Mitochondrial ATPase inhibitor

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9M8_LEIIN

TriTrypDb:

LINF_340011400

Length:

122

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.492
CLV_NRD_NRD_1	11	13	PF00675	0.645
CLV_PCSK_KEX2_1	11	13	PF00082	0.613
CLV_PCSK_KEX2_1	77	79	PF00082	0.497
CLV_PCSK_KEX2_1	95	97	PF00082	0.597
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.491
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.597
CLV_PCSK_SKI1_1	107	111	PF00082	0.406
CLV_PCSK_SKI1_1	12	16	PF00082	0.656
CLV_PCSK_SKI1_1	37	41	PF00082	0.589
DEG_Nend_UBRbox_3	1	3	PF02207	0.618
DOC_CKS1_1	60	65	PF01111	0.531
DOC_USP7_MATH_1	14	18	PF00917	0.660
DOC_USP7_MATH_1	5	9	PF00917	0.621
DOC_USP7_UBL2_3	114	118	PF12436	0.628
DOC_USP7_UBL2_3	37	41	PF12436	0.589
DOC_USP7_UBL2_3	84	88	PF12436	0.487
DOC_WW_Pin1_4	59	64	PF00397	0.480
LIG_14-3-3_CanoR_1	11	19	PF00244	0.543
LIG_14-3-3_CanoR_1	29	35	PF00244	0.554
LIG_14-3-3_CanoR_1	98	105	PF00244	0.490
LIG_FHA_1	13	19	PF00498	0.552
LIG_FHA_2	60	66	PF00498	0.521
LIG_SH2_GRB2like	34	37	PF00017	0.605
LIG_SH2_SRC	67	70	PF00017	0.503
LIG_SH2_STAT5	34	37	PF00017	0.605
LIG_TRAF2_1	62	65	PF00917	0.487
MOD_CDK_SPxxK_3	59	66	PF00069	0.476
MOD_CK1_1	17	23	PF00069	0.663
MOD_CK2_1	58	64	PF00069	0.463
MOD_CK2_1	97	103	PF00069	0.403
MOD_GlcNHglycan	19	22	PF01048	0.657
MOD_GSK3_1	97	104	PF00069	0.576
MOD_N-GLC_1	58	63	PF02516	0.591
MOD_PIKK_1	78	84	PF00454	0.493
MOD_PKA_1	114	120	PF00069	0.367
MOD_PKA_2	28	34	PF00069	0.640
MOD_PKA_2	97	103	PF00069	0.546
MOD_Plk_2-3	97	103	PF00069	0.363
MOD_Plk_4	14	20	PF00069	0.555
MOD_Plk_4	5	11	PF00069	0.565
MOD_ProDKin_1	59	65	PF00069	0.477
MOD_SUMO_for_1	105	108	PF00179	0.497
MOD_SUMO_for_1	83	86	PF00179	0.497
TRG_ER_diArg_1	10	12	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXR7	Leptomonas seymouri	58%	97%
A0A1X0P8N6	Trypanosomatidae	39%	100%
A0A3Q8IUE6	Leishmania donovani	100%	100%
A0A3R7KP65	Trypanosoma rangeli	33%	100%
A4HAG8	Leishmania braziliensis	80%	100%
D0A1Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B4M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3E9	Leishmania major	91%	100%
V5DIQ6	Trypanosoma cruzi	32%	100%