Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9E4_LEIIN

TriTrypDb:

LINF_330039800

Length:

1053

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1030	1034	PF00656	0.447
CLV_C14_Caspase3-7	578	582	PF00656	0.755
CLV_MEL_PAP_1	388	394	PF00089	0.636
CLV_NRD_NRD_1	1035	1037	PF00675	0.437
CLV_NRD_NRD_1	1045	1047	PF00675	0.515
CLV_NRD_NRD_1	16	18	PF00675	0.604
CLV_NRD_NRD_1	184	186	PF00675	0.573
CLV_NRD_NRD_1	24	26	PF00675	0.671
CLV_NRD_NRD_1	3	5	PF00675	0.707
CLV_NRD_NRD_1	427	429	PF00675	0.609
CLV_NRD_NRD_1	57	59	PF00675	0.639
CLV_NRD_NRD_1	707	709	PF00675	0.357
CLV_NRD_NRD_1	855	857	PF00675	0.471
CLV_NRD_NRD_1	89	91	PF00675	0.716
CLV_NRD_NRD_1	982	984	PF00675	0.642
CLV_NRD_NRD_1	990	992	PF00675	0.452
CLV_PCSK_FUR_1	3	7	PF00082	0.660
CLV_PCSK_KEX2_1	1045	1047	PF00082	0.546
CLV_PCSK_KEX2_1	16	18	PF00082	0.604
CLV_PCSK_KEX2_1	184	186	PF00082	0.573
CLV_PCSK_KEX2_1	24	26	PF00082	0.667
CLV_PCSK_KEX2_1	3	5	PF00082	0.707
CLV_PCSK_KEX2_1	426	428	PF00082	0.568
CLV_PCSK_KEX2_1	57	59	PF00082	0.678
CLV_PCSK_KEX2_1	706	708	PF00082	0.354
CLV_PCSK_KEX2_1	876	878	PF00082	0.597
CLV_PCSK_KEX2_1	89	91	PF00082	0.693
CLV_PCSK_KEX2_1	982	984	PF00082	0.642
CLV_PCSK_KEX2_1	990	992	PF00082	0.452
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.668
CLV_PCSK_PC1ET2_1	706	708	PF00082	0.325
CLV_PCSK_PC1ET2_1	876	878	PF00082	0.597
CLV_PCSK_PC7_1	422	428	PF00082	0.460
CLV_PCSK_SKI1_1	1036	1040	PF00082	0.435
CLV_PCSK_SKI1_1	188	192	PF00082	0.661
CLV_PCSK_SKI1_1	449	453	PF00082	0.520
CLV_PCSK_SKI1_1	491	495	PF00082	0.648
CLV_PCSK_SKI1_1	608	612	PF00082	0.555
CLV_PCSK_SKI1_1	707	711	PF00082	0.359
CLV_PCSK_SKI1_1	731	735	PF00082	0.462
CLV_PCSK_SKI1_1	997	1001	PF00082	0.521
DEG_APCC_DBOX_1	1035	1043	PF00400	0.426
DEG_APCC_DBOX_1	706	714	PF00400	0.328
DEG_COP1_1	354	362	PF00400	0.589
DEG_SCF_FBW7_1	511	517	PF00400	0.660
DEG_SPOP_SBC_1	30	34	PF00917	0.628
DOC_CKS1_1	148	153	PF01111	0.576
DOC_CKS1_1	255	260	PF01111	0.654
DOC_CKS1_1	511	516	PF01111	0.659
DOC_CYCLIN_yCln2_LP_2	691	697	PF00134	0.491
DOC_MAPK_gen_1	184	191	PF00069	0.578
DOC_MAPK_gen_1	856	863	PF00069	0.514
DOC_MAPK_RevD_3	843	857	PF00069	0.394
DOC_PP1_RVXF_1	186	192	PF00149	0.657
DOC_PP2B_LxvP_1	237	240	PF13499	0.534
DOC_PP4_FxxP_1	238	241	PF00568	0.559
DOC_PP4_FxxP_1	88	91	PF00568	0.695
DOC_PP4_FxxP_1	947	950	PF00568	0.531
DOC_PP4_MxPP_1	262	265	PF00568	0.653
DOC_SPAK_OSR1_1	1046	1050	PF12202	0.460
DOC_USP7_MATH_1	1031	1035	PF00917	0.411
DOC_USP7_MATH_1	183	187	PF00917	0.572
DOC_USP7_MATH_1	206	210	PF00917	0.797
DOC_USP7_MATH_1	271	275	PF00917	0.552
DOC_USP7_MATH_1	295	299	PF00917	0.778
DOC_USP7_MATH_1	301	305	PF00917	0.733
DOC_USP7_MATH_1	461	465	PF00917	0.706
DOC_USP7_MATH_1	477	481	PF00917	0.594
DOC_USP7_MATH_1	485	489	PF00917	0.667
DOC_USP7_MATH_1	493	497	PF00917	0.610
DOC_USP7_MATH_1	541	545	PF00917	0.698
DOC_USP7_MATH_1	697	701	PF00917	0.527
DOC_USP7_MATH_1	800	804	PF00917	0.527
DOC_USP7_MATH_1	810	814	PF00917	0.429
DOC_USP7_MATH_1	897	901	PF00917	0.626
DOC_USP7_MATH_1	971	975	PF00917	0.428
DOC_WW_Pin1_4	107	112	PF00397	0.660
DOC_WW_Pin1_4	147	152	PF00397	0.577
DOC_WW_Pin1_4	207	212	PF00397	0.818
DOC_WW_Pin1_4	227	232	PF00397	0.495
DOC_WW_Pin1_4	254	259	PF00397	0.684
DOC_WW_Pin1_4	314	319	PF00397	0.649
DOC_WW_Pin1_4	334	339	PF00397	0.523
DOC_WW_Pin1_4	473	478	PF00397	0.690
DOC_WW_Pin1_4	503	508	PF00397	0.664
DOC_WW_Pin1_4	510	515	PF00397	0.613
DOC_WW_Pin1_4	537	542	PF00397	0.808
DOC_WW_Pin1_4	594	599	PF00397	0.465
LIG_14-3-3_CanoR_1	1045	1050	PF00244	0.541
LIG_14-3-3_CanoR_1	116	120	PF00244	0.609
LIG_14-3-3_CanoR_1	184	191	PF00244	0.578
LIG_14-3-3_CanoR_1	391	396	PF00244	0.668
LIG_14-3-3_CanoR_1	657	663	PF00244	0.481
LIG_14-3-3_CanoR_1	711	720	PF00244	0.424
LIG_14-3-3_CanoR_1	799	807	PF00244	0.552
LIG_14-3-3_CanoR_1	83	89	PF00244	0.673
LIG_14-3-3_CanoR_1	991	999	PF00244	0.483
LIG_Actin_WH2_2	623	638	PF00022	0.452
LIG_BRCT_BRCA1_1	234	238	PF00533	0.666
LIG_BRCT_BRCA1_1	456	460	PF00533	0.618
LIG_DLG_GKlike_1	57	64	PF00625	0.580
LIG_EH_1	178	182	PF12763	0.576
LIG_EH1_1	765	773	PF00400	0.483
LIG_eIF4E_1	232	238	PF01652	0.545
LIG_eIF4E_1	766	772	PF01652	0.470
LIG_EVH1_1	249	253	PF00568	0.677
LIG_FHA_1	354	360	PF00498	0.673
LIG_FHA_1	383	389	PF00498	0.630
LIG_FHA_1	588	594	PF00498	0.624
LIG_FHA_1	623	629	PF00498	0.561
LIG_FHA_1	806	812	PF00498	0.492
LIG_FHA_1	848	854	PF00498	0.456
LIG_FHA_1	926	932	PF00498	0.470
LIG_FHA_1	951	957	PF00498	0.480
LIG_FHA_1	998	1004	PF00498	0.514
LIG_FHA_2	576	582	PF00498	0.758
LIG_FHA_2	642	648	PF00498	0.616
LIG_FHA_2	659	665	PF00498	0.403
LIG_FHA_2	836	842	PF00498	0.465
LIG_FHA_2	960	966	PF00498	0.455
LIG_LIR_Apic_2	235	241	PF02991	0.561
LIG_LIR_Apic_2	86	91	PF02991	0.694
LIG_LIR_Apic_2	944	950	PF02991	0.528
LIG_LIR_Gen_1	304	314	PF02991	0.594
LIG_LIR_Gen_1	60	69	PF02991	0.572
LIG_LIR_Gen_1	739	746	PF02991	0.438
LIG_LIR_Nem_3	60	64	PF02991	0.576
LIG_LIR_Nem_3	739	743	PF02991	0.429
LIG_LIR_Nem_3	797	801	PF02991	0.479
LIG_NRBOX	447	453	PF00104	0.545
LIG_PCNA_yPIPBox_3	840	849	PF02747	0.484
LIG_Pex14_2	734	738	PF04695	0.447
LIG_Pex14_2	943	947	PF04695	0.524
LIG_PTB_Apo_2	727	734	PF02174	0.398
LIG_SH2_CRK	798	802	PF00017	0.494
LIG_SH2_CRK	952	956	PF00017	0.484
LIG_SH2_NCK_1	766	770	PF00017	0.424
LIG_SH2_SRC	1028	1031	PF00017	0.421
LIG_SH2_SRC	603	606	PF00017	0.470
LIG_SH2_STAP1	1028	1032	PF00017	0.441
LIG_SH2_STAP1	679	683	PF00017	0.463
LIG_SH2_STAP1	724	728	PF00017	0.579
LIG_SH2_STAP1	952	956	PF00017	0.472
LIG_SH2_STAT3	724	727	PF00017	0.497
LIG_SH2_STAT5	232	235	PF00017	0.646
LIG_SH2_STAT5	254	257	PF00017	0.628
LIG_SH2_STAT5	268	271	PF00017	0.577
LIG_SH2_STAT5	952	955	PF00017	0.475
LIG_SH3_1	247	253	PF00018	0.629
LIG_SH3_2	126	131	PF14604	0.604
LIG_SH3_3	1010	1016	PF00018	0.505
LIG_SH3_3	106	112	PF00018	0.716
LIG_SH3_3	123	129	PF00018	0.586
LIG_SH3_3	145	151	PF00018	0.637
LIG_SH3_3	194	200	PF00018	0.607
LIG_SH3_3	205	211	PF00018	0.650
LIG_SH3_3	225	231	PF00018	0.553
LIG_SH3_3	233	239	PF00018	0.617
LIG_SH3_3	247	253	PF00018	0.578
LIG_SH3_3	273	279	PF00018	0.620
LIG_SH3_3	312	318	PF00018	0.692
LIG_SH3_3	340	346	PF00018	0.693
LIG_SH3_3	467	473	PF00018	0.604
LIG_SH3_3	489	495	PF00018	0.664
LIG_SH3_3	508	514	PF00018	0.711
LIG_SH3_3	517	523	PF00018	0.617
LIG_SH3_3	577	583	PF00018	0.709
LIG_SH3_4	134	141	PF00018	0.598
LIG_SUMO_SIM_anti_2	767	775	PF11976	0.444
LIG_SUMO_SIM_par_1	682	688	PF11976	0.450
LIG_SUMO_SIM_par_1	952	958	PF11976	0.470
LIG_TRAF2_1	196	199	PF00917	0.665
LIG_TRAF2_1	522	525	PF00917	0.697
LIG_TRAF2_1	862	865	PF00917	0.546
LIG_TYR_ITIM	796	801	PF00017	0.477
LIG_UBA3_1	955	963	PF00899	0.453
LIG_WRC_WIRS_1	345	350	PF05994	0.675
LIG_WRC_WIRS_1	392	397	PF05994	0.699
LIG_WW_2	250	253	PF00397	0.673
MOD_CDC14_SPxK_1	506	509	PF00782	0.614
MOD_CDK_SPK_2	473	478	PF00069	0.649
MOD_CDK_SPxK_1	503	509	PF00069	0.610
MOD_CK1_1	105	111	PF00069	0.628
MOD_CK1_1	118	124	PF00069	0.558
MOD_CK1_1	159	165	PF00069	0.706
MOD_CK1_1	218	224	PF00069	0.640
MOD_CK1_1	29	35	PF00069	0.631
MOD_CK1_1	36	42	PF00069	0.594
MOD_CK1_1	476	482	PF00069	0.684
MOD_CK1_1	483	489	PF00069	0.729
MOD_CK1_1	510	516	PF00069	0.775
MOD_CK1_1	534	540	PF00069	0.716
MOD_CK1_1	544	550	PF00069	0.791
MOD_CK1_1	682	688	PF00069	0.489
MOD_CK1_1	722	728	PF00069	0.666
MOD_CK1_1	805	811	PF00069	0.488
MOD_CK1_1	84	90	PF00069	0.749
MOD_CK1_1	905	911	PF00069	0.586
MOD_CK1_1	920	926	PF00069	0.366
MOD_CK1_1	966	972	PF00069	0.515
MOD_CK1_1	974	980	PF00069	0.555
MOD_CK2_1	483	489	PF00069	0.671
MOD_CK2_1	641	647	PF00069	0.626
MOD_CK2_1	658	664	PF00069	0.408
MOD_CK2_1	800	806	PF00069	0.506
MOD_CK2_1	835	841	PF00069	0.578
MOD_CK2_1	859	865	PF00069	0.556
MOD_CK2_1	883	889	PF00069	0.657
MOD_CK2_1	938	944	PF00069	0.376
MOD_CK2_1	959	965	PF00069	0.504
MOD_Cter_Amidation	1	4	PF01082	0.707
MOD_Cter_Amidation	22	25	PF01082	0.640
MOD_GlcNHglycan	1008	1011	PF01048	0.558
MOD_GlcNHglycan	1013	1016	PF01048	0.484
MOD_GlcNHglycan	104	107	PF01048	0.735
MOD_GlcNHglycan	1049	1052	PF01048	0.609
MOD_GlcNHglycan	144	147	PF01048	0.699
MOD_GlcNHglycan	160	164	PF01048	0.697
MOD_GlcNHglycan	167	170	PF01048	0.697
MOD_GlcNHglycan	175	179	PF01048	0.573
MOD_GlcNHglycan	28	31	PF01048	0.700
MOD_GlcNHglycan	485	488	PF01048	0.672
MOD_GlcNHglycan	557	560	PF01048	0.820
MOD_GlcNHglycan	570	573	PF01048	0.719
MOD_GlcNHglycan	679	682	PF01048	0.514
MOD_GlcNHglycan	699	702	PF01048	0.326
MOD_GlcNHglycan	746	749	PF01048	0.516
MOD_GlcNHglycan	812	815	PF01048	0.487
MOD_GlcNHglycan	83	86	PF01048	0.709
MOD_GlcNHglycan	904	907	PF01048	0.659
MOD_GlcNHglycan	944	947	PF01048	0.454
MOD_GlcNHglycan	965	968	PF01048	0.528
MOD_GlcNHglycan	973	976	PF01048	0.429
MOD_GlcNHglycan	987	990	PF01048	0.391
MOD_GSK3_1	1045	1052	PF00069	0.578
MOD_GSK3_1	149	156	PF00069	0.689
MOD_GSK3_1	214	221	PF00069	0.685
MOD_GSK3_1	26	33	PF00069	0.750
MOD_GSK3_1	334	341	PF00069	0.770
MOD_GSK3_1	354	361	PF00069	0.559
MOD_GSK3_1	473	480	PF00069	0.753
MOD_GSK3_1	483	490	PF00069	0.690
MOD_GSK3_1	503	510	PF00069	0.777
MOD_GSK3_1	53	60	PF00069	0.628
MOD_GSK3_1	537	544	PF00069	0.692
MOD_GSK3_1	547	554	PF00069	0.670
MOD_GSK3_1	658	665	PF00069	0.493
MOD_GSK3_1	71	78	PF00069	0.615
MOD_GSK3_1	754	761	PF00069	0.699
MOD_GSK3_1	79	86	PF00069	0.629
MOD_GSK3_1	847	854	PF00069	0.455
MOD_GSK3_1	878	885	PF00069	0.613
MOD_GSK3_1	913	920	PF00069	0.467
MOD_GSK3_1	934	941	PF00069	0.476
MOD_GSK3_1	955	962	PF00069	0.453
MOD_GSK3_1	993	1000	PF00069	0.510
MOD_N-GLC_1	215	220	PF02516	0.634
MOD_N-GLC_1	36	41	PF02516	0.652
MOD_N-GLC_1	483	488	PF02516	0.651
MOD_N-GLC_1	744	749	PF02516	0.407
MOD_N-GLC_1	79	84	PF02516	0.676
MOD_N-GLC_1	985	990	PF02516	0.562
MOD_NEK2_1	1047	1052	PF00069	0.600
MOD_NEK2_1	551	556	PF00069	0.654
MOD_NEK2_1	630	635	PF00069	0.515
MOD_NEK2_1	662	667	PF00069	0.460
MOD_NEK2_1	720	725	PF00069	0.463
MOD_NEK2_1	942	947	PF00069	0.503
MOD_NEK2_1	985	990	PF00069	0.562
MOD_NEK2_1	992	997	PF00069	0.433
MOD_NEK2_2	1031	1036	PF00069	0.417
MOD_PIKK_1	110	116	PF00454	0.691
MOD_PIKK_1	118	124	PF00454	0.624
MOD_PIKK_1	218	224	PF00454	0.733
MOD_PIKK_1	301	307	PF00454	0.641
MOD_PIKK_1	382	388	PF00454	0.692
MOD_PIKK_1	541	547	PF00454	0.592
MOD_PIKK_1	587	593	PF00454	0.636
MOD_PIKK_1	685	691	PF00454	0.357
MOD_PIKK_1	759	765	PF00454	0.570
MOD_PIKK_1	89	95	PF00454	0.729
MOD_PIKK_1	917	923	PF00454	0.398
MOD_PIKK_1	969	975	PF00454	0.516
MOD_PK_1	1045	1051	PF00069	0.524
MOD_PK_1	384	390	PF00069	0.682
MOD_PKA_1	1005	1011	PF00069	0.397
MOD_PKA_1	1045	1051	PF00069	0.524
MOD_PKA_1	184	190	PF00069	0.575
MOD_PKA_1	24	30	PF00069	0.631
MOD_PKA_1	57	63	PF00069	0.631
MOD_PKA_1	89	95	PF00069	0.633
MOD_PKA_2	1045	1051	PF00069	0.549
MOD_PKA_2	115	121	PF00069	0.654
MOD_PKA_2	183	189	PF00069	0.572
MOD_PKA_2	214	220	PF00069	0.650
MOD_PKA_2	24	30	PF00069	0.796
MOD_PKA_2	390	396	PF00069	0.662
MOD_PKA_2	547	553	PF00069	0.676
MOD_PKA_2	57	63	PF00069	0.638
MOD_PKA_2	71	77	PF00069	0.586
MOD_PKA_2	89	95	PF00069	0.607
MOD_PKA_2	993	999	PF00069	0.460
MOD_Plk_1	39	45	PF00069	0.750
MOD_Plk_1	621	627	PF00069	0.468
MOD_Plk_4	338	344	PF00069	0.752
MOD_Plk_4	354	360	PF00069	0.599
MOD_Plk_4	384	390	PF00069	0.798
MOD_Plk_4	596	602	PF00069	0.430
MOD_Plk_4	658	664	PF00069	0.486
MOD_Plk_4	679	685	PF00069	0.457
MOD_Plk_4	841	847	PF00069	0.489
MOD_Plk_4	938	944	PF00069	0.474
MOD_Plk_4	950	956	PF00069	0.392
MOD_ProDKin_1	107	113	PF00069	0.660
MOD_ProDKin_1	147	153	PF00069	0.579
MOD_ProDKin_1	207	213	PF00069	0.819
MOD_ProDKin_1	227	233	PF00069	0.496
MOD_ProDKin_1	254	260	PF00069	0.675
MOD_ProDKin_1	314	320	PF00069	0.650
MOD_ProDKin_1	334	340	PF00069	0.523
MOD_ProDKin_1	473	479	PF00069	0.690
MOD_ProDKin_1	503	509	PF00069	0.668
MOD_ProDKin_1	510	516	PF00069	0.615
MOD_ProDKin_1	537	543	PF00069	0.806
MOD_ProDKin_1	594	600	PF00069	0.452
MOD_SUMO_rev_2	639	644	PF00179	0.408
MOD_SUMO_rev_2	747	757	PF00179	0.493
TRG_DiLeu_BaEn_1	767	772	PF01217	0.415
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.630
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.584
TRG_DiLeu_BaLyEn_6	663	668	PF01217	0.418
TRG_DiLeu_BaLyEn_6	705	710	PF01217	0.392
TRG_DiLeu_BaLyEn_6	988	993	PF01217	0.475
TRG_ENDOCYTIC_2	306	309	PF00928	0.599
TRG_ENDOCYTIC_2	345	348	PF00928	0.625
TRG_ENDOCYTIC_2	766	769	PF00928	0.480
TRG_ENDOCYTIC_2	798	801	PF00928	0.479
TRG_ENDOCYTIC_2	952	955	PF00928	0.487
TRG_ER_diArg_1	1045	1047	PF00400	0.541
TRG_ER_diArg_1	15	17	PF00400	0.595
TRG_ER_diArg_1	3	6	PF00400	0.659
TRG_ER_diArg_1	426	428	PF00400	0.639
TRG_ER_diArg_1	707	709	PF00400	0.360
TRG_ER_diArg_1	88	90	PF00400	0.703
TRG_ER_diArg_1	982	984	PF00400	0.642
TRG_ER_diArg_1	990	992	PF00400	0.452
TRG_NLS_MonoExtN_4	3	8	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	799	804	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF45	Leishmania donovani	99%	100%
A4HM10	Leishmania braziliensis	58%	100%
E9B4E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q3N6	Leishmania major	88%	100%