Mediator of RNA polymerase II transcription subunit 15

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I9E1_LEIIN

TriTrypDb:

LINF_330039700

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I9E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I9E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.603
CLV_NRD_NRD_1	239	241	PF00675	0.684
CLV_NRD_NRD_1	299	301	PF00675	0.621
CLV_NRD_NRD_1	305	307	PF00675	0.601
CLV_PCSK_KEX2_1	293	295	PF00082	0.654
CLV_PCSK_KEX2_1	299	301	PF00082	0.600
CLV_PCSK_KEX2_1	305	307	PF00082	0.569
CLV_PCSK_KEX2_1	319	321	PF00082	0.459
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.678
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.610
DEG_Nend_UBRbox_3	1	3	PF02207	0.703
DOC_CYCLIN_RxL_1	194	205	PF00134	0.405
DOC_USP7_MATH_1	133	137	PF00917	0.686
DOC_USP7_MATH_1	224	228	PF00917	0.577
DOC_USP7_MATH_1	275	279	PF00917	0.549
DOC_USP7_MATH_1	30	34	PF00917	0.712
LIG_14-3-3_CanoR_1	294	299	PF00244	0.680
LIG_14-3-3_CanoR_1	300	305	PF00244	0.722
LIG_BRCT_BRCA1_1	144	148	PF00533	0.453
LIG_EVH1_1	173	177	PF00568	0.452
LIG_FHA_1	283	289	PF00498	0.667
LIG_FHA_1	41	47	PF00498	0.528
LIG_LIR_Nem_3	145	151	PF02991	0.506
LIG_LIR_Nem_3	205	210	PF02991	0.419
LIG_LIR_Nem_3	212	217	PF02991	0.439
LIG_LYPXL_yS_3	203	206	PF13949	0.418
LIG_Pex14_2	148	152	PF04695	0.539
LIG_RPA_C_Fungi	23	35	PF08784	0.645
LIG_SH2_CRK	196	200	PF00017	0.390
LIG_SH2_CRK	266	270	PF00017	0.644
LIG_SH2_SRC	266	269	PF00017	0.597
LIG_SH2_STAT3	100	103	PF00017	0.571
LIG_SH2_STAT3	188	191	PF00017	0.433
LIG_SH2_STAT3	8	11	PF00017	0.630
LIG_SH2_STAT5	210	213	PF00017	0.539
LIG_SH2_STAT5	214	217	PF00017	0.486
LIG_SH3_1	171	177	PF00018	0.452
LIG_SH3_1	256	262	PF00018	0.622
LIG_SH3_3	171	177	PF00018	0.473
LIG_SH3_3	256	262	PF00018	0.666
LIG_SH3_3	265	271	PF00018	0.613
LIG_TRFH_1	36	40	PF08558	0.578
LIG_TYR_ITIM	193	198	PF00017	0.446
LIG_TYR_ITIM	201	206	PF00017	0.369
LIG_WW_1	185	188	PF00397	0.452
MOD_CK1_1	227	233	PF00069	0.633
MOD_CK1_1	286	292	PF00069	0.623
MOD_GlcNHglycan	135	138	PF01048	0.723
MOD_GlcNHglycan	153	156	PF01048	0.416
MOD_GlcNHglycan	288	291	PF01048	0.665
MOD_GSK3_1	105	112	PF00069	0.743
MOD_GSK3_1	138	145	PF00069	0.598
MOD_GSK3_1	282	289	PF00069	0.619
MOD_N-GLC_1	286	291	PF02516	0.608
MOD_NEK2_1	105	110	PF00069	0.535
MOD_NEK2_1	246	251	PF00069	0.590
MOD_NEK2_1	281	286	PF00069	0.591
MOD_PIKK_1	246	252	PF00454	0.696
MOD_PIKK_1	99	105	PF00454	0.650
MOD_PKA_1	293	299	PF00069	0.675
MOD_PKA_2	282	288	PF00069	0.665
MOD_PKA_2	293	299	PF00069	0.546
MOD_PKA_2	49	55	PF00069	0.561
MOD_SUMO_for_1	312	315	PF00179	0.587
MOD_SUMO_rev_2	163	173	PF00179	0.583
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.506
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.576
TRG_ENDOCYTIC_2	195	198	PF00928	0.461
TRG_ENDOCYTIC_2	203	206	PF00928	0.418
TRG_ENDOCYTIC_2	213	216	PF00928	0.434
TRG_ENDOCYTIC_2	218	221	PF00928	0.461
TRG_ER_diArg_1	298	300	PF00400	0.623
TRG_ER_diArg_1	304	306	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I737	Leptomonas seymouri	43%	95%
A0A3Q8IHR4	Leishmania donovani	96%	98%
A4HM09	Leishmania braziliensis	62%	99%
E9B4E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q3N7	Leishmania major	80%	100%