	0.535
MOD_N-GLC_1	738	743	PF02516	0.633
MOD_N-GLC_1	823	828	PF02516	0.658
MOD_NEK2_1	1	6	PF00069	0.828
MOD_NEK2_1	138	143	PF00069	0.575
MOD_NEK2_1	145	150	PF00069	0.524
MOD_NEK2_1	159	164	PF00069	0.639
MOD_NEK2_1	268	273	PF00069	0.586
MOD_NEK2_1	341	346	PF00069	0.538
MOD_NEK2_1	415	420	PF00069	0.535
MOD_NEK2_1	45	50	PF00069	0.628
MOD_NEK2_1	617	622	PF00069	0.641
MOD_NEK2_1	703	708	PF00069	0.699
MOD_NEK2_1	710	715	PF00069	0.704
MOD_NEK2_1	746	751	PF00069	0.691
MOD_NEK2_1	823	828	PF00069	0.619
MOD_NEK2_1	95	100	PF00069	0.737
MOD_NEK2_2	196	201	PF00069	0.634
MOD_PIKK_1	10	16	PF00454	0.710
MOD_PIKK_1	229	235	PF00454	0.625
MOD_PIKK_1	53	59	PF00454	0.574
MOD_PIKK_1	78	84	PF00454	0.786
MOD_PK_1	688	694	PF00069	0.744
MOD_PKA_2	138	144	PF00069	0.607
MOD_PKA_2	374	380	PF00069	0.643
MOD_PKA_2	45	51	PF00069	0.692
MOD_PKA_2	466	472	PF00069	0.611
MOD_PKA_2	500	506	PF00069	0.705
MOD_PKA_2	568	574	PF00069	0.562
MOD_PKA_2	655	661	PF00069	0.823
MOD_PKA_2	668	674	PF00069	0.684
MOD_PKA_2	708	714	PF00069	0.711
MOD_PKA_2	768	774	PF00069	0.628
MOD_PKB_1	461	469	PF00069	0.562
MOD_Plk_1	118	124	PF00069	0.636
MOD_Plk_1	341	347	PF00069	0.537
MOD_Plk_1	490	496	PF00069	0.818
MOD_Plk_1	823	829	PF00069	0.641
MOD_Plk_2-3	394	400	PF00069	0.642
MOD_Plk_2-3	760	766	PF00069	0.614
MOD_Plk_2-3	781	787	PF00069	0.452
MOD_Plk_4	145	151	PF00069	0.632
MOD_Plk_4	199	205	PF00069	0.613
MOD_ProDKin_1	102	108	PF00069	0.782
MOD_ProDKin_1	17	23	PF00069	0.723
MOD_ProDKin_1	192	198	PF00069	0.755
MOD_ProDKin_1	546	552	PF00069	0.669
MOD_ProDKin_1	557	563	PF00069	0.772
MOD_ProDKin_1	569	575	PF00069	0.612
MOD_ProDKin_1	592	598	PF00069	0.734
MOD_ProDKin_1	608	614	PF00069	0.573
MOD_ProDKin_1	622	628	PF00069	0.814
MOD_ProDKin_1	632	638	PF00069	0.681
MOD_ProDKin_1	682	688	PF00069	0.776
MOD_ProDKin_1	795	801	PF00069	0.704
MOD_SUMO_for_1	347	350	PF00179	0.526
MOD_SUMO_for_1	410	413	PF00179	0.490
MOD_SUMO_for_1	450	453	PF00179	0.537
MOD_SUMO_rev_2	47	56	PF00179	0.697
MOD_SUMO_rev_2	781	790	PF00179	0.684
MOD_SUMO_rev_2	96	101	PF00179	0.826
TRG_DiLeu_BaEn_1	342	347	PF01217	0.536
TRG_DiLeu_BaEn_2	275	281	PF01217	0.650
TRG_DiLeu_BaEn_4	167	173	PF01217	0.625
TRG_DiLeu_BaEn_4	453	459	PF01217	0.532
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.566
TRG_ENDOCYTIC_2	308	311	PF00928	0.476
TRG_ENDOCYTIC_2	327	330	PF00928	0.555
TRG_ENDOCYTIC_2	513	516	PF00928	0.571
TRG_ER_diArg_1	138	140	PF00400	0.585
TRG_ER_diArg_1	287	289	PF00400	0.570
TRG_ER_diArg_1	353	356	PF00400	0.628
TRG_ER_diArg_1	372	375	PF00400	0.546
TRG_ER_diArg_1	432	434	PF00400	0.551
TRG_ER_diArg_1	437	439	PF00400	0.555
TRG_ER_diArg_1	457	460	PF00400	0.310
TRG_ER_diArg_1	461	464	PF00400	0.552
TRG_ER_diArg_1	777	780	PF00400	0.500
TRG_NES_CRM1_1	336	350	PF08389	0.632
TRG_NES_CRM1_1	453	468	PF08389	0.647
TRG_NES_CRM1_1	53	65	PF08389	0.594
TRG_NLS_MonoExtC_3	787	793	PF00514	0.713
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	780	785	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.739

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X2	Leptomonas seymouri	65%	97%
A0A3S7X7I5	Leishmania donovani	100%	100%
A4HAH0	Leishmania braziliensis	72%	99%
E9B4M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	97%
Q4Q3E7	Leishmania major	91%	100%