AP2 domain transcription factor AP2X-11

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9I7_LEIIN

TriTrypDb:

LINF_340006800

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.683
CLV_NRD_NRD_1	418	420	PF00675	0.684
CLV_NRD_NRD_1	604	606	PF00675	0.732
CLV_NRD_NRD_1	618	620	PF00675	0.602
CLV_NRD_NRD_1	9	11	PF00675	0.595
CLV_PCSK_FUR_1	602	606	PF00082	0.610
CLV_PCSK_KEX2_1	418	420	PF00082	0.659
CLV_PCSK_KEX2_1	604	606	PF00082	0.665
CLV_PCSK_KEX2_1	617	619	PF00082	0.577
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.710
CLV_PCSK_SKI1_1	499	503	PF00082	0.611
CLV_PCSK_SKI1_1	595	599	PF00082	0.698
DEG_COP1_1	393	402	PF00400	0.567
DEG_SCF_FBW7_1	219	225	PF00400	0.660
DEG_SPOP_SBC_1	177	181	PF00917	0.623
DEG_SPOP_SBC_1	378	382	PF00917	0.585
DOC_CKS1_1	212	217	PF01111	0.695
DOC_CKS1_1	219	224	PF01111	0.653
DOC_CKS1_1	288	293	PF01111	0.644
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.664
DOC_PP2B_LxvP_1	256	259	PF13499	0.613
DOC_USP7_MATH_1	120	124	PF00917	0.630
DOC_USP7_MATH_1	146	150	PF00917	0.661
DOC_USP7_MATH_1	158	162	PF00917	0.564
DOC_USP7_MATH_1	163	167	PF00917	0.507
DOC_USP7_MATH_1	222	226	PF00917	0.664
DOC_USP7_MATH_1	249	253	PF00917	0.673
DOC_USP7_MATH_1	309	313	PF00917	0.731
DOC_USP7_MATH_1	316	320	PF00917	0.621
DOC_USP7_MATH_1	398	402	PF00917	0.704
DOC_USP7_MATH_1	417	421	PF00917	0.633
DOC_USP7_MATH_1	424	428	PF00917	0.562
DOC_USP7_MATH_1	43	47	PF00917	0.664
DOC_USP7_MATH_1	451	455	PF00917	0.611
DOC_USP7_MATH_1	530	534	PF00917	0.682
DOC_USP7_MATH_1	536	540	PF00917	0.656
DOC_USP7_MATH_2	524	530	PF00917	0.637
DOC_WW_Pin1_4	138	143	PF00397	0.713
DOC_WW_Pin1_4	184	189	PF00397	0.667
DOC_WW_Pin1_4	191	196	PF00397	0.624
DOC_WW_Pin1_4	211	216	PF00397	0.519
DOC_WW_Pin1_4	218	223	PF00397	0.654
DOC_WW_Pin1_4	245	250	PF00397	0.630
DOC_WW_Pin1_4	267	272	PF00397	0.638
DOC_WW_Pin1_4	27	32	PF00397	0.625
DOC_WW_Pin1_4	278	283	PF00397	0.586
DOC_WW_Pin1_4	287	292	PF00397	0.506
DOC_WW_Pin1_4	305	310	PF00397	0.538
DOC_WW_Pin1_4	325	330	PF00397	0.462
DOC_WW_Pin1_4	332	337	PF00397	0.599
DOC_WW_Pin1_4	343	348	PF00397	0.489
DOC_WW_Pin1_4	390	395	PF00397	0.747
DOC_WW_Pin1_4	412	417	PF00397	0.683
DOC_WW_Pin1_4	47	52	PF00397	0.543
DOC_WW_Pin1_4	56	61	PF00397	0.587
LIG_14-3-3_CanoR_1	10	14	PF00244	0.631
LIG_14-3-3_CanoR_1	110	119	PF00244	0.653
LIG_14-3-3_CanoR_1	16	25	PF00244	0.650
LIG_14-3-3_CanoR_1	366	376	PF00244	0.702
LIG_14-3-3_CanoR_1	418	422	PF00244	0.684
LIG_14-3-3_CanoR_1	461	470	PF00244	0.661
LIG_14-3-3_CanoR_1	557	563	PF00244	0.638
LIG_14-3-3_CanoR_1	565	574	PF00244	0.586
LIG_14-3-3_CanoR_1	580	584	PF00244	0.707
LIG_14-3-3_CanoR_1	604	609	PF00244	0.628
LIG_AP2alpha_2	493	495	PF02296	0.608
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_BIR_III_2	139	143	PF00653	0.667
LIG_BRCT_BRCA1_1	1	5	PF00533	0.621
LIG_BRCT_BRCA1_1	140	144	PF00533	0.666
LIG_BRCT_BRCA1_1	280	284	PF00533	0.624
LIG_BRCT_BRCA1_1	345	349	PF00533	0.681
LIG_BRCT_BRCA1_1	433	437	PF00533	0.662
LIG_BRCT_BRCA1_1	49	53	PF00533	0.653
LIG_BRCT_BRCA1_1	521	525	PF00533	0.695
LIG_BRCT_BRCA1_1	558	562	PF00533	0.641
LIG_CaM_IQ_9	596	612	PF13499	0.610
LIG_FHA_1	178	184	PF00498	0.654
LIG_FHA_2	166	172	PF00498	0.676
LIG_FHA_2	378	384	PF00498	0.736
LIG_FHA_2	406	412	PF00498	0.687
LIG_FHA_2	474	480	PF00498	0.672
LIG_FHA_2	488	494	PF00498	0.559
LIG_Integrin_RGD_1	137	139	PF01839	0.670
LIG_IRF3_LxIS_1	334	340	PF10401	0.601
LIG_LIR_Apic_2	420	424	PF02991	0.774
LIG_LIR_Gen_1	321	331	PF02991	0.620
LIG_LIR_Gen_1	492	503	PF02991	0.768
LIG_LIR_Gen_1	529	538	PF02991	0.637
LIG_LIR_Nem_3	3	9	PF02991	0.539
LIG_LIR_Nem_3	321	326	PF02991	0.624
LIG_LIR_Nem_3	346	352	PF02991	0.691
LIG_LIR_Nem_3	434	440	PF02991	0.609
LIG_LIR_Nem_3	492	498	PF02991	0.764
LIG_LIR_Nem_3	529	534	PF02991	0.634
LIG_MLH1_MIPbox_1	2	6	PF16413	0.619
LIG_MLH1_MIPbox_1	433	437	PF16413	0.662
LIG_MLH1_MIPbox_1	558	562	PF16413	0.551
LIG_Pex14_2	198	202	PF04695	0.691
LIG_Pex14_2	274	278	PF04695	0.651
LIG_PTAP_UEV_1	340	345	PF05743	0.620
LIG_PTB_Apo_2	12	19	PF02174	0.536
LIG_PTB_Phospho_1	12	18	PF10480	0.536
LIG_REV1ctd_RIR_1	559	569	PF16727	0.528
LIG_SH2_CRK	323	327	PF00017	0.654
LIG_SH2_CRK	421	425	PF00017	0.697
LIG_SH2_SRC	37	40	PF00017	0.543
LIG_SH2_STAT5	37	40	PF00017	0.543
LIG_SH3_3	140	146	PF00018	0.701
LIG_SH3_3	152	158	PF00018	0.546
LIG_SH3_3	216	222	PF00018	0.576
LIG_SH3_3	261	267	PF00018	0.631
LIG_SH3_3	338	344	PF00018	0.652
LIG_SH3_3	388	394	PF00018	0.656
LIG_SH3_3	54	60	PF00018	0.632
LIG_SUMO_SIM_anti_2	252	257	PF11976	0.617
LIG_SUMO_SIM_par_1	335	340	PF11976	0.601
LIG_TRAF2_1	453	456	PF00917	0.711
LIG_TRAF2_1	548	551	PF00917	0.657
LIG_WRC_WIRS_1	433	438	PF05994	0.658
LIG_WRC_WIRS_1	99	104	PF05994	0.698
LIG_WW_3	30	34	PF00397	0.614
MOD_CDC14_SPxK_1	30	33	PF00782	0.562
MOD_CDC14_SPxK_1	415	418	PF00782	0.679
MOD_CDK_SPK_2	56	61	PF00069	0.683
MOD_CDK_SPxK_1	27	33	PF00069	0.566
MOD_CDK_SPxK_1	412	418	PF00069	0.684
