Deoxyhypusine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyhypusine synthase

Species:

Leishmania infantum

UniProt:

A4I9K3_LEIIN

TriTrypDb:

LINF_340008400

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I9K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9K3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	3	12
GO:0009058	biosynthetic process	2	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018205	peptidyl-lysine modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0051604	protein maturation	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	5
GO:0034038	deoxyhypusine synthase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.356
CLV_NRD_NRD_1	193	195	PF00675	0.348
CLV_NRD_NRD_1	417	419	PF00675	0.673
CLV_NRD_NRD_1	437	439	PF00675	0.481
CLV_NRD_NRD_1	64	66	PF00675	0.421
CLV_PCSK_FUR_1	152	156	PF00082	0.375
CLV_PCSK_KEX2_1	154	156	PF00082	0.381
CLV_PCSK_KEX2_1	193	195	PF00082	0.370
CLV_PCSK_KEX2_1	435	437	PF00082	0.620
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.381
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.604
CLV_PCSK_SKI1_1	432	436	PF00082	0.634
CLV_PCSK_SKI1_1	79	83	PF00082	0.441
CLV_Separin_Metazoa	170	174	PF03568	0.447
DEG_SPOP_SBC_1	440	444	PF00917	0.601
DOC_CKS1_1	406	411	PF01111	0.517
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	82	85	PF00134	0.302
DOC_PP2B_LxvP_1	82	85	PF13499	0.302
DOC_SPAK_OSR1_1	121	125	PF12202	0.417
DOC_USP7_MATH_1	327	331	PF00917	0.557
DOC_USP7_MATH_1	428	432	PF00917	0.621
DOC_USP7_MATH_1	440	444	PF00917	0.543
DOC_USP7_UBL2_3	435	439	PF12436	0.620
DOC_WW_Pin1_4	302	307	PF00397	0.404
DOC_WW_Pin1_4	390	395	PF00397	0.337
DOC_WW_Pin1_4	405	410	PF00397	0.475
LIG_14-3-3_CanoR_1	173	178	PF00244	0.528
LIG_14-3-3_CanoR_1	193	201	PF00244	0.396
LIG_14-3-3_CanoR_1	334	341	PF00244	0.685
LIG_14-3-3_CanoR_1	375	381	PF00244	0.417
LIG_Actin_WH2_2	269	286	PF00022	0.488
LIG_BIR_II_1	1	5	PF00653	0.408
LIG_BRCT_BRCA1_1	261	265	PF00533	0.404
LIG_BRCT_BRCA1_1	392	396	PF00533	0.355
LIG_deltaCOP1_diTrp_1	308	316	PF00928	0.398
LIG_DLG_GKlike_1	173	181	PF00625	0.478
LIG_FHA_1	106	112	PF00498	0.284
LIG_FHA_1	330	336	PF00498	0.523
LIG_FHA_1	376	382	PF00498	0.442
LIG_FHA_1	400	406	PF00498	0.513
LIG_FHA_2	258	264	PF00498	0.559
LIG_FHA_2	303	309	PF00498	0.425
LIG_GBD_Chelix_1	317	325	PF00786	0.445
LIG_GBD_Chelix_1	55	63	PF00786	0.350
LIG_HCF-1_HBM_1	97	100	PF13415	0.400
LIG_LIR_Apic_2	159	164	PF02991	0.514
LIG_LIR_Apic_2	402	407	PF02991	0.549
LIG_LIR_Gen_1	262	273	PF02991	0.353
LIG_LIR_Gen_1	294	304	PF02991	0.439
LIG_LIR_Gen_1	42	50	PF02991	0.426
LIG_LIR_Gen_1	77	87	PF02991	0.417
LIG_LIR_Nem_3	262	268	PF02991	0.349
LIG_LIR_Nem_3	294	299	PF02991	0.459
LIG_LIR_Nem_3	77	83	PF02991	0.417
LIG_LIR_Nem_3	97	103	PF02991	0.308
LIG_LYPXL_S_1	99	103	PF13949	0.417
LIG_LYPXL_yS_3	100	103	PF13949	0.417
LIG_NRP_CendR_1	452	454	PF00754	0.451
LIG_Pex14_2	392	396	PF04695	0.399
LIG_PTB_Apo_2	248	255	PF02174	0.381
LIG_PTB_Phospho_1	248	254	PF10480	0.383
LIG_SH2_CRK	161	165	PF00017	0.573
LIG_SH2_PTP2	80	83	PF00017	0.350
LIG_SH2_SRC	296	299	PF00017	0.440
LIG_SH2_STAP1	204	208	PF00017	0.607
LIG_SH2_STAT3	254	257	PF00017	0.524
LIG_SH2_STAT5	157	160	PF00017	0.477
LIG_SH2_STAT5	199	202	PF00017	0.488
LIG_SH2_STAT5	404	407	PF00017	0.556
LIG_SH2_STAT5	80	83	PF00017	0.417
LIG_SH3_1	161	167	PF00018	0.515
LIG_SH3_3	161	167	PF00018	0.570
LIG_SH3_3	23	29	PF00018	0.422
LIG_SH3_3	249	255	PF00018	0.405
LIG_SH3_3	78	84	PF00018	0.455
LIG_TRAF2_1	167	170	PF00917	0.484
LIG_TRFH_1	80	84	PF08558	0.350
LIG_UBA3_1	149	154	PF00899	0.501
LIG_WRC_WIRS_1	269	274	PF05994	0.322
MOD_CK1_1	12	18	PF00069	0.516
MOD_CK1_1	214	220	PF00069	0.749
MOD_CK1_1	259	265	PF00069	0.512
MOD_CK1_1	330	336	PF00069	0.552
MOD_CK1_1	390	396	PF00069	0.455
MOD_CK1_1	42	48	PF00069	0.447
MOD_CK1_1	441	447	PF00069	0.749
MOD_CK2_1	257	263	PF00069	0.567
MOD_CK2_1	302	308	PF00069	0.435
MOD_GlcNHglycan	12	15	PF01048	0.478
MOD_GlcNHglycan	134	138	PF01048	0.673
MOD_GlcNHglycan	139	142	PF01048	0.603
MOD_GlcNHglycan	183	186	PF01048	0.335
MOD_GlcNHglycan	30	33	PF01048	0.491
MOD_GlcNHglycan	336	339	PF01048	0.672
MOD_GlcNHglycan	364	367	PF01048	0.475
MOD_GlcNHglycan	446	449	PF01048	0.753
MOD_GlcNHglycan	6	9	PF01048	0.458
MOD_GSK3_1	129	136	PF00069	0.546
MOD_GSK3_1	137	144	PF00069	0.617
MOD_GSK3_1	210	217	PF00069	0.697
MOD_GSK3_1	298	305	PF00069	0.416
MOD_GSK3_1	329	336	PF00069	0.558
MOD_GSK3_1	434	441	PF00069	0.700
MOD_GSK3_1	9	16	PF00069	0.483
MOD_LATS_1	417	423	PF00433	0.619
MOD_NEK2_1	10	15	PF00069	0.503
MOD_NEK2_1	105	110	PF00069	0.283
MOD_NEK2_1	111	116	PF00069	0.264
MOD_NEK2_1	133	138	PF00069	0.727
MOD_NEK2_1	268	273	PF00069	0.438
MOD_NEK2_1	434	439	PF00069	0.573
MOD_NEK2_1	48	53	PF00069	0.287
MOD_NEK2_1	55	60	PF00069	0.295
MOD_PIKK_1	21	27	PF00454	0.456
MOD_PK_1	419	425	PF00069	0.614
MOD_PKA_1	438	444	PF00069	0.584
MOD_PKA_2	333	339	PF00069	0.669
MOD_PKA_2	376	382	PF00069	0.440
MOD_PKB_1	436	444	PF00069	0.586
MOD_Plk_1	399	405	PF00069	0.399
MOD_Plk_4	173	179	PF00069	0.494
MOD_Plk_4	376	382	PF00069	0.328
MOD_Plk_4	387	393	PF00069	0.331
MOD_Plk_4	400	406	PF00069	0.463
MOD_ProDKin_1	302	308	PF00069	0.397
MOD_ProDKin_1	390	396	PF00069	0.336
MOD_ProDKin_1	405	411	PF00069	0.485
MOD_SUMO_for_1	153	156	PF00179	0.508
MOD_SUMO_rev_2	431	437	PF00179	0.593
MOD_SUMO_rev_2	86	94	PF00179	0.381
TRG_DiLeu_BaEn_1	6	11	PF01217	0.544
TRG_DiLeu_BaEn_2	117	123	PF01217	0.308
TRG_ENDOCYTIC_2	100	103	PF00928	0.397
TRG_ENDOCYTIC_2	296	299	PF00928	0.443
TRG_ENDOCYTIC_2	43	46	PF00928	0.308
TRG_ENDOCYTIC_2	80	83	PF00928	0.417
TRG_ER_diArg_1	192	194	PF00400	0.343
TRG_NLS_Bipartite_1	418	439	PF00514	0.592
TRG_NLS_MonoExtC_3	434	439	PF00514	0.596
TRG_NLS_MonoExtN_4	432	439	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXU4	Leptomonas seymouri	52%	75%
A0A0S4KFM4	Bodo saltans	26%	100%
A0A1X0P8R7	Trypanosomatidae	34%	88%
A0A3Q8IH77	Leishmania donovani	100%	76%
A0A422NFI0	Trypanosoma rangeli	33%	96%
A4HAE7	Leishmania braziliensis	75%	100%
B5APK2	Leishmania donovani	99%	76%
D0A1W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	98%
E9B4K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q38BX0	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	34%	98%
Q4Q3H5	Leishmania major	93%	100%
V5BRS6	Trypanosoma cruzi	36%	97%