LeishMANIAdb
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Trypsin-like peptidase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Trypsin-like peptidase domain-containing protein
Gene product:
Trypsin-like peptidase domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I9F4_LEIIN
TriTrypDb:
LINF_330041400
Length:
305

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4I9F4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9F4

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004175 endopeptidase activity 4 1
GO:0004252 serine-type endopeptidase activity 5 1
GO:0008233 peptidase activity 3 1
GO:0008236 serine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0017171 serine hydrolase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 109 113 PF00656 0.508
CLV_C14_Caspase3-7 231 235 PF00656 0.554
CLV_NRD_NRD_1 224 226 PF00675 0.522
CLV_NRD_NRD_1 298 300 PF00675 0.387
CLV_PCSK_KEX2_1 224 226 PF00082 0.522
CLV_PCSK_KEX2_1 300 302 PF00082 0.588
CLV_PCSK_PC1ET2_1 300 302 PF00082 0.588
CLV_PCSK_SKI1_1 209 213 PF00082 0.580
CLV_PCSK_SKI1_1 224 228 PF00082 0.558
DOC_AGCK_PIF_2 78 83 PF00069 0.448
DOC_ANK_TNKS_1 107 114 PF00023 0.501
DOC_CYCLIN_RxL_1 36 47 PF00134 0.457
DOC_MAPK_gen_1 222 232 PF00069 0.566
DOC_MAPK_JIP1_4 39 45 PF00069 0.456
DOC_MAPK_MEF2A_6 21 30 PF00069 0.437
DOC_MAPK_MEF2A_6 36 45 PF00069 0.330
DOC_PP2B_LxvP_1 31 34 PF13499 0.367
DOC_PP2B_LxvP_1 90 93 PF13499 0.441
DOC_SPAK_OSR1_1 100 104 PF12202 0.437
DOC_USP7_MATH_1 15 19 PF00917 0.472
DOC_USP7_MATH_1 174 178 PF00917 0.526
DOC_USP7_MATH_1 65 69 PF00917 0.636
DOC_USP7_MATH_1 74 78 PF00917 0.437
DOC_USP7_UBL2_3 94 98 PF12436 0.503
DOC_WW_Pin1_4 151 156 PF00397 0.639
DOC_WW_Pin1_4 279 284 PF00397 0.409
DOC_WW_Pin1_4 76 81 PF00397 0.428
LIG_14-3-3_CanoR_1 224 233 PF00244 0.575
LIG_BIR_II_1 1 5 PF00653 0.747
LIG_BIR_III_4 110 114 PF00653 0.515
LIG_BIR_III_4 234 238 PF00653 0.548
LIG_BIR_III_4 274 278 PF00653 0.554
LIG_Clathr_ClatBox_1 136 140 PF01394 0.515
LIG_FHA_1 225 231 PF00498 0.509
LIG_FHA_1 36 42 PF00498 0.462
LIG_FHA_2 107 113 PF00498 0.561
LIG_LIR_Apic_2 151 155 PF02991 0.531
LIG_LIR_Apic_2 58 64 PF02991 0.472
LIG_LIR_Apic_2 95 99 PF02991 0.451
LIG_LIR_Gen_1 29 37 PF02991 0.389
LIG_LIR_Nem_3 29 33 PF02991 0.365
LIG_LYPXL_SIV_4 172 180 PF13949 0.491
LIG_LYPXL_yS_3 25 28 PF13949 0.287
LIG_SH2_CRK 152 156 PF00017 0.491
LIG_SH2_CRK 61 65 PF00017 0.630
LIG_SH2_CRK 96 100 PF00017 0.523
LIG_SH2_NCK_1 152 156 PF00017 0.491
LIG_SH2_STAP1 83 87 PF00017 0.589
LIG_SH2_STAT5 281 284 PF00017 0.355
LIG_SH2_STAT5 83 86 PF00017 0.508
LIG_SH3_1 61 67 PF00018 0.486
LIG_SH3_3 270 276 PF00018 0.592
LIG_SH3_3 61 67 PF00018 0.589
LIG_SUMO_SIM_anti_2 133 138 PF11976 0.408
LIG_SUMO_SIM_anti_2 227 234 PF11976 0.556
LIG_SUMO_SIM_par_1 12 18 PF11976 0.318
LIG_SUMO_SIM_par_1 135 140 PF11976 0.480
LIG_SUMO_SIM_par_1 227 234 PF11976 0.563
LIG_UBA3_1 27 36 PF00899 0.496
LIG_WRC_WIRS_1 27 32 PF05994 0.390
MOD_GlcNHglycan 252 255 PF01048 0.382
MOD_GSK3_1 192 199 PF00069 0.530
MOD_GSK3_1 224 231 PF00069 0.513
MOD_GSK3_1 66 73 PF00069 0.447
MOD_GSK3_1 81 88 PF00069 0.387
MOD_NEK2_1 257 262 PF00069 0.498
MOD_NEK2_1 44 49 PF00069 0.353
MOD_NEK2_1 70 75 PF00069 0.366
MOD_PIKK_1 15 21 PF00454 0.567
MOD_PIKK_1 85 91 PF00454 0.585
MOD_PKA_1 224 230 PF00069 0.514
MOD_PKA_2 224 230 PF00069 0.554
MOD_Plk_1 57 63 PF00069 0.651
MOD_Plk_1 85 91 PF00069 0.585
MOD_Plk_2-3 192 198 PF00069 0.517
MOD_Plk_4 196 202 PF00069 0.543
MOD_Plk_4 228 234 PF00069 0.494
MOD_Plk_4 26 32 PF00069 0.354
MOD_Plk_4 66 72 PF00069 0.531
MOD_ProDKin_1 151 157 PF00069 0.638
MOD_ProDKin_1 279 285 PF00069 0.414
MOD_ProDKin_1 76 82 PF00069 0.439
TRG_DiLeu_BaEn_1 208 213 PF01217 0.542
TRG_DiLeu_BaLyEn_6 121 126 PF01217 0.539
TRG_ENDOCYTIC_2 249 252 PF00928 0.439
TRG_ENDOCYTIC_2 25 28 PF00928 0.382
TRG_ER_diArg_1 298 301 PF00400 0.384

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I6J2 Leptomonas seymouri 59% 100%
A0A0S4J2F7 Bodo saltans 36% 100%
A0A0S4JI53 Bodo saltans 37% 100%
A0A1X0NRD6 Trypanosomatidae 42% 100%
A0A3Q8IHS3 Leishmania donovani 99% 100%
A4HM21 Leishmania braziliensis 80% 100%
C9ZJS4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 99%
E9B4F2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q3M3 Leishmania major 93% 100%
V5D3Q6 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS