Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4I9L5_LEIIN

TriTrypDb:

LINF_340009600

Length:

936

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.718
CLV_C14_Caspase3-7	154	158	PF00656	0.673
CLV_C14_Caspase3-7	51	55	PF00656	0.727
CLV_C14_Caspase3-7	687	691	PF00656	0.751
CLV_NRD_NRD_1	114	116	PF00675	0.790
CLV_NRD_NRD_1	413	415	PF00675	0.623
CLV_NRD_NRD_1	420	422	PF00675	0.658
CLV_NRD_NRD_1	457	459	PF00675	0.664
CLV_NRD_NRD_1	48	50	PF00675	0.566
CLV_NRD_NRD_1	701	703	PF00675	0.793
CLV_NRD_NRD_1	742	744	PF00675	0.789
CLV_NRD_NRD_1	928	930	PF00675	0.515
CLV_PCSK_KEX2_1	114	116	PF00082	0.790
CLV_PCSK_KEX2_1	190	192	PF00082	0.652
CLV_PCSK_KEX2_1	413	415	PF00082	0.623
CLV_PCSK_KEX2_1	420	422	PF00082	0.658
CLV_PCSK_KEX2_1	48	50	PF00082	0.569
CLV_PCSK_KEX2_1	513	515	PF00082	0.582
CLV_PCSK_KEX2_1	701	703	PF00082	0.789
CLV_PCSK_KEX2_1	741	743	PF00082	0.711
CLV_PCSK_KEX2_1	749	751	PF00082	0.604
CLV_PCSK_KEX2_1	854	856	PF00082	0.583
CLV_PCSK_KEX2_1	879	881	PF00082	0.687
CLV_PCSK_KEX2_1	928	930	PF00082	0.515
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.722
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.660
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.587
CLV_PCSK_PC1ET2_1	854	856	PF00082	0.583
CLV_PCSK_PC1ET2_1	879	881	PF00082	0.687
CLV_PCSK_SKI1_1	42	46	PF00082	0.647
CLV_PCSK_SKI1_1	488	492	PF00082	0.576
CLV_PCSK_SKI1_1	513	517	PF00082	0.607
CLV_PCSK_SKI1_1	522	526	PF00082	0.494
CLV_PCSK_SKI1_1	857	861	PF00082	0.677
DEG_APCC_KENBOX_2	139	143	PF00400	0.778
DEG_SCF_FBW7_1	25	31	PF00400	0.660
DEG_SCF_FBW7_1	344	349	PF00400	0.726
DEG_SPOP_SBC_1	15	19	PF00917	0.692
DEG_SPOP_SBC_1	212	216	PF00917	0.566
DEG_SPOP_SBC_1	227	231	PF00917	0.574
DEG_SPOP_SBC_1	691	695	PF00917	0.706
DEG_SPOP_SBC_1	756	760	PF00917	0.658
DEG_SPOP_SBC_1	831	835	PF00917	0.671
DOC_CKS1_1	25	30	PF01111	0.662
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.657
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.567
DOC_MAPK_DCC_7	38	46	PF00069	0.656
DOC_MAPK_gen_1	525	536	PF00069	0.605
DOC_PP2B_LxvP_1	210	213	PF13499	0.672
DOC_PP2B_LxvP_1	259	262	PF13499	0.689
DOC_PP2B_LxvP_1	323	326	PF13499	0.700
DOC_PP2B_LxvP_1	431	434	PF13499	0.706
DOC_PP2B_LxvP_1	491	494	PF13499	0.557
DOC_PP4_FxxP_1	22	25	PF00568	0.784
DOC_PP4_FxxP_1	358	361	PF00568	0.791
DOC_PP4_MxPP_1	359	362	PF00568	0.754
DOC_USP7_MATH_1	145	149	PF00917	0.722
DOC_USP7_MATH_1	194	198	PF00917	0.737
DOC_USP7_MATH_1	199	203	PF00917	0.683
DOC_USP7_MATH_1	2	6	PF00917	0.729
DOC_USP7_MATH_1	213	217	PF00917	0.581
DOC_USP7_MATH_1	227	231	PF00917	0.572
