Small nuclear ribonucleoprotein Sm D2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein SmD2

Species:

Leishmania infantum

UniProt:

A4I9G0_LEIIN

TriTrypDb:

LINF_330042000

Length:

103

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Small nuclear ribonucleo SmD2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005682	U5 snRNP	5	1
GO:0005685	U1 snRNP	5	1
GO:0005686	U2 snRNP	5	1
GO:0005829	cytosol	2	12
GO:0030532	small nuclear ribonucleoprotein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071011	precatalytic spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1

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Expansion

Sequence features

A4I9G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9G0

Function

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Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.506
CLV_PCSK_KEX2_1	40	42	PF00082	0.347
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.347
CLV_PCSK_SKI1_1	17	21	PF00082	0.553
CLV_PCSK_SKI1_1	40	44	PF00082	0.323
CLV_PCSK_SKI1_1	50	54	PF00082	0.319
CLV_Separin_Metazoa	18	22	PF03568	0.660
DEG_Nend_UBRbox_2	1	3	PF02207	0.717
DOC_CYCLIN_RxL_1	11	23	PF00134	0.666
DOC_MAPK_gen_1	37	44	PF00069	0.419

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M6	Leptomonas seymouri	97%	100%
A0A0S4J4L5	Bodo saltans	50%	96%
A0A1X0NRD5	Trypanosomatidae	58%	93%
A0A3S7X782	Leishmania donovani	100%	100%
A0A422MRQ5	Trypanosoma rangeli	57%	93%
A4HM26	Leishmania braziliensis	96%	100%
C9ZJS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	93%
E9B4F8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O14036	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	90%
P62316	Homo sapiens	41%	87%

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