LeishMANIAdb
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Putative importin beta-1 subunit

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative importin beta-1 subunit
Gene product:
importin beta-1 subunit - putative
Species:
Leishmania infantum
UniProt:
A4I9L9_LEIIN
TriTrypDb:
LINF_340010100
Length:
870

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, importin beta-1 subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 1
GO:0005643 nuclear pore 3 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4I9L9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9L9

Function

Biological processes
Term Name Level Count
GO:0006606 protein import into nucleus 5 12
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0006913 nucleocytoplasmic transport 5 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0033365 protein localization to organelle 5 12
GO:0034504 protein localization to nucleus 6 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051169 nuclear transport 4 12
GO:0051170 import into nucleus 6 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0072594 establishment of protein localization to organelle 4 12
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0019899 enzyme binding 3 11
GO:0031267 small GTPase binding 5 11
GO:0051020 GTPase binding 4 11
GO:0005048 signal sequence binding 4 1
GO:0008139 nuclear localization sequence binding 5 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1
GO:0061608 nuclear import signal receptor activity 3 1
GO:0140104 molecular carrier activity 1 1
GO:0140142 nucleocytoplasmic carrier activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 561 565 PF00656 0.612
CLV_C14_Caspase3-7 650 654 PF00656 0.561
CLV_C14_Caspase3-7 772 776 PF00656 0.556
CLV_NRD_NRD_1 376 378 PF00675 0.510
CLV_NRD_NRD_1 583 585 PF00675 0.471
CLV_PCSK_KEX2_1 378 380 PF00082 0.519
CLV_PCSK_PC1ET2_1 378 380 PF00082 0.519
CLV_PCSK_SKI1_1 296 300 PF00082 0.508
CLV_PCSK_SKI1_1 323 327 PF00082 0.480
CLV_PCSK_SKI1_1 695 699 PF00082 0.383
CLV_PCSK_SKI1_1 76 80 PF00082 0.368
CLV_PCSK_SKI1_1 829 833 PF00082 0.471
CLV_PCSK_SKI1_1 855 859 PF00082 0.592
DEG_APCC_DBOX_1 860 868 PF00400 0.532
DEG_ODPH_VHL_1 777 789 PF01847 0.415
DOC_ANK_TNKS_1 741 748 PF00023 0.528
DOC_CKS1_1 443 448 PF01111 0.515
DOC_CYCLIN_RxL_1 320 330 PF00134 0.497
DOC_MAPK_gen_1 377 386 PF00069 0.380
DOC_MAPK_gen_1 731 741 PF00069 0.441
DOC_MAPK_MEF2A_6 495 504 PF00069 0.524
DOC_MIT_MIM_1 664 674 PF04212 0.443
DOC_PP1_RVXF_1 853 860 PF00149 0.501
DOC_PP4_FxxP_1 649 652 PF00568 0.569
DOC_USP7_MATH_1 14 18 PF00917 0.527
DOC_USP7_MATH_1 140 144 PF00917 0.495
DOC_USP7_MATH_1 243 247 PF00917 0.435
DOC_USP7_MATH_1 424 428 PF00917 0.412
DOC_USP7_MATH_1 619 623 PF00917 0.442
DOC_USP7_MATH_1 675 679 PF00917 0.462
DOC_USP7_MATH_1 844 848 PF00917 0.523
DOC_USP7_UBL2_3 854 858 PF12436 0.573
DOC_WW_Pin1_4 101 106 PF00397 0.360
DOC_WW_Pin1_4 442 447 PF00397 0.466
LIG_14-3-3_CanoR_1 559 566 PF00244 0.572
LIG_14-3-3_CanoR_1 670 674 PF00244 0.464
LIG_14-3-3_CanoR_1 734 741 PF00244 0.515
LIG_Actin_WH2_2 402 419 PF00022 0.532
LIG_Actin_WH2_2 50 65 PF00022 0.368
LIG_Actin_WH2_2 544 561 PF00022 0.484
LIG_Actin_WH2_2 802 819 PF00022 0.356
LIG_AP2alpha_1 438 442 PF02296 0.361
LIG_APCC_ABBA_1 590 595 PF00400 0.498
LIG_BIR_II_1 1 5 PF00653 0.499
LIG_BRCT_BRCA1_1 714 718 PF00533 0.539
LIG_Clathr_ClatBox_1 673 677 PF01394 0.443
LIG_FHA_1 175 181 PF00498 0.431
LIG_FHA_1 198 204 PF00498 0.390
LIG_FHA_1 268 274 PF00498 0.382
LIG_FHA_1 3 9 PF00498 0.472
LIG_FHA_1 314 320 PF00498 0.441
LIG_FHA_1 37 43 PF00498 0.454
LIG_FHA_1 443 449 PF00498 0.507
LIG_FHA_1 488 494 PF00498 0.452
LIG_FHA_1 607 613 PF00498 0.461
LIG_FHA_1 681 687 PF00498 0.544
LIG_FHA_2 189 195 PF00498 0.527
LIG_FHA_2 255 261 PF00498 0.511
LIG_FHA_2 332 338 PF00498 0.533
LIG_FHA_2 510 516 PF00498 0.493
LIG_FHA_2 687 693 PF00498 0.457
LIG_FHA_2 847 853 PF00498 0.553
LIG_GBD_Chelix_1 112 120 PF00786 0.413
LIG_GBD_Chelix_1 781 789 PF00786 0.483
LIG_Integrin_RGD_1 742 744 PF01839 0.606
LIG_LIR_Gen_1 252 263 PF02991 0.396
LIG_LIR_Gen_1 365 375 PF02991 0.557
LIG_LIR_Gen_1 436 446 PF02991 0.395
LIG_LIR_Gen_1 683 693 PF02991 0.472
LIG_LIR_Gen_1 703 713 PF02991 0.181
LIG_LIR_Gen_1 760 769 PF02991 0.390
LIG_LIR_LC3C_4 499 502 PF02991 0.530
LIG_LIR_Nem_3 127 133 PF02991 0.461
LIG_LIR_Nem_3 252 258 PF02991 0.384
LIG_LIR_Nem_3 365 371 PF02991 0.545
LIG_LIR_Nem_3 436 441 PF02991 0.370
LIG_LIR_Nem_3 494 500 PF02991 0.366
LIG_LIR_Nem_3 589 593 PF02991 0.490
LIG_LIR_Nem_3 653 659 PF02991 0.519
LIG_LIR_Nem_3 683 688 PF02991 0.444
LIG_LIR_Nem_3 69 73 PF02991 0.391
LIG_LIR_Nem_3 703 708 PF02991 0.180
LIG_LIR_Nem_3 715 721 PF02991 0.340
LIG_LIR_Nem_3 760 765 PF02991 0.385
LIG_LIR_Nem_3 80 86 PF02991 0.291
LIG_PCNA_yPIPBox_3 517 528 PF02747 0.441
LIG_Pex14_2 438 442 PF04695 0.351
LIG_Pex14_2 701 705 PF04695 0.447
LIG_PTB_Apo_2 679 686 PF02174 0.505
LIG_PTB_Phospho_1 679 685 PF10480 0.499
LIG_SH2_CRK 255 259 PF00017 0.385
LIG_SH2_CRK 368 372 PF00017 0.506
LIG_SH2_CRK 656 660 PF00017 0.516
LIG_SH2_CRK 762 766 PF00017 0.343
LIG_SH2_GRB2like 368 371 PF00017 0.533
LIG_SH2_GRB2like 685 688 PF00017 0.541
LIG_SH2_NCK_1 368 372 PF00017 0.456
LIG_SH2_NCK_1 762 766 PF00017 0.477
LIG_SH2_PTP2 685 688 PF00017 0.541
LIG_SH2_SRC 368 371 PF00017 0.559
LIG_SH2_STAT3 310 313 PF00017 0.476
LIG_SH2_STAT3 539 542 PF00017 0.536
LIG_SH2_STAT3 611 614 PF00017 0.531
LIG_SH2_STAT5 158 161 PF00017 0.424
LIG_SH2_STAT5 209 212 PF00017 0.510
LIG_SH2_STAT5 222 225 PF00017 0.394
LIG_SH2_STAT5 261 264 PF00017 0.390
LIG_SH2_STAT5 415 418 PF00017 0.406
LIG_SH2_STAT5 539 542 PF00017 0.417
LIG_SH2_STAT5 611 614 PF00017 0.496
LIG_SH2_STAT5 625 628 PF00017 0.437
LIG_SH2_STAT5 634 637 PF00017 0.377
LIG_SH2_STAT5 645 648 PF00017 0.303
LIG_SH2_STAT5 685 688 PF00017 0.473
LIG_SH2_STAT5 750 753 PF00017 0.387
LIG_SH2_STAT5 780 783 PF00017 0.473
LIG_SH3_3 352 358 PF00018 0.499
LIG_SH3_3 816 822 PF00018 0.528
LIG_SUMO_SIM_anti_2 176 185 PF11976 0.465
LIG_SUMO_SIM_anti_2 499 505 PF11976 0.495
LIG_SUMO_SIM_par_1 603 610 PF11976 0.549
LIG_SUMO_SIM_par_1 615 622 PF11976 0.469
LIG_TRAF2_1 396 399 PF00917 0.525
LIG_TRAF2_1 481 484 PF00917 0.468
LIG_TRAF2_1 519 522 PF00917 0.475
LIG_TRAF2_1 78 81 PF00917 0.480
LIG_TYR_ITIM 253 258 PF00017 0.463
LIG_WRC_WIRS_1 34 39 PF05994 0.454
LIG_WRPW_2 718 721 PF00400 0.529
MOD_CDC14_SPxK_1 104 107 PF00782 0.475
MOD_CDK_SPxK_1 101 107 PF00069 0.368
MOD_CK1_1 233 239 PF00069 0.468
MOD_CK1_1 49 55 PF00069 0.388
MOD_CK1_1 700 706 PF00069 0.499
MOD_CK1_1 760 766 PF00069 0.388
MOD_CK1_1 847 853 PF00069 0.578
MOD_CK2_1 140 146 PF00069 0.494
MOD_CK2_1 187 193 PF00069 0.423
MOD_CK2_1 287 293 PF00069 0.354
MOD_CK2_1 347 353 PF00069 0.475
MOD_CK2_1 66 72 PF00069 0.435
MOD_CK2_1 686 692 PF00069 0.465
MOD_CK2_1 750 756 PF00069 0.378
MOD_CK2_1 845 851 PF00069 0.617
MOD_GlcNHglycan 126 129 PF01048 0.541
MOD_GlcNHglycan 142 145 PF01048 0.416
MOD_GlcNHglycan 197 200 PF01048 0.496
MOD_GlcNHglycan 310 313 PF01048 0.472
MOD_GlcNHglycan 425 429 PF01048 0.416
MOD_GlcNHglycan 517 520 PF01048 0.503
MOD_GlcNHglycan 536 539 PF01048 0.548
MOD_GlcNHglycan 561 564 PF01048 0.578
MOD_GlcNHglycan 579 582 PF01048 0.451
MOD_GSK3_1 116 123 PF00069 0.215
MOD_GSK3_1 175 182 PF00069 0.489
MOD_GSK3_1 218 225 PF00069 0.447
MOD_GSK3_1 232 239 PF00069 0.359
MOD_GSK3_1 29 36 PF00069 0.454
MOD_GSK3_1 304 311 PF00069 0.508
MOD_GSK3_1 487 494 PF00069 0.430
MOD_GSK3_1 665 672 PF00069 0.464
MOD_GSK3_1 750 757 PF00069 0.383
MOD_GSK3_1 97 104 PF00069 0.389
MOD_N-GLC_1 2 7 PF02516 0.605
MOD_N-GLC_1 308 313 PF02516 0.522
MOD_N-GLC_1 338 343 PF02516 0.418
MOD_N-GLC_1 371 376 PF02516 0.563
MOD_N-GLC_1 686 691 PF02516 0.545
MOD_N-GLC_2 533 535 PF02516 0.429
MOD_NEK2_1 197 202 PF00069 0.499
MOD_NEK2_1 227 232 PF00069 0.386
MOD_NEK2_1 253 258 PF00069 0.394
MOD_NEK2_1 287 292 PF00069 0.345
MOD_NEK2_1 308 313 PF00069 0.484
MOD_NEK2_1 347 352 PF00069 0.344
MOD_NEK2_1 37 42 PF00069 0.418
MOD_NEK2_1 558 563 PF00069 0.555
MOD_NEK2_1 57 62 PF00069 0.353
MOD_NEK2_1 586 591 PF00069 0.462
MOD_NEK2_1 594 599 PF00069 0.467
MOD_NEK2_1 665 670 PF00069 0.414
MOD_NEK2_1 697 702 PF00069 0.383
MOD_NEK2_1 754 759 PF00069 0.363
MOD_NEK2_1 761 766 PF00069 0.354
MOD_NEK2_1 798 803 PF00069 0.454
MOD_NEK2_1 845 850 PF00069 0.580
MOD_OFUCOSY 228 234 PF10250 0.470
MOD_OFUCOSY 699 704 PF10250 0.482
MOD_PIKK_1 763 769 PF00454 0.448
MOD_PIKK_1 798 804 PF00454 0.505
MOD_PK_1 379 385 PF00069 0.505
MOD_PKA_2 416 422 PF00069 0.504
MOD_PKA_2 558 564 PF00069 0.574
MOD_PKA_2 669 675 PF00069 0.494
MOD_PKA_2 733 739 PF00069 0.527
MOD_PKB_1 377 385 PF00069 0.513
MOD_Plk_1 338 344 PF00069 0.398
MOD_Plk_1 379 385 PF00069 0.505
MOD_Plk_1 424 430 PF00069 0.477
MOD_Plk_1 491 497 PF00069 0.398
MOD_Plk_1 594 600 PF00069 0.522
MOD_Plk_1 663 669 PF00069 0.378
MOD_Plk_1 798 804 PF00069 0.477
MOD_Plk_2-3 331 337 PF00069 0.534
MOD_Plk_4 179 185 PF00069 0.540
MOD_Plk_4 243 249 PF00069 0.365
MOD_Plk_4 313 319 PF00069 0.392
MOD_Plk_4 33 39 PF00069 0.424
MOD_Plk_4 379 385 PF00069 0.505
MOD_Plk_4 57 63 PF00069 0.368
MOD_Plk_4 586 592 PF00069 0.511
MOD_Plk_4 651 657 PF00069 0.533
MOD_Plk_4 669 675 PF00069 0.338
MOD_Plk_4 680 686 PF00069 0.387
MOD_Plk_4 697 703 PF00069 0.247
MOD_Plk_4 750 756 PF00069 0.394
MOD_Plk_4 757 763 PF00069 0.378
MOD_Plk_4 811 817 PF00069 0.391
MOD_ProDKin_1 101 107 PF00069 0.360
MOD_ProDKin_1 442 448 PF00069 0.461
MOD_SUMO_for_1 94 97 PF00179 0.405
MOD_SUMO_rev_2 190 198 PF00179 0.522
MOD_SUMO_rev_2 44 52 PF00179 0.350
MOD_SUMO_rev_2 509 519 PF00179 0.538
MOD_SUMO_rev_2 692 700 PF00179 0.452
TRG_DiLeu_BaEn_1 129 134 PF01217 0.440
TRG_DiLeu_BaEn_4 277 283 PF01217 0.395
TRG_ENDOCYTIC_2 255 258 PF00928 0.363
TRG_ENDOCYTIC_2 368 371 PF00928 0.428
TRG_ENDOCYTIC_2 497 500 PF00928 0.430
TRG_ENDOCYTIC_2 656 659 PF00928 0.507
TRG_ENDOCYTIC_2 685 688 PF00928 0.479
TRG_ENDOCYTIC_2 762 765 PF00928 0.343
TRG_ER_diArg_1 376 379 PF00400 0.530
TRG_Pf-PMV_PEXEL_1 584 588 PF00026 0.489
TRG_Pf-PMV_PEXEL_1 84 89 PF00026 0.409

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB22 Leptomonas seymouri 81% 100%
A0A0S4J2L0 Bodo saltans 48% 100%
A0A1X0P8K4 Trypanosomatidae 55% 100%
A0A3Q8IUD8 Leishmania donovani 100% 100%
A0A3R7LLX8 Trypanosoma rangeli 53% 100%
A4HAG4 Leishmania braziliensis 88% 100%
D0A1Y4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9B4L7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O00410 Homo sapiens 21% 79%
O13864 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 100%
O18388 Drosophila melanogaster 28% 98%
P52296 Rattus norvegicus 28% 99%
P52297 Xenopus laevis 29% 99%
P70168 Mus musculus 29% 99%
Q06142 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
Q14974 Homo sapiens 29% 99%
Q4Q3F9 Leishmania major 99% 100%
Q8BKC5 Mus musculus 21% 79%
Q8H0U4 Arabidopsis thaliana 20% 98%
Q9FJD4 Arabidopsis thaliana 31% 100%
V5BHR5 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS