GAR domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9F8_LEIIN

TriTrypDb:

LINF_330041800

Length:

531

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I9F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9F8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.629
CLV_C14_Caspase3-7	310	314	PF00656	0.575
CLV_C14_Caspase3-7	82	86	PF00656	0.611
CLV_NRD_NRD_1	120	122	PF00675	0.539
CLV_NRD_NRD_1	514	516	PF00675	0.573
CLV_PCSK_KEX2_1	120	122	PF00082	0.485
CLV_PCSK_KEX2_1	296	298	PF00082	0.567
CLV_PCSK_KEX2_1	300	302	PF00082	0.581
CLV_PCSK_KEX2_1	514	516	PF00082	0.629
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.606
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.619
CLV_PCSK_SKI1_1	120	124	PF00082	0.532
CLV_PCSK_SKI1_1	230	234	PF00082	0.500
CLV_PCSK_SKI1_1	297	301	PF00082	0.561
CLV_PCSK_SKI1_1	332	336	PF00082	0.450
CLV_PCSK_SKI1_1	343	347	PF00082	0.518
CLV_PCSK_SKI1_1	355	359	PF00082	0.392
CLV_PCSK_SKI1_1	73	77	PF00082	0.613
DEG_APCC_DBOX_1	354	362	PF00400	0.476
DEG_MDM2_SWIB_1	28	36	PF02201	0.525
DEG_Nend_UBRbox_1	1	4	PF02207	0.699
DOC_CDC14_PxL_1	517	525	PF14671	0.630
DOC_CYCLIN_RxL_1	117	125	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.630
DOC_MAPK_gen_1	309	317	PF00069	0.581
DOC_MAPK_MEF2A_6	217	224	PF00069	0.524
DOC_PP2B_LxvP_1	315	318	PF13499	0.634
DOC_USP7_MATH_1	103	107	PF00917	0.581
DOC_USP7_MATH_1	20	24	PF00917	0.492
DOC_USP7_MATH_1	349	353	PF00917	0.572
DOC_USP7_MATH_1	432	436	PF00917	0.679
DOC_USP7_MATH_1	466	470	PF00917	0.744
DOC_USP7_MATH_1	488	492	PF00917	0.770
DOC_USP7_MATH_1	506	510	PF00917	0.457
DOC_USP7_MATH_1	59	63	PF00917	0.540
DOC_USP7_MATH_1	87	91	PF00917	0.573
DOC_USP7_UBL2_3	292	296	PF12436	0.599
DOC_WW_Pin1_4	215	220	PF00397	0.622
DOC_WW_Pin1_4	482	487	PF00397	0.748
DOC_WW_Pin1_4	495	500	PF00397	0.555
LIG_14-3-3_CanoR_1	130	134	PF00244	0.595
LIG_14-3-3_CanoR_1	158	168	PF00244	0.559
LIG_14-3-3_CanoR_1	225	229	PF00244	0.592
LIG_14-3-3_CanoR_1	235	240	PF00244	0.522
LIG_14-3-3_CanoR_1	430	439	PF00244	0.759
LIG_14-3-3_CanoR_1	515	521	PF00244	0.640
LIG_14-3-3_CanoR_1	70	80	PF00244	0.705
LIG_Actin_WH2_2	115	132	PF00022	0.531
LIG_APCC_Cbox_2	97	103	PF00515	0.572
LIG_BRCT_BRCA1_1	243	247	PF00533	0.574
LIG_CaM_IQ_9	277	292	PF13499	0.653
LIG_Clathr_ClatBox_1	13	17	PF01394	0.656
LIG_FHA_1	107	113	PF00498	0.592
