Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9F7_LEIIN

TriTrypDb:

LINF_330041700

Length:

489

Annotations

LeishMANIAdb annotations

A protein with very uncertain structure. However, it does not appear to be transmembrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9F7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.502
CLV_C14_Caspase3-7	280	284	PF00656	0.405
CLV_NRD_NRD_1	11	13	PF00675	0.454
CLV_NRD_NRD_1	164	166	PF00675	0.434
CLV_NRD_NRD_1	2	4	PF00675	0.459
CLV_NRD_NRD_1	276	278	PF00675	0.638
CLV_NRD_NRD_1	289	291	PF00675	0.618
CLV_NRD_NRD_1	303	305	PF00675	0.515
CLV_NRD_NRD_1	390	392	PF00675	0.608
CLV_NRD_NRD_1	400	402	PF00675	0.588
CLV_NRD_NRD_1	433	435	PF00675	0.612
CLV_NRD_NRD_1	456	458	PF00675	0.585
CLV_NRD_NRD_1	46	48	PF00675	0.407
CLV_PCSK_KEX2_1	11	13	PF00082	0.437
CLV_PCSK_KEX2_1	120	122	PF00082	0.416
CLV_PCSK_KEX2_1	163	165	PF00082	0.377
CLV_PCSK_KEX2_1	2	4	PF00082	0.459
CLV_PCSK_KEX2_1	276	278	PF00082	0.591
CLV_PCSK_KEX2_1	289	291	PF00082	0.574
CLV_PCSK_KEX2_1	305	307	PF00082	0.518
CLV_PCSK_KEX2_1	390	392	PF00082	0.606
CLV_PCSK_KEX2_1	400	402	PF00082	0.556
CLV_PCSK_KEX2_1	433	435	PF00082	0.612
CLV_PCSK_KEX2_1	456	458	PF00082	0.585
CLV_PCSK_KEX2_1	46	48	PF00082	0.431
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.416
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.377
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.609
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.529
CLV_PCSK_SKI1_1	12	16	PF00082	0.383
CLV_PCSK_SKI1_1	205	209	PF00082	0.345
CLV_PCSK_SKI1_1	235	239	PF00082	0.289
CLV_PCSK_SKI1_1	296	300	PF00082	0.599
CLV_PCSK_SKI1_1	400	404	PF00082	0.584
CLV_PCSK_SKI1_1	456	460	PF00082	0.587
DEG_APCC_DBOX_1	305	313	PF00400	0.386
DEG_Nend_UBRbox_1	1	4	PF02207	0.630
DEG_SPOP_SBC_1	135	139	PF00917	0.639
DOC_CKS1_1	98	103	PF01111	0.662
DOC_CYCLIN_RxL_1	453	464	PF00134	0.386
DOC_MAPK_MEF2A_6	179	187	PF00069	0.563
DOC_MAPK_MEF2A_6	235	243	PF00069	0.346
DOC_PP1_RVXF_1	118	125	PF00149	0.615
DOC_PP4_FxxP_1	124	127	PF00568	0.635
DOC_PP4_FxxP_1	60	63	PF00568	0.678
DOC_USP7_MATH_1	105	109	PF00917	0.742
DOC_USP7_MATH_1	372	376	PF00917	0.561
DOC_USP7_UBL2_3	292	296	PF12436	0.373
DOC_USP7_UBL2_3	31	35	PF12436	0.639
DOC_WW_Pin1_4	153	158	PF00397	0.657
DOC_WW_Pin1_4	362	367	PF00397	0.482
DOC_WW_Pin1_4	97	102	PF00397	0.645
LIG_14-3-3_CanoR_1	11	19	PF00244	0.702
LIG_14-3-3_CanoR_1	20	26	PF00244	0.660
LIG_14-3-3_CanoR_1	253	259	PF00244	0.364
LIG_14-3-3_CanoR_1	407	415	PF00244	0.462
LIG_14-3-3_CanoR_1	53	63	PF00244	0.699
LIG_BRCT_BRCA1_1	56	60	PF00533	0.715
LIG_Clathr_ClatBox_1	184	188	PF01394	0.534
LIG_deltaCOP1_diTrp_1	221	226	PF00928	0.556
LIG_deltaCOP1_diTrp_1	412	419	PF00928	0.430
LIG_eIF4E_1	228	234	PF01652	0.388
LIG_FHA_1	11	17	PF00498	0.688
LIG_FHA_1	136	142	PF00498	0.631
LIG_FHA_1	228	234	PF00498	0.323
LIG_FHA_1	236	242	PF00498	0.209
LIG_FHA_1	94	100	PF00498	0.649
LIG_FHA_2	197	203	PF00498	0.535
LIG_FHA_2	354	360	PF00498	0.450
LIG_FHA_2	378	384	PF00498	0.418
LIG_FHA_2	81	87	PF00498	0.624
LIG_GBD_Chelix_1	339	347	PF00786	0.550
LIG_LIR_Apic_2	484	488	PF02991	0.401
LIG_LIR_Apic_2	57	63	PF02991	0.629
LIG_LIR_Gen_1	180	189	PF02991	0.550
LIG_LIR_Gen_1	238	246	PF02991	0.313
LIG_LIR_Gen_1	257	266	PF02991	0.371
LIG_LIR_Gen_1	341	349	PF02991	0.507
LIG_LIR_Gen_1	412	422	PF02991	0.417
LIG_LIR_Gen_1	92	101	PF02991	0.718
LIG_LIR_Nem_3	180	185	PF02991	0.556
LIG_LIR_Nem_3	223	229	PF02991	0.459
LIG_LIR_Nem_3	257	262	PF02991	0.406
LIG_LIR_Nem_3	294	298	PF02991	0.340
LIG_LIR_Nem_3	341	347	PF02991	0.503
LIG_LIR_Nem_3	412	418	PF02991	0.412
LIG_LIR_Nem_3	82	88	PF02991	0.619
LIG_LIR_Nem_3	92	98	PF02991	0.627
LIG_NRBOX	232	238	PF00104	0.350
LIG_NRBOX	338	344	PF00104	0.398
LIG_PCNA_PIPBox_1	243	252	PF02747	0.396
LIG_Pex14_1	222	226	PF04695	0.558
LIG_SH2_CRK	229	233	PF00017	0.308
LIG_SH2_SRC	485	488	PF00017	0.466
LIG_SH2_STAP1	229	233	PF00017	0.369
LIG_SH2_STAP1	250	254	PF00017	0.318
LIG_SH2_STAP1	259	263	PF00017	0.327
LIG_SH2_STAT5	229	232	PF00017	0.390
LIG_SH2_STAT5	440	443	PF00017	0.435
LIG_SH3_4	292	299	PF00018	0.394
LIG_SUMO_SIM_par_1	183	188	PF11976	0.535
LIG_SUMO_SIM_par_1	61	67	PF11976	0.538
LIG_SxIP_EBH_1	442	456	PF03271	0.431
LIG_TRAF2_1	199	202	PF00917	0.567
LIG_TRAF2_1	284	287	PF00917	0.367
LIG_TRAF2_1	316	319	PF00917	0.456
LIG_TRAF2_1	381	384	PF00917	0.469
LIG_UBA3_1	183	191	PF00899	0.563
LIG_WRC_WIRS_1	16	21	PF05994	0.681
MOD_CK1_1	406	412	PF00069	0.471
MOD_CK1_1	448	454	PF00069	0.440
MOD_CK1_1	97	103	PF00069	0.659
MOD_CK2_1	196	202	PF00069	0.548
MOD_CK2_1	21	27	PF00069	0.640
MOD_CK2_1	294	300	PF00069	0.443
MOD_CK2_1	353	359	PF00069	0.537
MOD_CK2_1	377	383	PF00069	0.416
MOD_CK2_1	406	412	PF00069	0.483
MOD_GlcNHglycan	107	110	PF01048	0.525
MOD_GlcNHglycan	372	375	PF01048	0.677
MOD_GlcNHglycan	408	411	PF01048	0.662
MOD_GlcNHglycan	66	69	PF01048	0.405
MOD_GSK3_1	15	22	PF00069	0.709
MOD_GSK3_1	167	174	PF00069	0.581
MOD_GSK3_1	444	451	PF00069	0.382
MOD_GSK3_1	6	13	PF00069	0.693
MOD_GSK3_1	89	96	PF00069	0.604
MOD_N-GLC_1	205	210	PF02516	0.356
MOD_NEK2_1	10	15	PF00069	0.721
MOD_NEK2_1	19	24	PF00069	0.690
MOD_NEK2_1	254	259	PF00069	0.337
MOD_NEK2_1	405	410	PF00069	0.490
MOD_PIKK_1	54	60	PF00454	0.714
MOD_PKA_1	400	406	PF00069	0.506
MOD_PKA_2	10	16	PF00069	0.649
MOD_PKA_2	19	25	PF00069	0.596
MOD_PKA_2	332	338	PF00069	0.508
MOD_PKA_2	400	406	PF00069	0.483
MOD_PKA_2	79	85	PF00069	0.686
MOD_Plk_1	151	157	PF00069	0.681
MOD_Plk_1	378	384	PF00069	0.554
MOD_Plk_1	93	99	PF00069	0.719
MOD_Plk_2-3	294	300	PF00069	0.374
MOD_Plk_2-3	325	331	PF00069	0.502
MOD_Plk_4	136	142	PF00069	0.637
MOD_Plk_4	228	234	PF00069	0.289
MOD_Plk_4	235	241	PF00069	0.289
MOD_Plk_4	254	260	PF00069	0.389
MOD_Plk_4	294	300	PF00069	0.443
MOD_Plk_4	94	100	PF00069	0.727
MOD_ProDKin_1	153	159	PF00069	0.655
MOD_ProDKin_1	362	368	PF00069	0.483
MOD_ProDKin_1	97	103	PF00069	0.647
MOD_SUMO_for_1	30	33	PF00179	0.679
MOD_SUMO_rev_2	22	30	PF00179	0.695
MOD_SUMO_rev_2	365	372	PF00179	0.549
TRG_DiLeu_BaEn_1	180	185	PF01217	0.548
TRG_ENDOCYTIC_2	229	232	PF00928	0.293
TRG_ENDOCYTIC_2	259	262	PF00928	0.319
TRG_ER_diArg_1	1	3	PF00400	0.665
TRG_ER_diArg_1	10	12	PF00400	0.640
TRG_ER_diArg_1	125	128	PF00400	0.640
TRG_ER_diArg_1	288	290	PF00400	0.462
TRG_ER_diArg_1	399	401	PF00400	0.407
TRG_ER_diArg_1	432	434	PF00400	0.412
TRG_ER_diArg_1	455	457	PF00400	0.380
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE42	Leptomonas seymouri	65%	100%
A0A0S4JAR7	Bodo saltans	38%	87%
A0A1X0NS34	Trypanosomatidae	48%	92%
A0A3R7N841	Trypanosoma rangeli	50%	95%
A0A3S5H7V5	Leishmania donovani	99%	100%
A4HM23	Leishmania braziliensis	80%	99%
C9ZJT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	93%
E9B4F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3M0	Leishmania major	93%	100%
V5B2X5	Trypanosoma cruzi	45%	100%