Nucleolar protein 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 12 (25kDa) - putative

Species:

Leishmania infantum

UniProt:

A4I9I6_LEIIN

TriTrypDb:

LINF_340006700

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I9I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9I6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.693
CLV_C14_Caspase3-7	234	238	PF00656	0.606
CLV_C14_Caspase3-7	42	46	PF00656	0.688
CLV_NRD_NRD_1	105	107	PF00675	0.144
CLV_NRD_NRD_1	176	178	PF00675	0.588
CLV_NRD_NRD_1	19	21	PF00675	0.631
CLV_NRD_NRD_1	241	243	PF00675	0.573
CLV_NRD_NRD_1	250	252	PF00675	0.555
CLV_NRD_NRD_1	303	305	PF00675	0.523
CLV_NRD_NRD_1	306	308	PF00675	0.565
CLV_NRD_NRD_1	310	312	PF00675	0.592
CLV_NRD_NRD_1	316	318	PF00675	0.598
CLV_NRD_NRD_1	322	324	PF00675	0.502
CLV_NRD_NRD_1	325	327	PF00675	0.483
CLV_NRD_NRD_1	63	65	PF00675	0.323
CLV_NRD_NRD_1	77	79	PF00675	0.318
CLV_NRD_NRD_1	86	88	PF00675	0.346
CLV_NRD_NRD_1	89	91	PF00675	0.353
CLV_NRD_NRD_1	97	99	PF00675	0.287
CLV_PCSK_FUR_1	174	178	PF00082	0.684
CLV_PCSK_KEX2_1	105	107	PF00082	0.144
CLV_PCSK_KEX2_1	174	176	PF00082	0.552
CLV_PCSK_KEX2_1	179	181	PF00082	0.539
CLV_PCSK_KEX2_1	316	318	PF00082	0.648
CLV_PCSK_KEX2_1	32	34	PF00082	0.562
CLV_PCSK_KEX2_1	322	324	PF00082	0.592
CLV_PCSK_KEX2_1	63	65	PF00082	0.366
CLV_PCSK_KEX2_1	77	79	PF00082	0.328
CLV_PCSK_KEX2_1	86	88	PF00082	0.346
CLV_PCSK_KEX2_1	97	99	PF00082	0.299
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.619
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.660
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.595
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.609
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.416
CLV_PCSK_PC7_1	101	107	PF00082	0.432
CLV_PCSK_PC7_1	175	181	PF00082	0.690
CLV_PCSK_SKI1_1	180	184	PF00082	0.620
CLV_PCSK_SKI1_1	21	25	PF00082	0.554
CLV_PCSK_SKI1_1	228	232	PF00082	0.557
CLV_PCSK_SKI1_1	295	299	PF00082	0.526
CLV_PCSK_SKI1_1	32	36	PF00082	0.498
CLV_PCSK_SKI1_1	54	58	PF00082	0.336
DEG_APCC_DBOX_1	273	281	PF00400	0.622
DEG_APCC_DBOX_1	63	71	PF00400	0.348
DEG_SPOP_SBC_1	212	216	PF00917	0.745
DOC_CDC14_PxL_1	111	119	PF14671	0.328
DOC_CYCLIN_RxL_1	51	62	PF00134	0.440
DOC_MAPK_gen_1	63	70	PF00069	0.400
DOC_MAPK_JIP1_4	52	58	PF00069	0.440
DOC_PP1_RVXF_1	52	59	PF00149	0.328
DOC_PP2B_PxIxI_1	161	167	PF00149	0.469
DOC_USP7_MATH_1	169	173	PF00917	0.642
DOC_USP7_MATH_1	212	216	PF00917	0.672
DOC_USP7_UBL2_3	17	21	PF12436	0.583
DOC_USP7_UBL2_3	285	289	PF12436	0.587
DOC_USP7_UBL2_3	298	302	PF12436	0.523
DOC_USP7_UBL2_3	308	312	PF12436	0.592
DOC_USP7_UBL2_3	318	322	PF12436	0.437
DOC_USP7_UBL2_3	324	328	PF12436	0.630
DOC_USP7_UBL2_3	37	41	PF12436	0.365
DOC_USP7_UBL2_3	91	95	PF12436	0.410
LIG_14-3-3_CanoR_1	180	185	PF00244	0.732
LIG_FHA_1	119	125	PF00498	0.328
LIG_FHA_1	222	228	PF00498	0.547
LIG_FHA_1	256	262	PF00498	0.667
LIG_FHA_2	200	206	PF00498	0.760
LIG_FHA_2	40	46	PF00498	0.681
LIG_FHA_2	5	11	PF00498	0.668
LIG_FHA_2	55	61	PF00498	0.187
LIG_FHA_2	94	100	PF00498	0.388
LIG_LIR_Apic_2	119	125	PF02991	0.326
LIG_LIR_Gen_1	160	171	PF02991	0.443
LIG_LIR_Gen_1	219	230	PF02991	0.551
LIG_LIR_LC3C_4	268	273	PF02991	0.623
LIG_LIR_Nem_3	160	166	PF02991	0.403
LIG_LIR_Nem_3	219	225	PF02991	0.561
LIG_SH2_CRK	111	115	PF00017	0.355
LIG_SH2_CRK	122	126	PF00017	0.265
LIG_SH2_NCK_1	111	115	PF00017	0.440
LIG_SH2_PTP2	222	225	PF00017	0.667
LIG_SH2_STAP1	120	124	PF00017	0.440
LIG_SH2_STAT3	147	150	PF00017	0.440
LIG_SH2_STAT5	120	123	PF00017	0.440
LIG_SH2_STAT5	222	225	PF00017	0.667
LIG_SH2_STAT5	4	7	PF00017	0.675
LIG_SH2_STAT5	66	69	PF00017	0.348
LIG_SH3_3	112	118	PF00018	0.315
LIG_SH3_3	206	212	PF00018	0.774
LIG_TRAF2_2	125	130	PF00917	0.469
LIG_UBA3_1	296	305	PF00899	0.571
LIG_UBA3_1	67	74	PF00899	0.328
MOD_CK1_1	148	154	PF00069	0.469
MOD_CK1_1	213	219	PF00069	0.671
MOD_CK1_1	232	238	PF00069	0.461
MOD_CK1_1	257	263	PF00069	0.640
MOD_CK1_1	93	99	PF00069	0.440
MOD_CK2_1	93	99	PF00069	0.408
MOD_Cter_Amidation	314	317	PF01082	0.620
MOD_Cter_Amidation	320	323	PF01082	0.618
MOD_GlcNHglycan	150	153	PF01048	0.484
MOD_GlcNHglycan	186	189	PF01048	0.737
MOD_GlcNHglycan	234	237	PF01048	0.663
MOD_GlcNHglycan	319	322	PF01048	0.697
MOD_GlcNHglycan	92	95	PF01048	0.424
MOD_GSK3_1	180	187	PF00069	0.682
MOD_GSK3_1	199	206	PF00069	0.477
MOD_GSK3_1	213	220	PF00069	0.666
MOD_GSK3_1	4	11	PF00069	0.634
MOD_GSK3_1	54	61	PF00069	0.408
MOD_NEK2_1	230	235	PF00069	0.673
MOD_NEK2_1	58	63	PF00069	0.440
MOD_NEK2_2	66	71	PF00069	0.371
MOD_PIKK_1	146	152	PF00454	0.457
MOD_PIKK_1	169	175	PF00454	0.580
MOD_PKA_1	307	313	PF00069	0.588
MOD_PKA_1	317	323	PF00069	0.621
MOD_PKA_1	90	96	PF00069	0.440
MOD_PKB_1	279	287	PF00069	0.606
MOD_Plk_1	118	124	PF00069	0.328
MOD_Plk_2-3	221	227	PF00069	0.553
MOD_SUMO_rev_2	220	230	PF00179	0.547
TRG_ENDOCYTIC_2	111	114	PF00928	0.324
TRG_ENDOCYTIC_2	222	225	PF00928	0.667
TRG_ENDOCYTIC_2	31	34	PF00928	0.615
TRG_ER_diArg_1	174	177	PF00400	0.622
TRG_ER_diArg_1	292	295	PF00400	0.609
TRG_ER_diArg_1	77	79	PF00400	0.327
TRG_NLS_Bipartite_1	304	326	PF00514	0.600
TRG_NLS_Bipartite_1	72	91	PF00514	0.440
TRG_NLS_MonoExtC_3	16	21	PF00514	0.690
TRG_NLS_MonoExtC_3	303	308	PF00514	0.544
TRG_NLS_MonoExtC_3	321	326	PF00514	0.619
TRG_NLS_MonoExtC_3	85	90	PF00514	0.440
TRG_NLS_MonoExtN_4	302	308	PF00514	0.541
TRG_NLS_MonoExtN_4	322	327	PF00514	0.438
TRG_NLS_MonoExtN_4	86	91	PF00514	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ5	Leptomonas seymouri	65%	97%
A0A1X0P8J9	Trypanosomatidae	46%	100%
A0A3Q8IH68	Leishmania donovani	97%	100%
A0A422N280	Trypanosoma rangeli	45%	100%
D0A1U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B4I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
Q4Q3J1	Leishmania major	88%	97%
V5DIL2	Trypanosoma cruzi	48%	93%