LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I9F9_LEIIN
TriTrypDb:
LINF_330041900
Length:
612

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 4
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4I9F9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9F9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 260 266 PF00089 0.597
CLV_NRD_NRD_1 346 348 PF00675 0.534
CLV_NRD_NRD_1 533 535 PF00675 0.487
CLV_PCSK_KEX2_1 345 347 PF00082 0.539
CLV_PCSK_SKI1_1 2 6 PF00082 0.577
DEG_Kelch_Keap1_1 469 474 PF01344 0.731
DEG_Kelch_Keap1_1 515 520 PF01344 0.763
DEG_Nend_UBRbox_1 1 4 PF02207 0.785
DEG_SCF_FBW7_1 206 211 PF00400 0.379
DOC_ANK_TNKS_1 369 376 PF00023 0.711
DOC_CKS1_1 420 425 PF01111 0.752
DOC_MAPK_DCC_7 7 16 PF00069 0.491
DOC_MAPK_gen_1 279 288 PF00069 0.467
DOC_MAPK_MEF2A_6 213 220 PF00069 0.508
DOC_MAPK_MEF2A_6 7 16 PF00069 0.511
DOC_PP1_RVXF_1 328 335 PF00149 0.580
DOC_USP7_MATH_1 112 116 PF00917 0.449
DOC_USP7_MATH_1 30 34 PF00917 0.540
DOC_USP7_MATH_1 39 43 PF00917 0.522
DOC_USP7_MATH_1 493 497 PF00917 0.824
DOC_USP7_MATH_1 79 83 PF00917 0.508
DOC_USP7_UBL2_3 233 237 PF12436 0.397
DOC_WW_Pin1_4 204 209 PF00397 0.381
DOC_WW_Pin1_4 222 227 PF00397 0.366
DOC_WW_Pin1_4 419 424 PF00397 0.793
DOC_WW_Pin1_4 6 11 PF00397 0.616
DOC_WW_Pin1_4 66 71 PF00397 0.410
LIG_14-3-3_CanoR_1 137 146 PF00244 0.490
LIG_14-3-3_CanoR_1 165 173 PF00244 0.503
LIG_14-3-3_CanoR_1 2 7 PF00244 0.772
LIG_14-3-3_CanoR_1 263 271 PF00244 0.535
LIG_14-3-3_CanoR_1 295 305 PF00244 0.511
LIG_14-3-3_CanoR_1 93 101 PF00244 0.486
LIG_BIR_III_4 364 368 PF00653 0.854
LIG_BIR_III_4 435 439 PF00653 0.764
LIG_EVH1_2 372 376 PF00568 0.859
LIG_FHA_1 114 120 PF00498 0.398
LIG_FHA_1 183 189 PF00498 0.382
LIG_FHA_1 3 9 PF00498 0.720
LIG_FHA_1 35 41 PF00498 0.501
LIG_FHA_1 452 458 PF00498 0.694
LIG_FHA_1 590 596 PF00498 0.860
LIG_FHA_1 60 66 PF00498 0.496
LIG_FHA_1 67 73 PF00498 0.373
LIG_FHA_1 96 102 PF00498 0.396
LIG_FHA_2 205 211 PF00498 0.499
LIG_FHA_2 510 516 PF00498 0.762
LIG_FHA_2 562 568 PF00498 0.826
LIG_FHA_2 579 585 PF00498 0.765
LIG_LIR_Apic_2 157 163 PF02991 0.450
LIG_LIR_Apic_2 466 470 PF02991 0.747
LIG_LIR_Apic_2 512 516 PF02991 0.747
LIG_LIR_Apic_2 546 552 PF02991 0.789
LIG_LIR_Apic_2 559 563 PF02991 0.684
LIG_LIR_Gen_1 167 178 PF02991 0.502
LIG_LIR_Gen_1 225 235 PF02991 0.375
LIG_LIR_Gen_1 521 532 PF02991 0.774
LIG_LIR_Nem_3 115 120 PF02991 0.433
LIG_LIR_Nem_3 167 173 PF02991 0.501
LIG_LIR_Nem_3 225 230 PF02991 0.372
LIG_LIR_Nem_3 310 316 PF02991 0.538
LIG_LIR_Nem_3 508 513 PF02991 0.764
LIG_LIR_Nem_3 521 527 PF02991 0.670
LIG_Pex14_1 314 318 PF04695 0.414
LIG_Pex14_2 318 322 PF04695 0.463
LIG_Pex14_2 329 333 PF04695 0.645
LIG_SH2_CRK 160 164 PF00017 0.475
LIG_SH2_CRK 170 174 PF00017 0.511
LIG_SH2_CRK 227 231 PF00017 0.421
LIG_SH2_CRK 524 528 PF00017 0.707
LIG_SH2_CRK 549 553 PF00017 0.750
LIG_SH2_GRB2like 467 470 PF00017 0.763
LIG_SH2_GRB2like 549 552 PF00017 0.775
LIG_SH2_NCK_1 524 528 PF00017 0.843
LIG_SH2_NCK_1 549 553 PF00017 0.750
LIG_SH2_NCK_1 607 611 PF00017 0.786
LIG_SH2_PTP2 467 470 PF00017 0.730
LIG_SH2_PTP2 513 516 PF00017 0.745
LIG_SH2_PTP2 538 541 PF00017 0.661
LIG_SH2_PTP2 560 563 PF00017 0.729
LIG_SH2_PTP2 596 599 PF00017 0.759
LIG_SH2_SRC 172 175 PF00017 0.586
LIG_SH2_SRC 467 470 PF00017 0.746
LIG_SH2_SRC 513 516 PF00017 0.745
LIG_SH2_SRC 536 539 PF00017 0.805
LIG_SH2_SRC 547 550 PF00017 0.753
LIG_SH2_SRC 558 561 PF00017 0.729
LIG_SH2_SRC 596 599 PF00017 0.759
LIG_SH2_STAP1 399 403 PF00017 0.734
LIG_SH2_STAP1 571 575 PF00017 0.791
LIG_SH2_STAT5 118 121 PF00017 0.447
LIG_SH2_STAT5 172 175 PF00017 0.547
LIG_SH2_STAT5 187 190 PF00017 0.414
LIG_SH2_STAT5 198 201 PF00017 0.402
LIG_SH2_STAT5 202 205 PF00017 0.424
LIG_SH2_STAT5 227 230 PF00017 0.477
LIG_SH2_STAT5 245 248 PF00017 0.431
LIG_SH2_STAT5 331 334 PF00017 0.642
LIG_SH2_STAT5 431 434 PF00017 0.738
LIG_SH2_STAT5 467 470 PF00017 0.738
LIG_SH2_STAT5 478 481 PF00017 0.778
LIG_SH2_STAT5 513 516 PF00017 0.756
LIG_SH2_STAT5 524 527 PF00017 0.783
LIG_SH2_STAT5 538 541 PF00017 0.649
LIG_SH2_STAT5 560 563 PF00017 0.744
LIG_SH2_STAT5 571 574 PF00017 0.788
LIG_SH2_STAT5 596 599 PF00017 0.759
LIG_SH3_3 215 221 PF00018 0.513
LIG_TRAF2_1 485 488 PF00917 0.867
LIG_TRFH_1 187 191 PF08558 0.487
MOD_CK1_1 104 110 PF00069 0.409
MOD_CK1_1 130 136 PF00069 0.341
MOD_CK1_1 149 155 PF00069 0.425
MOD_CK1_1 222 228 PF00069 0.496
MOD_CK1_1 298 304 PF00069 0.593
MOD_CK1_1 34 40 PF00069 0.512
MOD_CK1_1 448 454 PF00069 0.861
MOD_CK1_1 66 72 PF00069 0.403
MOD_CK1_1 82 88 PF00069 0.506
MOD_CK1_1 95 101 PF00069 0.435
MOD_CK2_1 204 210 PF00069 0.466
MOD_CK2_1 286 292 PF00069 0.495
MOD_CK2_1 493 499 PF00069 0.784
MOD_CK2_1 514 520 PF00069 0.789
MOD_CK2_1 561 567 PF00069 0.823
MOD_CK2_1 578 584 PF00069 0.679
MOD_GlcNHglycan 139 142 PF01048 0.608
MOD_GlcNHglycan 33 36 PF01048 0.787
MOD_GlcNHglycan 434 439 PF01048 0.580
MOD_GlcNHglycan 49 52 PF01048 0.568
MOD_GlcNHglycan 65 68 PF01048 0.469
MOD_GlcNHglycan 77 80 PF01048 0.634
MOD_GlcNHglycan 81 84 PF01048 0.670
MOD_GSK3_1 101 108 PF00069 0.468
MOD_GSK3_1 125 132 PF00069 0.481
MOD_GSK3_1 137 144 PF00069 0.311
MOD_GSK3_1 145 152 PF00069 0.381
MOD_GSK3_1 164 171 PF00069 0.414
MOD_GSK3_1 2 9 PF00069 0.723
MOD_GSK3_1 204 211 PF00069 0.495
MOD_GSK3_1 287 294 PF00069 0.479
MOD_GSK3_1 297 304 PF00069 0.566
MOD_GSK3_1 30 37 PF00069 0.504
MOD_GSK3_1 472 479 PF00069 0.825
MOD_GSK3_1 489 496 PF00069 0.735
MOD_GSK3_1 514 521 PF00069 0.779
MOD_GSK3_1 53 60 PF00069 0.380
MOD_GSK3_1 561 568 PF00069 0.769
MOD_GSK3_1 68 75 PF00069 0.345
MOD_N-GLC_1 113 118 PF02516 0.717
MOD_N-GLC_1 126 131 PF02516 0.558
MOD_N-GLC_1 45 50 PF02516 0.547
MOD_N-GLC_1 577 582 PF02516 0.633
MOD_N-GLC_1 72 77 PF02516 0.665
MOD_NEK2_1 101 106 PF00069 0.446
MOD_NEK2_1 146 151 PF00069 0.423
MOD_NEK2_1 153 158 PF00069 0.382
MOD_NEK2_1 376 381 PF00069 0.823
MOD_NEK2_1 45 50 PF00069 0.405
MOD_NEK2_2 182 187 PF00069 0.475
MOD_NEK2_2 208 213 PF00069 0.464
MOD_PIKK_1 118 124 PF00454 0.427
MOD_PIKK_1 445 451 PF00454 0.872
MOD_PIKK_1 522 528 PF00454 0.786
MOD_PKA_2 136 142 PF00069 0.487
MOD_PKA_2 164 170 PF00069 0.574
MOD_PKA_2 212 218 PF00069 0.455
MOD_PKA_2 301 307 PF00069 0.603
MOD_PKA_2 92 98 PF00069 0.499
MOD_PKB_1 335 343 PF00069 0.705
MOD_Plk_1 113 119 PF00069 0.514
MOD_Plk_1 126 132 PF00069 0.359
MOD_Plk_1 291 297 PF00069 0.539
MOD_Plk_1 376 382 PF00069 0.767
MOD_Plk_1 45 51 PF00069 0.276
MOD_Plk_1 493 499 PF00069 0.800
MOD_Plk_1 72 78 PF00069 0.471
MOD_Plk_1 95 101 PF00069 0.424
MOD_Plk_4 101 107 PF00069 0.421
MOD_Plk_4 113 119 PF00069 0.431
MOD_Plk_4 168 174 PF00069 0.502
MOD_Plk_4 182 188 PF00069 0.418
MOD_Plk_4 212 218 PF00069 0.452
MOD_Plk_4 225 231 PF00069 0.394
MOD_Plk_4 463 469 PF00069 0.736
MOD_Plk_4 509 515 PF00069 0.753
MOD_ProDKin_1 204 210 PF00069 0.383
MOD_ProDKin_1 222 228 PF00069 0.358
MOD_ProDKin_1 419 425 PF00069 0.792
MOD_ProDKin_1 6 12 PF00069 0.616
MOD_ProDKin_1 66 72 PF00069 0.403
TRG_ENDOCYTIC_2 117 120 PF00928 0.437
TRG_ENDOCYTIC_2 170 173 PF00928 0.511
TRG_ENDOCYTIC_2 227 230 PF00928 0.362
TRG_ENDOCYTIC_2 280 283 PF00928 0.469
TRG_ENDOCYTIC_2 313 316 PF00928 0.445
TRG_ENDOCYTIC_2 331 334 PF00928 0.518
TRG_ENDOCYTIC_2 524 527 PF00928 0.716
TRG_ENDOCYTIC_2 536 539 PF00928 0.659
TRG_ENDOCYTIC_2 558 561 PF00928 0.755
TRG_ER_diArg_1 334 337 PF00400 0.702
TRG_ER_diArg_1 345 347 PF00400 0.691

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Z7 Leptomonas seymouri 43% 100%
A0A3S7X786 Leishmania donovani 100% 100%
A4HM25 Leishmania braziliensis 61% 97%
E9B4F7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 76%
Q4Q3L8 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS