RIIa domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulatory subunit of type II PKA R-subunit - putative

Species:

Leishmania infantum

UniProt:

A4I9J6_LEIIN

TriTrypDb:

LINF_340007700

Length:

120

Annotations

Annotations by Jardim et al.

Protein kinase, Regulatory subunit of type II PKA R-subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9J6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	5	9	PF00082	0.638
DOC_CYCLIN_RxL_1	2	10	PF00134	0.595
LIG_BRCT_BRCA1_1	110	114	PF00533	0.411
LIG_BRCT_BRCA1_1	22	26	PF00533	0.621
LIG_FHA_1	2	8	PF00498	0.593
LIG_FHA_2	16	22	PF00498	0.694
LIG_FHA_2	42	48	PF00498	0.567
LIG_SH2_STAT5	108	111	PF00017	0.411
LIG_SH2_STAT5	75	78	PF00017	0.556
LIG_SH3_3	95	101	PF00018	0.367
LIG_TRAF2_1	44	47	PF00917	0.590
LIG_TRAF2_1	54	57	PF00917	0.468
LIG_TRAF2_1	85	88	PF00917	0.411
MOD_CK1_1	15	21	PF00069	0.666
MOD_CK2_1	15	21	PF00069	0.689
MOD_CK2_1	41	47	PF00069	0.520
MOD_CK2_1	51	57	PF00069	0.482
MOD_GlcNHglycan	9	12	PF01048	0.601
MOD_GSK3_1	15	22	PF00069	0.698
MOD_GSK3_1	31	38	PF00069	0.517
MOD_GSK3_1	60	67	PF00069	0.555
MOD_LATS_1	17	23	PF00433	0.612
MOD_NEK2_1	31	36	PF00069	0.696
MOD_NEK2_1	7	12	PF00069	0.600
MOD_PIKK_1	103	109	PF00454	0.426
MOD_Plk_1	15	21	PF00069	0.635
MOD_Plk_4	35	41	PF00069	0.651
TRG_DiLeu_BaEn_4	56	62	PF01217	0.526
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU2	Leptomonas seymouri	65%	100%
A0A3S7X7D0	Leishmania donovani	100%	100%
A4HAE4	Leishmania braziliensis	80%	100%
E9B4J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3I2	Leishmania major	95%	100%