Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pyridine nucleotide-disulphide oxidoreductase - putative

Species:

Leishmania infantum

UniProt:

A4I9J7_LEIIN

TriTrypDb:

LINF_340007800

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	4
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I9J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9J7

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019418	sulfide oxidation	4	1
GO:0044237	cellular metabolic process	2	1
GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0070224	sulfide:quinone oxidoreductase activity	5	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.416
CLV_C14_Caspase3-7	366	370	PF00656	0.450
CLV_NRD_NRD_1	198	200	PF00675	0.512
CLV_NRD_NRD_1	2	4	PF00675	0.677
CLV_NRD_NRD_1	546	548	PF00675	0.597
CLV_NRD_NRD_1	558	560	PF00675	0.595
CLV_NRD_NRD_1	563	565	PF00675	0.592
CLV_NRD_NRD_1	591	593	PF00675	0.522
CLV_NRD_NRD_1	67	69	PF00675	0.501
CLV_PCSK_KEX2_1	198	200	PF00082	0.512
CLV_PCSK_KEX2_1	2	4	PF00082	0.677
CLV_PCSK_KEX2_1	546	548	PF00082	0.597
CLV_PCSK_KEX2_1	558	560	PF00082	0.599
CLV_PCSK_KEX2_1	591	593	PF00082	0.522
CLV_PCSK_KEX2_1	69	71	PF00082	0.455
CLV_PCSK_KEX2_1	714	716	PF00082	0.635
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.399
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.635
CLV_PCSK_SKI1_1	163	167	PF00082	0.525
CLV_PCSK_SKI1_1	171	175	PF00082	0.492
CLV_PCSK_SKI1_1	64	68	PF00082	0.497
CLV_PCSK_SKI1_1	740	744	PF00082	0.616
CLV_Separin_Metazoa	154	158	PF03568	0.279
CLV_Separin_Metazoa	644	648	PF03568	0.483
CLV_Separin_Metazoa	65	69	PF03568	0.692
DEG_APCC_DBOX_1	2	10	PF00400	0.477
DEG_APCC_DBOX_1	267	275	PF00400	0.398
DEG_APCC_DBOX_1	739	747	PF00400	0.416
DEG_COP1_1	768	777	PF00400	0.368
DEG_Nend_UBRbox_1	1	4	PF02207	0.479
DEG_SCF_FBW7_1	324	330	PF00400	0.518
DOC_CKS1_1	324	329	PF01111	0.563
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.304
DOC_MAPK_gen_1	105	112	PF00069	0.340
DOC_MAPK_gen_1	188	196	PF00069	0.294
DOC_MAPK_gen_1	198	206	PF00069	0.252
DOC_MAPK_gen_1	2	11	PF00069	0.478
DOC_MAPK_gen_1	68	78	PF00069	0.554
DOC_MAPK_HePTP_8	196	208	PF00069	0.303
DOC_MAPK_MEF2A_6	198	206	PF00069	0.303
DOC_MAPK_MEF2A_6	502	509	PF00069	0.272
DOC_PP2B_LxvP_1	516	519	PF13499	0.301
DOC_PP2B_LxvP_1	520	523	PF13499	0.307
DOC_PP4_FxxP_1	345	348	PF00568	0.503
DOC_PP4_FxxP_1	772	775	PF00568	0.367
DOC_USP7_MATH_1	239	243	PF00917	0.340
DOC_USP7_MATH_1	306	310	PF00917	0.560
DOC_USP7_MATH_1	331	335	PF00917	0.550
DOC_USP7_MATH_1	82	86	PF00917	0.403
DOC_USP7_UBL2_3	13	17	PF12436	0.451
DOC_USP7_UBL2_3	662	666	PF12436	0.408
DOC_WW_Pin1_4	135	140	PF00397	0.279
DOC_WW_Pin1_4	318	323	PF00397	0.458
DOC_WW_Pin1_4	335	340	PF00397	0.520
DOC_WW_Pin1_4	361	366	PF00397	0.522
DOC_WW_Pin1_4	389	394	PF00397	0.438
DOC_WW_Pin1_4	701	706	PF00397	0.494
DOC_WW_Pin1_4	765	770	PF00397	0.391
DOC_WW_Pin1_4	775	780	PF00397	0.361
LIG_14-3-3_CanoR_1	205	213	PF00244	0.285
LIG_14-3-3_CanoR_1	297	303	PF00244	0.425
LIG_14-3-3_CanoR_1	58	67	PF00244	0.625
LIG_14-3-3_CanoR_1	697	705	PF00244	0.453
LIG_Actin_WH2_2	344	361	PF00022	0.449
LIG_Actin_WH2_2	37	55	PF00022	0.322
LIG_Actin_WH2_2	530	548	PF00022	0.308
LIG_Actin_WH2_2	83	101	PF00022	0.403
LIG_BRCT_BRCA1_1	28	32	PF00533	0.397
LIG_CaM_NSCaTE_8	354	361	PF13499	0.434
LIG_Clathr_ClatBox_1	513	517	PF01394	0.301
LIG_EVH1_2	285	289	PF00568	0.324
LIG_FHA_1	208	214	PF00498	0.362
LIG_FHA_1	255	261	PF00498	0.456
LIG_FHA_1	33	39	PF00498	0.294
LIG_FHA_1	342	348	PF00498	0.494
LIG_FHA_1	41	47	PF00498	0.261
LIG_FHA_1	781	787	PF00498	0.434
LIG_FHA_2	129	135	PF00498	0.340
LIG_FHA_2	264	270	PF00498	0.415
LIG_FHA_2	495	501	PF00498	0.349
LIG_FHA_2	564	570	PF00498	0.371
LIG_FHA_2	786	792	PF00498	0.440
LIG_FHA_2	99	105	PF00498	0.279
LIG_LIR_Apic_2	344	348	PF02991	0.500
LIG_LIR_Apic_2	686	692	PF02991	0.436
LIG_LIR_Apic_2	770	775	PF02991	0.372
LIG_LIR_Gen_1	229	237	PF02991	0.279
LIG_LIR_Gen_1	47	55	PF02991	0.351
LIG_LIR_Gen_1	476	486	PF02991	0.370
LIG_LIR_Gen_1	577	588	PF02991	0.323
LIG_LIR_Gen_1	668	677	PF02991	0.376
LIG_LIR_LC3C_4	231	235	PF02991	0.340
LIG_LIR_Nem_3	229	233	PF02991	0.279
LIG_LIR_Nem_3	419	424	PF02991	0.331
LIG_LIR_Nem_3	47	52	PF02991	0.403
LIG_LIR_Nem_3	476	481	PF02991	0.380
LIG_LIR_Nem_3	577	583	PF02991	0.321
LIG_LIR_Nem_3	610	614	PF02991	0.347
LIG_LIR_Nem_3	668	673	PF02991	0.369
LIG_LIR_Nem_3	733	739	PF02991	0.389
LIG_LIR_Nem_3	754	760	PF02991	0.379
LIG_LIR_Nem_3	768	774	PF02991	0.371
LIG_LIR_Nem_3	776	780	PF02991	0.358
LIG_LIR_Nem_3	788	792	PF02991	0.305
LIG_PALB2_WD40_1	350	358	PF16756	0.430
LIG_PCNA_TLS_4	567	574	PF02747	0.396
LIG_PCNA_yPIPBox_3	450	460	PF02747	0.366
LIG_PDZ_Class_3	788	793	PF00595	0.469
LIG_Pex14_1	400	404	PF04695	0.351
LIG_Pex14_2	478	482	PF04695	0.357
LIG_PTB_Apo_2	741	748	PF02174	0.357
LIG_Rb_pABgroove_1	493	501	PF01858	0.373
LIG_SH2_CRK	230	234	PF00017	0.279
LIG_SH2_CRK	427	431	PF00017	0.357
LIG_SH2_CRK	435	439	PF00017	0.306
LIG_SH2_CRK	511	515	PF00017	0.347
LIG_SH2_CRK	611	615	PF00017	0.348
LIG_SH2_GRB2like	426	429	PF00017	0.428
LIG_SH2_NCK_1	125	129	PF00017	0.340
LIG_SH2_NCK_1	593	597	PF00017	0.312
LIG_SH2_NCK_1	689	693	PF00017	0.451
LIG_SH2_NCK_1	777	781	PF00017	0.416
LIG_SH2_SRC	125	128	PF00017	0.340
LIG_SH2_SRC	593	596	PF00017	0.377
LIG_SH2_SRC	689	692	PF00017	0.369
LIG_SH2_STAP1	230	234	PF00017	0.279
LIG_SH2_STAP1	593	597	PF00017	0.312
LIG_SH2_STAP1	753	757	PF00017	0.388
LIG_SH2_STAT5	10	13	PF00017	0.482
LIG_SH2_STAT5	423	426	PF00017	0.339
LIG_SH2_STAT5	485	488	PF00017	0.305
LIG_SH2_STAT5	536	539	PF00017	0.344
LIG_SH2_STAT5	667	670	PF00017	0.348
LIG_SH2_STAT5	757	760	PF00017	0.397
LIG_SH2_STAT5	773	776	PF00017	0.373
LIG_SH3_2	12	17	PF14604	0.474
LIG_SH3_3	133	139	PF00018	0.340
LIG_SH3_3	279	285	PF00018	0.371
LIG_SH3_3	441	447	PF00018	0.321
LIG_SH3_3	504	510	PF00018	0.318
LIG_SH3_3	640	646	PF00018	0.452
LIG_SH3_3	655	661	PF00018	0.522
LIG_SH3_3	716	722	PF00018	0.377
LIG_SH3_3	781	787	PF00018	0.366
LIG_SH3_3	9	15	PF00018	0.478
LIG_SUMO_SIM_anti_2	129	138	PF11976	0.340
LIG_SUMO_SIM_par_1	42	47	PF11976	0.351
LIG_SUMO_SIM_par_1	512	517	PF11976	0.307
LIG_TYR_ITIM	509	514	PF00017	0.370
LIG_TYR_ITIM	755	760	PF00017	0.378
LIG_WRC_WIRS_1	670	675	PF05994	0.376
MOD_CDK_SPK_2	780	785	PF00069	0.376
MOD_CDK_SPxxK_3	318	325	PF00069	0.496
MOD_CK1_1	209	215	PF00069	0.343
MOD_CK1_1	222	228	PF00069	0.228
MOD_CK1_1	242	248	PF00069	0.183
MOD_CK1_1	346	352	PF00069	0.450
MOD_CK1_1	416	422	PF00069	0.320
MOD_CK1_1	59	65	PF00069	0.626
MOD_CK1_1	607	613	PF00069	0.405
MOD_CK1_1	648	654	PF00069	0.502
MOD_CK1_1	700	706	PF00069	0.492
MOD_CK2_1	335	341	PF00069	0.557
MOD_CK2_1	563	569	PF00069	0.454
MOD_CK2_1	59	65	PF00069	0.626
MOD_CK2_1	98	104	PF00069	0.279
MOD_GlcNHglycan	275	278	PF01048	0.560
MOD_GlcNHglycan	306	309	PF01048	0.748
MOD_GlcNHglycan	384	387	PF01048	0.690
MOD_GlcNHglycan	470	473	PF01048	0.649
MOD_GlcNHglycan	528	531	PF01048	0.531
MOD_GlcNHglycan	614	617	PF01048	0.564
MOD_GlcNHglycan	649	653	PF01048	0.697
MOD_GlcNHglycan	84	87	PF01048	0.403
MOD_GlcNHglycan	93	96	PF01048	0.469
MOD_GSK3_1	175	182	PF00069	0.235
MOD_GSK3_1	215	222	PF00069	0.336
MOD_GSK3_1	306	313	PF00069	0.507
MOD_GSK3_1	323	330	PF00069	0.479
MOD_GSK3_1	331	338	PF00069	0.565
MOD_GSK3_1	343	350	PF00069	0.542
MOD_GSK3_1	382	389	PF00069	0.442
MOD_GSK3_1	40	47	PF00069	0.372
MOD_GSK3_1	408	415	PF00069	0.338
MOD_GSK3_1	665	672	PF00069	0.351
MOD_GSK3_1	697	704	PF00069	0.489
MOD_N-GLC_1	142	147	PF02516	0.479
MOD_N-GLC_1	219	224	PF02516	0.476
MOD_NEK2_1	1	6	PF00069	0.477
MOD_NEK2_1	166	171	PF00069	0.303
MOD_NEK2_1	206	211	PF00069	0.303
MOD_NEK2_1	316	321	PF00069	0.529
MOD_NEK2_1	32	37	PF00069	0.279
MOD_NEK2_1	387	392	PF00069	0.461
MOD_NEK2_1	402	407	PF00069	0.365
MOD_NEK2_1	413	418	PF00069	0.415
MOD_NEK2_1	481	486	PF00069	0.298
MOD_NEK2_1	563	568	PF00069	0.383
MOD_NEK2_1	730	735	PF00069	0.411
MOD_NEK2_1	759	764	PF00069	0.392
MOD_NEK2_1	98	103	PF00069	0.311
MOD_NEK2_2	354	359	PF00069	0.434
MOD_NEK2_2	669	674	PF00069	0.370
MOD_PIKK_1	26	32	PF00454	0.447
MOD_PIKK_1	628	634	PF00454	0.441
MOD_PIKK_1	697	703	PF00454	0.454
MOD_PKA_2	1	7	PF00069	0.476
MOD_PKA_2	167	173	PF00069	0.340
MOD_PKA_2	526	532	PF00069	0.328
MOD_PKA_2	563	569	PF00069	0.404
MOD_PKA_2	59	65	PF00069	0.631
MOD_PKB_1	380	388	PF00069	0.459
MOD_Plk_1	409	415	PF00069	0.339
MOD_Plk_1	576	582	PF00069	0.324
MOD_Plk_2-3	576	582	PF00069	0.324
MOD_Plk_4	223	229	PF00069	0.272
MOD_Plk_4	285	291	PF00069	0.400
MOD_Plk_4	40	46	PF00069	0.351
MOD_Plk_4	409	415	PF00069	0.339
MOD_Plk_4	416	422	PF00069	0.328
MOD_Plk_4	481	487	PF00069	0.299
MOD_Plk_4	494	500	PF00069	0.307
MOD_Plk_4	521	527	PF00069	0.358
MOD_Plk_4	576	582	PF00069	0.324
MOD_Plk_4	767	773	PF00069	0.379
MOD_ProDKin_1	135	141	PF00069	0.279
MOD_ProDKin_1	318	324	PF00069	0.461
MOD_ProDKin_1	335	341	PF00069	0.524
MOD_ProDKin_1	361	367	PF00069	0.524
MOD_ProDKin_1	389	395	PF00069	0.432
MOD_ProDKin_1	701	707	PF00069	0.493
MOD_ProDKin_1	765	771	PF00069	0.388
MOD_ProDKin_1	775	781	PF00069	0.361
MOD_SUMO_rev_2	159	165	PF00179	0.264
MOD_SUMO_rev_2	94	101	PF00179	0.303
TRG_DiLeu_BaEn_1	476	481	PF01217	0.380
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.371
TRG_ENDOCYTIC_2	230	233	PF00928	0.279
TRG_ENDOCYTIC_2	427	430	PF00928	0.355
TRG_ENDOCYTIC_2	435	438	PF00928	0.305
TRG_ENDOCYTIC_2	511	514	PF00928	0.347
TRG_ENDOCYTIC_2	593	596	PF00928	0.316
TRG_ENDOCYTIC_2	611	614	PF00928	0.349
TRG_ENDOCYTIC_2	670	673	PF00928	0.375
TRG_ENDOCYTIC_2	753	756	PF00928	0.384
TRG_ENDOCYTIC_2	757	760	PF00928	0.414
TRG_ENDOCYTIC_2	777	780	PF00928	0.256
TRG_ER_diArg_1	1	3	PF00400	0.482
TRG_ER_diArg_1	197	199	PF00400	0.315
TRG_ER_diArg_1	380	383	PF00400	0.402
TRG_ER_diArg_1	533	536	PF00400	0.350
TRG_ER_diArg_1	545	547	PF00400	0.372
TRG_ER_diArg_1	557	559	PF00400	0.402
TRG_ER_diArg_1	58	61	PF00400	0.624
TRG_ER_diArg_1	591	593	PF00400	0.322
TRG_ER_diArg_1	67	70	PF00400	0.618
TRG_NLS_Bipartite_1	546	568	PF00514	0.414
TRG_NLS_MonoCore_2	67	72	PF00514	0.580
TRG_NLS_MonoExtC_3	563	568	PF00514	0.407
TRG_NLS_MonoExtN_4	561	568	PF00514	0.404
TRG_NLS_MonoExtN_4	68	73	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A2	Leptomonas seymouri	56%	95%
A0A3Q8IMW0	Leishmania donovani	100%	100%
A4HAE5	Leishmania braziliensis	83%	100%
E9B4J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q3I1	Leishmania major	93%	100%