LIG_FHA_1	135	141	PF00498	0.574
LIG_FHA_1	149	155	PF00498	0.484
LIG_FHA_1	16	22	PF00498	0.547
LIG_FHA_1	170	176	PF00498	0.562
LIG_FHA_1	192	198	PF00498	0.776
LIG_FHA_1	231	237	PF00498	0.552
LIG_FHA_1	263	269	PF00498	0.676
LIG_FHA_1	90	96	PF00498	0.607
LIG_FHA_2	100	106	PF00498	0.634
LIG_FHA_2	308	314	PF00498	0.502
LIG_FHA_2	325	331	PF00498	0.575
LIG_FHA_2	457	463	PF00498	0.776
LIG_FHA_2	471	477	PF00498	0.474
LIG_LIR_Apic_2	461	466	PF02991	0.681
LIG_LIR_Gen_1	302	312	PF02991	0.546
LIG_LIR_Nem_3	302	307	PF02991	0.544
LIG_LIR_Nem_3	352	357	PF02991	0.487
LIG_Pex14_2	28	32	PF04695	0.527
LIG_SH2_CRK	439	443	PF00017	0.697
LIG_SH2_CRK	463	467	PF00017	0.690
LIG_SH2_NCK_1	525	529	PF00017	0.576
LIG_SH2_STAP1	504	508	PF00017	0.549
LIG_SH2_STAT5	267	270	PF00017	0.680
LIG_SH3_2	416	421	PF14604	0.652
LIG_SH3_3	408	414	PF00018	0.744
LIG_SH3_3	518	524	PF00018	0.547
LIG_SUMO_SIM_par_1	218	223	PF11976	0.587
LIG_TRAF2_1	376	379	PF00917	0.764
LIG_WRC_WIRS_1	221	226	PF05994	0.506
LIG_WRC_WIRS_1	60	65	PF05994	0.546
MOD_CDK_SPK_2	482	487	PF00069	0.710
MOD_CK1_1	106	112	PF00069	0.633
MOD_CK1_1	132	138	PF00069	0.623
MOD_CK1_1	141	147	PF00069	0.506
MOD_CK1_1	187	193	PF00069	0.566
MOD_CK1_1	201	207	PF00069	0.699
MOD_CK1_1	210	216	PF00069	0.498
MOD_CK1_1	445	451	PF00069	0.709
MOD_CK1_1	5	11	PF00069	0.730
MOD_CK2_1	16	22	PF00069	0.590
MOD_CK2_1	324	330	PF00069	0.505
MOD_CK2_1	373	379	PF00069	0.715
MOD_CK2_1	417	423	PF00069	0.775
MOD_CK2_1	456	462	PF00069	0.778
MOD_CK2_1	470	476	PF00069	0.744
MOD_CK2_1	5	11	PF00069	0.699
MOD_CK2_1	99	105	PF00069	0.619
MOD_GlcNHglycan	105	108	PF01048	0.647
MOD_GlcNHglycan	134	137	PF01048	0.577
MOD_GlcNHglycan	164	167	PF01048	0.545
MOD_GlcNHglycan	17	21	PF01048	0.533
MOD_GlcNHglycan	186	189	PF01048	0.643
MOD_GlcNHglycan	198	201	PF01048	0.637
MOD_GlcNHglycan	203	206	PF01048	0.617
MOD_GlcNHglycan	272	275	PF01048	0.621
MOD_GlcNHglycan	4	7	PF01048	0.730
MOD_GlcNHglycan	432	435	PF01048	0.685
MOD_GlcNHglycan	45	48	PF01048	0.498
MOD_GlcNHglycan	456	459	PF01048	0.637
MOD_GlcNHglycan	89	92	PF01048	0.663
MOD_GSK3_1	1	8	PF00069	0.664
MOD_GSK3_1	134	141	PF00069	0.571
MOD_GSK3_1	158	165	PF00069	0.545
MOD_GSK3_1	16	23	PF00069	0.506
MOD_GSK3_1	187	194	PF00069	0.632
MOD_GSK3_1	220	227	PF00069	0.585
MOD_GSK3_1	230	237	PF00069	0.489
MOD_GSK3_1	303	310	PF00069	0.468
MOD_GSK3_1	357	364	PF00069	0.583