DOC_USP7_MATH_1	232	236	PF00917	0.592
DOC_USP7_MATH_1	244	248	PF00917	0.671
DOC_USP7_MATH_1	255	259	PF00917	0.746
DOC_USP7_MATH_1	34	38	PF00917	0.702
DOC_USP7_MATH_1	346	350	PF00917	0.685
DOC_USP7_MATH_1	434	438	PF00917	0.685
DOC_USP7_MATH_1	496	500	PF00917	0.554
DOC_USP7_MATH_1	515	519	PF00917	0.632
DOC_USP7_MATH_1	594	598	PF00917	0.636
DOC_USP7_MATH_1	627	631	PF00917	0.843
DOC_USP7_MATH_1	680	684	PF00917	0.631
DOC_USP7_MATH_1	7	11	PF00917	0.691
DOC_USP7_MATH_1	708	712	PF00917	0.655
DOC_USP7_MATH_1	745	749	PF00917	0.706
DOC_USP7_MATH_1	786	790	PF00917	0.563
DOC_USP7_MATH_1	800	804	PF00917	0.633
DOC_USP7_MATH_1	815	819	PF00917	0.594
DOC_USP7_MATH_1	831	835	PF00917	0.538
DOC_USP7_MATH_1	902	906	PF00917	0.684
DOC_USP7_MATH_1	98	102	PF00917	0.673
DOC_USP7_MATH_2	472	478	PF00917	0.596
DOC_USP7_UBL2_3	522	526	PF12436	0.642
DOC_USP7_UBL2_3	667	671	PF12436	0.622
DOC_WW_Pin1_4	21	26	PF00397	0.591
DOC_WW_Pin1_4	257	262	PF00397	0.666
DOC_WW_Pin1_4	28	33	PF00397	0.651
DOC_WW_Pin1_4	303	308	PF00397	0.815
DOC_WW_Pin1_4	342	347	PF00397	0.792
DOC_WW_Pin1_4	389	394	PF00397	0.754
DOC_WW_Pin1_4	405	410	PF00397	0.549
DOC_WW_Pin1_4	5	10	PF00397	0.739
DOC_WW_Pin1_4	590	595	PF00397	0.706
DOC_WW_Pin1_4	599	604	PF00397	0.537
DOC_WW_Pin1_4	618	623	PF00397	0.734
DOC_WW_Pin1_4	629	634	PF00397	0.605
DOC_WW_Pin1_4	784	789	PF00397	0.622
DOC_WW_Pin1_4	795	800	PF00397	0.643
DOC_WW_Pin1_4	898	903	PF00397	0.573
LIG_14-3-3_CanoR_1	26	32	PF00244	0.713
LIG_14-3-3_CanoR_1	277	287	PF00244	0.691
LIG_14-3-3_CanoR_1	292	300	PF00244	0.586
LIG_14-3-3_CanoR_1	351	356	PF00244	0.684
LIG_14-3-3_CanoR_1	420	425	PF00244	0.628
LIG_14-3-3_CanoR_1	426	434	PF00244	0.633
LIG_14-3-3_CanoR_1	577	583	PF00244	0.704
LIG_14-3-3_CanoR_1	584	594	PF00244	0.650
LIG_14-3-3_CanoR_1	660	666	PF00244	0.637
LIG_14-3-3_CanoR_1	734	739	PF00244	0.821
LIG_14-3-3_CanoR_1	781	786	PF00244	0.631
LIG_14-3-3_CanoR_1	808	816	PF00244	0.664
LIG_14-3-3_CanoR_1	864	873	PF00244	0.725
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BIR_III_4	120	124	PF00653	0.602
LIG_BRCT_BRCA1_1	215	219	PF00533	0.571
LIG_BRCT_BRCA1_1	232	236	PF00533	0.605
LIG_BRCT_BRCA1_1	505	509	PF00533	0.629
LIG_BRCT_BRCA1_1	642	646	PF00533	0.643
LIG_CaM_IQ_9	921	936	PF13499	0.533
LIG_deltaCOP1_diTrp_1	638	646	PF00928	0.642
LIG_FHA_1	392	398	PF00498	0.770
LIG_FHA_1	426	432	PF00498	0.637
LIG_FHA_1	594	600	PF00498	0.746
LIG_FHA_1	824	830	PF00498	0.622
LIG_FHA_2	122	128	PF00498	0.720
LIG_FHA_2	152	158	PF00498	0.598
LIG_FHA_2	297	303	PF00498	0.598
LIG_FHA_2	503	509	PF00498	0.656
LIG_Integrin_isoDGR_2	402	404	PF01839	0.756
LIG_LIR_Apic_2	19	25	PF02991	0.781
LIG_LIR_Apic_2	234	240	PF02991	0.686
LIG_LIR_Apic_2	357	361	PF02991	0.784
LIG_LIR_Gen_1	216	227	PF02991	0.551
LIG_LIR_Gen_1	506	515	PF02991	0.631
LIG_LIR_Nem_3	216	222	PF02991	0.555
LIG_LIR_Nem_3	481	486	PF02991	0.570
LIG_LIR_Nem_3	499	504	PF02991	0.624
LIG_LIR_Nem_3	506	512	PF02991	0.637
LIG_LYPXL_S_1	500	504	PF13949	0.532
LIG_LYPXL_yS_3	501	504	PF13949	0.532
LIG_MLH1_MIPbox_1	215	219	PF16413	0.546
LIG_NRP_CendR_1	934	936	PF00754	0.532
LIG_SH2_CRK	237	241	PF00017	0.686
LIG_SH2_CRK	483	487	PF00017	0.493
LIG_SH2_STAT5	218	221	PF00017	0.555
LIG_SH3_3	165	171	PF00018	0.758
LIG_SH3_3	22	28	PF00018	0.713
LIG_SH3_3	259	265	PF00018	0.700
LIG_SH3_3	315	321	PF00018	0.729
LIG_SH3_3	323	329	PF00018	0.562
LIG_SH3_3	702	708	PF00018	0.620
LIG_SH3_3	733	739	PF00018	0.744
LIG_SUMO_SIM_par_1	287	293	PF11976	0.664
LIG_SUMO_SIM_par_1	792	798	PF11976	0.559
LIG_TRAF2_1	530	533	PF00917	0.548
LIG_TRAF2_1	77	80	PF00917	0.579
LIG_TRAF2_1	886	889	PF00917	0.706
LIG_WRC_WIRS_1	475	480	PF05994	0.644
LIG_WRC_WIRS_1	924	929	PF05994	0.533
MOD_CDK_SPK_2	21	26	PF00069	0.776
MOD_CDK_SPxK_1	618	624	PF00069	0.692
MOD_CDK_SPxK_1	629	635	PF00069	0.573
MOD_CK1_1	148	154	PF00069	0.697
MOD_CK1_1	21	27	PF00069	0.584
MOD_CK1_1	214	220	PF00069	0.598
MOD_CK1_1	223	229	PF00069	0.598
MOD_CK1_1	230	236	PF00069	0.581
MOD_CK1_1	278	284	PF00069	0.776
MOD_CK1_1	296	302	PF00069	0.535
MOD_CK1_1	336	342	PF00069	0.747
MOD_CK1_1	349	355	PF00069	0.599
MOD_CK1_1	391	397	PF00069	0.660
MOD_CK1_1	419	425	PF00069	0.661
MOD_CK1_1	429	435	PF00069	0.645
MOD_CK1_1	5	11	PF00069	0.793
MOD_CK1_1	518	524	PF00069	0.588
MOD_CK1_1	560	566	PF00069	0.516
MOD_CK1_1	585	591	PF00069	0.636
MOD_CK1_1	593	599	PF00069	0.671
MOD_CK1_1	64	70	PF00069	0.634
MOD_CK1_1	692	698	PF00069	0.791
MOD_CK1_1	723	729	PF00069	0.680
MOD_CK1_1	758	764	PF00069	0.724
MOD_CK1_1	784	790	PF00069	0.605
MOD_CK1_1	807	813	PF00069	0.630
MOD_CK1_1	823	829	PF00069	0.637
MOD_CK1_1	834	840	PF00069	0.603
MOD_CK1_1	866	872	PF00069	0.719
MOD_CK1_1	898	904	PF00069	0.572
MOD_CK1_1	923	929	PF00069	0.534
MOD_CK2_1	277	283	PF00069	0.700
MOD_CK2_1	296	302	PF00069	0.471
MOD_CK2_1	364	370	PF00069	0.602
MOD_CK2_1	429	435	PF00069	0.625
MOD_CK2_1	599	605	PF00069	0.609
MOD_CK2_1	680	686	PF00069	0.674
MOD_CK2_1	692	698	PF00069	0.566
MOD_CK2_1	74	80	PF00069	0.762
MOD_CK2_1	762	768	PF00069	0.679
MOD_CK2_1	830	836	PF00069	0.656
MOD_GlcNHglycan	135	138	PF01048	0.669
MOD_GlcNHglycan	181	184	PF01048	0.730
MOD_GlcNHglycan	201	204	PF01048	0.661
MOD_GlcNHglycan	222	225	PF01048	0.627
MOD_GlcNHglycan	230	233	PF01048	0.601
MOD_GlcNHglycan	246	249	PF01048	0.540
MOD_GlcNHglycan	277	280	PF01048	0.698
MOD_GlcNHglycan	295	298	PF01048	0.497
MOD_GlcNHglycan	311	314	PF01048	0.597
MOD_GlcNHglycan	335	338	PF01048	0.682
MOD_GlcNHglycan	366	369	PF01048	0.731
MOD_GlcNHglycan	383	386	PF01048	0.687
MOD_GlcNHglycan	438	441	PF01048	0.741
MOD_GlcNHglycan	452	455	PF01048	0.651
MOD_GlcNHglycan	462	465	PF01048	0.592
MOD_GlcNHglycan	584	587	PF01048	0.746
MOD_GlcNHglycan	615	619	PF01048	0.707
MOD_GlcNHglycan	70	73	PF01048	0.577
MOD_GlcNHglycan	710	713	PF01048	0.739
MOD_GlcNHglycan	783	786	PF01048	0.741
MOD_GlcNHglycan	789	792	PF01048	0.655
MOD_GlcNHglycan	804	807	PF01048	0.592
MOD_GlcNHglycan	811	814	PF01048	0.687
MOD_GlcNHglycan	868	871	PF01048	0.657
MOD_GlcNHglycan	884	887	PF01048	0.542
MOD_GlcNHglycan	9	12	PF01048	0.559
MOD_GSK3_1	145	152	PF00069	0.683
MOD_GSK3_1	169	176	PF00069	0.661
MOD_GSK3_1	213	220	PF00069	0.599
MOD_GSK3_1	222	229	PF00069	0.705
MOD_GSK3_1	24	31	PF00069	0.568
MOD_GSK3_1	275	282	PF00069	0.789
MOD_GSK3_1	303	310	PF00069	0.714
MOD_GSK3_1	329	336	PF00069	0.782
MOD_GSK3_1	342	349	PF00069	0.612
MOD_GSK3_1	350	357	PF00069	0.711
MOD_GSK3_1	360	367	PF00069	0.561
MOD_GSK3_1	416	423	PF00069	0.639
MOD_GSK3_1	425	432	PF00069	0.678
MOD_GSK3_1	474	481	PF00069	0.577
MOD_GSK3_1	557	564	PF00069	0.557
MOD_GSK3_1	578	585	PF00069	0.643
MOD_GSK3_1	590	597	PF00069	0.553
MOD_GSK3_1	60	67	PF00069	0.655
MOD_GSK3_1	614	621	PF00069	0.827
MOD_GSK3_1	692	699	PF00069	0.693
MOD_GSK3_1	7	14	PF00069	0.708
MOD_GSK3_1	708	715	PF00069	0.676
MOD_GSK3_1	721	728	PF00069	0.718
MOD_GSK3_1	755	762	PF00069	0.693
MOD_GSK3_1	777	784	PF00069	0.647
MOD_GSK3_1	800	807	PF00069	0.688
MOD_GSK3_1	816	823	PF00069	0.724
MOD_GSK3_1	830	837	PF00069	0.552
MOD_GSK3_1	862	869	PF00069	0.641
MOD_GSK3_1	891	898	PF00069	0.785
MOD_LATS_1	511	517	PF00433	0.569
MOD_N-GLC_1	194	199	PF02516	0.599
MOD_N-GLC_1	220	225	PF02516	0.607
MOD_N-GLC_1	275	280	PF02516	0.631
MOD_N-GLC_1	349	354	PF02516	0.776
MOD_N-GLC_1	429	434	PF02516	0.772
MOD_N-GLC_1	823	828	PF02516	0.698
MOD_N-GLC_2	73	75	PF02516	0.672
MOD_NEK2_1	222	227	PF00069	0.725
MOD_NEK2_1	290	295	PF00069	0.586
MOD_NEK2_1	424	429	PF00069	0.614
MOD_NEK2_1	478	483	PF00069	0.561
MOD_NEK2_1	561	566	PF00069	0.543
MOD_NEK2_1	567	572	PF00069	0.515
MOD_NEK2_1	582	587	PF00069	0.674
MOD_NEK2_1	646	651	PF00069	0.692
MOD_NEK2_1	816	821	PF00069	0.765
MOD_NEK2_1	830	835	PF00069	0.558
MOD_NEK2_1	862	867	PF00069	0.639
MOD_NEK2_2	232	237	PF00069	0.687
MOD_NEK2_2	496	501	PF00069	0.535
MOD_PIKK_1	478	484	PF00454	0.565
MOD_PIKK_1	627	633	PF00454	0.697
MOD_PIKK_1	734	740	PF00454	0.644
MOD_PIKK_1	864	870	PF00454	0.717
MOD_PIKK_1	902	908	PF00454	0.686
MOD_PK_1	360	366	PF00069	0.717
MOD_PKA_1	420	426	PF00069	0.629
MOD_PKA_1	458	464	PF00069	0.667
MOD_PKA_1	48	54	PF00069	0.580
MOD_PKA_1	513	519	PF00069	0.561
MOD_PKA_2	244	250	PF00069	0.654
MOD_PKA_2	350	356	PF00069	0.670
MOD_PKA_2	419	425	PF00069	0.640
MOD_PKA_2	48	54	PF00069	0.580
MOD_PKA_2	513	519	PF00069	0.561
MOD_PKA_2	578	584	PF00069	0.581
MOD_PKA_2	659	665	PF00069	0.628
MOD_PKA_2	700	706	PF00069	0.787
MOD_PKA_2	777	783	PF00069	0.644
MOD_PKA_2	807	813	PF00069	0.577
MOD_PKA_2	863	869	PF00069	0.563
MOD_PKB_1	575	583	PF00069	0.543
MOD_Plk_1	194	200	PF00069	0.586
MOD_Plk_1	429	435	PF00069	0.704
MOD_Plk_1	502	508	PF00069	0.613
MOD_Plk_1	604	610	PF00069	0.778
MOD_Plk_1	902	908	PF00069	0.563
MOD_Plk_2-3	503	509	PF00069	0.560
MOD_Plk_4	214	220	PF00069	0.556
MOD_Plk_4	232	238	PF00069	0.608
MOD_Plk_4	354	360	PF00069	0.661
MOD_Plk_4	474	480	PF00069	0.650
MOD_Plk_4	496	502	PF00069	0.577
MOD_Plk_4	561	567	PF00069	0.699
MOD_Plk_4	594	600	PF00069	0.746
MOD_Plk_4	869	875	PF00069	0.623
MOD_ProDKin_1	21	27	PF00069	0.591
MOD_ProDKin_1	257	263	PF00069	0.664
MOD_ProDKin_1	28	34	PF00069	0.650
MOD_ProDKin_1	303	309	PF00069	0.817
MOD_ProDKin_1	342	348	PF00069	0.791
MOD_ProDKin_1	389	395	PF00069	0.752
MOD_ProDKin_1	405	411	PF00069	0.550
MOD_ProDKin_1	5	11	PF00069	0.740
MOD_ProDKin_1	590	596	PF00069	0.705
MOD_ProDKin_1	599	605	PF00069	0.538
MOD_ProDKin_1	618	624	PF00069	0.737
MOD_ProDKin_1	629	635	PF00069	0.604
MOD_ProDKin_1	784	790	PF00069	0.620
MOD_ProDKin_1	795	801	PF00069	0.643
MOD_ProDKin_1	898	904	PF00069	0.572
MOD_SUMO_for_1	670	673	PF00179	0.612
MOD_SUMO_rev_2	278	287	PF00179	0.689
MOD_SUMO_rev_2	885	893	PF00179	0.656
TRG_DiLeu_BaEn_2	473	479	PF01217	0.536
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.611
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.634
TRG_ENDOCYTIC_2	483	486	PF00928	0.524
TRG_ENDOCYTIC_2	501	504	PF00928	0.532
TRG_ENDOCYTIC_2	93	96	PF00928	0.559
TRG_ER_diArg_1	114	117	PF00400	0.720
TRG_ER_diArg_1	413	415	PF00400	0.600
TRG_ER_diArg_1	534	537	PF00400	0.501
TRG_ER_diArg_1	574	577	PF00400	0.538
TRG_ER_diArg_1	700	702	PF00400	0.794
TRG_ER_diArg_1	741	743	PF00400	0.792
TRG_ER_diArg_1	927	929	PF00400	0.524
TRG_NLS_MonoCore_2	853	858	PF00514	0.583
TRG_NLS_MonoExtN_4	852	858	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC30	Leptomonas seymouri	35%	94%
A0A3Q8IGY8	Leishmania donovani	100%	100%
A4HAF9	Leishmania braziliensis	59%	98%
E9B4L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	95%
Q4Q3G3	Leishmania major	87%	100%