MOD_CDK_SPxxK_3	412	419	PF00069	0.684
MOD_CK1_1	101	107	PF00069	0.701
MOD_CK1_1	121	127	PF00069	0.494
MOD_CK1_1	17	23	PF00069	0.641
MOD_CK1_1	181	187	PF00069	0.702
MOD_CK1_1	200	206	PF00069	0.493
MOD_CK1_1	225	231	PF00069	0.690
MOD_CK1_1	287	293	PF00069	0.666
MOD_CK1_1	360	366	PF00069	0.660
MOD_CK1_1	370	376	PF00069	0.601
MOD_CK1_1	386	392	PF00069	0.560
MOD_CK1_1	393	399	PF00069	0.633
MOD_CK1_1	401	407	PF00069	0.647
MOD_CK1_1	432	438	PF00069	0.627
MOD_CK1_1	473	479	PF00069	0.712
MOD_CK1_1	509	515	PF00069	0.638
MOD_CK1_1	586	592	PF00069	0.646
MOD_CK2_1	110	116	PF00069	0.727
MOD_CK2_1	377	383	PF00069	0.580
MOD_CK2_1	401	407	PF00069	0.652
MOD_CK2_1	424	430	PF00069	0.617
MOD_CK2_1	473	479	PF00069	0.647
MOD_CK2_1	507	513	PF00069	0.667
MOD_GlcNHglycan	112	115	PF01048	0.657
MOD_GlcNHglycan	120	123	PF01048	0.662
MOD_GlcNHglycan	124	127	PF01048	0.630
MOD_GlcNHglycan	134	137	PF01048	0.569
MOD_GlcNHglycan	148	151	PF01048	0.531
MOD_GlcNHglycan	165	168	PF01048	0.528
MOD_GlcNHglycan	199	202	PF01048	0.658
MOD_GlcNHglycan	207	210	PF01048	0.636
MOD_GlcNHglycan	227	230	PF01048	0.529
MOD_GlcNHglycan	341	344	PF01048	0.670
MOD_GlcNHglycan	369	372	PF01048	0.701
MOD_GlcNHglycan	388	391	PF01048	0.529
MOD_GlcNHglycan	395	398	PF01048	0.551
MOD_GlcNHglycan	463	466	PF01048	0.690
MOD_GlcNHglycan	521	524	PF01048	0.675
MOD_GlcNHglycan	528	531	PF01048	0.617
MOD_GlcNHglycan	54	57	PF01048	0.556
MOD_GlcNHglycan	574	577	PF01048	0.712
MOD_GSK3_1	118	125	PF00069	0.699
MOD_GSK3_1	138	145	PF00069	0.713
MOD_GSK3_1	16	23	PF00069	0.668
MOD_GSK3_1	177	184	PF00069	0.695
MOD_GSK3_1	187	194	PF00069	0.592
MOD_GSK3_1	196	203	PF00069	0.499
MOD_GSK3_1	214	221	PF00069	0.559
MOD_GSK3_1	245	252	PF00069	0.659
MOD_GSK3_1	286	293	PF00069	0.745
MOD_GSK3_1	305	312	PF00069	0.635
MOD_GSK3_1	321	328	PF00069	0.509
MOD_GSK3_1	335	342	PF00069	0.528
MOD_GSK3_1	379	386	PF00069	0.621
MOD_GSK3_1	401	408	PF00069	0.749
MOD_GSK3_1	425	432	PF00069	0.637
MOD_GSK3_1	43	50	PF00069	0.671
MOD_GSK3_1	469	476	PF00069	0.672
MOD_GSK3_1	52	59	PF00069	0.617
MOD_GSK3_1	526	533	PF00069	0.680
MOD_GSK3_1	552	559	PF00069	0.563
MOD_GSK3_1	579	586	PF00069	0.679
MOD_GSK3_1	591	598	PF00069	0.582
MOD_GSK3_1	64	71	PF00069	0.546
MOD_GSK3_1	72	79	PF00069	0.570
MOD_GSK3_1	82	89	PF00069	0.517
MOD_LATS_1	14	20	PF00433	0.624
MOD_N-GLC_1	14	19	PF02516	0.623
MOD_N-GLC_1	249	254	PF02516	0.671
MOD_N-GLC_1	446	451	PF02516	0.616
MOD_N-GLC_1	552	557	PF02516	0.566
MOD_N-GLC_1	583	588	PF02516	0.653
