Malate dehydrogenase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial malate dehydrogenase

Species:

Leishmania infantum

UniProt:

A4I9I5_LEIIN

TriTrypDb:

LINF_340006600

Length:

325

Annotations

LeishMANIAdb annotations

A group of metabolic enzymes without any likely TM segment. Very conserved in Eukaryota.

Annotations by Jardim et al.

Tricarboxylic acid cycle, Malate dehydrogenase mMDH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I9I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9I5

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	18
GO:0006099	tricarboxylic acid cycle	3	18
GO:0006108	malate metabolic process	7	17
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	18
GO:0019752	carboxylic acid metabolic process	5	18
GO:0043436	oxoacid metabolic process	4	18
GO:0043648	dicarboxylic acid metabolic process	6	17
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0016491	oxidoreductase activity	2	18
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	18
GO:0016615	malate dehydrogenase activity	4	18
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	18
GO:0030060	L-malate dehydrogenase activity	5	18

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	309	311	PF00675	0.281
CLV_NRD_NRD_1	86	88	PF00675	0.293
CLV_PCSK_SKI1_1	204	208	PF00082	0.324
CLV_PCSK_SKI1_1	71	75	PF00082	0.392
DEG_Nend_UBRbox_1	1	4	PF02207	0.617
DOC_MAPK_gen_1	71	80	PF00069	0.392
DOC_MAPK_MEF2A_6	74	82	PF00069	0.329
DOC_PP1_RVXF_1	207	213	PF00149	0.427
DOC_PP1_RVXF_1	309	316	PF00149	0.341
DOC_PP2B_LxvP_1	285	288	PF13499	0.389

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H7	Leptomonas seymouri	49%	100%
A0A0N0P6W7	Leptomonas seymouri	65%	100%
A0A0N1HYD1	Leptomonas seymouri	46%	100%
A0A0N1I818	Leptomonas seymouri	40%	95%
A0A0N1ILF3	Leptomonas seymouri	74%	100%
A0A0S3QTC6	Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6)	32%	100%
A0A0S4IRQ1	Bodo saltans	59%	80%
A0A0S4ITJ4	Bodo saltans	42%	98%
A0A1X0P752	Trypanosomatidae	46%	100%
A0A1X0P9G5	Trypanosomatidae	40%	90%

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