MOD_GSK3_1	426	433	PF00069	0.684
MOD_GSK3_1	441	448	PF00069	0.656
MOD_GSK3_1	454	461	PF00069	0.621
MOD_GSK3_1	466	473	PF00069	0.525
MOD_GSK3_1	506	513	PF00069	0.662
MOD_GSK3_1	59	66	PF00069	0.504
MOD_GSK3_1	99	106	PF00069	0.608
MOD_NEK2_1	1	6	PF00069	0.742
MOD_NEK2_1	16	21	PF00069	0.540
MOD_NEK2_1	167	172	PF00069	0.497
MOD_NEK2_1	196	201	PF00069	0.722
MOD_NEK2_1	220	225	PF00069	0.559
MOD_NEK2_1	247	252	PF00069	0.533
MOD_NEK2_1	280	285	PF00069	0.613
MOD_NEK2_1	307	312	PF00069	0.565
MOD_NEK2_1	357	362	PF00069	0.617
MOD_NEK2_1	442	447	PF00069	0.774
MOD_NEK2_1	63	68	PF00069	0.558
MOD_NEK2_1	99	104	PF00069	0.593
MOD_PIKK_1	159	165	PF00454	0.541
MOD_PIKK_1	361	367	PF00454	0.657
MOD_PIKK_1	432	438	PF00454	0.727
MOD_PIKK_1	456	462	PF00454	0.776
MOD_PIKK_1	470	476	PF00454	0.472
MOD_PIKK_1	497	503	PF00454	0.590
MOD_PIKK_1	89	95	PF00454	0.597
MOD_PK_1	235	241	PF00069	0.576
MOD_PKA_2	1	7	PF00069	0.691
MOD_PKA_2	129	135	PF00069	0.546
MOD_PKA_2	224	230	PF00069	0.558
MOD_PKA_2	234	240	PF00069	0.483
MOD_PKA_2	393	399	PF00069	0.758
MOD_PKB_1	428	436	PF00069	0.566
MOD_Plk_1	16	22	PF00069	0.590
MOD_Plk_1	488	494	PF00069	0.704
MOD_Plk_2-3	207	213	PF00069	0.703
MOD_Plk_4	192	198	PF00069	0.749
MOD_Plk_4	210	216	PF00069	0.651
MOD_Plk_4	224	230	PF00069	0.490
MOD_Plk_4	235	241	PF00069	0.544
MOD_Plk_4	303	309	PF00069	0.579
MOD_Plk_4	311	317	PF00069	0.625
MOD_Plk_4	393	399	PF00069	0.744
MOD_Plk_4	488	494	PF00069	0.755
MOD_Plk_4	59	65	PF00069	0.562
MOD_ProDKin_1	215	221	PF00069	0.614
MOD_ProDKin_1	482	488	PF00069	0.749
MOD_ProDKin_1	495	501	PF00069	0.549
TRG_DiLeu_BaEn_1	303	308	PF01217	0.540
TRG_DiLeu_BaEn_1	353	358	PF01217	0.606
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.525
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.567
TRG_ENDOCYTIC_2	439	442	PF00928	0.701
TRG_ENDOCYTIC_2	504	507	PF00928	0.610
TRG_ER_diArg_1	120	122	PF00400	0.533
TRG_ER_diArg_1	427	430	PF00400	0.689
TRG_NES_CRM1_1	169	184	PF08389	0.574
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K5	Leptomonas seymouri	46%	97%
A0A0S4J1S4	Bodo saltans	26%	68%
A0A3Q8IMT0	Leishmania donovani	98%	100%
A0A422N0Y7	Trypanosoma rangeli	27%	100%
A4HM24	Leishmania braziliensis	66%	100%
C9ZJT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9B4F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q3L9	Leishmania major	89%	100%