LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
emp24/gp25L/p24 family/GOLD - putative
Species:
Leishmania infantum
UniProt:
A4I9J2_LEIIN
TriTrypDb:
LINF_340007300
Length:
335

Annotations

Annotations by Jardim et al.

Transporters, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 1
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005783 endoplasmic reticulum 5 1
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 5 1
GO:0005794 Golgi apparatus 5 1
GO:0030134 COPII-coated ER to Golgi transport vesicle 8 1
GO:0030135 coated vesicle 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

A4I9J2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9J2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 1
GO:0006996 organelle organization 4 1
GO:0007030 Golgi organization 5 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0016192 vesicle-mediated transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0048193 Golgi vesicle transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 106 110 PF00656 0.621
CLV_NRD_NRD_1 124 126 PF00675 0.404
CLV_NRD_NRD_1 246 248 PF00675 0.284
CLV_NRD_NRD_1 290 292 PF00675 0.269
CLV_PCSK_FUR_1 288 292 PF00082 0.269
CLV_PCSK_KEX2_1 124 126 PF00082 0.404
CLV_PCSK_KEX2_1 290 292 PF00082 0.269
CLV_PCSK_SKI1_1 235 239 PF00082 0.269
CLV_PCSK_SKI1_1 247 251 PF00082 0.269
CLV_PCSK_SKI1_1 273 277 PF00082 0.251
CLV_PCSK_SKI1_1 8 12 PF00082 0.636
DEG_APCC_DBOX_1 301 309 PF00400 0.430
DEG_MDM2_SWIB_1 300 308 PF02201 0.469
DEG_Nend_Nbox_1 1 3 PF02207 0.555
DOC_CYCLIN_RxL_1 232 242 PF00134 0.516
DOC_USP7_MATH_1 209 213 PF00917 0.445
DOC_USP7_MATH_1 255 259 PF00917 0.488
DOC_USP7_MATH_1 74 78 PF00917 0.549
DOC_USP7_MATH_1 95 99 PF00917 0.606
DOC_USP7_UBL2_3 42 46 PF12436 0.390
LIG_14-3-3_CanoR_1 136 144 PF00244 0.585
LIG_14-3-3_CanoR_1 195 205 PF00244 0.516
LIG_14-3-3_CanoR_1 239 249 PF00244 0.516
LIG_14-3-3_CanoR_1 291 300 PF00244 0.469
LIG_14-3-3_CanoR_1 72 82 PF00244 0.538
LIG_Clathr_ClatBox_1 60 64 PF01394 0.304
LIG_FHA_1 135 141 PF00498 0.629
LIG_FHA_1 308 314 PF00498 0.285
LIG_FHA_1 323 329 PF00498 0.327
LIG_FHA_1 4 10 PF00498 0.528
LIG_FHA_2 177 183 PF00498 0.430
LIG_FHA_2 220 226 PF00498 0.430
LIG_LIR_Gen_1 178 189 PF02991 0.516
LIG_LIR_Gen_1 229 238 PF02991 0.506
LIG_LIR_Gen_1 297 308 PF02991 0.505
LIG_LIR_Gen_1 47 52 PF02991 0.401
LIG_LIR_Nem_3 178 184 PF02991 0.533
LIG_LIR_Nem_3 297 303 PF02991 0.469
LIG_LIR_Nem_3 317 322 PF02991 0.183
LIG_LIR_Nem_3 32 38 PF02991 0.422
LIG_LIR_Nem_3 47 51 PF02991 0.296
LIG_NRBOX 11 17 PF00104 0.590
LIG_NRBOX 245 251 PF00104 0.469
LIG_PCNA_PIPBox_1 272 281 PF02747 0.469
LIG_PCNA_yPIPBox_3 269 279 PF02747 0.469
LIG_Pex14_2 300 304 PF04695 0.469
LIG_PTB_Apo_2 278 285 PF02174 0.469
LIG_PTB_Phospho_1 278 284 PF10480 0.469
LIG_RPA_C_Fungi 131 143 PF08784 0.529
LIG_RPA_C_Fungi 223 235 PF08784 0.303
LIG_SH2_CRK 48 52 PF00017 0.491
LIG_SH2_SRC 181 184 PF00017 0.325
LIG_SH2_SRC 284 287 PF00017 0.293
LIG_SH2_STAP1 160 164 PF00017 0.352
LIG_SH2_STAP1 230 234 PF00017 0.352
LIG_SH2_STAP1 324 328 PF00017 0.303
LIG_SH2_STAP1 75 79 PF00017 0.391
LIG_SH2_STAT5 201 204 PF00017 0.304
LIG_SH2_STAT5 284 287 PF00017 0.347
LIG_SH2_STAT5 324 327 PF00017 0.369
LIG_SH2_STAT5 38 41 PF00017 0.429
LIG_SH3_3 30 36 PF00018 0.481
LIG_SUMO_SIM_anti_2 101 106 PF11976 0.504
LIG_SUMO_SIM_anti_2 310 315 PF11976 0.285
LIG_SUMO_SIM_par_1 59 64 PF11976 0.304
LIG_TRAF2_1 118 121 PF00917 0.439
LIG_TRAF2_1 257 260 PF00917 0.304
LIG_TYR_ITSM 177 184 PF00017 0.248
MOD_CK1_1 135 141 PF00069 0.573
MOD_CK1_1 197 203 PF00069 0.359
MOD_CK1_1 240 246 PF00069 0.483
MOD_CK1_1 77 83 PF00069 0.472
MOD_CK1_1 98 104 PF00069 0.506
MOD_CK2_1 115 121 PF00069 0.436
MOD_CK2_1 176 182 PF00069 0.334
MOD_CK2_1 219 225 PF00069 0.270
MOD_CK2_1 254 260 PF00069 0.317
MOD_CK2_1 41 47 PF00069 0.522
MOD_GlcNHglycan 117 120 PF01048 0.405
MOD_GlcNHglycan 19 22 PF01048 0.529
MOD_GlcNHglycan 242 245 PF01048 0.332
MOD_GlcNHglycan 43 46 PF01048 0.523
MOD_GlcNHglycan 55 58 PF01048 0.313
MOD_GlcNHglycan 95 98 PF01048 0.429
MOD_GSK3_1 111 118 PF00069 0.430
MOD_GSK3_1 134 141 PF00069 0.542
MOD_GSK3_1 190 197 PF00069 0.307
MOD_GSK3_1 233 240 PF00069 0.353
MOD_GSK3_1 292 299 PF00069 0.304
MOD_GSK3_1 314 321 PF00069 0.322
MOD_GSK3_1 73 80 PF00069 0.417
MOD_GSK3_1 89 96 PF00069 0.320
MOD_N-GLC_1 77 82 PF02516 0.467
MOD_NEK2_1 1 6 PF00069 0.538
MOD_NEK2_1 11 16 PF00069 0.471
MOD_NEK2_1 166 171 PF00069 0.390
MOD_NEK2_1 233 238 PF00069 0.346
MOD_NEK2_1 314 319 PF00069 0.331
MOD_NEK2_1 322 327 PF00069 0.362
MOD_NEK2_1 73 78 PF00069 0.371
MOD_NEK2_1 89 94 PF00069 0.378
MOD_NEK2_2 304 309 PF00069 0.248
MOD_PIKK_1 176 182 PF00454 0.362
MOD_PIKK_1 209 215 PF00454 0.270
MOD_PIKK_1 3 9 PF00454 0.532
MOD_PKA_2 135 141 PF00069 0.693
MOD_PKA_2 194 200 PF00069 0.418
MOD_PKA_2 238 244 PF00069 0.304
MOD_PKA_2 292 298 PF00069 0.328
MOD_Plk_1 296 302 PF00069 0.304
MOD_Plk_4 11 17 PF00069 0.546
MOD_Plk_4 197 203 PF00069 0.265
MOD_Plk_4 304 310 PF00069 0.298
MOD_Plk_4 314 320 PF00069 0.310
MOD_Plk_4 324 330 PF00069 0.352
MOD_SUMO_rev_2 177 186 PF00179 0.325
MOD_SUMO_rev_2 254 263 PF00179 0.347
MOD_SUMO_rev_2 34 44 PF00179 0.511
TRG_DiLeu_BaEn_4 266 272 PF01217 0.303
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.272
TRG_ENDOCYTIC_2 181 184 PF00928 0.411
TRG_ENDOCYTIC_2 230 233 PF00928 0.352
TRG_ENDOCYTIC_2 279 282 PF00928 0.363
TRG_ENDOCYTIC_2 48 51 PF00928 0.473
TRG_ER_diArg_1 124 127 PF00400 0.504
TRG_ER_diArg_1 289 291 PF00400 0.279
TRG_ER_diLys_1 331 335 PF00400 0.466
TRG_Pf-PMV_PEXEL_1 247 251 PF00026 0.304
TRG_Pf-PMV_PEXEL_1 269 274 PF00026 0.325

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCV9 Leptomonas seymouri 52% 100%
A0A3S7X7B6 Leishmania donovani 100% 100%
A4HAE0 Leishmania braziliensis 69% 100%
E9B4J0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q3I6 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS