LeishMANIAdb
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Short-chain dehydrogenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Short-chain dehydrogenase
Gene product:
short chain dehydrogenase - putative
Species:
Leishmania infantum
UniProt:
A4I9G9_LEIIN
TriTrypDb:
LINF_340005000 *
Length:
306

Annotations

LeishMANIAdb annotations

These proteins belong to short-chain dehydrogenases / reductases using NAD or NADP as cofactor. All homologs are used for very long fatty acid biosynthesis.. Expanded in multiple organisms, but especially Strigomonas. Localization: ER (by homology)

Annotations by Jardim et al.

Phospholipid biosynthesis, 1-acyldihydroxyacetone phosphate reductase short chain dehydrogenase, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I9G9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9G9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016491 oxidoreductase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 236 238 PF00675 0.359
CLV_NRD_NRD_1 302 304 PF00675 0.338
CLV_NRD_NRD_1 64 66 PF00675 0.254
CLV_PCSK_KEX2_1 170 172 PF00082 0.242
CLV_PCSK_KEX2_1 304 306 PF00082 0.363
CLV_PCSK_KEX2_1 36 38 PF00082 0.287
CLV_PCSK_KEX2_1 64 66 PF00082 0.223
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.267
CLV_PCSK_PC1ET2_1 304 306 PF00082 0.375
CLV_PCSK_PC1ET2_1 36 38 PF00082 0.287
CLV_PCSK_SKI1_1 147 151 PF00082 0.207
CLV_PCSK_SKI1_1 295 299 PF00082 0.300
DOC_CKS1_1 263 268 PF01111 0.512
DOC_MAPK_gen_1 168 178 PF00069 0.428
DOC_MAPK_gen_1 237 246 PF00069 0.509
DOC_MAPK_gen_1 64 71 PF00069 0.423
DOC_MAPK_MEF2A_6 117 124 PF00069 0.489
DOC_PP1_RVXF_1 17 24 PF00149 0.249
DOC_PP1_RVXF_1 92 99 PF00149 0.428
DOC_USP7_UBL2_3 166 170 PF12436 0.485
DOC_USP7_UBL2_3 300 304 PF12436 0.600
DOC_WW_Pin1_4 101 106 PF00397 0.530
DOC_WW_Pin1_4 182 187 PF00397 0.430
DOC_WW_Pin1_4 219 224 PF00397 0.410
DOC_WW_Pin1_4 262 267 PF00397 0.516
LIG_BRCT_BRCA1_1 96 100 PF00533 0.453
LIG_FHA_1 158 164 PF00498 0.462
LIG_FHA_1 229 235 PF00498 0.449
LIG_FHA_1 281 287 PF00498 0.548
LIG_LIR_Apic_2 160 165 PF02991 0.428
LIG_LIR_Gen_1 109 120 PF02991 0.474
LIG_LIR_Gen_1 134 142 PF02991 0.508
LIG_LIR_Gen_1 241 251 PF02991 0.509
LIG_LIR_Gen_1 43 50 PF02991 0.419
LIG_LIR_Nem_3 109 115 PF02991 0.429
LIG_LIR_Nem_3 134 140 PF02991 0.455
LIG_LIR_Nem_3 241 246 PF02991 0.520
LIG_LIR_Nem_3 43 47 PF02991 0.410
LIG_Pex14_2 199 203 PF04695 0.418
LIG_REV1ctd_RIR_1 15 23 PF16727 0.254
LIG_SH2_GRB2like 133 136 PF00017 0.428
LIG_SH2_PTP2 162 165 PF00017 0.467
LIG_SH2_STAP1 108 112 PF00017 0.486
LIG_SH2_STAP1 133 137 PF00017 0.428
LIG_SH2_STAP1 56 60 PF00017 0.475
LIG_SH2_STAT5 131 134 PF00017 0.418
LIG_SH2_STAT5 162 165 PF00017 0.467
LIG_SH2_STAT5 28 31 PF00017 0.476
LIG_SH2_STAT5 285 288 PF00017 0.525
LIG_SH3_3 260 266 PF00018 0.607
LIG_SUMO_SIM_anti_2 119 124 PF11976 0.449
LIG_SUMO_SIM_par_1 174 180 PF11976 0.439
LIG_SUMO_SIM_par_1 217 222 PF11976 0.418
LIG_TRAF2_2 105 110 PF00917 0.430
LIG_UBA3_1 111 117 PF00899 0.486
MOD_CDK_SPK_2 101 106 PF00069 0.430
MOD_CDK_SPxxK_3 262 269 PF00069 0.457
MOD_CK1_1 182 188 PF00069 0.426
MOD_CK1_1 202 208 PF00069 0.491
MOD_CK1_1 228 234 PF00069 0.428
MOD_CK2_1 74 80 PF00069 0.491
MOD_Cter_Amidation 62 65 PF01082 0.301
MOD_GlcNHglycan 101 104 PF01048 0.296
MOD_GlcNHglycan 181 184 PF01048 0.240
MOD_GlcNHglycan 204 207 PF01048 0.326
MOD_GSK3_1 153 160 PF00069 0.441
MOD_GSK3_1 189 196 PF00069 0.428
MOD_GSK3_1 228 235 PF00069 0.422
MOD_GSK3_1 258 265 PF00069 0.524
MOD_GSK3_1 280 287 PF00069 0.583
MOD_GSK3_1 74 81 PF00069 0.485
MOD_N-GLC_1 129 134 PF02516 0.237
MOD_N-GLC_1 199 204 PF02516 0.267
MOD_N-GLC_2 68 70 PF02516 0.218
MOD_NEK2_1 177 182 PF00069 0.467
MOD_NEK2_1 189 194 PF00069 0.392
MOD_NEK2_1 199 204 PF00069 0.404
MOD_NEK2_1 225 230 PF00069 0.416
MOD_NEK2_2 153 158 PF00069 0.467
MOD_PIKK_1 228 234 PF00454 0.418
MOD_PK_1 258 264 PF00069 0.563
MOD_PK_1 78 84 PF00069 0.486
MOD_PKA_2 157 163 PF00069 0.428
MOD_PKA_2 239 245 PF00069 0.534
MOD_Plk_1 129 135 PF00069 0.433
MOD_Plk_1 153 159 PF00069 0.476
MOD_Plk_1 199 205 PF00069 0.467
MOD_Plk_4 239 245 PF00069 0.539
MOD_Plk_4 3 9 PF00069 0.275
MOD_Plk_4 78 84 PF00069 0.488
MOD_ProDKin_1 101 107 PF00069 0.530
MOD_ProDKin_1 182 188 PF00069 0.430
MOD_ProDKin_1 219 225 PF00069 0.410
MOD_ProDKin_1 262 268 PF00069 0.513
MOD_SUMO_rev_2 205 214 PF00179 0.478
MOD_SUMO_rev_2 80 89 PF00179 0.457
TRG_DiLeu_BaEn_1 119 124 PF01217 0.445
TRG_DiLeu_BaLyEn_6 144 149 PF01217 0.476
TRG_DiLeu_BaLyEn_6 185 190 PF01217 0.467
TRG_ENDOCYTIC_2 108 111 PF00928 0.406
TRG_NES_CRM1_1 141 154 PF08389 0.486
TRG_Pf-PMV_PEXEL_1 279 284 PF00026 0.305

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0E3D8L9 Penicillium crustosum 29% 100%
A0A0N1I6F8 Leptomonas seymouri 79% 99%
A0A0S4IR33 Bodo saltans 53% 90%
A0A0S4IWL0 Bodo saltans 55% 96%
A0A0S4JBE7 Bodo saltans 49% 94%
A0A0S4JSF1 Bodo saltans 29% 76%
A0A140FAN3 Pinus massoniana 27% 86%
A0A1A9TAK5 Narcissus pseudonarcissus 24% 100%
A0A1B2CTA9 Penicillium thymicola 29% 100%
A0A1C9II22 Narcissus aff. pseudonarcissus MK-2014 24% 100%
A0A1X0NWL8 Trypanosomatidae 58% 99%
A0A1X0P1C4 Trypanosomatidae 31% 94%
A0A3Q8IE20 Leishmania donovani 99% 100%
A0A3S7X793 Leishmania donovani 99% 100%
A0A411PQN6 Paecilomyces divaricatus 28% 100%
A0A422NG64 Trypanosoma rangeli 30% 94%
A0A422NJG3 Trypanosoma rangeli 61% 99%
A0A422NNE9 Trypanosoma rangeli 27% 90%
A1C6J8 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 33% 89%
A1DH66 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 32% 89%
A2QCH3 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 30% 88%
A3LXZ3 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 30% 88%
A4HAC6 Leishmania braziliensis 86% 100%
A4HME4 Leishmania braziliensis 24% 100%
A4QTE3 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 31% 92%
A5DND6 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 36% 90%
A5E0R1 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 31% 87%
A5PJF6 Bos taurus 32% 93%
A5WWC6 Danio rerio 27% 96%
A6RBW9 Ajellomyces capsulatus (strain NAm1 / WU24) 32% 90%
A6SG70 Botryotinia fuckeliana (strain B05.10) 30% 92%
A6ZLA1 Saccharomyces cerevisiae (strain YJM789) 31% 88%
A7F8T1 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 31% 92%
A7TMJ2 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 32% 88%
A8N6B4 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) 35% 90%
A8Q1U2 Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) 34% 94%
B0D8R3 Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) 31% 91%
B0XSI3 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 32% 89%
B0ZT44 Elsinoe fawcettii 24% 100%
B2B3L4 Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) 30% 90%
B2WMJ3 Pyrenophora tritici-repentis (strain Pt-1C-BFP) 32% 90%
B3LN00 Saccharomyces cerevisiae (strain RM11-1a) 31% 88%
C9ZNQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 98%
D0A2C4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 88%
D4A1J4 Rattus norvegicus 28% 100%
E3VWI6 Streptomyces arenae 26% 100%
E3VWK2 Streptomyces exfoliatus 28% 100%
E9AEU5 Leishmania major 23% 100%
E9B3Z6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B4G7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
F9XMW6 Zymoseptoria tritici (strain CBS 115943 / IPO323) 24% 100%
G9FRD7 Clostridium sardiniense 26% 100%
O07399 Mycobacterium avium 24% 100%
O16925 Caenorhabditis elegans 28% 100%
O17795 Caenorhabditis elegans 27% 97%
O32229 Bacillus subtilis (strain 168) 28% 100%
O34896 Bacillus subtilis (strain 168) 24% 100%
O49332 Arabidopsis thaliana 28% 100%
O54438 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 32% 100%
O54939 Rattus norvegicus 33% 100%
O57314 Anas platyrhynchos 37% 98%
O70503 Mus musculus 34% 98%
P06234 Rhizobium meliloti (strain 1021) 28% 100%
P07772 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 26% 100%
P0A9P9 Escherichia coli (strain K12) 26% 100%
P0A9Q0 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 26% 100%
P0CG22 Homo sapiens 25% 100%
P0CR34 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 28% 85%
P0CR35 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 28% 85%
P0DKC7 Arabidopsis thaliana 25% 100%
P0DKI3 Arabidopsis thaliana 24% 100%
P37058 Homo sapiens 32% 99%
P37959 Bacillus subtilis (strain 168) 28% 100%
P38286 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 88%
P39577 Bacillus subtilis (strain 168) 25% 100%
P40397 Bacillus subtilis (strain 168) 25% 100%
P40471 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P50162 Datura stramonium 23% 100%
P50163 Datura stramonium 24% 100%
P50164 Hyoscyamus niger 23% 100%
P50200 Paeniclostridium sordellii 26% 100%
P50202 Agrobacterium tumefaciens (strain 15955) 26% 71%
P50941 Rickettsia prowazekii (strain Madrid E) 26% 100%
P55336 Vibrio harveyi 30% 100%
P70385 Mus musculus 31% 100%
P87025 Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) 25% 100%
P9WGR6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 24% 100%
P9WGR7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 24% 100%
Q06136 Homo sapiens 21% 92%
Q09517 Caenorhabditis elegans 33% 97%
Q0CY11 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 33% 87%
Q0IH28 Xenopus laevis 23% 95%
Q0U3N7 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 32% 90%
Q0VFE7 Xenopus tropicalis 23% 99%
Q10130 Caenorhabditis elegans 30% 81%
Q10245 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 90%
Q12634 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 26% 100%
Q15SS0 Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) 24% 100%
Q17703 Caenorhabditis elegans 26% 97%
Q17704 Caenorhabditis elegans 25% 97%
Q1DNC5 Coccidioides immitis (strain RS) 32% 88%
Q28IU1 Xenopus tropicalis 38% 96%
Q2H1V7 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 32% 89%
Q2KIJ5 Bos taurus 22% 92%
Q2UET3 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 32% 88%
Q3SXM5 Homo sapiens 31% 93%
Q3T0R4 Bos taurus 23% 94%
Q3U0B3 Mus musculus 27% 100%
Q42182 Arabidopsis thaliana 29% 100%
Q49117 Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) 31% 100%
Q49WS9 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 27% 100%
Q4P622 Ustilago maydis (strain 521 / FGSC 9021) 32% 87%
Q4Q3K8 Leishmania major 93% 100%
Q4R5G7 Macaca fascicularis 35% 98%
Q4V8B7 Rattus norvegicus 29% 93%
Q4X117 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 32% 89%
Q53GQ0 Homo sapiens 33% 98%
Q59787 Cereibacter sphaeroides 28% 100%
Q59V93 Candida albicans (strain SC5314 / ATCC MYA-2876) 27% 88%
Q5B0R9 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 32% 88%
Q5E9H7 Bos taurus 33% 98%
Q5M875 Rattus norvegicus 24% 100%
Q5NVG2 Pongo abelii 24% 100%
Q5R6U1 Pongo abelii 24% 94%
Q5R7K0 Pongo abelii 32% 93%
Q5RCF8 Pongo abelii 27% 100%
Q5RJY4 Rattus norvegicus 25% 94%
Q5XG41 Xenopus laevis 36% 96%
Q5ZJG8 Gallus gallus 34% 92%
Q60V51 Caenorhabditis briggsae 32% 97%
Q68VY7 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 26% 100%
Q6AYS8 Rattus norvegicus 24% 100%
Q6BIG0 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 31% 88%
Q6CHP1 Yarrowia lipolytica (strain CLIB 122 / E 150) 31% 79%
Q6CVS4 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 32% 88%
Q6F7B8 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 26% 100%
Q6FRM0 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 30% 87%
Q6GV12 Mus musculus 23% 92%
Q6IAN0 Homo sapiens 24% 94%
Q6P3L6 Danio rerio 37% 96%
Q6P7R8 Rattus norvegicus 35% 98%
Q6QA32 Danio rerio 32% 100%
Q6QA33 Danio rerio 33% 98%
Q6UWP2 Homo sapiens 27% 100%
Q71R50 Gallus gallus 25% 100%
Q75A60 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 33% 87%
Q7Q732 Anopheles gambiae 26% 97%
Q7RYE5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 32% 92%
Q7SHI2 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%
Q7TQA3 Mus musculus 23% 99%
Q7Z5P4 Homo sapiens 24% 100%
Q82IY9 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 27% 100%
Q84ST4 Oryza sativa subsp. japonica 28% 89%
Q8AVY8 Xenopus laevis 37% 96%
Q8BTX9 Mus musculus 28% 93%
Q8JZV9 Mus musculus 28% 100%
Q8L9C4 Arabidopsis thaliana 30% 96%
Q8LEU3 Arabidopsis thaliana 24% 88%
Q8LKV5 Sesamum indicum 25% 85%
Q8NBQ5 Homo sapiens 24% 100%
Q8SPU8 Bos taurus 27% 100%
Q8WNV7 Sus scrofa 28% 100%
Q92EK7 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) 24% 100%
Q988B7 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 28% 100%
Q99J47 Mus musculus 25% 95%
Q99LB2 Mus musculus 28% 100%
Q9BTZ2 Homo sapiens 27% 100%
Q9CXR1 Mus musculus 26% 91%
Q9FYL6 Arabidopsis thaliana 37% 98%
Q9GKX2 Oryctolagus cuniculus 25% 100%
Q9HK58 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 28% 100%
Q9KQH7 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 30% 100%
Q9LHT0 Arabidopsis thaliana 25% 100%
Q9LUF2 Arabidopsis thaliana 25% 100%
Q9N126 Bos taurus 26% 98%
Q9X248 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 30% 100%
Q9Y140 Drosophila melanogaster 25% 94%
Q9ZW12 Arabidopsis thaliana 24% 95%
Q9ZW13 Arabidopsis thaliana 24% 100%
Q9ZW15 Arabidopsis thaliana 28% 100%
Q9ZW16 Arabidopsis thaliana 27% 100%
Q9ZW19 Arabidopsis thaliana 25% 100%
V5B6S6 Trypanosoma cruzi 57% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS