LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative leucine-rich repeat protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative leucine-rich repeat protein
Gene product:
leucine-rich repeat protein - putative
Species:
Leishmania infantum
UniProt:
A4I9M5_LEIIN
TriTrypDb:
LINF_340011100
Length:
621

Annotations

Annotations by Jardim et al.

Structural Proteins, leucine-rich repeat

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7
GO:0000151 ubiquitin ligase complex 3 1
GO:0005634 nucleus 5 1
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 1
GO:0019005 SCF ubiquitin ligase complex 5 1
GO:0031461 cullin-RING ubiquitin ligase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Phosphorylation

Promastigote: 609, 610

Expansion

Sequence features

A4I9M5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9M5

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 7 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 571 573 PF00675 0.615
CLV_PCSK_KEX2_1 500 502 PF00082 0.446
CLV_PCSK_PC1ET2_1 500 502 PF00082 0.446
CLV_PCSK_SKI1_1 23 27 PF00082 0.645
CLV_PCSK_SKI1_1 285 289 PF00082 0.495
CLV_PCSK_SKI1_1 500 504 PF00082 0.441
CLV_PCSK_SKI1_1 551 555 PF00082 0.460
DEG_SPOP_SBC_1 140 144 PF00917 0.615
DEG_SPOP_SBC_1 211 215 PF00917 0.644
DOC_CDC14_PxL_1 543 551 PF14671 0.485
DOC_CKS1_1 595 600 PF01111 0.587
DOC_CYCLIN_RxL_1 432 440 PF00134 0.480
DOC_MAPK_gen_1 500 507 PF00069 0.485
DOC_MAPK_gen_1 572 580 PF00069 0.511
DOC_MAPK_MEF2A_6 519 528 PF00069 0.436
DOC_PP1_RVXF_1 458 465 PF00149 0.570
DOC_PP2B_LxvP_1 466 469 PF13499 0.610
DOC_PP4_FxxP_1 229 232 PF00568 0.709
DOC_PP4_FxxP_1 97 100 PF00568 0.683
DOC_USP7_MATH_1 139 143 PF00917 0.713
DOC_USP7_MATH_1 200 204 PF00917 0.675
DOC_USP7_MATH_1 212 216 PF00917 0.667
DOC_USP7_MATH_1 244 248 PF00917 0.785
DOC_USP7_MATH_1 259 263 PF00917 0.333
DOC_USP7_MATH_1 378 382 PF00917 0.434
DOC_USP7_MATH_1 474 478 PF00917 0.486
DOC_USP7_MATH_1 581 585 PF00917 0.611
DOC_USP7_MATH_1 76 80 PF00917 0.782
DOC_WW_Pin1_4 142 147 PF00397 0.697
DOC_WW_Pin1_4 162 167 PF00397 0.677
DOC_WW_Pin1_4 305 310 PF00397 0.573
DOC_WW_Pin1_4 594 599 PF00397 0.704
DOC_WW_Pin1_4 607 612 PF00397 0.682
DOC_WW_Pin1_4 72 77 PF00397 0.703
LIG_14-3-3_CanoR_1 336 343 PF00244 0.375
LIG_14-3-3_CanoR_1 403 410 PF00244 0.466
LIG_14-3-3_CanoR_1 501 506 PF00244 0.482
LIG_14-3-3_CanoR_1 519 526 PF00244 0.479
LIG_Actin_WH2_2 487 505 PF00022 0.419
LIG_BIR_II_1 1 5 PF00653 0.688
LIG_BIR_III_1 1 5 PF00653 0.790
LIG_BIR_III_2 339 343 PF00653 0.436
LIG_BIR_III_3 1 5 PF00653 0.790
LIG_BRCT_BRCA1_1 346 350 PF00533 0.468
LIG_FHA_1 152 158 PF00498 0.751
LIG_FHA_1 165 171 PF00498 0.581
LIG_FHA_1 359 365 PF00498 0.561
LIG_FHA_1 412 418 PF00498 0.268
LIG_FHA_1 424 430 PF00498 0.425
LIG_FHA_1 502 508 PF00498 0.472
LIG_FHA_1 548 554 PF00498 0.555
LIG_FHA_1 76 82 PF00498 0.723
LIG_FHA_2 142 148 PF00498 0.795
LIG_FHA_2 5 11 PF00498 0.488
LIG_FHA_2 511 517 PF00498 0.514
LIG_FHA_2 536 542 PF00498 0.473
LIG_FHA_2 572 578 PF00498 0.538
LIG_FHA_2 611 617 PF00498 0.777
LIG_LIR_Apic_2 592 598 PF02991 0.615
LIG_LIR_Nem_3 171 176 PF02991 0.772
LIG_LIR_Nem_3 63 67 PF02991 0.686
LIG_LYPXL_yS_3 67 70 PF13949 0.677
LIG_NRBOX 461 467 PF00104 0.573
LIG_Rb_pABgroove_1 344 352 PF01858 0.462
LIG_SH2_CRK 595 599 PF00017 0.586
LIG_SH2_CRK 98 102 PF00017 0.721
LIG_SH2_SRC 98 101 PF00017 0.725
LIG_SH2_STAP1 404 408 PF00017 0.463
LIG_SH2_STAT3 96 99 PF00017 0.809
LIG_SH2_STAT5 401 404 PF00017 0.384
LIG_SH2_STAT5 96 99 PF00017 0.731
LIG_SH3_1 601 607 PF00018 0.789
LIG_SH3_1 98 104 PF00018 0.798
LIG_SH3_3 160 166 PF00018 0.701
LIG_SH3_3 185 191 PF00018 0.771
LIG_SH3_3 204 210 PF00018 0.593
LIG_SH3_3 601 607 PF00018 0.789
LIG_SH3_3 98 104 PF00018 0.745
LIG_SUMO_SIM_par_1 479 484 PF11976 0.442
LIG_TRAF2_1 513 516 PF00917 0.470
LIG_WRC_WIRS_1 489 494 PF05994 0.511
MOD_CDK_SPxxK_3 594 601 PF00069 0.725
MOD_CK1_1 142 148 PF00069 0.620
MOD_CK1_1 165 171 PF00069 0.671
MOD_CK1_1 213 219 PF00069 0.709
MOD_CK1_1 488 494 PF00069 0.473
MOD_CK1_1 518 524 PF00069 0.516
MOD_CK1_1 605 611 PF00069 0.733
MOD_CK1_1 75 81 PF00069 0.777
MOD_CK2_1 141 147 PF00069 0.793
MOD_CK2_1 259 265 PF00069 0.471
MOD_CK2_1 510 516 PF00069 0.516
MOD_CK2_1 571 577 PF00069 0.590
MOD_CK2_1 610 616 PF00069 0.774
MOD_GlcNHglycan 167 170 PF01048 0.774
MOD_GlcNHglycan 354 357 PF01048 0.431
MOD_GlcNHglycan 51 54 PF01048 0.604
MOD_GlcNHglycan 520 523 PF01048 0.461
MOD_GlcNHglycan 591 594 PF01048 0.820
MOD_GSK3_1 15 22 PF00069 0.636
MOD_GSK3_1 164 171 PF00069 0.702
MOD_GSK3_1 212 219 PF00069 0.683
MOD_GSK3_1 245 252 PF00069 0.594
MOD_GSK3_1 354 361 PF00069 0.435
MOD_GSK3_1 383 390 PF00069 0.427
MOD_GSK3_1 501 508 PF00069 0.517
MOD_GSK3_1 602 609 PF00069 0.615
MOD_GSK3_1 68 75 PF00069 0.761
MOD_GSK3_1 82 89 PF00069 0.637
MOD_N-GLC_1 244 249 PF02516 0.771
MOD_N-GLC_1 30 35 PF02516 0.666
MOD_N-GLC_1 352 357 PF02516 0.430
MOD_N-GLC_1 392 397 PF02516 0.569
MOD_N-GLC_1 79 84 PF02516 0.805
MOD_N-GLC_2 330 332 PF02516 0.550
MOD_N-GLC_2 380 382 PF02516 0.440
MOD_NEK2_1 201 206 PF00069 0.696
MOD_NEK2_1 249 254 PF00069 0.598
MOD_NEK2_1 352 357 PF00069 0.430
MOD_NEK2_1 358 363 PF00069 0.460
MOD_NEK2_1 437 442 PF00069 0.591
MOD_NEK2_1 494 499 PF00069 0.546
MOD_NEK2_1 507 512 PF00069 0.409
MOD_NEK2_1 571 576 PF00069 0.534
MOD_PIKK_1 454 460 PF00454 0.467
MOD_PIKK_1 79 85 PF00454 0.686
MOD_PIKK_1 86 92 PF00454 0.651
MOD_PKA_2 324 330 PF00069 0.458
MOD_PKA_2 335 341 PF00069 0.469
MOD_PKA_2 402 408 PF00069 0.431
MOD_PKA_2 505 511 PF00069 0.475
MOD_PKA_2 518 524 PF00069 0.492
MOD_PKA_2 571 577 PF00069 0.536
MOD_Plk_1 244 250 PF00069 0.672
MOD_Plk_1 30 36 PF00069 0.667
MOD_Plk_1 386 392 PF00069 0.459
MOD_Plk_1 454 460 PF00069 0.448
MOD_Plk_1 515 521 PF00069 0.514
MOD_Plk_1 79 85 PF00069 0.633
MOD_Plk_4 153 159 PF00069 0.789
MOD_Plk_4 201 207 PF00069 0.772
MOD_Plk_4 344 350 PF00069 0.471
MOD_Plk_4 354 360 PF00069 0.441
MOD_Plk_4 485 491 PF00069 0.419
MOD_Plk_4 524 530 PF00069 0.385
MOD_ProDKin_1 142 148 PF00069 0.697
MOD_ProDKin_1 162 168 PF00069 0.676
MOD_ProDKin_1 305 311 PF00069 0.567
MOD_ProDKin_1 594 600 PF00069 0.704
MOD_ProDKin_1 607 613 PF00069 0.683
MOD_ProDKin_1 72 78 PF00069 0.702
MOD_SUMO_rev_2 115 120 PF00179 0.803
MOD_SUMO_rev_2 390 400 PF00179 0.455
MOD_SUMO_rev_2 561 565 PF00179 0.537
TRG_ENDOCYTIC_2 67 70 PF00928 0.677
TRG_Pf-PMV_PEXEL_1 392 396 PF00026 0.454

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5N0 Leptomonas seymouri 64% 99%
A0A3S7X7J0 Leishmania donovani 99% 100%
A4H7D3 Leishmania braziliensis 82% 100%
E9B4M4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q3F2 Leishmania major 95% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS