Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9L2_LEIIN

TriTrypDb:

LINF_340009300

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9L2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.653
CLV_MEL_PAP_1	194	200	PF00089	0.566
CLV_NRD_NRD_1	287	289	PF00675	0.557
CLV_NRD_NRD_1	406	408	PF00675	0.482
CLV_NRD_NRD_1	98	100	PF00675	0.765
CLV_PCSK_KEX2_1	286	288	PF00082	0.504
CLV_PCSK_KEX2_1	406	408	PF00082	0.482
CLV_PCSK_KEX2_1	98	100	PF00082	0.757
CLV_PCSK_SKI1_1	180	184	PF00082	0.636
CLV_PCSK_SKI1_1	224	228	PF00082	0.625
CLV_PCSK_SKI1_1	340	344	PF00082	0.517
CLV_Separin_Metazoa	366	370	PF03568	0.522
DEG_APCC_DBOX_1	196	204	PF00400	0.602
DOC_CKS1_1	68	73	PF01111	0.706
DOC_CKS1_1	85	90	PF01111	0.542
DOC_MAPK_gen_1	246	254	PF00069	0.587
DOC_MAPK_gen_1	389	396	PF00069	0.656
DOC_MAPK_MEF2A_6	192	200	PF00069	0.569
DOC_MAPK_MEF2A_6	248	256	PF00069	0.565
DOC_PP1_RVXF_1	367	373	PF00149	0.521
DOC_PP2B_LxvP_1	256	259	PF13499	0.590
DOC_USP7_MATH_1	117	121	PF00917	0.750
DOC_USP7_MATH_1	122	126	PF00917	0.560
DOC_USP7_MATH_1	145	149	PF00917	0.683
DOC_USP7_MATH_1	174	178	PF00917	0.657
DOC_USP7_MATH_1	196	200	PF00917	0.482
DOC_USP7_MATH_1	210	214	PF00917	0.567
DOC_USP7_MATH_1	322	326	PF00917	0.652
DOC_USP7_MATH_1	349	353	PF00917	0.555
DOC_WW_Pin1_4	107	112	PF00397	0.704
DOC_WW_Pin1_4	113	118	PF00397	0.731
DOC_WW_Pin1_4	170	175	PF00397	0.690
DOC_WW_Pin1_4	271	276	PF00397	0.745
DOC_WW_Pin1_4	67	72	PF00397	0.674
DOC_WW_Pin1_4	84	89	PF00397	0.818
DOC_WW_Pin1_4	9	14	PF00397	0.635
LIG_14-3-3_CanoR_1	197	201	PF00244	0.592
LIG_14-3-3_CanoR_1	271	275	PF00244	0.704
LIG_14-3-3_CanoR_1	288	298	PF00244	0.286
LIG_14-3-3_CanoR_1	321	329	PF00244	0.669
LIG_14-3-3_CanoR_1	395	402	PF00244	0.639
LIG_14-3-3_CanoR_1	411	418	PF00244	0.588
LIG_Actin_WH2_2	187	203	PF00022	0.575
LIG_BRCT_BRCA1_1	29	33	PF00533	0.567
LIG_Clathr_ClatBox_1	157	161	PF01394	0.605
LIG_FHA_1	144	150	PF00498	0.679
LIG_FHA_1	227	233	PF00498	0.489
LIG_FHA_1	37	43	PF00498	0.654
LIG_FHA_2	167	173	PF00498	0.655
LIG_FHA_2	183	189	PF00498	0.345
LIG_FHA_2	374	380	PF00498	0.664
LIG_FHA_2	383	389	PF00498	0.700
LIG_GBD_Chelix_1	132	140	PF00786	0.455
LIG_HP1_1	196	200	PF01393	0.579
LIG_LIR_Apic_2	12	17	PF02991	0.620
LIG_LIR_Gen_1	181	190	PF02991	0.584
LIG_LIR_Nem_3	181	186	PF02991	0.603
LIG_SH2_PTP2	14	17	PF00017	0.737
LIG_SH2_SRC	14	17	PF00017	0.665
LIG_SH2_STAT3	231	234	PF00017	0.569
LIG_SH2_STAT5	14	17	PF00017	0.744
LIG_SH2_STAT5	231	234	PF00017	0.569
LIG_SH2_STAT5	38	41	PF00017	0.501
LIG_SH3_1	10	16	PF00018	0.661
LIG_SH3_1	168	174	PF00018	0.703
LIG_SH3_3	10	16	PF00018	0.735
LIG_SH3_3	168	174	PF00018	0.777
LIG_SH3_3	82	88	PF00018	0.798
LIG_SH3_3	91	97	PF00018	0.700
LIG_SUMO_SIM_anti_2	249	255	PF11976	0.471
LIG_SUMO_SIM_par_1	156	161	PF11976	0.596
LIG_SUMO_SIM_par_1	249	255	PF11976	0.499
LIG_SUMO_SIM_par_1	352	359	PF11976	0.514
LIG_TRAF2_1	112	115	PF00917	0.703
LIG_WRC_WIRS_1	4	9	PF05994	0.679
MOD_CDK_SPxK_1	67	73	PF00069	0.658
MOD_CK1_1	163	169	PF00069	0.622
MOD_CK1_1	269	275	PF00069	0.732
MOD_CK1_1	276	282	PF00069	0.613
MOD_CK1_1	356	362	PF00069	0.646
MOD_CK1_1	390	396	PF00069	0.718
MOD_CK2_1	2	8	PF00069	0.763
MOD_CK2_1	373	379	PF00069	0.707
MOD_CK2_1	382	388	PF00069	0.614
MOD_GlcNHglycan	124	127	PF01048	0.598
MOD_GlcNHglycan	324	327	PF01048	0.742
MOD_GlcNHglycan	413	416	PF01048	0.558
MOD_GlcNHglycan	50	54	PF01048	0.693
MOD_GlcNHglycan	88	91	PF01048	0.761
MOD_GSK3_1	113	120	PF00069	0.695
MOD_GSK3_1	145	152	PF00069	0.657
MOD_GSK3_1	166	173	PF00069	0.703
MOD_GSK3_1	242	249	PF00069	0.520
MOD_GSK3_1	262	269	PF00069	0.539
MOD_GSK3_1	276	283	PF00069	0.530
MOD_GSK3_1	329	336	PF00069	0.640
MOD_GSK3_1	343	350	PF00069	0.437
MOD_GSK3_1	378	385	PF00069	0.731
MOD_GSK3_1	390	397	PF00069	0.524
MOD_N-GLC_1	143	148	PF02516	0.548
MOD_NEK2_1	121	126	PF00069	0.633
MOD_NEK2_1	160	165	PF00069	0.594
MOD_NEK2_1	182	187	PF00069	0.600
MOD_NEK2_1	226	231	PF00069	0.429
MOD_NEK2_1	254	259	PF00069	0.556
MOD_NEK2_1	263	268	PF00069	0.510
MOD_NEK2_1	270	275	PF00069	0.507
MOD_NEK2_1	343	348	PF00069	0.508
MOD_NEK2_1	355	360	PF00069	0.543
MOD_NEK2_1	394	399	PF00069	0.640
MOD_NEK2_2	196	201	PF00069	0.594
MOD_OFUCOSY	35	40	PF10250	0.638
MOD_PIKK_1	289	295	PF00454	0.422
MOD_PIKK_1	304	310	PF00454	0.440
MOD_PIKK_1	349	355	PF00454	0.545
MOD_PIKK_1	394	400	PF00454	0.592
MOD_PK_1	246	252	PF00069	0.498
MOD_PKA_2	196	202	PF00069	0.599
MOD_PKA_2	270	276	PF00069	0.714
MOD_PKA_2	320	326	PF00069	0.653
MOD_PKA_2	390	396	PF00069	0.643
MOD_PKA_2	64	70	PF00069	0.723
MOD_Plk_1	254	260	PF00069	0.527
MOD_Plk_4	160	166	PF00069	0.679
MOD_Plk_4	227	233	PF00069	0.489
MOD_ProDKin_1	107	113	PF00069	0.701
MOD_ProDKin_1	170	176	PF00069	0.686
MOD_ProDKin_1	271	277	PF00069	0.749
MOD_ProDKin_1	67	73	PF00069	0.673
MOD_ProDKin_1	84	90	PF00069	0.822
MOD_ProDKin_1	9	15	PF00069	0.638
MOD_SUMO_for_1	281	284	PF00179	0.584
MOD_SUMO_rev_2	274	283	PF00179	0.725
TRG_DiLeu_BaEn_1	366	371	PF01217	0.517
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.596
TRG_DiLeu_LyEn_5	366	371	PF01217	0.517
TRG_ER_diArg_1	285	288	PF00400	0.600
TRG_ER_diArg_1	406	408	PF00400	0.539
TRG_ER_diArg_1	97	99	PF00400	0.731
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW8	Leptomonas seymouri	39%	72%
A0A3S7X7D6	Leishmania donovani	99%	100%
A4HAF6	Leishmania braziliensis	70%	98%
E9B4L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3G6	Leishmania major	91%	100%