MOD_N-GLC_1	73	78	PF02516	0.698
MOD_NEK2_1	196	201	PF00069	0.681
MOD_NEK2_1	284	289	PF00069	0.667
MOD_NEK2_1	367	372	PF00069	0.653
MOD_NEK2_1	552	557	PF00069	0.566
MOD_NEK2_1	70	75	PF00069	0.662
MOD_NEK2_1	84	89	PF00069	0.578
MOD_NEK2_1	9	14	PF00069	0.532
MOD_NEK2_1	95	100	PF00069	0.576
MOD_PIKK_1	200	206	PF00454	0.640
MOD_PIKK_1	307	313	PF00454	0.581
MOD_PIKK_1	355	361	PF00454	0.632
MOD_PIKK_1	586	592	PF00454	0.646
MOD_PKA_1	604	610	PF00069	0.710
MOD_PKA_2	360	366	PF00069	0.699
MOD_PKA_2	378	384	PF00069	0.533
MOD_PKA_2	386	392	PF00069	0.601
MOD_PKA_2	417	423	PF00069	0.682
MOD_PKA_2	460	466	PF00069	0.649
MOD_PKA_2	556	562	PF00069	0.640
MOD_PKA_2	566	572	PF00069	0.567
MOD_PKA_2	579	585	PF00069	0.671
MOD_PKA_2	604	610	PF00069	0.625
MOD_PKA_2	9	15	PF00069	0.634
MOD_PKB_1	108	116	PF00069	0.676
MOD_PKB_1	602	610	PF00069	0.634
MOD_Plk_1	14	20	PF00069	0.540
MOD_Plk_1	249	255	PF00069	0.652
MOD_Plk_1	284	290	PF00069	0.687
MOD_Plk_1	429	435	PF00069	0.719
MOD_Plk_1	446	452	PF00069	0.518
MOD_Plk_1	583	589	PF00069	0.628
MOD_Plk_1	610	616	PF00069	0.608
MOD_Plk_1	73	79	PF00069	0.698
MOD_Plk_4	148	154	PF00069	0.682
MOD_Plk_4	214	220	PF00069	0.709
MOD_Plk_4	222	228	PF00069	0.631
MOD_Plk_4	251	257	PF00069	0.619
MOD_Plk_4	321	327	PF00069	0.674
MOD_Plk_4	432	438	PF00069	0.656
MOD_ProDKin_1	138	144	PF00069	0.714
MOD_ProDKin_1	184	190	PF00069	0.666
MOD_ProDKin_1	191	197	PF00069	0.624
MOD_ProDKin_1	211	217	PF00069	0.518
MOD_ProDKin_1	218	224	PF00069	0.654
MOD_ProDKin_1	245	251	PF00069	0.630
MOD_ProDKin_1	267	273	PF00069	0.638
MOD_ProDKin_1	27	33	PF00069	0.626
MOD_ProDKin_1	278	284	PF00069	0.586
MOD_ProDKin_1	287	293	PF00069	0.509
MOD_ProDKin_1	305	311	PF00069	0.537
MOD_ProDKin_1	325	331	PF00069	0.462
MOD_ProDKin_1	332	338	PF00069	0.600
MOD_ProDKin_1	343	349	PF00069	0.493
MOD_ProDKin_1	390	396	PF00069	0.748
MOD_ProDKin_1	412	418	PF00069	0.684
MOD_ProDKin_1	47	53	PF00069	0.545
MOD_ProDKin_1	56	62	PF00069	0.590
TRG_DiLeu_BaEn_1	321	326	PF01217	0.673
TRG_ENDOCYTIC_2	323	326	PF00928	0.772
TRG_ER_diArg_1	107	110	PF00400	0.669
TRG_ER_diArg_1	364	367	PF00400	0.662
TRG_ER_diArg_1	384	387	PF00400	0.562
TRG_ER_diArg_1	602	605	PF00400	0.772
TRG_NLS_Bipartite_1	604	621	PF00514	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IUC2	Leishmania donovani	98%	100%
A4HAD5	Leishmania braziliensis	56%	100%
E9AEH6	Leishmania major	88%	100%
E9B4I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%